Protective effect of FK506 on myocardial ischemia/reperfusion injury by suppression of CaN and ASK1 signaling circuitry.

abstract：:Trichloroethylene is an organic solvent used as an industrial degreasing agent. Due to its widespread use and volatile nature, TCE is a common environmental contaminant. Trichloroethylene exposure has been implicated in the etiology of heart defects in human populations and animal models. Recent data suggest misregula...

journal_title：Cardiovascular toxicology

authors： Makwana O,King NM,Ahles L,Selmin O,Granzier HL,Runyan RB

更新日期：2010-06-01 00:00:00

abstract：:Grape seed proanthocyanidin extract (GSPE), a polyphenolic compound with antioxidant properties, may protect against cardiac ischemia and reperfusion injury. However, its potential toxicity at higher doses is unknown. The authors tested the effects of GSPE on reactive oxygen species (ROS) generation, cell survival, la...

journal_title：Cardiovascular toxicology

authors： Shao ZH,Vanden Hoek TL,Xie J,Wojcik K,Chan KC,Li CQ,Hamann K,Qin Y,Schumacker PT,Becker LB,Yuan CS

更新日期：2003-01-01 00:00:00

abstract：:Peroxynitrite is a powerful oxidant, formed from the reaction of nitric oxide and superoxide. It is known to interact and modify different biological molecules such as DNA, lipids and proteins leading to alterations in their structure and functions. These events elicit various cellular responses, including cell signal...

journal_title：Cardiovascular toxicology

authors： Islam BU,Habib S,Ali SA,Moinuddin,Ali A

更新日期：2017-10-01 00:00:00

abstract：:Doxorubicin (Dox), an antitumor anthracycline antibiotic, plays a key role in the treatment of many neoplastic diseases. However, its chronic administration induces cardiomyopathy. Increased oxidative stress is a major factor implicated in Dox-induced cardiotoxicity. We hypothesized that a pre-treatment with grape see...

journal_title：Cardiovascular toxicology

authors： Mokni M,Hamlaoui-Guesmi S,Amri M,Marzouki L,Limam F,Aouani E

更新日期：2012-06-01 00:00:00

abstract：:It has been suggested that prenatal exposure to cadmium may alter the cardiovascular function during adulthood. Using the left coronary artery ligation model of acute myocardial infarction, we studied the cardiac function of female adult offspring rats exposed to cadmium (30 ppm) during gestation. The cardiac ischemic...

journal_title：Cardiovascular toxicology

authors： Zepeda R,Castillo P,Sáez D,Llanos MN,Ronco AM

更新日期：2012-03-01 00:00:00

abstract：:This study was aimed at evaluation of changes in activities of selected antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and contents of key nonenzymatic antioxidants (glutathione, protein thiol groups, and α- and γ-tocopherols) in the left heart ventricle of youn...

journal_title：Cardiovascular toxicology

authors： Sadowska-Krępa E,Kłapcińska B,Jagsz S,Sobczak A,Chrapusta SJ,Chalimoniuk M,Grieb P,Poprzęcki S,Langfort J

更新日期：2011-06-01 00:00:00

abstract：:Anthracycline chemotherapy produces cardiac repolarization abnormalities and arrhythmias because of cardiac toxicity of drugs. Ventricular arrhythmogenesis is attributable to increase in repolarization heterogeneity that is characterized by spatial dispersion of repolarization. The purpose of this work was to study th...

journal_title：Cardiovascular toxicology

authors： Kharin SN,Krandycheva VV,Strelkova MV,Tsvetkova AS,Shmakov DN

更新日期：2012-12-01 00:00:00

abstract：:The present study was undertaken to evaluate protective role of S. rhomboidea. Roxb (SR) leaf extract against in vitro low-density lipoprotein (LDL) oxidation and oxidized LDL (Ox-LDL) induced macrophage apoptosis. Copper and cell-mediated LDL oxidation, Ox-LDL-induced peroxyl radical generation, mitochondrial activit...

journal_title：Cardiovascular toxicology

authors： Thounaojam MC,Jadeja RN,Devkar RV,Ramachandran AV

更新日期：2011-06-01 00:00:00

abstract：:Caffeine, a naturally occurring purine-based alkaloid, is the most consumed psychostimulant worldwide. Since caffeine pharmacokinetics shows extreme interindividual variability, it is not easy to establish its toxic dose. Only a few cases of death due to acute caffeine intoxication have been described so far, the majo...

journal_title：Cardiovascular toxicology

authors： Maiese A,La Russa R,Del Fante Z,Turillazzi E,David MC,Frati P,Fineschi V

更新日期：2021-01-01 00:00:00

abstract：:Elevated levels of homocysteine (Hcy) (known as hyperhomocysteinemia HHcy) are involved in dilated cardiomyopathy. Hcy chelates copper and impairs copper-dependent enzymes. Copper deficiency has been linked to cardiovascular disease. We tested the hypothesis that copper supplement regresses left ventricular hypertroph...

journal_title：Cardiovascular toxicology

authors： Hughes WM Jr,Rodriguez WE,Rosenberger D,Chen J,Sen U,Tyagi N,Moshal KS,Vacek T,Kang YJ,Tyagi SC

更新日期：2008-10-01 00:00:00

abstract：:Choerospondias axillaris (Guangzao) is a medicinal plant used in Mongolia, and its fruit is commonly used for the treatment of cardiovascular diseases in clinic. The constituents responsible for this effect are always conceded to be the total flavonoids of C. axillaries (TFC). The present study was to evaluate the pre...

journal_title：Cardiovascular toxicology

authors： Li C,He J,Gao Y,Xing Y,Hou J,Tian J

更新日期：2014-06-01 00:00:00

abstract：:The use of anthracycline anticancer drugs is limited by a cumulative, dose-dependent cardiac toxicity. Iron chelation has long been considered as a promising strategy to limit this unfavorable side effect, either by restoring the disturbed cellular iron homeostasis or by removing redox-active iron, which may promote a...

journal_title：Cardiovascular toxicology

authors： Kaiserová H,Simunek T,Sterba M,den Hartog GJ,Schröterová L,Popelová O,Gersl V,Kvasnicková E,Bast A

更新日期：2007-01-01 00:00:00

abstract：:DLBS1425 is a bioactive compound extracted from Phaleria macrocarpa, with anti-proliferative, anti-inflammatory and anti-angiogenic properties against cancer cells. The present study was aimed to assess cardiotoxicity of DLBS1425, compared to the mainstay regimen for breast cancer, 5-fluorouracil:doxorubicin:cyclophos...

journal_title：Cardiovascular toxicology

authors： Anggadiredja K,Tjandrawinata RR

更新日期：2015-01-01 00:00:00

abstract：:Congestive heart failure (CHF) afflicts over 5 million individuals in the United States, and most die within 5 yr of diagnosis. Because of the high morbidity and mortality associated with CHF, the search for biomarkers to predict, diagnose, and manage this disease has intensified. Calcium homeostasis and alterations i...

journal_title：Cardiovascular toxicology

authors： Jortani SA,Valdes R Jr

更新日期：2001-01-01 00:00:00

abstract：:Intracellular Na(+) ([Na(+)](i)) is an important modulator of excitation-contraction coupling via regulating Ca(2+) efflux/influx, and no investigation has been so far performed in diabetic rat heart. Here, we examined whether any change of [Na(+)](i) in paced cardiomyocytes could contribute to functional alterations ...

journal_title：Cardiovascular toxicology

authors： Bilginoglu A,Kandilci HB,Turan B

更新日期：2013-06-01 00:00:00

abstract：:Tropomyosins are a family of actin-binding proteins that show cell-specific diversity by a combination of multiple genes and alternative RNA splicing. Of the 4 different tropomyosin genes, TPM4 plays a pivotal role in myofibrillogenesis as well as cardiac contractility in amphibians. In this study, we amplified and se...

journal_title：Cardiovascular toxicology

authors： Denz CR,Zhang C,Jia P,Du J,Huang X,Dube S,Thomas A,Poiesz BJ,Dube DK

更新日期：2011-09-01 00:00:00

abstract：:The anticancer drug lapatinib (Tykerb) is a dual tyrosine kinase inhibitor targeting the HER2 (ERBB2) and EGFR (ERBB1, HER1) pathways that have been shown in clinical trials to display some cardiotoxicity. Because trastuzumab also targets HER2 receptors, the lapatinib/doxorubicin combination provides a good model to p...

journal_title：Cardiovascular toxicology

authors： Hasinoff BB,Patel D,Wu X

更新日期：2013-03-01 00:00:00

abstract：:Serotonergic drugs may lead to valvular heart disease in humans and more recently also in rats. Although clinical data suggest that dose dependency and reversibility after drug cessation might occur, proof of this is lacking. For that purpose, a total of 106 rats were prospectively enrolled: 22 control animals and 7 g...

journal_title：Cardiovascular toxicology

authors： Droogmans S,Roosens B,Cosyns B,Degaillier C,Hernot S,Weytjens C,Garbar C,Caveliers V,Pipeleers-Marichal M,Franken PR,Bossuyt A,Schoors D,Lahoutte T,Van Camp G

更新日期：2009-09-01 00:00:00

abstract：:Cardiac toxicity has been associated with HIV infection and exposure to nucleoside reverse transcriptase inhibitors (NRTIs), but the role of the latter in the development of cardiac disease of HIV-infected patients is uncertain. To investigate the cardiotoxicity of transplacentally administered zidovudine (AZT) or AZT...

journal_title：Cardiovascular toxicology

authors： Walker DM,Poirier MC,Campen MJ,Cook DL Jr,Divi RL,Nagashima K,Lund AK,Cossey PY,Hahn FF,Walker VE

更新日期：2004-01-01 00:00:00

abstract：:The incidence of arsenic toxicity has been observed in various countries including Taiwan, Bangladesh, India, Argentina, Australia, Chile, China, Hungary, Peru, Thailand, Mexico and United States of America. Arsenic is a ubiquitous element present in drinking water, and its exposure is associated with various cardiova...

journal_title：Cardiovascular toxicology

authors： Balakumar P,Kaur J

更新日期：2009-12-01 00:00:00

abstract：:We present an experimental approach that allows exposure of cells plated on a single coverslip to multiple distinct environments. The original chamber design created a small region of injury using geometrically defined flows of the control and ischemic solutions. Modifications of the original chamber design presented ...

journal_title：Cardiovascular toxicology

authors： Arutunyan A,Swift L,Sarvazyan N

更新日期：2004-01-01 00:00:00

abstract：:We report a case of potential cardiovascular toxicity including syncope, bradycardia, and ECG pauses associated with the use of rivastigmine and atenolol. A 65-year-old African American female with a medical history of dementia, hypertension, seizure disorder, stroke, and peripheral vascular disease was admitted to th...

journal_title：Cardiovascular toxicology

authors： Paulison B,Léos CL

更新日期：2010-12-01 00:00:00

abstract：:Although studies have shown that endothelial nitric oxide synthase (eNOS) homozygous knockout mice (eNOS-/-) develop left ventricular (LV) hypertrophy, well compensated at least to 24 wks, uncertainty still exists as to the cardiac functional and molecular mechanistic consequences of eNOS deficiency at later time-poin...

journal_title：Cardiovascular toxicology

authors： Flaherty MP,Brown M,Grupp IL,Schultz JE,Murphree SS,Jones WK

更新日期：2007-01-01 00:00:00

abstract：:Heart rate variability (HRV) is a measure of cardiac pacing dynamics that has recently garnered a great deal of interest in environmental health studies. While the use of these measures has become popular, much uncertainty remains in the interpretation of results, both in terms of human and animal research. In humans,...

journal_title：Cardiovascular toxicology

authors： Rowan WH 3rd,Campen MJ,Wichers LB,Watkinson WP

更新日期：2007-01-01 00:00:00

abstract：:The exact mechanism of acute heart dysfunction caused by jellyfish venom remains unclear for the moment. In the present study, we examined the problem caused by the tentacle extract (TE) from the jellyfish Cyanea capillata at the levels of whole animal, isolated heart, primarily cultured cardiomyocytes, and intracellu...

journal_title：Cardiovascular toxicology

authors： Zhang L,He Q,Wang Q,Zhang B,Wang B,Xu F,Wang T,Xiao L,Zhang L

更新日期：2014-09-01 00:00:00

abstract：:3,4-Methylenedioxymethamphetamine (MDMA), more commonly known as "ecstasy," is a semi-synthetic entactogenic phenylethylamine. In recent years it has gained popularity as a recreational drug whose use has registered an upward trend especially among adolescents and young adults. Despite its unwarranted reputation of be...

journal_title：Cardiovascular toxicology

authors： Bonsignore A,Barranco R,Morando A,Fraternali Orcioni G,Ventura F

更新日期：2019-12-01 00:00:00

abstract：:The present study was designed to evaluate the cardioprotective potential of water extract of rhizomes of Acorus gramineus (AGR) against isoproterenol (ISO)-induced myocardial infarction. Male pigs were orally administered with 250 or 500 mg/kg of AGR or with vehicle for 9 days, with concurrent subcutaneous injections...

journal_title：Cardiovascular toxicology

authors： Kim JH,Chung HS,Antonisamy P,Lee SR,Bae H

更新日期：2014-06-01 00:00:00

abstract：:Recent evidence indicates that Ca2+ dysregulation is involved in the pathogenesis of isoproterenol (ISP)-induced biochemical toxicity and associated oxidative stress. In this study, we investigated the chemopreventive benefit of M3, a 1,4-dihydropyridine calcium channel blocker, against ISP-induced toxicity in male Wi...

journal_title：Cardiovascular toxicology

authors： Kale OE,Gündüz MG,Ogunbiyi BT,Ogundare TF,Ekor M,Awodele O

更新日期：2020-12-01 00:00:00

abstract：:Over 300,000 hip replacements occurred in the USA in 2010, and the frequency is likely increasing annually. Blood Cobalt (Co) concentrations in patients with well-functioning cobalt-chromium (Co-Cr) hip implants are usually elevated above background concentrations relative to the general population. Excessive Co expos...

journal_title：Cardiovascular toxicology

authors： Fung ES,Monnot A,Kovochich M,Unice KM,Tvermoes BE,Galbraith D,Finley BL,Paustenbach DJ

更新日期：2018-06-01 00:00:00

abstract：:Present study evaluates cardioprotective role of melatonin (Mel), alpha lipoic acid (ALA), a combination of melatonin and alpha lipoic acid (Mel + ALA) against cadmium (Cd)-induced oxidative damage. Female albino rats were subjected to 15-day exposure to Cd (5.12 mg/kg bw) alone or treated with ML (10 mg/kg bw) + ALA ...

journal_title：Cardiovascular toxicology

authors： Mukherjee R,Banerjee S,Joshi N,Singh PK,Baxi D,Ramachandran AV

更新日期：2011-03-01 00:00:00