Multiple injury approach and its use for toxicity studies.

abstract：:Lithium is one of the classical drugs that have been widely used for treating bipolar disorder. However, several cardiac side effects including sick sinus syndrome, bundle branch block, ventricular tachycardia/fibrillation, non-specific T-wave abnormalities in addition to Brugada-type electrocardiographic changes have...

journal_title：Cardiovascular toxicology

authors： Goto A,Nakamura Y,Lubna NJ,Chiba K,Hagiwara-Nagasawa M,Izumi-Nakaseko H,Ando K,Naito AT,Sugiyama A

更新日期：2018-12-01 00:00:00

abstract：:Elevated levels of homocysteine (Hcy) (known as hyperhomocysteinemia HHcy) are involved in dilated cardiomyopathy. Hcy chelates copper and impairs copper-dependent enzymes. Copper deficiency has been linked to cardiovascular disease. We tested the hypothesis that copper supplement regresses left ventricular hypertroph...

journal_title：Cardiovascular toxicology

authors： Hughes WM Jr,Rodriguez WE,Rosenberger D,Chen J,Sen U,Tyagi N,Moshal KS,Vacek T,Kang YJ,Tyagi SC

更新日期：2008-10-01 00:00:00

abstract：:Cardiac troponins not only allow for risk stratification and guidance of therapy in unstable angina and non-Q-wave acute myocardial infarction but also may be useful in the diagnostic workup and monitoring of patients with ST-segment elevation myocardial infarction. In clinical practice, troponins are used for confirm...

journal_title：Cardiovascular toxicology

authors： Lehrke S,Giannitsis E,Steen H,Katus HA

更新日期：2001-01-01 00:00:00

abstract：:Intracellular Na(+) ([Na(+)](i)) is an important modulator of excitation-contraction coupling via regulating Ca(2+) efflux/influx, and no investigation has been so far performed in diabetic rat heart. Here, we examined whether any change of [Na(+)](i) in paced cardiomyocytes could contribute to functional alterations ...

journal_title：Cardiovascular toxicology

authors： Bilginoglu A,Kandilci HB,Turan B

更新日期：2013-06-01 00:00:00

abstract：:Cardiac toxicity has been associated with HIV infection and exposure to nucleoside reverse transcriptase inhibitors (NRTIs), but the role of the latter in the development of cardiac disease of HIV-infected patients is uncertain. To investigate the cardiotoxicity of transplacentally administered zidovudine (AZT) or AZT...

journal_title：Cardiovascular toxicology

authors： Walker DM,Poirier MC,Campen MJ,Cook DL Jr,Divi RL,Nagashima K,Lund AK,Cossey PY,Hahn FF,Walker VE

更新日期：2004-01-01 00:00:00

abstract：:The present study was designed to evaluate the cardioprotective potential of water extract of rhizomes of Acorus gramineus (AGR) against isoproterenol (ISO)-induced myocardial infarction. Male pigs were orally administered with 250 or 500 mg/kg of AGR or with vehicle for 9 days, with concurrent subcutaneous injections...

journal_title：Cardiovascular toxicology

authors： Kim JH,Chung HS,Antonisamy P,Lee SR,Bae H

更新日期：2014-06-01 00:00:00

abstract：:Since an antipsychotic drug haloperidol has been clinically reported to induce QT interval prolongation and torsade de pointes, in this study its risk stratification for the onset of torsade de pointes was performed by using the chronic atrioventricular block canine model with a Holter electrocardiogram. Haloperidol i...

journal_title：Cardiovascular toxicology

authors： Izumi-Nakaseko H,Nakamura Y,Cao X,Wada T,Ando K,Sugiyama A

更新日期：2017-07-01 00:00:00

abstract：:We have compared the cardiotoxicity of five platinum complexes in a model of isolated rat heart using the Langendorff technique. These effects were assessed via coronary flow (CF) and cardiac functional parameters. cis-Diamminedichloroplatinum(II) (cisplatin, CDDP), dichloro-(1,2-diaminocyclohexane)platinum(II) (Pt((I...

journal_title：Cardiovascular toxicology

authors： Misic MM,Jakovljevic VL,Bugarcic ZD,Zivkovic VI,Srejovic IM,Barudzic NS,Djuric DM,Novokmet SS

更新日期：2015-07-01 00:00:00

abstract：:Coxsackievirus B3 (CVB3) induces myocarditis, especially in the immunodeficient or immature. To investigate whether CVB3 induced pronounced cardiomyopathy during the severe immune dysfunction of murine acquired immunodeficiency syndrome (AIDS), female C57BL/6 mice were infected with LP-BM5 retrovirus and then coinfect...

journal_title：Cardiovascular toxicology

authors： Sepúlveda RT,Zhang J,Watson RR

更新日期：2002-01-01 00:00:00

abstract：:The ubiquitous nature of plastics has raised concerns pertaining to continuous exposure to plastic polymers and human health risks. Of particular concern is the use of endocrine-disrupting chemicals in plastic production, including di(2-ethylhexyl)phthalate (DEHP) and bisphenol A (BPA). Widespread and continuous expos...

journal_title：Cardiovascular toxicology

authors： Posnack NG

更新日期：2014-12-01 00:00:00

abstract：:Doxorubicin (Dox) is widely used in cancer therapy, but the clinical application is limited by its cardiotoxicity. The underlying mechanism of Dox-induced cardiotoxicity remains unclear. Present study aimed to evaluate the role of NLRP3 inflammasome in Dox-induced cardiotoxicity. The NLRP3 inflammasome was activated i...

journal_title：Cardiovascular toxicology

authors： Wei S,Ma W,Li X,Jiang C,Sun T,Li Y,Zhang B,Li W

更新日期：2020-10-01 00:00:00

abstract：:The exact mechanism of acute heart dysfunction caused by jellyfish venom remains unclear for the moment. In the present study, we examined the problem caused by the tentacle extract (TE) from the jellyfish Cyanea capillata at the levels of whole animal, isolated heart, primarily cultured cardiomyocytes, and intracellu...

journal_title：Cardiovascular toxicology

authors： Zhang L,He Q,Wang Q,Zhang B,Wang B,Xu F,Wang T,Xiao L,Zhang L

更新日期：2014-09-01 00:00:00

abstract：:Cerium dioxide nanoparticles (CeO2 NPs) are an engineered nanomaterial (ENM) that possesses unique catalytic, oxidative, and reductive properties. Currently, CeO2 NPs are being used as a fuel catalyst but these properties are also utilized in the development of potential drug treatments for radiation and stroke protec...

journal_title：Cardiovascular toxicology

authors： Minarchick VC,Stapleton PA,Porter DW,Wolfarth MG,Çiftyürek E,Barger M,Sabolsky EM,Nurkiewicz TR

更新日期：2013-12-01 00:00:00

abstract：:3,4-Methylenedioxymethamphetamine (MDMA), more commonly known as "ecstasy," is a semi-synthetic entactogenic phenylethylamine. In recent years it has gained popularity as a recreational drug whose use has registered an upward trend especially among adolescents and young adults. Despite its unwarranted reputation of be...

journal_title：Cardiovascular toxicology

authors： Bonsignore A,Barranco R,Morando A,Fraternali Orcioni G,Ventura F

更新日期：2019-12-01 00:00:00

abstract：:We investigated protective effect of FK506 on rat hearts subjected to ischemia/reperfusion (I/R) injury by regulating CaN and ASK1. Wistar rats were divided into four groups: Ischemia/reperfusion group (I/R), FK506 + Ischemia/reperfusion group (FK506-I/R), sham group, and FK506 + sham group (FK506-sham). Ischemia/repe...

journal_title：Cardiovascular toxicology

authors： Feng X,Li J,Liu J,Jin M,Liu X,Du H,Zhang L,Sun Z,Li X

更新日期：2011-03-01 00:00:00

abstract：:The effects of magnesium (Mg2+) on ischaemic complications of pathological cardiac hypertrophy are unclear. In this study, we investigated effects of Mg2+ pretreatment on ischaemia/reperfusion (I/R) injury in isoprenaline (ISO)-induced hypertrophic hearts. Wistar rats were treated for 7 days with different combination...

journal_title：Cardiovascular toxicology

authors： Amoni M,Kelly-Laubscher R,Petersen M,Gwanyanya A

更新日期：2017-01-01 00:00:00

abstract：:Heart rate variability (HRV) is a measure of cardiac pacing dynamics that has recently garnered a great deal of interest in environmental health studies. While the use of these measures has become popular, much uncertainty remains in the interpretation of results, both in terms of human and animal research. In humans,...

journal_title：Cardiovascular toxicology

authors： Rowan WH 3rd,Campen MJ,Wichers LB,Watkinson WP

更新日期：2007-01-01 00:00:00

abstract：:This study investigated vildagliptin-induced vasodilation and its related mechanisms using phenylephrine induced precontracted rabbit aortic rings. Vildagliptin induced vasodilation in a concentration-dependent manner. Pretreatment with the large-conductance Ca2+-activated K+ channel blocker paxilline, ATP-sensitive K...

journal_title：Cardiovascular toxicology

authors： Seo MS,Li H,An JR,Jung ID,Jung WK,Ha KS,Han ET,Hong SH,Choi IW,Park WS

更新日期：2019-06-01 00:00:00

abstract：:Unintentional intravascular administration of bupivacaine may cause local anesthetic systemic toxicity (LAST). Although many systems are affected in LAST, the cardiovascular effects can be life-threatening. Remifentanil is a selective, ultra-short-acting, µ-opioid receptor agonist opioid. This study assessed the effec...

journal_title：Cardiovascular toxicology

authors： Pişkin Ö,Ayoğlu H

更新日期：2018-02-01 00:00:00

abstract：:This study investigated whether the whole-plant aqueous extract of Crataegus aronia (C. aronia) could protect against or alleviate high-fat diet (HFD)-induced aortic vascular inflammation in rats by inhibiting the NLRP-3 inflammasome pathway and examined some mechanisms of action with respect to its antioxidant and hy...

journal_title：Cardiovascular toxicology

authors： Shatoor AS,Al Humayed S

更新日期：2020-02-01 00:00:00

abstract：:Carbon soot is produced in the process of diamond manufacture. Recent experimental and epidemiological studies have associated exposure to carbon nanoparticles with effects on cardiovascular system and blood cells. The objective of this study is to assess the cardiovascular effects consequent to chronic respiratory ex...

journal_title：Cardiovascular toxicology

authors： Beniwal R,Shivgotra VK

更新日期：2009-12-01 00:00:00

abstract：:Cardiovascular disease represents one of the most important public health problem in the Western countries, with sudden cardiac death (SCD) being the most common cause of death in adults under 65 years of age. The objective of the present study is to evaluate the leading causes of SCD in young adults who died suddenly...

journal_title：Cardiovascular toxicology

authors： Silva AC,Santos L,Dinis-Oliveira RJ,Magalhães T,Santos A

更新日期：2014-12-01 00:00:00

abstract：:Normal pregnancy outcome is accomplished, in part, by rapid and expansive physiological adaptations to the systemic circulation, the extent of which is specific to gestational day (GD) and anatomical location. Pregnancy-related hemodynamic changes in uterine placental blood flow stimulate compensatory vascular signali...

journal_title：Cardiovascular toxicology

authors： Fournier SB,Kallontzi S,Fabris L,Love C,Stapleton PA

更新日期：2019-08-01 00:00:00

abstract：:Cardiac gene expression regulation is controlled not only by genetic factors but also by environmental, i.e., epigenetic factors. Several environmental toxic effects such as oxidative stress and ischemia can result in abnormal myofibril gene expression during heart development. Troponin, one of the regulatory myofibri...

journal_title：Cardiovascular toxicology

authors： Zhao W,Liu L,Pan B,Xu Y,Zhu J,Nan C,Huang X,Tian J

更新日期：2015-07-01 00:00:00

abstract：:Four decades of research on the link between hyperhomocysteinemia and cardiovascular disease has led to a crossroads. Several negative studies on the role of homocysteine-lowering B-vitamin therapy in reducing the risk of atherothrombotic cardiovascular disease have dampened enthusiasm for this important field of rese...

journal_title：Cardiovascular toxicology

authors： Joseph J,Handy DE,Loscalzo J

更新日期：2009-06-01 00:00:00

abstract：:We report a case of potential cardiovascular toxicity including syncope, bradycardia, and ECG pauses associated with the use of rivastigmine and atenolol. A 65-year-old African American female with a medical history of dementia, hypertension, seizure disorder, stroke, and peripheral vascular disease was admitted to th...

journal_title：Cardiovascular toxicology

authors： Paulison B,Léos CL

更新日期：2010-12-01 00:00:00

abstract：:Arsenic trioxide (As2O3) is used clinically in the management of acute promyelocytic leukemia, and the use of electrocardiogram (ECG) in this management is important as arsenic use may cause distortion of the electrical properties with its attendant sequel. We studied the effect of As2O3 on vasomotion in rat aortic ri...

journal_title：Cardiovascular toxicology

authors： Cifuentes F,Palacios J,Nwokocha CR

更新日期：2016-01-01 00:00:00

abstract：:Erythromycin is an antibiotic that prolongs the QT-interval and causes Torsade de Pointes (TdP) by blocking the rapid delayed rectifying potassium current (IKr) without affecting either the slow delayed rectifying potassium current (IKs) or inward rectifying potassium current (IK1). Erythromycin exerts this effect in ...

journal_title：Cardiovascular toxicology

authors： Podgurskaya AD,Tsvelaya VA,Slotvitsky MM,Dementyeva EV,Valetdinova KR,Agladze KI

更新日期：2019-12-01 00:00:00

abstract：:Caffeine, a naturally occurring purine-based alkaloid, is the most consumed psychostimulant worldwide. Since caffeine pharmacokinetics shows extreme interindividual variability, it is not easy to establish its toxic dose. Only a few cases of death due to acute caffeine intoxication have been described so far, the majo...

journal_title：Cardiovascular toxicology

authors： Maiese A,La Russa R,Del Fante Z,Turillazzi E,David MC,Frati P,Fineschi V

更新日期：2021-01-01 00:00:00

abstract：:Recent evidence indicates that Ca2+ dysregulation is involved in the pathogenesis of isoproterenol (ISP)-induced biochemical toxicity and associated oxidative stress. In this study, we investigated the chemopreventive benefit of M3, a 1,4-dihydropyridine calcium channel blocker, against ISP-induced toxicity in male Wi...

journal_title：Cardiovascular toxicology

authors： Kale OE,Gündüz MG,Ogunbiyi BT,Ogundare TF,Ekor M,Awodele O

更新日期：2020-12-01 00:00:00