Determination of procalcitonin levels in patients with nephropathia epidemica - a useful tool or an unnecessary diagnostic procedure?

Abstract:

BACKGROUND/AIMS:Puumala virus causes nephropathia epidemica (NE), a milder form of hemorrhagic fever with renal syndrome that occurs in Central and Northern Europe. Several studies have sought to identify risk factors for severe NE. However, elevated procalcitonin (PCT) levels have not previously been investigated as a predictive marker for a severe course of NE. METHODS:A cross-sectional prospective survey of 456 adults with serologically confirmed NE was performed. RESULTS:PCT levels at the time of diagnosis were available for 43 out of 456 patients, and in 24 of these patients (56%) PCT levels were elevated ("PCT positive"). C-reactive protein (CRP) levels at admission to hospital and peak CRP levels during the acute course of the disease were higher in the PCT-positive compared with the PCT-negative group (p<0.05). Severe acute kidney injury (AKI) (RIFLE I and F) was present in similar numbers of PCT-positive and -negative patients (p=0.7), but antibiotics were more frequently used in the PCT-positive than the PCT-negative group (p<0.05). Within the PCT-positive group, PCT levels were similar among those receiving and not receiving antibiotics (p=0.13), and neither the duration of hospital stay nor CRP peak levels were lower in those treated with antibiotics (p=0.12 and p=0.13, respectively). CONCLUSIONS:Elevated PCT levels are common in patients with acute NE. There was no association between PCT levels and severity of disease, including AKI or thrombocytopenia. It is important to distinguish Puumala virus infection from other causes of AKI with thrombocytopenia. However, PCT might not be useful in differentiating hantavirus infection from bacterial infection.

journal_name

Kidney Blood Press Res

authors

Latus J,Kitterer D,Segerer S,Artunc F,Alscher MD,Braun N

doi

10.1159/000368479

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

22-30

issue

1

eissn

1420-4096

issn

1423-0143

pii

000368479

journal_volume

40

pub_type

杂志文章
  • Urinary calcium excretion and renal calbindin-D28k.

    abstract::The present investigation examined the possible influence of urinary calcium excretion on the concentration of renal calbindin-D28k. Thiazide diuretics stimulate calcium transport across the epithelial cells of the distal tubule, which express calbindin-D28k in high concentrations. Calbindin-D28k is assumed to facilit...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000174153

    authors: Hemmingsen C,Staun M,Meibom K,Bang K,Olgaard K

    更新日期:1997-01-01 00:00:00

  • The adrenal glands as suppliers of plasma L-Dopa and sources of urinary dopamine.

    abstract::Dopamine (DA) is a natriuretic hormone synthesized in the kidneys by conversion of filtered 3,4-dihydroxyphenylalanine (L-Dopa), and is activated during hypervolaemia and increased dietary sodium intake. The natriuretic activity of endogenous DA is controversial, however, and the regulation of renal DA synthesis has y...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000174052

    authors: Hansell P,Källskog O,Wolgast M

    更新日期:1996-01-01 00:00:00

  • Association Between Risk Factors Including Bone-Derived Biomarkers and Aortic Arch Calcification in Maintenance Hemodialysis Patients.

    abstract:BACKGROUND/AIMS:Aortic arch calcification (AoAC) is frequently detected in maintenance hemodialysis (MHD) patients and is associated with cardiovascular and all-cause mortality. We investigated the factors associated with AoAC and analyzed the relationship between the factors including bone-derived biomarkers and AoAC....

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000494441

    authors: Nitta K,Hanafusa N,Okazaki M,Komatsu M,Kawaguchi H,Tsuchiya K

    更新日期:2018-01-01 00:00:00

  • Angiotensinogen polymorphisms and post-transplantation diabetes mellitus in Korean renal transplant subjects.

    abstract:BACKGROUND:Post-transplant diabetes mellitus (PTDM) is a common and serious metabolic complication. Genetic polymorphisms of angiotensin-converting enzyme (ACE) and angiotensinogen (AGT) genes have been reported to be related to diabetes mellitus and insulin sensitivity; however, the role of these genes in the developm...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000343404

    authors: Lee Sr,Moon JY,Lee SH,Ihm CG,Lee TW,Kim SK,Chung JH,Kang SW,Kim TH,Park SJ,Kim YH,Jeong KH

    更新日期:2013-01-01 00:00:00

  • Association Between GLCCI1 Promoter Polymorphism (Rs37972) and Post-Transplant Hypertension in Renal Transplant Recipients.

    abstract:BACKGROUND/AIMS:Post-transplant hypertension is highly prevalent in renal transplant recipients and is a risk factor for graft loss, cardiovascular disease and death. Glucocorticoid is used to prevent rejection, but simultaneously increases the risk of post-transplant hypertension. The glucocorticoid-induced transcript...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000485862

    authors: Hamada AM,Yamamoto I,Nakada Y,Kobayashi A,Koike Y,Miki J,Yamada H,Tanno Y,Ohkido I,Tsuboi N,Yamamoto H,Urashima M,Yokoo T

    更新日期:2017-01-01 00:00:00

  • Angiotensin II in the failing heart. Short communication.

    abstract::In the failing heart, the local angiotensin II concentration is increased, and the extent of cardiac angiotensin II release is related to the clinical signs of heart failure. The enzymes involved in myocardial generation of angiotensin II are the angiotensin-converting enzyme (ACE) and chymases. While myocardial angio...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章,评审

    doi:10.1159/000090189

    authors: Schulz R,Heusch G

    更新日期:2005-01-01 00:00:00

  • Detecting Proteomic Indicators to Distinguish Diabetic Nephropathy from Hypertensive Nephrosclerosis by Integrating Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging with High-Mass Accuracy Mass Spectrometry.

    abstract:INTRODUCTION:Diabetic nephropathy (DN) and hypertensive nephrosclerosis (HN) represent the most common causes of chronic kidney disease (CKD) and many patients progress to -end-stage renal disease. Patients are treated primarily through the management of cardiovas-cular risk factors and hypertension; however patients w...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000505187

    authors: Smith A,Iablokov V,Mazza M,Guarnerio S,Denti V,Ivanova M,Stella M,Piga I,Chinello C,Heijs B,van Veelen PA,Benediktsson H,Muruve DA,Magni F

    更新日期:2020-01-01 00:00:00

  • Relation between serum thyroid hormone and 'nondipper' circadian blood pressure variability.

    abstract::Currently, the pathogenesis of nondipper hypertension remains largely unclear in patients without any renal or endocrine pathology. It is well known that overt hypothyroidism is strongly associated with diastolic hypertension. However, no study has addressed the pathogenic role of TSH, free T3 (FT3), and free T4 (FT4)...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000110082

    authors: Kanbay M,Turgut F,Karakurt F,Isik B,Alkan R,Akcay A,Yigitoglu R,Covic A

    更新日期:2007-01-01 00:00:00

  • Loss of the Protein Cystathionine β-Synthase During Kidney Injury Promotes Renal Tubulointerstitial Fibrosis.

    abstract:BACKGROUND/AIMS:Renal tubulointerstitial fibrosis (TIF) is the common pathway of progressive chronic kidney disease. Inflammation has been widely accepted as the major driving force of TIF. Cystathionine β-synthase (CBS) is the first and rate-limiting enzyme in the transsulfuration pathway. CBS is considered to play pr...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000479295

    authors: Yuan X,Zhang J,Xie F,Tan W,Wang S,Huang L,Tao L,Xing Q,Yuan Q

    更新日期:2017-01-01 00:00:00

  • Prevalence, awareness, treatment and control of hypertension in adults with chronic kidney disease in Turkey: results from the CREDIT study.

    abstract:BACKGROUND:In the Chronic REnal Disease in Turkey-CREDIT Study, a large populationbased study on 10,748 adults, the prevalence of chronic kidney disease (CKD) and relationship between CKD and other cardiovascular risk factors had been studied. METHODS:This report presents the results of CREDIT study on the prevalence,...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000339025

    authors: Altun B,Süleymanlar G,Utaş C,Arınsoy T,Ateş K,Ecder T,Camsarı T,Serdengeçti K

    更新日期:2012-01-01 00:00:00

  • Efficacy and tolerability of angiotensin II type 1 receptor antagonists in dialysis patients using AN69 dialysis membranes.

    abstract:AIMS AND METHODS:Our aim was to evaluate the antihypertensive efficacy and tolerability of angiotensin II type 1 (AT1) receptor antagonists. Valsartan or candesartan cilexetil was administered to 11 dialysis patients with elevated blood pressure. The patients (6 male, 5 female; mean age +/- SD 61+/-11 years) were on re...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000054209

    authors: Tepel M,van der Giet M,Zidek W

    更新日期:2001-01-01 00:00:00

  • A program of physical rehabilitation during hemodialysis sessions improves the fitness of dialysis patients.

    abstract:AIM:The aim of the present study was to evaluate the influence of cycle exercise during hemodialysis (HD) on patients' physical proficiency, muscle strength, quality of life and selected laboratory parameters. PATIENTS AND METHODS:In a group of 29 (15 female, 14 male) HD patients (age 64.2 ± 13.1 years), 3 months of c...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000335411

    authors: Gołębiowski T,Kusztal M,Weyde W,Dziubek W,Woźniewski M,Madziarska K,Krajewska M,Letachowicz K,Strempska B,Klinger M

    更新日期:2012-01-01 00:00:00

  • Characterization of glucose uptake by cultured rat podocytes.

    abstract::The nonmetabolizable glucose analogue [(3)H]-2-deoxy-D-glucose ((3)H-2DG) was used to study glucose transport in cultured rat podocytes. Intracellular accumulation of (3)H-2DG was linear up to 20 min and was inhibited by cytochalasin B (80% inhibition) and by phlorizin (20% inhibition). Pretreatment with insulin stimu...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000080889

    authors: Lewko B,Bryl E,Witkowski JM,Latawiec E,Gołos M,Endlich N,Hähnel B,Koksch C,Angielski S,Kriz W,Stepinski J

    更新日期:2005-01-01 00:00:00

  • How to calculate clearance of highly protein-bound drugs during continuous venovenous hemofiltration demonstrated with flucloxacillin.

    abstract:BACKGROUND:Flucloxacillin is an important antimicrobial drug in the treatment of infections with Staphylococcus aureus and therefore is often used in staphylococcal infections. Furthermore, flucloxacillin has a high protein binding rate as for example ceftriaxone or teicoplanin--drugs which have formerly been character...

    journal_title:Kidney & blood pressure research

    pub_type: 临床试验,杂志文章

    doi:10.1159/000070997

    authors: Meyer B,Ahmed el Gendy S,Delle Karth G,Locker GJ,Heinz G,Jaeger W,Thalhammer F

    更新日期:2003-01-01 00:00:00

  • Urinary Metabolic Profile of Patients with Transfusion-Dependent β-Thalassemia Major Undergoing Deferasirox Therapy.

    abstract:INTRODUCTION:Renal dysfunction is a frequent complication in patients suffering from β-thalassemia major (β-TM). The aim of this study was to analyze the renal function and urine metabolomic profile of β-TM patients undergoing transfusions and deferasirox (DFX) therapy, in order to better characterize and shed light on...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000507369

    authors: Capolongo G,Zacchia M,Beneduci A,Costantini S,Cinque P,Spasiano A,De Luca G,Di Pietro ME,Ricchi P,Trepiccione F,Capasso G,Filosa A

    更新日期:2020-01-01 00:00:00

  • Causes and consequences of increased arterial stiffness in chronic kidney disease patients.

    abstract::Cardiovascular (CV) morbidity and mortality is greatly enhanced in patients with chronic kidney disease, compared to the non-renal population. One key element of this high CV burden appears to be arterial stiffness, as an expression of premature vascular aging. Increased arterial stiffness in renal patients may be a c...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章,评审

    doi:10.1159/000100905

    authors: Gusbeth-Tatomir P,Covic A

    更新日期:2007-01-01 00:00:00

  • Protein kinase C beta isoenzymes in diabetic kidneys and their relation to nephroprotective actions of the ACE inhibitor lisinopril.

    abstract::Inhibitors of angiotensin-converting enzyme (ACE) or beta isoforms of protein kinase C (PKC) are nephroprotective in diabetes mellitus. We investigated the influence of streptozotocin (STZ)-induced diabetes mellitus and of treatment with the ACE inhibitor lisinopril (4 mg/kg p.o. twice daily for 4 weeks) on the expres...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000066789

    authors: Pfaff IL,Vallon V

    更新日期:2002-01-01 00:00:00

  • Interleukin-18 in urine and serum of children with idiopathic nephrotic syndrome.

    abstract:BACKGROUND/AIMS:Interleukin (IL)-18, a member of the IL-1 cytokine superfamily, is recognized as an important regulator of immune responses. The aim of our study was to investigate the IL-18 levels in serum and urine from children with idiopathic nephrotic syndrome (INS) during relapse and remission, and to evaluate th...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000124284

    authors: Kiliś-Pstrusińska K,Medyńska A,Zwolińska D,Wawro A

    更新日期:2008-01-01 00:00:00

  • Diagnostic and prognostic utility of neutrophil gelatinase-associated lipocalin (NGAL) in patients with cardiovascular diseases--review.

    abstract::NGAL (neutrophil gelatinase-associated lipocalin) is an acute phase protein, participating in antibacterial immunity. NGAL forms a complex with metalloproteinase 9 (MMP-9), thereby increasing its activity and preventing its degradation. NGAL is freely filtered through the glomerular membrane and reabsorbed by endocyto...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章,评审

    doi:10.1159/000368474

    authors: Helanova K,Spinar J,Parenica J

    更新日期:2014-01-01 00:00:00

  • Effects of pravastatin on superoxide and fibronectin production of mesangial cells induced by low-density lipoprotein.

    abstract::Pravastatin is a potent inhibitor of HMG-CoA reductase and is effective in lowering serum lipid levels. Recent studies have shown that pravastatin also reduces the oxidative modification of low-density lipoprotein (LDL). To determine whether pravastatin has a direct effect on glomerular mesangial cells, we have measur...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000049428

    authors: Chen HC,Guh JY,Shin SJ,Tomino Y,Lai YH

    更新日期:2002-01-01 00:00:00

  • Common Variants in Serum/Glucocorticoid Regulated Kinase 1 (SGK1) and Blood Pressure Responses to Dietary Sodium or Potassium Interventions: A family-Based Association Study.

    abstract:BACKGROUND/AIMS:Serum/Glucocorticoid Regulated Kinase 1 (SGK1) plays a significant role in regulating renal Na(+) reabsorption, K(+) secretion, and blood pressure (BP). This study aimed to assess the association of common genetic variants in the SGK1 gene with BP responses to controlled dietary sodium or potassium inte...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000368518

    authors: Chu C,Wang Y,Wang M,Mu JJ,Liu FQ,Wang L,Ren KY,Wang D,Yuan ZY

    更新日期:2015-01-01 00:00:00

  • Gender-related determinants of advanced subclinical atherosclerosis in patients undergoing kidney transplantation.

    abstract:BACKGROUND:Cardiovascular disease caused by atherosclerosis remains a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). We evaluated the potential association of cardiovascular risk factors including asymmetric dimethyl L-arginine (ADMA) and the soluble receptor for advanced glycat...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000316709

    authors: Pitha J,Teplan V,Kalousova M,Racek J,Stollova M,Marečková O,Lanska V

    更新日期:2010-01-01 00:00:00

  • Mitochondrial Dysfunction and Altered Renal Metabolism in Dahl Salt-Sensitive Rats.

    abstract:BACKGROUND/AIMS:The kidney plays a critical role in the control of blood pressure and its elevation in salt-induced hypertension. Mitochondrial dysfunction, especially in energy metabolism, has been associated with hypertension. Here, we aimed to investigate mitochondrial function and metabolic features in renal mitoch...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000479846

    authors: Wang Z,Sun Q,Sun N,Liang M,Tian Z

    更新日期:2017-01-01 00:00:00

  • Molecular mechanisms in the regulation of renal proximal tubular Na/phosphate cotransport.

    abstract::Renal proximal tubular Na/phosphate cotransport is the key target in the control of renal phosphate handling. Using molecular tools for the type II Na/phosphate cotransporter, it could be documented that altered brush border membrane phosphate transport reflects a state of altered brush border expression of the specif...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章,评审

    doi:10.1159/000174063

    authors: Murer H,Lötscher M,Kaissling B,Biber J

    更新日期:1996-01-01 00:00:00

  • The ovaries attenuate the aggravating effect of testosterone on glomerular injury in Adriamycin-induced nephropathy of female rats.

    abstract::To clarify whether the ovaries have a potential to attenuate the aggravating effect of testosterone (T) on glomerular injury, we investigated the effect of T in female rats with or without ovaries, using Adriamycin (ADR)-induced nephropathy in female Sprague-Dawley rats. Group 1 consisted of female control rats, group...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000174110

    authors: Sakemi T,Ohtsuka N,Tomiyoshi Y,Morito F

    更新日期:1997-01-01 00:00:00

  • Effects of spironolactone in combination with angiotensin-converting enzyme inhibitors or Angiotensin receptor blockers in patients with proteinuria.

    abstract:BACKGROUND/AIMS:This study aimed to investigate the potential beneficial anti-proteinuric effect of an add-on aldosterone blockade and the impact of the aldosterone escape phenomenon. METHODS:We retrospectively analyzed data of 304 patients with persistent proteinuria, who were administered spironolactone (25 mg/day) ...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000368470

    authors: Kim HY,Bae EH,Ma SK,Kim SW

    更新日期:2014-01-01 00:00:00

  • Intestinal Na+ loss and volume depletion in JAK3-deficient mice.

    abstract:BACKGROUND/AIMS:The Janus kinase 3 JAK3 participates in the signaling of immune cells. Lack of JAK3 triggers inflammatory bowel disease, which in turn has been shown to affect intestinal activity of the epithelial Na(+) channel ENaC and thus colonic sodium absorption. At least in theory, inflammatory bowel disease in J...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000355731

    authors: Umbach AT,Luo D,Bhavsar SK,Hosseinzadeh Z,Lang F

    更新日期:2013-01-01 00:00:00

  • Role of kinins in the renoprotective effect of angiotensin-converting enzyme inhibitors in experimental chronic renal failure.

    abstract::The aim of this study was to investigate whether the renoprotective effect of angiotensin-converting enzyme inhibitors (ACEIs) following 5/6 renal mass reduction is due in part to the potentiation of kinins. Three groups of rats with 5/6 renal mass reduction were studied during the 14 weeks following surgery. One grou...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000025890

    authors: MacLaughlin M,Monserrat AJ,Muller A,Matoso M,Amorena C

    更新日期:1998-01-01 00:00:00

  • Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in patients with chronic heart failure and coronary artery disease.

    abstract::Heart failure and chronic kidney disease share a number of risk factors and pathophysiological pathways. Renal insufficiency is common in patients with chronic heart failure (CHF). The aim of the study was to assess whether neutrophil gelatinase-associated lipocalin (NGAL) could represent a novel, sensitive marker of ...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000208989

    authors: Poniatowski B,Malyszko J,Bachorzewska-Gajewska H,Malyszko JS,Dobrzycki S

    更新日期:2009-01-01 00:00:00

  • Fatty acid-bearing albumin induces VCAM-1 expression through c-Src kinase-AP-1/NF-kB pathways: effect of L-carnitine.

    abstract:BACKGROUND:Fatty acid-bearing albumin [FA(+) albumin] exerts more deleterious effects in tubular cells than albumin alone. We investigated the effect of FA(+) albumin on the vascular cell adhesion molecule-1 (VCAM-1) expression and elucidated the underlying signaling pathways. We further examined the effect of L-carnit...

    journal_title:Kidney & blood pressure research

    pub_type: 杂志文章

    doi:10.1159/000289576

    authors: Baek JE,Yang WS,Chang JW,Kim SB,Park SK,Park JS,Lee SK

    更新日期:2010-01-01 00:00:00