Abstract:
BACKGROUND/AIMS:We explored the effects of catechins (decaffeinated green tea extracts containing (-)-epicatechin, (-)-epigallocatechin, (-)-epicatechin gallate and (-)-epigallocatechin gallate) on atherosclerosis risk factors, oxidized low-density lipoprotein (oxLDL) and its primary metabolite, phosphatidylcholine hydroperoxide (PCOOH) induced oxidative injury in cultured endothelial cell line and rats. METHODS:We used endothelial cell line and male Wistar rats to determine the effect of catechins on oxLDL or PCOOH induced oxidative injury including apoptosis, H2O2 level, vascular responses and urinary 8-isoprostane and nitrite/nitrate concentration. Plasma catechins concentration was determined by a CoulArray HPLC. Responses of aortic and renal vasoconstriction were evaluated by a transonic meter and a full-field laser perfusion imager. RESULTS:PCOOH administration significantly increased H2O2 amounts and cell apoptosis and decreased endothelial nitric oxide synthase (eNOS) expression in the cultured endothelial cells. Catechins pretreatment significantly reduced PCOOH-elevated H2O2 amounts, endothelial cell apoptosis and partly recovered eNOS expression. Intravenous administration of oxLDL, PCOOH or H2O2, not native LDL, significantly decreased renal and aortic blood flow associated with enhanced ICAM-1 expression and 4-hydroxynoneal (4-HNE) accumulation, and decreased eNOS expression in the male Wistrar rats. One hour after oral intake of green tea extracts, 4 peaks of catechins were found in the rat plasma. The increased plasma catechins significantly inhibited oxLDL-, PCOOH- or H2O2-induced renal and aortic vasoconstriction, decreased urinary 8-isoprostane levels, renal ICAM-1 expression and 4-HNE accumulation, and restored nitrite/nitrate amounts and eNOS activity. CONCLUSIONS:Our data suggests that catechins pretreatment decrease PCOOH-induced endothelial apoptosis and arterial vasoconstriction through the action of H2O2 inhibition and eNOS restoration.
journal_name
Kidney Blood Press Resjournal_title
Kidney & blood pressure researchauthors
Chang HH,Chien CY,Chen KH,Huang SC,Chien CTdoi
10.1159/000485082subject
Has Abstractpub_date
2017-01-01 00:00:00pages
919-932issue
5eissn
1420-4096issn
1423-0143pii
000485082journal_volume
42pub_type
杂志文章abstract:AIM:This study investigated the impact of hypertension combined with diabetic nephropathy on rat renal alpha(1)-adrenoceptor subtype composition. METHODS:In streptozotocin-induced diabetic spontaneously hypertensive rats (SHR), diabetic nephropathy developed as reflected by increased kidney index, plasma creatinine, a...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000249149
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND AND AIM:Cinacalcet effectively reduces calcium in patients with persistent hyperparathyroidism (HPT) after kidney transplantation. We aimed to assess the association of cinacalcet with a decrease in renal function based on a meta-analysis of observational studies in kidney transplant patients with persistent...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,meta分析
doi:10.1159/000323902
更新日期:2011-01-01 00:00:00
abstract::Acute kidney injury (AKI) is a complex kidney disorder that leads to numerous complications, such as elevated nitrogenous wastes, metabolic acidosis, high potassium levels and even death. The pathogenesis of AKI is very complicated, and its causes are commonly categorized as prerenal, intrinsic or postrenal. In the pa...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000450566
更新日期:2016-01-01 00:00:00
abstract:AIM:The aim of the present study was to evaluate the influence of cycle exercise during hemodialysis (HD) on patients' physical proficiency, muscle strength, quality of life and selected laboratory parameters. PATIENTS AND METHODS:In a group of 29 (15 female, 14 male) HD patients (age 64.2 ± 13.1 years), 3 months of c...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000335411
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:To date, there is no imaging technique to assess tubular function in vivo. Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) measures tissue oxygenation based on the transverse relaxation rate (R2*). The present study investigates whether BOLD MRI can assess tubular function using a tub...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000485600
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:The kidney plays a critical role in the control of blood pressure and its elevation in salt-induced hypertension. Mitochondrial dysfunction, especially in energy metabolism, has been associated with hypertension. Here, we aimed to investigate mitochondrial function and metabolic features in renal mitoch...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000479846
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:IgA nephropathy is the most prevalent form of primary glomerulonephritis worldwide. Among patients with kidney disease, hypertension is one of the most important risk factors of disease progression. Considering the limited evidence regarding the appropriate blood pressure (BP) goal for patients with IgA...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,多中心研究
doi:10.1159/000495636
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Neutrophil gelatinase-associated lipocalin (NGAL), a widely accepted diagnostic marker of acute renal injury (AKI) may be involved in the development of atherosclerosis. PURPOSE:To assess the prognostic significance of serum and urinary NGAL and serum cystatin C in patients with stable angina undergoing per...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000350155
更新日期:2013-01-01 00:00:00
abstract:BACKGROUNDS:ANCA-associated vasculitis (AAV) frequently present with a chronic relapsing course. Relapse leads to an increased need for therapeutic agents and consequent toxicity. SUMMARY:When referring to the available options for the management of AAV, the efficacy of glucocorticoids (GCs) is unquestionable. However...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000509608
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Elevated serum uric acid experimentally stimulates renal vasoconstriction and activation of the renin- angiotensin system and consequently modulates erythropoietin (EPO) production. We used a dopamine-induced glomerular filtration response test (DIR) to assess whether elevated uric acid is associated with do...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000330717
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIM:Our aim was to determine whether altered human β-defensin (HBD), pro-inflammatory cytokines including interleukin (IL)-6 and tumor necrotic factor (TNF)-α could increase the risk of developing and exacerbation of chronic kidney disease (CKD), especially for patients with diabetic nephropathy (DN). METHO...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000355740
更新日期:2013-01-01 00:00:00
abstract::Since reports of the first data on cytokines in renal diseases about 10 years ago, the field has seen an explosive growth over the last decade. It is now realized that cytokines can be synthesized by many different types of cells, including glomerular cells, upon adequate stimulation and exert a wide range of actions ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000174088
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND/AIMS:Serum/Glucocorticoid Regulated Kinase 1 (SGK1) plays a significant role in regulating renal Na(+) reabsorption, K(+) secretion, and blood pressure (BP). This study aimed to assess the association of common genetic variants in the SGK1 gene with BP responses to controlled dietary sodium or potassium inte...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368518
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND/AIMS:Post-transplant hypertension is highly prevalent in renal transplant recipients and is a risk factor for graft loss, cardiovascular disease and death. Glucocorticoid is used to prevent rejection, but simultaneously increases the risk of post-transplant hypertension. The glucocorticoid-induced transcript...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000485862
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:Renal dysfunction is a frequent complication in patients suffering from β-thalassemia major (β-TM). The aim of this study was to analyze the renal function and urine metabolomic profile of β-TM patients undergoing transfusions and deferasirox (DFX) therapy, in order to better characterize and shed light on...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000507369
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:In uremic patients coronary surgery and the entire perioperative management is demanding. METHODS:We analyzed retrospectively data from all patients requiring chronic hemodialysis who under went coronary artery bypass grafting (CABG) between January 1 2001 and December 31 2004 at the Deutsches Herzzentrum B...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000090180
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND/AIMS:Renalase (gene name RNLS), a recently discovered enzyme with monoamine oxidase activity, is implicated in the degradation of catecholamines. Recent studies indicate that common variations in the gene with RNLS are associated with hypertension. The aim of this study was to examine the association between...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000368460
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND/AIMS:Hypertensive patients present with increased oxidative stress and frequently receive angiotensin II (ANGII) receptor type I blockers (ARB) for blood pressure (BP) reduction. Recent studies revealed an important role of ANGII in maintaining vascular oxidative homeostasis, including sustaining normal sodi...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000450562
更新日期:2016-01-01 00:00:00
abstract:AIMS AND METHODS:By analyzing data from 2,861 individuals who underwent general health screening 2 years running, we have investigated the impact of changes in waist circumference (WC) and body mass index (BMI) over a 1-year period on systolic blood pressure (BPs). We termed WC, BMI, and BPs at the first visit as WC1, ...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000264233
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:To evaluate the relationship between FGF23 and changes in biochemical parameters, left ventricle mass index, coronary, aortic and, valve calcifications. METHODS:Totally 185 patients with chronic renal disease were included in this prospective, cross-sectional study. The patients were stratified according to...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000339026
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Hypertension in the elderly is commonly characterized by an elevation of pulse pressure. With regard to advanced arteriosclerosis and limited physical fitness, doubt was casted whether elderly patients still achieve relevant cardiovascular benefits by physical exercise. The present work examines the impact o...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000104093
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Diabetic nephropathy constitutes a large proportion of end-stage kidney failure in diabetic patients. However, the underlying molecular mechanisms remain unclear. METHODS:Db/db diabetic mouse models and high glucose (HG)-induced human renal mesangial cells (HRMCs) were used as research models in vivo and in...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000508078
更新日期:2020-01-01 00:00:00
abstract::Currently, the pathogenesis of nondipper hypertension remains largely unclear in patients without any renal or endocrine pathology. It is well known that overt hypothyroidism is strongly associated with diastolic hypertension. However, no study has addressed the pathogenic role of TSH, free T3 (FT3), and free T4 (FT4)...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000110082
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND/AIMS:We examined the factors associated with blood pressure variability in a multi-ethnicity prospective study in China to gain more evidence to guide the prevention and management of hypertension through risk factor intervention. METHODS:A total of 318 consecutive adult subjects aged 29-94 years with suspe...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000477424
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Uremic toxins have been shown to promote glomerular hypertrophy. The present study was performed to elucidate the relation between uremic toxins and tubulointerstitial changes. METHODS:Sixty male Sprague-Dawley rats underwent 2/3 nephrectomy (Nx; n = 30) and 4/5 Nx (n = 30). Experiments were initiated 2 wee...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000080935
更新日期:2005-01-01 00:00:00
abstract::The interaction between renal nerves, endothelins acting via endothelin-A receptors and vasopressin in the regulation of renal excretory function was investigated. In conscious intact and renal denervated diabetes insipidus (DI) Brattleboro rats, as well as their controls, Long-Evans (LE) rats, an infusion of 16.4 nmo...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000054199
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND/AIMS:Additional validation study was warranted to confirm the clinical significance of C score, which was recently added to the Oxford classification for immunoglobulin A nephropathy (IgAN). METHODS:We performed a multicenter retrospective cohort study in four hospitals in Korea. Patients who had biopsied g...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,多中心研究
doi:10.1159/000497808
更新日期:2019-01-01 00:00:00
abstract::NGAL (neutrophil gelatinase-associated lipocalin) is an acute phase protein, participating in antibacterial immunity. NGAL forms a complex with metalloproteinase 9 (MMP-9), thereby increasing its activity and preventing its degradation. NGAL is freely filtered through the glomerular membrane and reabsorbed by endocyto...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章,评审
doi:10.1159/000368474
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND AND METHODS:We investigated kidney function, renal endothelin-1 concentration, prepro-endothelin-1 mRNA as well as endothelin receptor A and B mRNA expression and receptor properties in normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) with intact renal nerves and 7 days after re...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000094571
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND/AIMS:Cardiorenal syndrome type 1 (CRS1) is a syndrome characterized by a rapid worsening of cardiac function leading to acute kidney injury (AKI). The aims of this study were to investigate the risk factors and the prognosis of CRS1 in elderly patients. METHODS:A total of 312 elderly patients (≥60 years old...
journal_title:Kidney & blood pressure research
pub_type: 杂志文章
doi:10.1159/000447936
更新日期:2016-01-01 00:00:00