abstract：:Acute cardiovascular poisoning is a major cause of adverse outcomes in poisoning emergencies. The prognostic validity of corrected QT (QTc) and dispersed QT (QTd) in these outcomes is still limited. The present study aimed to determine the risk factors of mortality, adverse cardiovascular events (ACVE), and intensive ...

journal_title：Cardiovascular toxicology

authors： El-Sarnagawy GN,Shaban AE,Lashin HI

更新日期：2021-01-05 00:00:00

abstract：:Caffeine, a naturally occurring purine-based alkaloid, is the most consumed psychostimulant worldwide. Since caffeine pharmacokinetics shows extreme interindividual variability, it is not easy to establish its toxic dose. Only a few cases of death due to acute caffeine intoxication have been described so far, the majo...

journal_title：Cardiovascular toxicology

authors： Maiese A,La Russa R,Del Fante Z,Turillazzi E,David MC,Frati P,Fineschi V

更新日期：2021-01-01 00:00:00

abstract：:Recent evidence indicates that Ca2+ dysregulation is involved in the pathogenesis of isoproterenol (ISP)-induced biochemical toxicity and associated oxidative stress. In this study, we investigated the chemopreventive benefit of M3, a 1,4-dihydropyridine calcium channel blocker, against ISP-induced toxicity in male Wi...

journal_title：Cardiovascular toxicology

authors： Kale OE,Gündüz MG,Ogunbiyi BT,Ogundare TF,Ekor M,Awodele O

更新日期：2020-12-01 00:00:00

abstract：:Hypertension, as one of the major risk factors for cardiovascular disease, significantly affects human health. Prostaglandin E2 (PGE2) and the E3-class prostanoid (EP3) receptor have previously been demonstrated to modulate blood pressure and hemodynamics in various animal models of hypertension. The PGE2-evoked press...

journal_title：Cardiovascular toxicology

authors： Wang FF,Ba J,Yu XJ,Shi XL,Liu JJ,Liu KL,Fu LY,Su Q,Li HB,Kang KB,Yi QY,Wang SQ,Gao HL,Qi J,Li Y,Zhu GQ,Kang YM

更新日期：2020-11-09 00:00:00

abstract：:Doxorubicin (Dox) is widely used in cancer therapy, but the clinical application is limited by its cardiotoxicity. The underlying mechanism of Dox-induced cardiotoxicity remains unclear. Present study aimed to evaluate the role of NLRP3 inflammasome in Dox-induced cardiotoxicity. The NLRP3 inflammasome was activated i...

journal_title：Cardiovascular toxicology

authors： Wei S,Ma W,Li X,Jiang C,Sun T,Li Y,Zhang B,Li W

更新日期：2020-10-01 00:00:00

abstract：:Arsenic toxicity is one of the major environmental problems causing various diseases, cardiovascular disorders is one of them. Several epidemiological studies have shown that arsenic causes cardiac hypertrophy but the detailed molecular mechanism is to be studied yet. This study is designed to determine the molecules ...

journal_title：Cardiovascular toxicology

authors： Samanta J,Mondal A,Saha S,Chakraborty S,Sengupta A

更新日期：2020-06-01 00:00:00

abstract：:This study investigated whether the whole-plant aqueous extract of Crataegus aronia (C. aronia) could protect against or alleviate high-fat diet (HFD)-induced aortic vascular inflammation in rats by inhibiting the NLRP-3 inflammasome pathway and examined some mechanisms of action with respect to its antioxidant and hy...

journal_title：Cardiovascular toxicology

authors： Shatoor AS,Al Humayed S

更新日期：2020-02-01 00:00:00

abstract：:3,4-Methylenedioxymethamphetamine (MDMA), more commonly known as "ecstasy," is a semi-synthetic entactogenic phenylethylamine. In recent years it has gained popularity as a recreational drug whose use has registered an upward trend especially among adolescents and young adults. Despite its unwarranted reputation of be...

journal_title：Cardiovascular toxicology

authors： Bonsignore A,Barranco R,Morando A,Fraternali Orcioni G,Ventura F

更新日期：2019-12-01 00:00:00

abstract：:This study investigated if the cardioprotective effect of acylated ghrelin (AG) against doxorubicin (DOX)-induced cardiac toxicity in rats involves inhibition of Fas/FasL-mediated cell death. It also investigated if such an effect is mediated by restoring Ca+2 homeostasis from the aspect of stimulation of SERCA2a rece...

journal_title：Cardiovascular toxicology

authors： Shati AA,Dallak M

更新日期：2019-12-01 00:00:00

abstract：:Erythromycin is an antibiotic that prolongs the QT-interval and causes Torsade de Pointes (TdP) by blocking the rapid delayed rectifying potassium current (IKr) without affecting either the slow delayed rectifying potassium current (IKs) or inward rectifying potassium current (IK1). Erythromycin exerts this effect in ...

journal_title：Cardiovascular toxicology

authors： Podgurskaya AD,Tsvelaya VA,Slotvitsky MM,Dementyeva EV,Valetdinova KR,Agladze KI

更新日期：2019-12-01 00:00:00

abstract：:Normal pregnancy outcome is accomplished, in part, by rapid and expansive physiological adaptations to the systemic circulation, the extent of which is specific to gestational day (GD) and anatomical location. Pregnancy-related hemodynamic changes in uterine placental blood flow stimulate compensatory vascular signali...

journal_title：Cardiovascular toxicology

authors： Fournier SB,Kallontzi S,Fabris L,Love C,Stapleton PA

更新日期：2019-08-01 00:00:00

abstract：:This study investigated vildagliptin-induced vasodilation and its related mechanisms using phenylephrine induced precontracted rabbit aortic rings. Vildagliptin induced vasodilation in a concentration-dependent manner. Pretreatment with the large-conductance Ca2+-activated K+ channel blocker paxilline, ATP-sensitive K...

journal_title：Cardiovascular toxicology

authors： Seo MS,Li H,An JR,Jung ID,Jung WK,Ha KS,Han ET,Hong SH,Choi IW,Park WS

更新日期：2019-06-01 00:00:00

abstract：:Arsenic trioxide (ATO) is among the first-line chemotherapeutic drugs used in oncological practice. It has shown substantial efficacy in treating patients with relapsed or refractory acute promyelocytic leukaemia. The clinical use of ATO is hampered due to cardiotoxicity and hence many patients are precluded from rece...

journal_title：Cardiovascular toxicology

authors： Vineetha VP,Raghu KG

更新日期：2019-04-01 00:00:00

abstract：:Lithium is one of the classical drugs that have been widely used for treating bipolar disorder. However, several cardiac side effects including sick sinus syndrome, bundle branch block, ventricular tachycardia/fibrillation, non-specific T-wave abnormalities in addition to Brugada-type electrocardiographic changes have...

journal_title：Cardiovascular toxicology

authors： Goto A,Nakamura Y,Lubna NJ,Chiba K,Hagiwara-Nagasawa M,Izumi-Nakaseko H,Ando K,Naito AT,Sugiyama A

更新日期：2018-12-01 00:00:00

abstract：:This study was aimed at determining the efficacy of epinephrine, followed by chest compressions, in producing a return of spontaneous circulation (ROSC) during cyanide (CN)- or hydrogen sulfide (H2S)-induced toxic cardiac pulseless electrical activity (PEA) in the rat. Thirty-nine anesthetized rats were exposed to eit...

journal_title：Cardiovascular toxicology

authors： Judenherc-HaouzI A,Sonobe T,Bebarta VS,Haouzi P

更新日期：2018-10-01 00:00:00

abstract：:Clopidogrel is used in patients with coronary syndromes and at risk of thrombotic events or receiving percutaneous coronary intervention (PCI) for reducing heart attack and stroke. Here we present genotype and phenotype study of Iranian patients undergoing PCI treated with clopidogrel during a 6-month period of follow...

journal_title：Cardiovascular toxicology

authors： Mahdieh N,Rabbani A,Firouzi A,Zahedmehr A,Hoseinimoghaddam M,Saedi S,Sanati H,Basiri H,Noohi F,Rabbani B,Maleki M

更新日期：2018-10-01 00:00:00

abstract：:Over 300,000 hip replacements occurred in the USA in 2010, and the frequency is likely increasing annually. Blood Cobalt (Co) concentrations in patients with well-functioning cobalt-chromium (Co-Cr) hip implants are usually elevated above background concentrations relative to the general population. Excessive Co expos...

journal_title：Cardiovascular toxicology

authors： Fung ES,Monnot A,Kovochich M,Unice KM,Tvermoes BE,Galbraith D,Finley BL,Paustenbach DJ

更新日期：2018-06-01 00:00:00

abstract：:Asiatic acid (AA), a pentacyclic triterpenoid, is a key phytoconstituent of Centella asiatica. AA is a patented as a cytotoxic substance, and it exerts cytotoxicity against Hep3B, Hela and MCF-7 cell lines. However, pentacyclic triterpenoids also modulate the expression and transcriptional activities of Nrf2 and exert...

journal_title：Cardiovascular toxicology

authors： Kamble SM,Patil CR

更新日期：2018-04-01 00:00:00

abstract：:Unintentional intravascular administration of bupivacaine may cause local anesthetic systemic toxicity (LAST). Although many systems are affected in LAST, the cardiovascular effects can be life-threatening. Remifentanil is a selective, ultra-short-acting, µ-opioid receptor agonist opioid. This study assessed the effec...

journal_title：Cardiovascular toxicology

authors： Pişkin Ö,Ayoğlu H

更新日期：2018-02-01 00:00:00

abstract：:Peroxynitrite is a powerful oxidant, formed from the reaction of nitric oxide and superoxide. It is known to interact and modify different biological molecules such as DNA, lipids and proteins leading to alterations in their structure and functions. These events elicit various cellular responses, including cell signal...

journal_title：Cardiovascular toxicology

authors： Islam BU,Habib S,Ali SA,Moinuddin,Ali A

更新日期：2017-10-01 00:00:00

abstract：:Dofetilide is a class III antiarrhythmic used for treating atrial dysrhythmias. Though its adverse effects are well described in routine use, very little is known about dofetilide toxicity in overdose. This is a retrospective case series of consecutive patients reported to our poison center after dofetilide overdose. ...

journal_title：Cardiovascular toxicology

authors： Hieger MA,Maskell KF,Moss MJ,Powell SW,Cumpston KL

更新日期：2017-07-01 00:00:00

abstract：:Since an antipsychotic drug haloperidol has been clinically reported to induce QT interval prolongation and torsade de pointes, in this study its risk stratification for the onset of torsade de pointes was performed by using the chronic atrioventricular block canine model with a Holter electrocardiogram. Haloperidol i...

journal_title：Cardiovascular toxicology

authors： Izumi-Nakaseko H,Nakamura Y,Cao X,Wada T,Ando K,Sugiyama A

更新日期：2017-07-01 00:00:00

abstract：:Our aim is to investigate the correlation between 9p21 chromosome rs4977574 polymorphism genotypes and the development of coronary artery heart disease (CHD). Two hundred and eighty-nine patients with angiography-confirmed CHD were recruited as the CHD group, while 338 subjects without CHD symptoms were enrolled as th...

journal_title：Cardiovascular toxicology

authors： Tang O,Lv J,Cheng Y,Qin F

更新日期：2017-04-01 00:00:00

abstract：:The effects of magnesium (Mg2+) on ischaemic complications of pathological cardiac hypertrophy are unclear. In this study, we investigated effects of Mg2+ pretreatment on ischaemia/reperfusion (I/R) injury in isoprenaline (ISO)-induced hypertrophic hearts. Wistar rats were treated for 7 days with different combination...

journal_title：Cardiovascular toxicology

authors： Amoni M,Kelly-Laubscher R,Petersen M,Gwanyanya A

更新日期：2017-01-01 00:00:00

abstract：:Carfilzomib is a proteasome inhibitor, commonly used in multiple myeloma, but its clinical use may be limited due to cardiotoxicity. This study was aimed to evaluate the influence of rutin in carfilzomib-induced cardiotoxicity in rats. Wistar albino male rats weighing 200-250 g (approximately 10 weeks old) were taken ...

journal_title：Cardiovascular toxicology

authors： Imam F,Al-Harbi NO,Al-Harbia MM,Korashy HM,Ansari MA,Sayed-Ahmed MM,Nagi MN,Iqbal M,Khalid Anwer M,Kazmi I,Afzal M,Bahashwan S

更新日期：2017-01-01 00:00:00

abstract：:High-salt-induced inflammation and oxidative stress in the hypothalamic paraventricular nucleus (PVN) contribute to the pathogenesis of salt-sensitive hypertension. In this study, we hypothesized that chronic inhibition of nuclear factor-κB (NF-κB) activity in the PVN delays the progression of hypertension by upregula...

journal_title：Cardiovascular toxicology

authors： Qi J,Yu XJ,Shi XL,Gao HL,Yi QY,Tan H,Fan XY,Zhang Y,Song XA,Cui W,Liu JJ,Kang YM

更新日期：2016-10-01 00:00:00

abstract：:Oxidative stress plays an important role in the pathogenesis of hypertension. Epigallocatechin-3-O-gallate (EGCG) is the main polyphenol present in green tea and is known for its potent antioxidant and anti-inflammatory properties. In the present study, we hypothesize that EGCG attenuates oxidative stress in the parav...

journal_title：Cardiovascular toxicology

authors： Yi QY,Qi J,Yu XJ,Li HB,Zhang Y,Su Q,Shi T,Zhang DM,Guo J,Feng ZP,Wang ML,Zhu GQ,Liu JJ,Shi XL,Kang YM

更新日期：2016-07-01 00:00:00

abstract：:Huntington's disease is an autosomal dominant neurodegenerative disease caused by a CAG repeat expansion in the huntingtin gene. Heart disease is the second leading cause of death in patients with Huntington's disease. This study was to evaluate whether cardiac Fas-dependent and mitochondria-dependent apoptotic pathwa...

journal_title：Cardiovascular toxicology

authors： Wu BT,Chiang MC,Tasi CY,Kuo CH,Shyu WC,Kao CL,Huang CY,Lee SD

更新日期：2016-04-01 00:00:00

abstract：:In a previous study of breast cancer patients, we found changes in cardiac function and size during the early stages of adjuvant trastuzumab (Herceptin(®)) therapy. Here we present a subgroup analysis of this patient cohort. This subgroup received a anthracycline-embedded chemotherapy followed by at least 3 months up ...

journal_title：Cardiovascular toxicology

authors： Lange SA,Jung J,Jaeck A,Hitschold T,Ebner B

更新日期：2016-04-01 00:00:00

abstract：:Arsenic trioxide (As2O3) is used clinically in the management of acute promyelocytic leukemia, and the use of electrocardiogram (ECG) in this management is important as arsenic use may cause distortion of the electrical properties with its attendant sequel. We studied the effect of As2O3 on vasomotion in rat aortic ri...

journal_title：Cardiovascular toxicology

authors： Cifuentes F,Palacios J,Nwokocha CR

更新日期：2016-01-01 00:00:00

abstract：:This study investigated the effect of metyrosine against ketamine-induced cardiotoxicity in rats and compared the results with the effect of metoprolol. In this study, rats were divided into groups A, B and C. In group A, we investigated the effects of a single dose of metyrosine (150 mg/kg) and metoprolol (20 mg/kg) ...

journal_title：Cardiovascular toxicology

authors： Ahiskalioglu A,Ince I,Aksoy M,Ahiskalioglu EO,Comez M,Dostbil A,Celik M,Alp HH,Coskun R,Taghizadehghalehjoughi A,Suleyman B

更新日期：2015-10-01 00:00:00

abstract：:Cardiac gene expression regulation is controlled not only by genetic factors but also by environmental, i.e., epigenetic factors. Several environmental toxic effects such as oxidative stress and ischemia can result in abnormal myofibril gene expression during heart development. Troponin, one of the regulatory myofibri...

journal_title：Cardiovascular toxicology

authors： Zhao W,Liu L,Pan B,Xu Y,Zhu J,Nan C,Huang X,Tian J

更新日期：2015-07-01 00:00:00

abstract：:We have compared the cardiotoxicity of five platinum complexes in a model of isolated rat heart using the Langendorff technique. These effects were assessed via coronary flow (CF) and cardiac functional parameters. cis-Diamminedichloroplatinum(II) (cisplatin, CDDP), dichloro-(1,2-diaminocyclohexane)platinum(II) (Pt((I...

journal_title：Cardiovascular toxicology

authors： Misic MM,Jakovljevic VL,Bugarcic ZD,Zivkovic VI,Srejovic IM,Barudzic NS,Djuric DM,Novokmet SS

更新日期：2015-07-01 00:00:00

abstract：:In glyphosate (G)-based herbicides (GBHs), the declared active principle G is mixed with several adjuvants that help it to penetrate the plants' cell membranes and its stabilization and liposolubility. Its utilization is growing with genetically modified organisms engineered to tolerate GBH. Millions of farmers suffer...

journal_title：Cardiovascular toxicology

authors： Gress S,Lemoine S,Séralini GE,Puddu PE

更新日期：2015-04-01 00:00:00

abstract：:Heart failure is a common complication of doxorubicin (DOX) therapy. Previous studies have shown that DOX adversely impacts cardiac energy metabolism, and the ensuing energy deficiencies antedate clinical manifestations of cardiac toxicity. Brief exposure of cultured cardiomyocytes to DOX significantly decreases creat...

journal_title：Cardiovascular toxicology

authors： Santacruz L,Darrabie MD,Mantilla JG,Mishra R,Feger BJ,Jacobs DO

更新日期：2015-04-01 00:00:00

abstract：:DLBS1425 is a bioactive compound extracted from Phaleria macrocarpa, with anti-proliferative, anti-inflammatory and anti-angiogenic properties against cancer cells. The present study was aimed to assess cardiotoxicity of DLBS1425, compared to the mainstay regimen for breast cancer, 5-fluorouracil:doxorubicin:cyclophos...

journal_title：Cardiovascular toxicology

authors： Anggadiredja K,Tjandrawinata RR

更新日期：2015-01-01 00:00:00

abstract：:Cardiovascular disease represents one of the most important public health problem in the Western countries, with sudden cardiac death (SCD) being the most common cause of death in adults under 65 years of age. The objective of the present study is to evaluate the leading causes of SCD in young adults who died suddenly...

journal_title：Cardiovascular toxicology

authors： Silva AC,Santos L,Dinis-Oliveira RJ,Magalhães T,Santos A

更新日期：2014-12-01 00:00:00

abstract：:The ubiquitous nature of plastics has raised concerns pertaining to continuous exposure to plastic polymers and human health risks. Of particular concern is the use of endocrine-disrupting chemicals in plastic production, including di(2-ethylhexyl)phthalate (DEHP) and bisphenol A (BPA). Widespread and continuous expos...

journal_title：Cardiovascular toxicology

authors： Posnack NG

更新日期：2014-12-01 00:00:00

abstract：:The exact mechanism of acute heart dysfunction caused by jellyfish venom remains unclear for the moment. In the present study, we examined the problem caused by the tentacle extract (TE) from the jellyfish Cyanea capillata at the levels of whole animal, isolated heart, primarily cultured cardiomyocytes, and intracellu...

journal_title：Cardiovascular toxicology

authors： Zhang L,He Q,Wang Q,Zhang B,Wang B,Xu F,Wang T,Xiao L,Zhang L

更新日期：2014-09-01 00:00:00

abstract：:Choerospondias axillaris (Guangzao) is a medicinal plant used in Mongolia, and its fruit is commonly used for the treatment of cardiovascular diseases in clinic. The constituents responsible for this effect are always conceded to be the total flavonoids of C. axillaries (TFC). The present study was to evaluate the pre...

journal_title：Cardiovascular toxicology

authors： Li C,He J,Gao Y,Xing Y,Hou J,Tian J

更新日期：2014-06-01 00:00:00