Abstract:
BACKGROUND/AIMS:Cardiorenal syndrome type 1 (CRS1) is a syndrome characterized by a rapid worsening of cardiac function leading to acute kidney injury (AKI). The aims of this study were to investigate the risk factors and the prognosis of CRS1 in elderly patients. METHODS:A total of 312 elderly patients (≥60 years old) with acute heart failure (AHF) were studied. They were assigned as CRS1 (suffered from in-hospital AKI) or NCRS1 (without AKI) group. Clinical and laboratory data were recorded. Univariate and multivariate analysis were performed to clarify the risk factors for occurrence and mortality of CRS1 in this cohort. RESULTS:Incidence of CRS1 was 52.56%. Basic estimated glomerular filtration (eGFR <60 ml/(min.1.73m2) and use of diuretics were associated with the higher risk of CRS1 in elderly patients (OR=2.239, P=0.025; OR=2.555, P=0.001; respectively). Whereas higher concentration of serum albumin was protective factor for them (OR=0.907, P=0.007). The in-hospital mortality of CRS1 was 23.2%. Dialysis, use of beta blockers or diuretics were associated with all-cause death of CRS1 patients (OR=10.407, P<0.001; OR=0.312, P=0.011; OR=0.345, P=0.040; respectively). The in-hospital mortality of AHF patients was 13.1%. Higher Charlson comorbidity index, occurrence of CRS1 and dialysis were risk factors for in-hospital mortality of AHF patients (OR=4.723, P=0.041; OR=6.096, P=0.008; OR=18.743, P<0.001; respectively). CONCLUSIONS:Incidence of CRS1 in elderly patients is relatively high and associated with poor outcome. Reduced basic eGFR, lower serum albumin and use of diuretics are risk factors for the occurrence of CRS1 in elderly patients, while use of diuretics, beta blockers and dialysis during hospitalization are predictors of in-hospital mortality in patients with CRS1. These results above suggest that more suitable treatments for the elderly with CRS1 might be needed.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
Hu W,He W,Liu W,Fang X,Wu Y,Yu F,Hao Wdoi
10.1159/000447936subject
Has Abstractpub_date
2016-01-01 00:00:00pages
672-679issue
5eissn
1420-4096issn
1423-0143pii
000447936journal_volume
41pub_type
杂志文章abstract:BACKGROUND:Renal involvement in Takayasu's arteritis (TA) effects the disease outcome and endovascular treatment is an effective treatment of choice. We investigated nitric oxide (NO) levels and the effect of endovascular treatment in renovascular hypertensive TA patients. METHODS:In five hypertensive patients with re...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
doi:10.1159/000063514
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND/AIMS:This experimental study was designed to investigate protective and therapeutic effects of Dexpanthenol (Dxp), an alcoholic analogue of pantothenic acid, on kidney damage induced by ischemia-reperfusion (I/R) in rats. METHODS:Forty rats were randomly divided into a control group and 4 I/R groups (1 h is...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000343411
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:IgA nephropathy is the most prevalent form of primary glomerulonephritis worldwide. Among patients with kidney disease, hypertension is one of the most important risk factors of disease progression. Considering the limited evidence regarding the appropriate blood pressure (BP) goal for patients with IgA...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,多中心研究
doi:10.1159/000495636
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIMS:We explored the effects of catechins (decaffeinated green tea extracts containing (-)-epicatechin, (-)-epigallocatechin, (-)-epicatechin gallate and (-)-epigallocatechin gallate) on atherosclerosis risk factors, oxidized low-density lipoprotein (oxLDL) and its primary metabolite, phosphatidylcholine hyd...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000485082
更新日期:2017-01-01 00:00:00
abstract::A 70-year-old female patient with advanced Shy-Drager syndrome exhibited severe orthostatic hypotension, low serum catecholamine levels, and autonomic dysfunction. She was bedridden despite oral medication with fludrocortisone, etilefrin, dihydroergotamine, L-dopa, yohimbine, and amezinium methyl sulfate. Only intrave...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000025846
更新日期:1998-01-01 00:00:00
abstract::The effects on glomerular hemodynamics of angiotensin-converting enzyme (ACE) inhibition with captopril and of angiotensin II receptor blockade with EXP 3174, an active metabolite of losartan, either alone or in combination, were compared in anesthetized dogs. Administration of EXP 3174 intrarenally led to an increase...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000174256
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND/AIMS:Lung dysfunction associates with increased mortality but the impact of chronic kidney disease (CKD) is less clear. We evaluated lung function and its association with mortality among individuals with normal to severely reduced glomerular filtration rate (GFR). METHODS:404 individuals representing GFR c...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000488699
更新日期:2018-01-01 00:00:00
abstract::The aim of this study was to investigate whether the renoprotective effect of angiotensin-converting enzyme inhibitors (ACEIs) following 5/6 renal mass reduction is due in part to the potentiation of kinins. Three groups of rats with 5/6 renal mass reduction were studied during the 14 weeks following surgery. One grou...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000025890
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND/AIMS:Peritoneal dialysis (PD) has gained interest over the last decade as a viable option for early start dialysis. It is still unknown if shorter break-in periods and less time for proper patient evaluation and training could influence technique survival in comparison to planned-start PD. METHODS:A prospec...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000495386
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:There is still no evidence whether human peritoneal mesothelial cells (HPMC) from patients with end-stage renal failure are altered in cell viability or show a different pattern of the release of proinflammatory cytokines. Also the serum of patients with uremia may contain substances stimulating the cytoki...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000066347
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:The biological properties of oxidized and non-oxidized PTH are substantially different. Oxidized PTH (oxPTH) loses its PTH receptor-stimulating properties, whereas non-oxidized PTH (n-oxPTH) is a full agonist of the receptor. This was described in more than 20 well published studies in the 1970(s) and 80(s)....
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000350149
更新日期:2013-01-01 00:00:00
abstract::Inhibitors of type 4 dipeptidyl peptidase (DDP-4) were developed and approved for the oral treatment of type 2 diabetes. Its mode of action is to inhibit the degradation of incretins, such as type 1 glucagon like peptide (GLP-1), and GIP. GLP-1 stimulates glucose-dependent insulin secretion from pancreatic beta-cells ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000339028
更新日期:2012-01-01 00:00:00
abstract::The nonmetabolizable glucose analogue [(3)H]-2-deoxy-D-glucose ((3)H-2DG) was used to study glucose transport in cultured rat podocytes. Intracellular accumulation of (3)H-2DG was linear up to 20 min and was inhibited by cytochalasin B (80% inhibition) and by phlorizin (20% inhibition). Pretreatment with insulin stimu...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000080889
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Flucloxacillin is an important antimicrobial drug in the treatment of infections with Staphylococcus aureus and therefore is often used in staphylococcal infections. Furthermore, flucloxacillin has a high protein binding rate as for example ceftriaxone or teicoplanin--drugs which have formerly been character...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章
doi:10.1159/000070997
更新日期:2003-01-01 00:00:00
abstract::In developed countries, the incidence of end-stage renal failure is constantly increasing, and uremia will soon be a disease typically found in mature and elderly adults. Almost invariably, the physical condition of the elderly patient with terminal uremia is extremely poor, and therapeutic approach complex. Frequent ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000164277
更新日期:2008-01-01 00:00:00
abstract:AIMS AND METHODS:By analyzing data from 2,861 individuals who underwent general health screening 2 years running, we have investigated the impact of changes in waist circumference (WC) and body mass index (BMI) over a 1-year period on systolic blood pressure (BPs). We termed WC, BMI, and BPs at the first visit as WC1, ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000264233
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Diabetic nephropathy (DN) and hypertensive nephrosclerosis (HN) represent the most common causes of chronic kidney disease (CKD) and many patients progress to -end-stage renal disease. Patients are treated primarily through the management of cardiovas-cular risk factors and hypertension; however patients w...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000505187
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:Ischemia/reperfusion (I/R) is the most common cause of acute renal injury. I/R-induced oxidative stress is involved in the development of acute renal injury, which can be reversed by supplementation with L-arginine, a precursor of nitric oxide (NO). This study was conducted to evaluate alterations in th...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000480362
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIM:Calcifications of large arteries are frequent in chronic kidney disease (CKD) and may contribute to the high cardiovascular risk in this population. The aim of this study was to examine whether abdominal aortic calcification volume (AACV) was a predictor of the rate of decline in glomerular filtration ra...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000501687
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:Co-deposition of mannose-binding lectin (MBL) and IgG4 anti-phospholipase A2 receptor (anti-PLA2R) autoantibodies under subepithelial cells has been observed in patients with idiopathic membranous nephropathy (iMN), but the relationships of MBL deposition to iMN severity and progression remain unclear. METHO...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000508665
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:The WNK-dependent STE20/SPS1-related proline/alanine-rich kinase SPAK participates in the regulation of NaCl and Na(+),K(+),2Cl(-) cotransport and thus renal salt excretion. The present study explored whether SPAK has similarly the potential to regulate the epithelial Na(+) channel (ENaC). METHODS:ENaC...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368509
更新日期:2015-01-01 00:00:00
abstract::In the Prague hypertensive rat (PHR), a strain of genetic hypertension derived from Wistar, administration of various antihypertensive drugs (AHD) during the developmental phase of hypertension (weeks 5-9 of life) prevents the rise of blood pressure. However, only drugs blocking the renin-angiotensin system (RAS, i.e....
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000025898
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND/AIMS:Lowering dialysate temperature to increase intradialytic hemodynamic stability may interfere with the ultrafiltration-dependent intradialytic autonomic cardiovascular regulation. The present study aimed to investigate hemodynamic and autonomic responses depending on dialysate temperature and the presenc...
journal_title:Kidney & blood pressure research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000141926
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/AIMS:The metabolic syndrome (MetS), as assessed using dichotomous criteria, is associated with increased risk of future chronic kidney disease (CKD), though this relationship is unclear among African Americans, who have lower risk for MetS but higher risk for CKD. METHODS:We performed logistic regression us...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000488829
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIMS:OSR1 (oxidative-stress-responsive kinase 1) participates in the regulation of renal tubular ion transport, cell volume and blood pressure. Whether OSR1 contributes to the regulation of organic solute transport remained; however, elusive. The present study thus explored the OSR1 sensitivity of the peptid...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368469
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Cardiovascular disease is one of the main causes of morbidity and mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Autonomic dysfunction is associated with an increased risk for all cardiovascular events in the general population and can be evaluated with heart rate variabil...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000502419
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:This prospective, randomized study was to investigate the role of nicorandil in the prevention of contrast-induced nephropathy (CIN) in patients with chronic renal dysfunction undergoing an elective coronary procedure. METHODS:A total of 252 eligible patients were enrolled in this study and allocated into t...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000503160
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:Either protein-to-creatinine ratio (PCR) or albumin-to-creatinine ratio (ACR) can be adopted for estimation of proteinuria in patients with chronic kidney disease (CKD). Estimated protein excretion rate (ePER) and estimated albumin excretion rate (eAER) may be superior to ACR and PCR. Reports show that ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000443429
更新日期:2016-01-01 00:00:00
abstract::Post-transplant hypertension is a common occurrence during treatment with calcineurin inhibitors (CNIs) in kidney transplant population. The pathogenesis of vasoconstriction induced by CNIs involves vascular tone alterations and kidney sodium transport regulation. Among the factors involved a key role is played by the...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000483023
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and is considered to be a sterile inflammatory disease. Increasing evidence suggest that pyroptosis and subsequent inflammatory response play a key role in the pathogenesis of DN. However, the underlying cellular and molecular mechani...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000508372
更新日期:2020-01-01 00:00:00