Comparative Investigation of Protective Effects of Metyrosine and Metoprolol Against Ketamine Cardiotoxicity in Rats.

abstract：:Heart rate variability (HRV) is a measure of cardiac pacing dynamics that has recently garnered a great deal of interest in environmental health studies. While the use of these measures has become popular, much uncertainty remains in the interpretation of results, both in terms of human and animal research. In humans,...

journal_title：Cardiovascular toxicology

authors： Rowan WH 3rd,Campen MJ,Wichers LB,Watkinson WP

更新日期：2007-01-01 00:00:00

abstract：:Heart failure is a common complication of doxorubicin (DOX) therapy. Previous studies have shown that DOX adversely impacts cardiac energy metabolism, and the ensuing energy deficiencies antedate clinical manifestations of cardiac toxicity. Brief exposure of cultured cardiomyocytes to DOX significantly decreases creat...

journal_title：Cardiovascular toxicology

authors： Santacruz L,Darrabie MD,Mantilla JG,Mishra R,Feger BJ,Jacobs DO

更新日期：2015-04-01 00:00:00

abstract：:We have compared the cardiotoxicity of five platinum complexes in a model of isolated rat heart using the Langendorff technique. These effects were assessed via coronary flow (CF) and cardiac functional parameters. cis-Diamminedichloroplatinum(II) (cisplatin, CDDP), dichloro-(1,2-diaminocyclohexane)platinum(II) (Pt((I...

journal_title：Cardiovascular toxicology

authors： Misic MM,Jakovljevic VL,Bugarcic ZD,Zivkovic VI,Srejovic IM,Barudzic NS,Djuric DM,Novokmet SS

更新日期：2015-07-01 00:00:00

abstract：:The exact mechanism of acute heart dysfunction caused by jellyfish venom remains unclear for the moment. In the present study, we examined the problem caused by the tentacle extract (TE) from the jellyfish Cyanea capillata at the levels of whole animal, isolated heart, primarily cultured cardiomyocytes, and intracellu...

journal_title：Cardiovascular toxicology

authors： Zhang L,He Q,Wang Q,Zhang B,Wang B,Xu F,Wang T,Xiao L,Zhang L

更新日期：2014-09-01 00:00:00

abstract：:Epidemiological studies have associated air pollution particulate matter (PM) exposure with adverse cardiovascular effects. Identification of causal PM sources is critically needed to support regulatory decisions to protect public health. This research examines the in vitro cardiotoxicity of bioavailable constituents ...

journal_title：Cardiovascular toxicology

authors： Knuckles TL,Jaskot R,Richards JH,Miller CA,Ledbetter A,McGee J,Linak WP,Dreher KL

更新日期：2013-12-01 00:00:00

abstract：:Tropomyosins are a family of actin-binding proteins that show cell-specific diversity by a combination of multiple genes and alternative RNA splicing. Of the 4 different tropomyosin genes, TPM4 plays a pivotal role in myofibrillogenesis as well as cardiac contractility in amphibians. In this study, we amplified and se...

journal_title：Cardiovascular toxicology

authors： Denz CR,Zhang C,Jia P,Du J,Huang X,Dube S,Thomas A,Poiesz BJ,Dube DK

更新日期：2011-09-01 00:00:00

abstract：:Hypertension, as one of the major risk factors for cardiovascular disease, significantly affects human health. Prostaglandin E2 (PGE2) and the E3-class prostanoid (EP3) receptor have previously been demonstrated to modulate blood pressure and hemodynamics in various animal models of hypertension. The PGE2-evoked press...

journal_title：Cardiovascular toxicology

authors： Wang FF,Ba J,Yu XJ,Shi XL,Liu JJ,Liu KL,Fu LY,Su Q,Li HB,Kang KB,Yi QY,Wang SQ,Gao HL,Qi J,Li Y,Zhu GQ,Kang YM

更新日期：2020-11-09 00:00:00

abstract：:Acute cardiovascular poisoning is a major cause of adverse outcomes in poisoning emergencies. The prognostic validity of corrected QT (QTc) and dispersed QT (QTd) in these outcomes is still limited. The present study aimed to determine the risk factors of mortality, adverse cardiovascular events (ACVE), and intensive ...

journal_title：Cardiovascular toxicology

authors： El-Sarnagawy GN,Shaban AE,Lashin HI

更新日期：2021-01-05 00:00:00

abstract：:Caffeine, a naturally occurring purine-based alkaloid, is the most consumed psychostimulant worldwide. Since caffeine pharmacokinetics shows extreme interindividual variability, it is not easy to establish its toxic dose. Only a few cases of death due to acute caffeine intoxication have been described so far, the majo...

journal_title：Cardiovascular toxicology

authors： Maiese A,La Russa R,Del Fante Z,Turillazzi E,David MC,Frati P,Fineschi V

更新日期：2021-01-01 00:00:00

abstract：:Elevated levels of homocysteine (Hcy) (known as hyperhomocysteinemia HHcy) are involved in dilated cardiomyopathy. Hcy chelates copper and impairs copper-dependent enzymes. Copper deficiency has been linked to cardiovascular disease. We tested the hypothesis that copper supplement regresses left ventricular hypertroph...

journal_title：Cardiovascular toxicology

authors： Hughes WM Jr,Rodriguez WE,Rosenberger D,Chen J,Sen U,Tyagi N,Moshal KS,Vacek T,Kang YJ,Tyagi SC

更新日期：2008-10-01 00:00:00

abstract：:We present an experimental approach that allows exposure of cells plated on a single coverslip to multiple distinct environments. The original chamber design created a small region of injury using geometrically defined flows of the control and ischemic solutions. Modifications of the original chamber design presented ...

journal_title：Cardiovascular toxicology

authors： Arutunyan A,Swift L,Sarvazyan N

更新日期：2004-01-01 00:00:00

abstract：:Grape seed proanthocyanidin extract (GSPE), a polyphenolic compound with antioxidant properties, may protect against cardiac ischemia and reperfusion injury. However, its potential toxicity at higher doses is unknown. The authors tested the effects of GSPE on reactive oxygen species (ROS) generation, cell survival, la...

journal_title：Cardiovascular toxicology

authors： Shao ZH,Vanden Hoek TL,Xie J,Wojcik K,Chan KC,Li CQ,Hamann K,Qin Y,Schumacker PT,Becker LB,Yuan CS

更新日期：2003-01-01 00:00:00

abstract：:The ubiquitous nature of plastics has raised concerns pertaining to continuous exposure to plastic polymers and human health risks. Of particular concern is the use of endocrine-disrupting chemicals in plastic production, including di(2-ethylhexyl)phthalate (DEHP) and bisphenol A (BPA). Widespread and continuous expos...

journal_title：Cardiovascular toxicology

authors： Posnack NG

更新日期：2014-12-01 00:00:00

abstract：:In glyphosate (G)-based herbicides (GBHs), the declared active principle G is mixed with several adjuvants that help it to penetrate the plants' cell membranes and its stabilization and liposolubility. Its utilization is growing with genetically modified organisms engineered to tolerate GBH. Millions of farmers suffer...

journal_title：Cardiovascular toxicology

authors： Gress S,Lemoine S,Séralini GE,Puddu PE

更新日期：2015-04-01 00:00:00

abstract：:Controlled activation of the complement system is critical to the host-defense response of the immune system. Activated complement is responsible for the stimulation of a localized protective inflammatory response to either invading microorganisms or foreign molecules (toxins). However, the autologous activation of th...

journal_title：Cardiovascular toxicology

authors： Pugsley MK,Abramova M,Cole T,Yang X,Ammons WS

更新日期：2003-01-01 00:00:00

abstract：:Our aim is to investigate the correlation between 9p21 chromosome rs4977574 polymorphism genotypes and the development of coronary artery heart disease (CHD). Two hundred and eighty-nine patients with angiography-confirmed CHD were recruited as the CHD group, while 338 subjects without CHD symptoms were enrolled as th...

journal_title：Cardiovascular toxicology

authors： Tang O,Lv J,Cheng Y,Qin F

更新日期：2017-04-01 00:00:00

abstract：:In a previous study of breast cancer patients, we found changes in cardiac function and size during the early stages of adjuvant trastuzumab (Herceptin(®)) therapy. Here we present a subgroup analysis of this patient cohort. This subgroup received a anthracycline-embedded chemotherapy followed by at least 3 months up ...

journal_title：Cardiovascular toxicology

authors： Lange SA,Jung J,Jaeck A,Hitschold T,Ebner B

更新日期：2016-04-01 00:00:00

abstract：:Cardiac toxicity has been associated with HIV infection and exposure to nucleoside reverse transcriptase inhibitors (NRTIs), but the role of the latter in the development of cardiac disease of HIV-infected patients is uncertain. To investigate the cardiotoxicity of transplacentally administered zidovudine (AZT) or AZT...

journal_title：Cardiovascular toxicology

authors： Walker DM,Poirier MC,Campen MJ,Cook DL Jr,Divi RL,Nagashima K,Lund AK,Cossey PY,Hahn FF,Walker VE

更新日期：2004-01-01 00:00:00

abstract：:Over 300,000 hip replacements occurred in the USA in 2010, and the frequency is likely increasing annually. Blood Cobalt (Co) concentrations in patients with well-functioning cobalt-chromium (Co-Cr) hip implants are usually elevated above background concentrations relative to the general population. Excessive Co expos...

journal_title：Cardiovascular toxicology

authors： Fung ES,Monnot A,Kovochich M,Unice KM,Tvermoes BE,Galbraith D,Finley BL,Paustenbach DJ

更新日期：2018-06-01 00:00:00

abstract：:This study was aimed at evaluation of changes in activities of selected antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and contents of key nonenzymatic antioxidants (glutathione, protein thiol groups, and α- and γ-tocopherols) in the left heart ventricle of youn...

journal_title：Cardiovascular toxicology

authors： Sadowska-Krępa E,Kłapcińska B,Jagsz S,Sobczak A,Chrapusta SJ,Chalimoniuk M,Grieb P,Poprzęcki S,Langfort J

更新日期：2011-06-01 00:00:00

abstract：:Although the role of tropomyosin is well-defined in striated muscle, the precise mechanism of how tropomyosin functions is still unclear. It has been shown that extension of either N- or C-terminal ends of sarcomeric tropomyosin do not affect cardiac myofibrillogenesis, but it is not known whether simultaneous extensi...

journal_title：Cardiovascular toxicology

authors： Narshi A,Denz CR,Nakatsugawa M,Zajdel RW,Dube S,Poiesz BJ,Dube DK

更新日期：2005-01-01 00:00:00

abstract：:This study investigated whether the whole-plant aqueous extract of Crataegus aronia (C. aronia) could protect against or alleviate high-fat diet (HFD)-induced aortic vascular inflammation in rats by inhibiting the NLRP-3 inflammasome pathway and examined some mechanisms of action with respect to its antioxidant and hy...

journal_title：Cardiovascular toxicology

authors： Shatoor AS,Al Humayed S

更新日期：2020-02-01 00:00:00

abstract：:Scientific and medical evidence over the past 30 years has established striking parallels between atherosclerosis and cancer--pathogenetic relationships that cross the boundaries of fiction into the realm of reason. Both diseases in humans are characterized by uncontrolled regulation of cellular growth and differentia...

journal_title：Cardiovascular toxicology

authors： Ramos KS,Partridge CR

更新日期：2005-01-01 00:00:00

abstract：:Cardiovascular disease represents one of the most important public health problem in the Western countries, with sudden cardiac death (SCD) being the most common cause of death in adults under 65 years of age. The objective of the present study is to evaluate the leading causes of SCD in young adults who died suddenly...

journal_title：Cardiovascular toxicology

authors： Silva AC,Santos L,Dinis-Oliveira RJ,Magalhães T,Santos A

更新日期：2014-12-01 00:00:00

abstract：:The use of anthracycline anticancer drugs is limited by a cumulative, dose-dependent cardiac toxicity. Iron chelation has long been considered as a promising strategy to limit this unfavorable side effect, either by restoring the disturbed cellular iron homeostasis or by removing redox-active iron, which may promote a...

journal_title：Cardiovascular toxicology

authors： Kaiserová H,Simunek T,Sterba M,den Hartog GJ,Schröterová L,Popelová O,Gersl V,Kvasnicková E,Bast A

更新日期：2007-01-01 00:00:00

abstract：:3,4-Methylenedioxymethamphetamine (MDMA), more commonly known as "ecstasy," is a semi-synthetic entactogenic phenylethylamine. In recent years it has gained popularity as a recreational drug whose use has registered an upward trend especially among adolescents and young adults. Despite its unwarranted reputation of be...

journal_title：Cardiovascular toxicology

authors： Bonsignore A,Barranco R,Morando A,Fraternali Orcioni G,Ventura F

更新日期：2019-12-01 00:00:00

abstract：:It has been suggested that prenatal exposure to cadmium may alter the cardiovascular function during adulthood. Using the left coronary artery ligation model of acute myocardial infarction, we studied the cardiac function of female adult offspring rats exposed to cadmium (30 ppm) during gestation. The cardiac ischemic...

journal_title：Cardiovascular toxicology

authors： Zepeda R,Castillo P,Sáez D,Llanos MN,Ronco AM

更新日期：2012-03-01 00:00:00

abstract：:Serotonergic drugs may lead to valvular heart disease in humans and more recently also in rats. Although clinical data suggest that dose dependency and reversibility after drug cessation might occur, proof of this is lacking. For that purpose, a total of 106 rats were prospectively enrolled: 22 control animals and 7 g...

journal_title：Cardiovascular toxicology

authors： Droogmans S,Roosens B,Cosyns B,Degaillier C,Hernot S,Weytjens C,Garbar C,Caveliers V,Pipeleers-Marichal M,Franken PR,Bossuyt A,Schoors D,Lahoutte T,Van Camp G

更新日期：2009-09-01 00:00:00

abstract：:Our previous study described the cardioprotective effects of ellagic acid in an isoproterenol-induced myocardial infarction model. In this study, we are reporting the mechanism of protective action of ellagic acid with respect to apoptosis and mitochondrial respiratory enzymes. Ellagic acid (7.5 and 15 mg/kg) was admi...

journal_title：Cardiovascular toxicology

authors： Mari Kannan M,Darlin Quine S

更新日期：2012-03-01 00:00:00

abstract：:This study was aimed at determining the efficacy of epinephrine, followed by chest compressions, in producing a return of spontaneous circulation (ROSC) during cyanide (CN)- or hydrogen sulfide (H2S)-induced toxic cardiac pulseless electrical activity (PEA) in the rat. Thirty-nine anesthetized rats were exposed to eit...

journal_title：Cardiovascular toxicology

authors： Judenherc-HaouzI A,Sonobe T,Bebarta VS,Haouzi P

更新日期：2018-10-01 00:00:00