Abstract：
:This study investigated whether the whole-plant aqueous extract of Crataegus aronia (C. aronia) could protect against or alleviate high-fat diet (HFD)-induced aortic vascular inflammation in rats by inhibiting the NLRP-3 inflammasome pathway and examined some mechanisms of action with respect to its antioxidant and hypolipidemic effects. Adult male Wistar rats were divided into five groups (n = 6/each): standard diet (10% fat) fed to control rats, control + C. aronia (200 mg/kg), HFD (40% fat), HFD + C. aronia, and HFD post-treated with C. aronia. The HFD was fed for 8 weeks and C. aronia was administered orally for 4 weeks. In addition, isolated macrophages from control rats were pre-incubated with two doses of C. aronia (25 and 50 μg/mL) with or without lipopolysaccharide (LPS) stimulation. Only in HFD-fed rats, co- and post-C. aronia therapy lowered circulatory levels of LDL-C and ox-LDL-c and aortic protein levels of LOX-1 and CD36. C. aronia also inhibited the nuclear accumulation of NF-κB and lowered protein levels of NLRP-3, caspase-1, and mature IL-1β. In vitro, in the absence of ox-LDL-c, C. aronia led to reduced nuclear levels of NF-κB, ROS generation, and protein NLRP-3 levels, in both LPS-stimulated and unstimulated macrophages, in a dose-dependent manner. However, protein levels of LOX-1 were not affected by C. aronia in unstimulated cells. In conclusion, C. aronia inhibits the NLRP-3 inflammasome pathway, induced by HFD feeding in the aorta of rats, mainly by its hypolipidemic effect and in vitro, in LPS-stimulated macrophages, by its antioxidant effect.
journal_name
Cardiovasc Toxicoljournal_title
Cardiovascular toxicologyauthors
Shatoor AS,Al Humayed Sdoi
10.1007/s12012-019-09534-9subject
Has Abstractpub_date
2020-02-01 00:00:00pages
82-99issue
1eissn
1530-7905issn
1559-0259pii
10.1007/s12012-019-09534-9journal_volume
20pub_type
杂志文章abstract：:The aryl hydrocarbon receptor (AhR) is a member of the basic helix loop helix PAS (Per-ARNT-SIM) transcription family, which also includes hypoxiainducible factor-1alpha (HIF-1alpha) and its common dimerization partner AhR nuclear translocator (ARNT). Following ligand activation or hypoxia, AhR or HIF-1alpha, respecti...
journal_title：Cardiovascular toxicology
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doi：10.1385/ct:2:4:263
更新日期：2002-01-01 00:00:00
abstract：:The present study was undertaken to evaluate protective role of S. rhomboidea. Roxb (SR) leaf extract against in vitro low-density lipoprotein (LDL) oxidation and oxidized LDL (Ox-LDL) induced macrophage apoptosis. Copper and cell-mediated LDL oxidation, Ox-LDL-induced peroxyl radical generation, mitochondrial activit...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-011-9110-6
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1385/ct:1:2:165
更新日期：2001-01-01 00:00:00
abstract：:This study investigated the effect of metyrosine against ketamine-induced cardiotoxicity in rats and compared the results with the effect of metoprolol. In this study, rats were divided into groups A, B and C. In group A, we investigated the effects of a single dose of metyrosine (150 mg/kg) and metoprolol (20 mg/kg) ...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-014-9301-z
更新日期：2015-10-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-016-9394-7
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-016-9372-0
更新日期：2017-04-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1385/ct:4:2:133
更新日期：2004-01-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-013-9225-z
更新日期：2013-12-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
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更新日期：2004-01-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-010-9066-y
更新日期：2010-06-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-018-09504-7
更新日期：2019-04-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1385/ct:3:2:119
更新日期：2003-01-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1385/ct:4:1:01
更新日期：2004-01-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1385/ct:5:1:001
更新日期：2005-01-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-016-9388-5
更新日期：2017-07-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-019-09527-8
更新日期：2019-12-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-012-9172-0
更新日期：2012-12-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1385/ct:5:3:245
更新日期：2005-01-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-014-9250-6
更新日期：2014-09-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1385/ct:3:4:331
更新日期：2003-01-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1385/ct:2:1:53
更新日期：2002-01-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2019-08-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-011-9138-7
更新日期：2012-03-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2015-01-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-008-9012-4
更新日期：2008-03-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-016-9384-9
更新日期：2017-07-01 00:00:00
abstract：:The incidence of arsenic toxicity has been observed in various countries including Taiwan, Bangladesh, India, Argentina, Australia, Chile, China, Hungary, Peru, Thailand, Mexico and United States of America. Arsenic is a ubiquitous element present in drinking water, and its exposure is associated with various cardiova...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-009-9050-6
更新日期：2009-12-01 00:00:00
