解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND AND PURPOSE:Better understanding the incidence, predictors and mechanisms of early neurological deterioration (END) following intravenous thrombolysis (IVT) for acute stroke with mild symptoms and isolated internal carotid artery occlusion (iICAo) may inform therapeutic decisions. METHODS:From a multicenter...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14541
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:A transient ischemic attack (TIA) can occur without self-awareness of symptoms. We aimed to investigate characteristics of patients with a tissue-based diagnosis of TIA but having no self-awareness of their symptoms and whose symptoms were witnessed by bystanders. METHODS:We used data from the m...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14550
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with chronic focal epilepsy may have atrophy of brain structures important for the generation and maintenance of seizures. However, little research has been conducted in patients with newly diagnosed focal epilepsy (NDfE), despite it being a crucial point in time for understanding the un...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14565
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose was to report the results of ultrasound-guided lumbar puncture for the administration of nusinersen in spinal muscular atrophy (SMA) patients with complex spines. METHODS:Eighteen SMA patients (five children, five adolescents and eight adults) with either severe scoliosis or spondylo...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14586
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Falling is considered an important public health problem among older people. A recent cross-sectional study suggested that cognitive frailty (CF) is associated with falls. We aimed to explore whether CF is a risk factor for falls in a population-based longitudinal study. METHODS:Using data from ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14572
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Functional connectivity studies revealed alterations within thalamic, salience, and default mode networks in restless legs syndrome patients. METHODS:Eighty-two patients with restless legs syndrome (untreated, n = 30; on dopaminergic medication, n = 42; on alpha-2-delta ligands as mono- or polyt...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14577
更新日期:2021-02-01 00:00:00
abstract::Moyamoya angiopathy (MA) is a progressive cerebrovascular disease with a poorly understood pathophysiology. It is mainly characterized by progressive bilateral stenosis of the terminal intracranial part of the supraclinoid internal carotid arteries and the proximal parts of the middle and anterior cerebral arteries, a...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/ene.14754
更新日期:2021-01-23 00:00:00
abstract::We here present the case of a patient with a sleep disturbance attributed to the exploding head syndrome, recently redefined as 'episodic cranial sensory shock'. The patient, who suffered with concomitant migraine, was treated for headache prevention with daily single-pulse transcranial magnetic stimulation. Following...
journal_title:European journal of neurology
pub_type:
doi:10.1111/ene.14747
更新日期:2021-01-18 00:00:00
abstract:OBJECTIVE:Observational study to evaluate long-term effects of deep brain stimulation (DBS) of the globus pallidus internus (GPi) and the ventral intermediate thalamic nucleus (VIM) on patients with medically refractory myoclonus dystonia (MD). BACKGROUND:More recently, pallidal as well as thalamic DBS have been appli...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14737
更新日期:2021-01-16 00:00:00
abstract:BACKGROUND:Parkinson´s disease (PD) has a large phenotypic variability, which may, at least partly, be genetically driven including alterations of gene products. Candidates might not only be proteins associated with disease risk but also pathways that play a role in aging. OBJECTIVE:To evaluate phenotype-modifying eff...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14733
更新日期:2021-01-15 00:00:00
abstract:BACKGROUND AND PURPOSE:Although erenumab has demonstrated significant reduction in migraine frequency and improved quality of life in studies lasting 3 to 12 months, little is known about long-term therapy. METHODS:This study was an open-label, 5-year treatment phase following a 12-week, double-blind, placebo-controll...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14715
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND AND PURPOSE:In amyotrophic lateral sclerosis, studies using threshold-tracking transcranial magnetic stimulation (TMS) have identified corticomotoneuronal dysfunction as a key pathogenic mechanism. Some patients, however, display no motor response at maximal TMS intensities, termed here an 'inexcitable' moto...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14515
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Dimethyl fumarate (DMF) causes a mean lymphocyte count drop of approximately 30% in relapsing-remitting multiple sclerosis (RRMS) patients. The relationship between this reduction and DMF effectiveness is controversial. The objective was to investigate if the decrease in absolute lymphocyte count...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14538
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:To investigate changes in serum complements and their regulators in the pathogenesis of myasthenia gravis (MG). METHODS:Forty-four patients with acetylcholine receptor antibody-positive MG, as well as 20 patients with non-inflammatory neurological disorders were enrolled. Serum complements (C3, C4 and solubl...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14500
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Disease-modifying therapies provide new horizons for hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) to slow neuropathic progression. Initiating treatment at the earliest time requires biomarkers reflecting both small- and large-fiber degeneration in carriers. METHODS:This st...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14698
更新日期:2020-12-28 00:00:00
abstract:BACKGROUND AND PURPOSE:Charcot-Marie-Tooth (CMT) disease is a chronic, slowly progressing disorder. The lack of specific disease progression biomarkers limits the execution of clinical trials. However, neurofilament light chain (NfL) has been suggested as a potential biomarker for peripheral nervous system disorders. ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14689
更新日期:2020-12-19 00:00:00
abstract::No studies have prospectively investigated headache at onset of first-ever ischemic stroke along with a large concurrent control group. Our aims were to answer two important questions: (i) Are headaches at stroke onset causally related to the stroke, and what are their typical clinical characteristics? (ii) What etiol...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14684
更新日期:2020-12-16 00:00:00
abstract:BACKGROUND AND PURPOSE:Melkersson-Rosenthal syndrome (MRS) is a rare neuro-mucocutaneous disease. In addition to the traditional clinical triad, there is also a diversity of clinical signs, and it may be related to other systemic diseases. METHODS:In the present study, we report a case of MRS with endocrine disorders ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14615
更新日期:2020-12-03 00:00:00
abstract:BACKGROUND AND PURPOSE:In patients with spinal muscular atrophy (SMA), functional disease scores are frequently used to evaluate the course of the disease and the efficacy of treatment. The aim of the present study was to propose minimal clinically important difference (MCID) values for motor scores in order to estimat...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14472
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cranial nerve palsy is occasionally present in patients with chronic inflammatory demyelinating polyneuropathy (CIDP), but its prevalence, characteristics and relations with the CIDP subtypes have rarely been investigated. The aim of this study was to systematically assess cranial nerve involveme...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14497
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Clinical outcomes vary substantially among individuals with large vessel occlusion (LVO) stroke. A small infarct core and large imaging mismatch were found to be associated with good recovery. The aim of this study was to investigate whether those imaging variables would improve individual predic...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14651
更新日期:2020-11-21 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of this study was to investigate utilization rates, treatment pathways and survival prognosis in patients with amyotrophic lateral sclerosis (ALS) undergoing non-invasive (NIV) and tracheostomy invasive ventilation (TIV) in a real-world setting. METHODS:A prospective cohort study using a...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14647
更新日期:2020-11-19 00:00:00
abstract:OBJECTIVE:We aimed to investigate the prevalence of TOR1A, GNAL and THAP1 variants as the cause of dystonia in a cohort of Spanish patients with isolated dystonia and in the literature. METHODS:A population of 2028 subjects (including 1053 patients with different subtypes of isolated dystonia and 975 healthy controls)...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14638
更新日期:2020-11-11 00:00:00
abstract:BACKGROUND AND PURPOSE:Soluble ST2 (sST2) is a promising biomarker in inflammation, atherosclerosis and cardiovascular diseases. We investigated the association between serum sST2 and poor outcome in patients with transient ischaemic attack (TIA)/ischaemic stroke. METHODS:Patients within 24 h after onset and with meas...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14419
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The detection rate of diffusion-weighted (DWI) hyperintense lesions varies widely in patients with transient global amnesia (TGA). The aim was to examine the association of hyperintense lesions on DWI magnetic resonance imaging (MRI) with patient characteristics, precipitating factors, clinical p...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14408
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Basilar artery occlusion (BAO) leads to high rates of morbidity and mortality, despite successful recanalization. The discordance between flow restoration and long-term functional status clouds clinical decision-making regarding further aggressive care. We sought to develop and validate a practic...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14406
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Very-long-chain acyl-CoA dehydrogenase deficiency (VLCADD) is a hereditary disorder of mitochondrial long-chain fatty acid oxidation that has variable presentations, including exercise intolerance, cardiomyopathy and liver disease. The aim of this study was to describe the clinical and genetic ma...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14402
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although Labrune syndrome is a well-known disorder characterized by a typical neuroradiological triad, namely leukoencephalopathy, intracranial calcifications and cysts, there are no reports of systemic involvement in this disorder. This paper attempts to describe a peculiar clinical manifestatio...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14313
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Migraine is a complex and disabling neurological disorder, the exact neurological mechanisms of which remain unclear. The thalamus is considered to be the hub of the central processing and integration of nociceptive information, as well as the modulation of these processes. METHODS:A total of 48...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14411
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Progressive multifocal leukoencephalopathy (PML) is a severe infection caused by the polyomavirus JC that develops in the central nervous system (CNS) of immunosuppressed patients. The infection frequently starts in the brain hemispheres and can spread into other CNS regions such as the brainstem...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14617
更新日期:2020-10-30 00:00:00
abstract:BACKGROUND AND PURPOSE:Superficial siderosis of the central nervous system is a sporadic finding in magnetic resonance imaging, resulting from recurrent bleedings into the subarachnoid space. This study aimed to determine the frequency of spinal dural cerebrospinal fluid (CSF) leaks amongst patients with a symmetric in...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14611
更新日期:2020-10-24 00:00:00
abstract:BACKGROUND AND PURPOSE:In multiple sclerosis (MS), disease-related factors and dysfunctional coping might favor the development of mental distress induced by COVID-19 containment measures. Aim of this study was exploring the relationship between disability, coping strategies, daily life reorganization and neuropsychiat...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14580
更新日期:2020-10-11 00:00:00
abstract:BACKGROUND AND PURPOSE:Since the outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, several reports indicated neurological involvement in COVID-19 disease. Muscle involvement has also been reported as evidenced by creatine kinase (CK) elevations and reports of myalgia. METHODS:Creat...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14564
更新日期:2020-09-30 00:00:00
abstract:BACKGROUND AND PURPOSE:The coronavirus disease 2019 (COVID-19) pandemic challenges neurologists in counseling multiple sclerosis (MS) patients with respect to their risk for and by severe acute respiratory syndrome coronavirus 2 and in guiding disease-modifying treatment (DMT). The objective was to determine the freque...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14555
更新日期:2020-09-25 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with acute ischemic stroke are at high-risk for contracting COVID-19 infection. Additionally, healthcare professionals including neurovascular ultrasound providers are also at risk of being infected by SARS-CoV-2 virus. Yet, preparedness to continue to guarantee hyperacute treatment is v...
journal_title:European journal of neurology
pub_type: 杂志文章,实务指引
doi:10.1111/ene.14334
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Despite recent advances in neurogenetics that have facilitated the identification of a number of dystonia genes, many familial dystonia syndromes remain without known cause. The aim of the study was to identify the cause of autosomal dominant tremulous myoclonus-dystonia in a UK kindred with affe...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14228
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Multinodular and vacuolating neuronal tumor (MVNT) of the cerebrum is a rare brain lesion with suggestive imaging features. The aim of our study was to report the largest series of MVNTs so far and to evaluate the utility of advanced multiparametric magnetic resonance (MR) techniques. METHODS:Th...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14264
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Hereditary sensory and autonomic neuropathies (HSANs) are a group of clinically and genetically heterogeneous neurological disorders characterized by sensory dysfunctions. Here, 21 affected Chinese families are reported, including 19 with congenital insensitivity to pain with anhidrosis (CIPA; na...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14234
更新日期:2020-08-01 00:00:00
abstract::The role of genetics and its technological development have been fundamental in advancing the field of movement disorders, opening the door to precision medicine. Starting from the revolutionary discovery of the locus of the Huntington's disease gene, we review the milestones of genetic discoveries in movement disorde...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/ene.14294
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Isolated rapid eye movement sleep behaviour disorder (iRBD) is a parasomnia, recently recognized as a risk factor for progression to Parkinson's disease, dementia with Lewy body and multiple system atrophy. Biomarker studies in iRBD are relevant due to lack of evidence in this condition. The iden...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14215
更新日期:2020-07-01 00:00:00