听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览Clinics in Liver Disease期刊下所有文献
  • Surgical Resection: Old Dog, Any New Tricks?

    abstract::Patients with hepatocellular carcinoma (HCC) have many treatment options. For patients with surgical indication, consideration of future liver remnant and the surgical complexity of the procedure is essential. A new 3-level complexity classification categorizing 11 liver resection procedures predicts surgical complexi...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2020.07.004

    authors: Kawaguchi Y,Lillemoe HA,Vauthey JN

    更新日期:2020-11-01 00:00:00

  • Viral Hepatitis Other than A, B, and C: Evaluation and Management.

    abstract::Viral hepatitis can cause a wide spectrum of clinical presentations from a benign form with minimal or no symptoms to acute liver failure or death. Hepatitis D coinfection and superinfection have distinct clinical courses, with the latter more likely leading to chronic infection. Management of chronic hepatitis D viru...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2020.04.008

    authors: Cheung A,Kwo P

    更新日期:2020-08-01 00:00:00

  • Pharmacologic Management of Hepatic Encephalopathy.

    abstract::Pharmacologic management of hepatic encephalopathy includes a broad range of therapies. This article covers the specific mainstays of therapies, such as antimicrobials and laxatives, with an established evidence base. This article also covers newer modalities of therapies, such as fecal microbiota transplant, probioti...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2020.01.005

    authors: Mahpour NY,Pioppo-Phelan L,Reja M,Tawadros A,Rustgi VK

    更新日期:2020-05-01 00:00:00

  • Quantitative Systems Toxicology Approaches to Understand and Predict Drug-Induced Liver Injury.

    abstract::The DILI-sim Initiative is a public-private partnership using quantitative systems toxicology to build a model (DILIsym) capable of understanding and predicting liver safety liabilities in drug candidates. The effort has provided insights into mechanisms underlying dose-dependent drug-induced liver injury (DILI) and i...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2019.09.003

    authors: Watkins PB

    更新日期:2020-02-01 00:00:00

  • Role of Transjugular Intrahepatic Portosystemic Shunt in the Management of Portal Hypertension: Review and Update of the Literature.

    abstract::Transjugular intrahepatic portosystemic shunt (TIPS) is a well-established procedure used in the management of complications of portal hypertension. Although the most robust evidence supports the use of TIPS as salvage therapy in variceal hemorrhage, secondary prophylaxis of variceal bleeding, and treatment of refract...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2019.07.004

    authors: Hung ML,Lee EW

    更新日期:2019-11-01 00:00:00

  • HBV/HCV Coinfection in the Era of HCV-DAAs.

    abstract::Epidemiologic studies suggest that 10% to 15% of patients infected with hepatitis C virus (HCV) are coinfected with hepatitis B virus (HBV) in the United States as a result of the shared modality of transmission, but the true prevalence is not known. The progression of liver disease to cirrhosis and hepatocellular car...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2019.04.003

    authors: Abdelaal R,Yanny B,El Kabany M

    更新日期:2019-08-01 00:00:00

  • The Liver in Sickle Cell Disease.

    abstract::Patients with sickle cell disease can develop liver disease as a result of intrahepatic sickling of erythrocytes, viral hepatitis and iron overload secondary to multiple blood transfusions, and gallstone disease as a result of chronic hemolysis. The spectrum of clinical liver disease is wide and often multifactorial. ...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2018.12.002

    authors: Theocharidou E,Suddle AR

    更新日期:2019-05-01 00:00:00

  • Sarcoidosis and the Liver.

    abstract::Hepatic granulomas are a common finding in systemic sarcoidosis, but most patients remain asymptomatic. Elevated alkaline phosphatase is the most common sign of hepatic sarcoidosis (HS). Lacking a specific diagnostic test, the diagnosis of HS is one of exclusion. Therapy may be indicated in a minority of patients to c...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2018.12.012

    authors: Kumar M,Herrera JL

    更新日期:2019-05-01 00:00:00

  • Alcohol and the Law.

    abstract::In the intersection of alcohol ingestion with the law, medical ethics, and public safety, physicians are often unsure about how to proceed. Physicians' primary focus should be on patient education with an ethical and legal duty to warn the patient of the adverse effects of alcohol. Warning third parties of potential h...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2018.09.002

    authors: Balakrishnan M,Pappas SC

    更新日期:2019-02-01 00:00:00

  • Cirrhosis and Portal Hypertension in the Pediatric Population.

    abstract::Cirrhosis is a complex process in which the architecture of the liver is replaced by structurally abnormal nodules due to cirrhosis. Cirrhosis frequently leads to the development of portal hypertension. In children, portal hypertension may be caused by a wide range of etiologies, including extrahepatic portal vein obs...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2018.06.007

    authors: Chapin CA,Bass LM

    更新日期:2018-11-01 00:00:00

  • Understanding and Treating Pruritus in Primary Biliary Cholangitis.

    abstract::Pruritus is a common symptom with primary biliary cholangitis. Research has focused on refining understanding of the neurohumoral pathways involved in transduction of pruritus from peripheral cutaneous receptors to the central nervous system, and identifying modulating drugs. Current treatments have variable efficacy ...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2018.03.005

    authors: Carrion AF,Rosen JD,Levy C

    更新日期:2018-08-01 00:00:00

  • Nonviral or Drug-Induced Etiologies of Acute Liver Failure.

    abstract::Acute liver failure (ALF) is a rare but highly fatal condition. The most common causes include drug-induced and viral hepatitis, but other less common etiologies, especially autoimmune hepatitis, Budd-Chiari syndrome, and Wilson disease, need to be considered. Because diagnosis is frequently tied to potential for reve...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2018.01.008

    authors: Rosenblatt R,Brown RS Jr

    更新日期:2018-05-01 00:00:00

  • The Use of Liver Biopsy in Nonalcoholic Fatty Liver Disease: When to Biopsy and in Whom.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is a common liver disorder that can be divided into benign steatosis or nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). Elastography and scoring systems based on clinical features and routine biochemical testing can be used to assess fibrosis in patient...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2017.08.006

    authors: Gunn NT,Shiffman ML

    更新日期:2018-02-01 00:00:00

  • Risk Factors for the Development of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis, Including Genetics.

    abstract::Nonalcoholic fatty liver disease is emerging as the most common cause of chronic liver disease worldwide. This trend is, in part, secondary, to the growing incidence of obesity, type 2 diabetes, and metabolic syndrome. Other risk factors include age, gender, race/ethnicity, genetic predisposition, and polycystic ovari...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2017.08.008

    authors: Lim HW,Bernstein DE

    更新日期:2018-02-01 00:00:00

  • Treatment Strategies for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is recognized as a global health problem and as a common cause of chronic liver disease. Nonalcoholic steatohepatitis (NASH) carries an increased risk for development of advanced liver disease. Lifestyle modifications with diet and exercise have been the initial management reco...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2017.06.010

    authors: Golabi P,Bush H,Younossi ZM

    更新日期:2017-11-01 00:00:00

  • Chronic Hepatitis C Virus Infection and Depression.

    abstract::Hepatitis C virus (HCV) infection is a systemic disease with hepatic and extrahepatic manifestations, including neuropsychiatric conditions. Depression is a frequent disorder, which has been reported in one-third of patients with HCV infection and has an estimated prevalence of 1.5 to 4.0 times higher than that observ...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2017.03.007

    authors: Adinolfi LE,Nevola R,Rinaldi L,Romano C,Giordano M

    更新日期:2017-08-01 00:00:00

  • Liver Transplantation and Bariatric Surgery: Best Approach.

    abstract::Obesity has become increasingly prevalent, and the number of obese patients in need of liver transplant is expected to continue to increase. In addition, liver disease due to nonalcoholic fatty liver disease is expected to become the leading cause of liver transplantation in the near future. However, obesity remains a...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2016.12.001

    authors: Suraweera D,Dutson E,Saab S

    更新日期:2017-05-01 00:00:00

  • Autoimmune Hepatitis in the Liver Transplant Graft.

    abstract::Recurrent autoimmune hepatitis (AIH) and de novo AIH are 2 important causes of late graft failure after liver transplantation (LT). Recurrent AIH occurs in patients who undergo LT for AIH. De novo AIH occurs in patients who are transplanted for etiologies other than AIH. Although typically treated with standard treatm...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2016.12.010

    authors: Beal EW,Black SM,Michaels A

    更新日期:2017-05-01 00:00:00

  • Management of Acute Hepatotoxicity Including Medical Agents and Liver Support Systems.

    abstract::Drug-induced liver injury (DILI) can be predictable or idiosyncratic and has an estimated incidence of approximately 20 cases per 100,000 persons per year. DILI is a common cause of acute liver failure in the United States. No accurate tests for diagnosing DILI exist, and its diagnosis is based on exclusion of other c...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2016.08.012

    authors: Gonzalez HC,Jafri SM,Gordon SC

    更新日期:2017-02-01 00:00:00

  • The Management of Hepatitis B in Liver Transplant Recipients.

    abstract::Liver transplant (LT) is now an established indication for patients with chronic hepatitis B, mainly because of the development and use of hepatitis B immunoglobulin (HBIG) and oral antivirals for prophylaxis. The combination of low-dose HBIG and antivirals has been considered the standard prophylaxis regimen to preve...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2016.06.004

    authors: Saab S,Chen PY,Saab CE,Tong MJ

    更新日期:2016-11-01 00:00:00

  • The Pathology of Alcoholic Liver Disease.

    abstract::The term "alcoholic liver disease" encompasses a spectrum of pathologic conditions ranging from isolated steatosis to established cirrhosis. Within this spectrum, varying degrees of inflammation, hepatocellular ballooning degeneration, hepatocyte necrosis, cholestasis, and fibrosis may be encountered. This article rev...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2016.02.006

    authors: Alpert L,Hart J

    更新日期:2016-08-01 00:00:00

  • Histology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in Adults and Children.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is the liver disease associated with obesity, diabetes, and the metabolic syndrome. Although steatosis is a key histologic feature, liver biopsies of patients with NAFLD can show a wide range of findings. Nonalcoholic steatohepatitis (NASH) is a progressive subtype of NAFLD fir...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2015.10.011

    authors: Kleiner DE,Makhlouf HR

    更新日期:2016-05-01 00:00:00

  • New Thoughts on Immunoglobulin G4-Related Sclerosing Cholangitis.

    abstract::Immunoglobulin G4 (IgG4)-related sclerosing cholangitis (IgG4-SC) is the biliary manifestation of the multisystem IgG4-related disease. IgG4-SC presents with biliary strictures and/or masses that can bear a striking similarity to other malignant and inflammatory diseases. Diagnosis is based on a combination of clinica...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2015.08.004

    authors: Smit WL,Culver EL,Chapman RW

    更新日期:2016-02-01 00:00:00

  • Meet the Classes of Directly Acting Antiviral Agents: Strengths and Weaknesses.

    abstract::This article discusses direct-acting antiviral agents that target hepatitis C virus replication, their mechanism of action, strengths, and weaknesses. In addition, varying strategies using combinations of these agents are discussed. ...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2015.06.002

    authors: Chacko KR,Gaglio PJ

    更新日期:2015-11-01 00:00:00

  • New Methods of Testing and Brain Imaging in Hepatic Encephalopathy: A Review.

    abstract::The diagnosis of hepatic encephalopathy is predominantly clinical, and the tests available assist in the diagnosis only by excluding other causes. Covert hepatic encephalopathy, which is defined as abnormal performance on psychometric tests when standard neurologic examination is completely normal, has gained widespre...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2015.04.001

    authors: Edula RG,Pyrsopoulos NT

    更新日期:2015-08-01 00:00:00

  • Legal Responsibilities of Physicians When They Diagnose Hepatic Encephalopathy.

    abstract::Both covert hepatic encephalopathy (CHE) and overt hepatic encephalopathy (OHE) impair the ability to operate machinery. The legal responsibilities of US physicians who diagnose and treat patients with hepatic encephalopathy vary among states. It is imperative that physicians know the laws regarding reporting in their...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2015.04.004

    authors: Vierling JM

    更新日期:2015-08-01 00:00:00

  • Global epidemiology of hepatocellular carcinoma: an emphasis on demographic and regional variability.

    abstract::Liver cancer is the second leading cause of global cancer mortality. The major risk factors for hepatocellular carcinoma (HCC) are being addressed with success by prevention efforts. Vaccination against hepatitis B virus has reduced incidence of HCC in Taiwan and is partly responsible for lower rates in China. New inf...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2015.01.001

    authors: McGlynn KA,Petrick JL,London WT

    更新日期:2015-05-01 00:00:00

  • Locoregional therapy of hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma can be treated using minimally invasive, image-guided, catheter-based or percutaneous techniques. Such procedures offer compelling clinical outcomes with a favorable side-effect profile in a population of patients who are poor candidates for surgical or systemic treatment. This article discuss...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2015.01.008

    authors: Habib A,Desai K,Hickey R,Thornburg B,Lewandowski R,Salem R

    更新日期:2015-05-01 00:00:00

  • Contemporary assessment of hepatic fibrosis.

    abstract::Newer noninvasive tests have begun to replace liver biopsy for staging purposes. The clinician must evaluate these tools and apply them to individual patients. None of these modalities give the exact same staging of fibrosis as a liver biopsy, but they are excellent tools for risk stratification. Still, it should be r...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2014.09.007

    authors: Bonder A,Tapper EB,Afdhal NH

    更新日期:2015-02-01 00:00:00

  • Endoscopic retrograde cholangiopancreatography for primary sclerosing cholangitis.

    abstract::Although there are no randomized, controlled trials evaluating the efficacy of endoscopic retrograde cholangiography (ERC) in primary sclerosing cholangitis (PSC) patients, substantial indirect evidence supports the effectiveness of ERC in symptomatic PSC patients with a dominant stricture. Currently, cumulative evide...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2014.07.013

    authors: Thosani N,Banerjee S

    更新日期:2014-11-01 00:00:00

  • Expanded criteria donors.

    abstract::The greatest challenge facing liver transplantation today is the shortage of donor livers. Demand far exceeds supply, and this deficit has driven expansion of what is considered an acceptable organ. The evolving standard has not come without costs, however, as each new frontier of expanded donor quality (i.e., advanci...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2014.05.005

    authors: Feng S,Lai JC

    更新日期:2014-08-01 00:00:00

  • Secondary prophylaxis for esophageal variceal bleeding.

    abstract::Combination therapy with beta-blockers and endoscopic band ligation (EBL) is the standard prophylaxis of esophageal variceal rebleeding in cirrhosis. Beta-blockers are the backbone of combination therapy, since their benefit extend to other complications of portal hypertension. EBL carries the risk of post-banding ulc...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2014.01.007

    authors: Albillos A,Tejedor M

    更新日期:2014-05-01 00:00:00

  • The impact of obesity and metabolic syndrome on chronic hepatitis C.

    abstract::The metabolic syndrome and the hepatitis C virus (HCV) infection are 2 global health care challenges with a complex interaction. Insulin resistance, a central component of the metabolic syndrome, is epidemiologically and pathophysiologically intrinsically linked to HCV infection. Insulin resistance and diabetes affect...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2013.09.007

    authors: Goossens N,Negro F

    更新日期:2014-02-01 00:00:00

  • Acetaminophen-related hepatotoxicity.

    abstract::Acetaminophen (APAP) is the leading worldwide cause of drug overdose and acute liver failure (ALF). Single overdose ingestion and therapeutic misadventure may cause hepatotoxicity. Several factors, such as concomitant alcohol use or abuse, concurrent medications, genetic factors, and nutritional status, can influence ...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2013.07.005

    authors: Bunchorntavakul C,Reddy KR

    更新日期:2013-11-01 00:00:00

  • Cholestatic liver disease overlap syndromes.

    abstract::Primary biliary cirrhosis and primary sclerosing cholangitis share some clinical features with autoimmune hepatitis, but when features of autoimmune hepatitis are present, prognosis can be affected and immunosuppressive treatment warranted. The presence of severe interface hepatitis in primary biliary cirrhosis porten...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2012.12.006

    authors: Mayo MJ

    更新日期:2013-05-01 00:00:00

  • Hepatitis C viral kinetics: the past, present, and future.

    abstract::Mathematical modeling of hepatitis C viral kinetics has been an important tool in understanding hepatitis C virus (HCV) infection dynamics and in estimating crucial in vivo parameters characterizing the effectiveness of HCV therapy. Because of the introduction of direct-acting antiviral agents, there is a need to exte...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2012.09.003

    authors: Chatterjee A,Smith PF,Perelson AS

    更新日期:2013-02-01 00:00:00

  • Management of alcohol abuse.

    abstract::This article reviews the spectrum of alcohol use disorders. The pharmacologic properties of ethanol and its metabolism, and the historical, physical, and laboratory elements that may help diagnose an alcohol use disorder are examined. The concepts of motivational interviewing and stages of change are mentioned, along ...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2012.08.006

    authors: Albanese AP

    更新日期:2012-11-01 00:00:00

  • Mechanisms of disease progression in NASH: new paradigms.

    abstract::The incidence of nonalcoholic fatty liver disease is increasing at an astonishing rate in the US population. Although only a small proportion of these patients develop steatohepatitis (NASH), those who do have a greater likelihood of developing end-stage liver disease and complications. Research on liver fibrosis and ...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2012.05.002

    authors: Bohinc BN,Diehl AM

    更新日期:2012-08-01 00:00:00

  • Hepatic encephalopathy.

    abstract::Hepatic encephalopathy (HE) represents a continuum of transient and reversible neurologic and psychiatric dysfunction. It is a reversible state of impaired cognitive function or altered consciousness in patients with liver disease or portosystemic shunting. Over the last several years, high-quality studies have been c...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2012.03.009

    authors: Khungar V,Poordad F

    更新日期:2012-05-01 00:00:00

  • Extent of reversibility of hepatic encephalopathy following liver transplantation.

    abstract::Although hepatic encephalopathy (HE) is prevalent in the cirrhotic population, it has also been considered a potentially reversible condition. Liver transplantation represents the ultimate reversal of the decompensated cirrhotic state and should provide the best option for the reversibility of HE. However, the neurolo...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审

    doi:10.1016/j.cld.2011.12.004

    authors: Frederick RT

    更新日期:2012-02-01 00:00:00

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