Cardioprotective effect of rhizomes of Acorus gramineus against isoproterenol-induced cardiac damage in pigs.

abstract：:Controlled activation of the complement system is critical to the host-defense response of the immune system. Activated complement is responsible for the stimulation of a localized protective inflammatory response to either invading microorganisms or foreign molecules (toxins). However, the autologous activation of th...

journal_title：Cardiovascular toxicology

authors： Pugsley MK,Abramova M,Cole T,Yang X,Ammons WS

更新日期：2003-01-01 00:00:00

abstract：:Scientific and medical evidence over the past 30 years has established striking parallels between atherosclerosis and cancer--pathogenetic relationships that cross the boundaries of fiction into the realm of reason. Both diseases in humans are characterized by uncontrolled regulation of cellular growth and differentia...

journal_title：Cardiovascular toxicology

authors： Ramos KS,Partridge CR

更新日期：2005-01-01 00:00:00

abstract：:Dofetilide is a class III antiarrhythmic used for treating atrial dysrhythmias. Though its adverse effects are well described in routine use, very little is known about dofetilide toxicity in overdose. This is a retrospective case series of consecutive patients reported to our poison center after dofetilide overdose. ...

journal_title：Cardiovascular toxicology

authors： Hieger MA,Maskell KF,Moss MJ,Powell SW,Cumpston KL

更新日期：2017-07-01 00:00:00

abstract：:The use of anthracycline anticancer drugs is limited by a cumulative, dose-dependent cardiac toxicity. Iron chelation has long been considered as a promising strategy to limit this unfavorable side effect, either by restoring the disturbed cellular iron homeostasis or by removing redox-active iron, which may promote a...

journal_title：Cardiovascular toxicology

authors： Kaiserová H,Simunek T,Sterba M,den Hartog GJ,Schröterová L,Popelová O,Gersl V,Kvasnicková E,Bast A

更新日期：2007-01-01 00:00:00

abstract：:Hypertension, as one of the major risk factors for cardiovascular disease, significantly affects human health. Prostaglandin E2 (PGE2) and the E3-class prostanoid (EP3) receptor have previously been demonstrated to modulate blood pressure and hemodynamics in various animal models of hypertension. The PGE2-evoked press...

journal_title：Cardiovascular toxicology

authors： Wang FF,Ba J,Yu XJ,Shi XL,Liu JJ,Liu KL,Fu LY,Su Q,Li HB,Kang KB,Yi QY,Wang SQ,Gao HL,Qi J,Li Y,Zhu GQ,Kang YM

更新日期：2020-11-09 00:00:00

abstract：:Intracellular Na(+) ([Na(+)](i)) is an important modulator of excitation-contraction coupling via regulating Ca(2+) efflux/influx, and no investigation has been so far performed in diabetic rat heart. Here, we examined whether any change of [Na(+)](i) in paced cardiomyocytes could contribute to functional alterations ...

journal_title：Cardiovascular toxicology

authors： Bilginoglu A,Kandilci HB,Turan B

更新日期：2013-06-01 00:00:00

abstract：:Huntington's disease is an autosomal dominant neurodegenerative disease caused by a CAG repeat expansion in the huntingtin gene. Heart disease is the second leading cause of death in patients with Huntington's disease. This study was to evaluate whether cardiac Fas-dependent and mitochondria-dependent apoptotic pathwa...

journal_title：Cardiovascular toxicology

authors： Wu BT,Chiang MC,Tasi CY,Kuo CH,Shyu WC,Kao CL,Huang CY,Lee SD

更新日期：2016-04-01 00:00:00

abstract：:Coxsackievirus B3 (CVB3) induces myocarditis, especially in the immunodeficient or immature. To investigate whether CVB3 induced pronounced cardiomyopathy during the severe immune dysfunction of murine acquired immunodeficiency syndrome (AIDS), female C57BL/6 mice were infected with LP-BM5 retrovirus and then coinfect...

journal_title：Cardiovascular toxicology

authors： Sepúlveda RT,Zhang J,Watson RR

更新日期：2002-01-01 00:00:00

abstract：:In glyphosate (G)-based herbicides (GBHs), the declared active principle G is mixed with several adjuvants that help it to penetrate the plants' cell membranes and its stabilization and liposolubility. Its utilization is growing with genetically modified organisms engineered to tolerate GBH. Millions of farmers suffer...

journal_title：Cardiovascular toxicology

authors： Gress S,Lemoine S,Séralini GE,Puddu PE

更新日期：2015-04-01 00:00:00

abstract：:Carfilzomib is a proteasome inhibitor, commonly used in multiple myeloma, but its clinical use may be limited due to cardiotoxicity. This study was aimed to evaluate the influence of rutin in carfilzomib-induced cardiotoxicity in rats. Wistar albino male rats weighing 200-250 g (approximately 10 weeks old) were taken ...

journal_title：Cardiovascular toxicology

authors： Imam F,Al-Harbi NO,Al-Harbia MM,Korashy HM,Ansari MA,Sayed-Ahmed MM,Nagi MN,Iqbal M,Khalid Anwer M,Kazmi I,Afzal M,Bahashwan S

更新日期：2017-01-01 00:00:00

abstract：:The objective of this study was to characterize acute coronary artery injury evoked by the endothelin A receptor (ETAR) antagonist, CI-1034. Male dogs (n = 5) were intravenously administered CI-1034 at 120 mg/kg for 4 d. Control animals (n = 3) received vehicle. Macroscopically, drug-related hemorrhage was observed in...

journal_title：Cardiovascular toxicology

authors： McDuffie JE,Yu X,Sobocinski G,Song Y,Chupka J,Albassam M

更新日期：2006-01-01 00:00:00

abstract：:Doxorubicin (Dox) is widely used in cancer therapy, but the clinical application is limited by its cardiotoxicity. The underlying mechanism of Dox-induced cardiotoxicity remains unclear. Present study aimed to evaluate the role of NLRP3 inflammasome in Dox-induced cardiotoxicity. The NLRP3 inflammasome was activated i...

journal_title：Cardiovascular toxicology

authors： Wei S,Ma W,Li X,Jiang C,Sun T,Li Y,Zhang B,Li W

更新日期：2020-10-01 00:00:00

abstract：:Tropomyosins are a family of actin-binding proteins that show cell-specific diversity by a combination of multiple genes and alternative RNA splicing. Of the 4 different tropomyosin genes, TPM4 plays a pivotal role in myofibrillogenesis as well as cardiac contractility in amphibians. In this study, we amplified and se...

journal_title：Cardiovascular toxicology

authors： Denz CR,Zhang C,Jia P,Du J,Huang X,Dube S,Thomas A,Poiesz BJ,Dube DK

更新日期：2011-09-01 00:00:00

abstract：:High-salt-induced inflammation and oxidative stress in the hypothalamic paraventricular nucleus (PVN) contribute to the pathogenesis of salt-sensitive hypertension. In this study, we hypothesized that chronic inhibition of nuclear factor-κB (NF-κB) activity in the PVN delays the progression of hypertension by upregula...

journal_title：Cardiovascular toxicology

authors： Qi J,Yu XJ,Shi XL,Gao HL,Yi QY,Tan H,Fan XY,Zhang Y,Song XA,Cui W,Liu JJ,Kang YM

更新日期：2016-10-01 00:00:00

abstract：:The exact mechanism of acute heart dysfunction caused by jellyfish venom remains unclear for the moment. In the present study, we examined the problem caused by the tentacle extract (TE) from the jellyfish Cyanea capillata at the levels of whole animal, isolated heart, primarily cultured cardiomyocytes, and intracellu...

journal_title：Cardiovascular toxicology

authors： Zhang L,He Q,Wang Q,Zhang B,Wang B,Xu F,Wang T,Xiao L,Zhang L

更新日期：2014-09-01 00:00:00

abstract：:Since an antipsychotic drug haloperidol has been clinically reported to induce QT interval prolongation and torsade de pointes, in this study its risk stratification for the onset of torsade de pointes was performed by using the chronic atrioventricular block canine model with a Holter electrocardiogram. Haloperidol i...

journal_title：Cardiovascular toxicology

authors： Izumi-Nakaseko H,Nakamura Y,Cao X,Wada T,Ando K,Sugiyama A

更新日期：2017-07-01 00:00:00

abstract：:Acute alcohol intoxication leads to an inhibition of protein synthesis in heart that results in part through altered phosphorylation of protein factors controlling mRNA translation initiation. The purpose of the present set of experiments was designed to examine the effects of inhibitors of ethanol metabolism on the p...

journal_title：Cardiovascular toxicology

authors： Vary TC,Lang CH

更新日期：2008-03-01 00:00:00

abstract：:This study investigated whether the whole-plant aqueous extract of Crataegus aronia (C. aronia) could protect against or alleviate high-fat diet (HFD)-induced aortic vascular inflammation in rats by inhibiting the NLRP-3 inflammasome pathway and examined some mechanisms of action with respect to its antioxidant and hy...

journal_title：Cardiovascular toxicology

authors： Shatoor AS,Al Humayed S

更新日期：2020-02-01 00:00:00

abstract：:Four decades of research on the link between hyperhomocysteinemia and cardiovascular disease has led to a crossroads. Several negative studies on the role of homocysteine-lowering B-vitamin therapy in reducing the risk of atherothrombotic cardiovascular disease have dampened enthusiasm for this important field of rese...

journal_title：Cardiovascular toxicology

authors： Joseph J,Handy DE,Loscalzo J

更新日期：2009-06-01 00:00:00

abstract：:Doxorubicin (Dox), an antitumor anthracycline antibiotic, plays a key role in the treatment of many neoplastic diseases. However, its chronic administration induces cardiomyopathy. Increased oxidative stress is a major factor implicated in Dox-induced cardiotoxicity. We hypothesized that a pre-treatment with grape see...

journal_title：Cardiovascular toxicology

authors： Mokni M,Hamlaoui-Guesmi S,Amri M,Marzouki L,Limam F,Aouani E

更新日期：2012-06-01 00:00:00

abstract：:Oxygen-derived free radicals have been demonstrated to contribute to the pathogenesis of myocardial dysfunction, although the underlying mechanism remains not fully understood. This study was designed to examine the role of the superoxide generator pyrogallol on cardiac contractile function and possible intervention w...

journal_title：Cardiovascular toxicology

authors： Esberg LB,Ren J

更新日期：2004-01-01 00:00:00

abstract：:Serotonergic drugs may lead to valvular heart disease in humans and more recently also in rats. Although clinical data suggest that dose dependency and reversibility after drug cessation might occur, proof of this is lacking. For that purpose, a total of 106 rats were prospectively enrolled: 22 control animals and 7 g...

journal_title：Cardiovascular toxicology

authors： Droogmans S,Roosens B,Cosyns B,Degaillier C,Hernot S,Weytjens C,Garbar C,Caveliers V,Pipeleers-Marichal M,Franken PR,Bossuyt A,Schoors D,Lahoutte T,Van Camp G

更新日期：2009-09-01 00:00:00

abstract：:Lithium is one of the classical drugs that have been widely used for treating bipolar disorder. However, several cardiac side effects including sick sinus syndrome, bundle branch block, ventricular tachycardia/fibrillation, non-specific T-wave abnormalities in addition to Brugada-type electrocardiographic changes have...

journal_title：Cardiovascular toxicology

authors： Goto A,Nakamura Y,Lubna NJ,Chiba K,Hagiwara-Nagasawa M,Izumi-Nakaseko H,Ando K,Naito AT,Sugiyama A

更新日期：2018-12-01 00:00:00

abstract：:Anthracycline chemotherapy produces cardiac repolarization abnormalities and arrhythmias because of cardiac toxicity of drugs. Ventricular arrhythmogenesis is attributable to increase in repolarization heterogeneity that is characterized by spatial dispersion of repolarization. The purpose of this work was to study th...

journal_title：Cardiovascular toxicology

authors： Kharin SN,Krandycheva VV,Strelkova MV,Tsvetkova AS,Shmakov DN

更新日期：2012-12-01 00:00:00

abstract：:Tolerance to clinically important organic nitrates such as nitroglycerin (NTG) has been experimentally related to endothelial dysfunction and vascular oxidative stress. Anti-oxidant enzymes such as the glutathione-S-transferases GSTs) could potentially play a protective role in NTG tolerance. Our previous work showed ...

journal_title：Cardiovascular toxicology

authors： Wang L,Yang Y,Dwivedi S,Xu Y,Chu ET,Li J,Fitchett K,Boor PJ

更新日期：2006-01-01 00:00:00

abstract：:Clopidogrel is used in patients with coronary syndromes and at risk of thrombotic events or receiving percutaneous coronary intervention (PCI) for reducing heart attack and stroke. Here we present genotype and phenotype study of Iranian patients undergoing PCI treated with clopidogrel during a 6-month period of follow...

journal_title：Cardiovascular toxicology

authors： Mahdieh N,Rabbani A,Firouzi A,Zahedmehr A,Hoseinimoghaddam M,Saedi S,Sanati H,Basiri H,Noohi F,Rabbani B,Maleki M

更新日期：2018-10-01 00:00:00

abstract：:Elevated levels of homocysteine (Hcy) (known as hyperhomocysteinemia HHcy) are involved in dilated cardiomyopathy. Hcy chelates copper and impairs copper-dependent enzymes. Copper deficiency has been linked to cardiovascular disease. We tested the hypothesis that copper supplement regresses left ventricular hypertroph...

journal_title：Cardiovascular toxicology

authors： Hughes WM Jr,Rodriguez WE,Rosenberger D,Chen J,Sen U,Tyagi N,Moshal KS,Vacek T,Kang YJ,Tyagi SC

更新日期：2008-10-01 00:00:00

abstract：:Heart rate variability (HRV) is a measure of cardiac pacing dynamics that has recently garnered a great deal of interest in environmental health studies. While the use of these measures has become popular, much uncertainty remains in the interpretation of results, both in terms of human and animal research. In humans,...

journal_title：Cardiovascular toxicology

authors： Rowan WH 3rd,Campen MJ,Wichers LB,Watkinson WP

更新日期：2007-01-01 00:00:00

abstract：:Acute cardiovascular poisoning is a major cause of adverse outcomes in poisoning emergencies. The prognostic validity of corrected QT (QTc) and dispersed QT (QTd) in these outcomes is still limited. The present study aimed to determine the risk factors of mortality, adverse cardiovascular events (ACVE), and intensive ...

journal_title：Cardiovascular toxicology

authors： El-Sarnagawy GN,Shaban AE,Lashin HI

更新日期：2021-01-05 00:00:00

abstract：:Unintentional intravascular administration of bupivacaine may cause local anesthetic systemic toxicity (LAST). Although many systems are affected in LAST, the cardiovascular effects can be life-threatening. Remifentanil is a selective, ultra-short-acting, µ-opioid receptor agonist opioid. This study assessed the effec...

journal_title：Cardiovascular toxicology

authors： Pişkin Ö,Ayoğlu H

更新日期：2018-02-01 00:00:00