Atherosclerosis and cancer: flip sides of the neoplastic response in mammalian cells?

abstract：:Arsenic trioxide (As2O3) is used clinically in the management of acute promyelocytic leukemia, and the use of electrocardiogram (ECG) in this management is important as arsenic use may cause distortion of the electrical properties with its attendant sequel. We studied the effect of As2O3 on vasomotion in rat aortic ri...

journal_title：Cardiovascular toxicology

authors： Cifuentes F,Palacios J,Nwokocha CR

更新日期：2016-01-01 00:00:00

abstract：:Present study evaluates cardioprotective role of melatonin (Mel), alpha lipoic acid (ALA), a combination of melatonin and alpha lipoic acid (Mel + ALA) against cadmium (Cd)-induced oxidative damage. Female albino rats were subjected to 15-day exposure to Cd (5.12 mg/kg bw) alone or treated with ML (10 mg/kg bw) + ALA ...

journal_title：Cardiovascular toxicology

authors： Mukherjee R,Banerjee S,Joshi N,Singh PK,Baxi D,Ramachandran AV

更新日期：2011-03-01 00:00:00

abstract：:Unintentional intravascular administration of bupivacaine may cause local anesthetic systemic toxicity (LAST). Although many systems are affected in LAST, the cardiovascular effects can be life-threatening. Remifentanil is a selective, ultra-short-acting, µ-opioid receptor agonist opioid. This study assessed the effec...

journal_title：Cardiovascular toxicology

authors： Pişkin Ö,Ayoğlu H

更新日期：2018-02-01 00:00:00

abstract：:Tropomyosins are a family of actin-binding proteins that show cell-specific diversity by a combination of multiple genes and alternative RNA splicing. Of the 4 different tropomyosin genes, TPM4 plays a pivotal role in myofibrillogenesis as well as cardiac contractility in amphibians. In this study, we amplified and se...

journal_title：Cardiovascular toxicology

authors： Denz CR,Zhang C,Jia P,Du J,Huang X,Dube S,Thomas A,Poiesz BJ,Dube DK

更新日期：2011-09-01 00:00:00

abstract：:The purpose of this essay is to overview our findings that membrane-associated calcium-independent phospholipase A2 is markedly inhibited by low, clinically relevant concentrations of anthracyclines. Our studies suggest that due to the essential role of this enzyme in membrane homeostasis, its inhibition can be one of...

journal_title：Cardiovascular toxicology

authors： Swift L,McHowat J,Sarvazyan N

更新日期：2007-01-01 00:00:00

abstract：:High-salt-induced inflammation and oxidative stress in the hypothalamic paraventricular nucleus (PVN) contribute to the pathogenesis of salt-sensitive hypertension. In this study, we hypothesized that chronic inhibition of nuclear factor-κB (NF-κB) activity in the PVN delays the progression of hypertension by upregula...

journal_title：Cardiovascular toxicology

authors： Qi J,Yu XJ,Shi XL,Gao HL,Yi QY,Tan H,Fan XY,Zhang Y,Song XA,Cui W,Liu JJ,Kang YM

更新日期：2016-10-01 00:00:00

abstract：:We present an experimental approach that allows exposure of cells plated on a single coverslip to multiple distinct environments. The original chamber design created a small region of injury using geometrically defined flows of the control and ischemic solutions. Modifications of the original chamber design presented ...

journal_title：Cardiovascular toxicology

authors： Arutunyan A,Swift L,Sarvazyan N

更新日期：2004-01-01 00:00:00

abstract：:Nucleoside reverse transcriptase inhibitor (NRTI)-induced cardiomyopathy has been suggested to reflect mitochondrial targets of drug toxicity. The prevailing hypothesis is that, through structural mimicry, the NRTIs are mistaken as substrates for DNA polymerase and incorporated into replicating DNA, where they cause t...

journal_title：Cardiovascular toxicology

authors： Lund KC,Wallace KB

更新日期：2004-01-01 00:00:00

abstract：:The effects of magnesium (Mg2+) on ischaemic complications of pathological cardiac hypertrophy are unclear. In this study, we investigated effects of Mg2+ pretreatment on ischaemia/reperfusion (I/R) injury in isoprenaline (ISO)-induced hypertrophic hearts. Wistar rats were treated for 7 days with different combination...

journal_title：Cardiovascular toxicology

authors： Amoni M,Kelly-Laubscher R,Petersen M,Gwanyanya A

更新日期：2017-01-01 00:00:00

abstract：:This study investigated vildagliptin-induced vasodilation and its related mechanisms using phenylephrine induced precontracted rabbit aortic rings. Vildagliptin induced vasodilation in a concentration-dependent manner. Pretreatment with the large-conductance Ca2+-activated K+ channel blocker paxilline, ATP-sensitive K...

journal_title：Cardiovascular toxicology

authors： Seo MS,Li H,An JR,Jung ID,Jung WK,Ha KS,Han ET,Hong SH,Choi IW,Park WS

更新日期：2019-06-01 00:00:00

abstract：:In glyphosate (G)-based herbicides (GBHs), the declared active principle G is mixed with several adjuvants that help it to penetrate the plants' cell membranes and its stabilization and liposolubility. Its utilization is growing with genetically modified organisms engineered to tolerate GBH. Millions of farmers suffer...

journal_title：Cardiovascular toxicology

authors： Gress S,Lemoine S,Séralini GE,Puddu PE

更新日期：2015-04-01 00:00:00

abstract：:Asiatic acid (AA), a pentacyclic triterpenoid, is a key phytoconstituent of Centella asiatica. AA is a patented as a cytotoxic substance, and it exerts cytotoxicity against Hep3B, Hela and MCF-7 cell lines. However, pentacyclic triterpenoids also modulate the expression and transcriptional activities of Nrf2 and exert...

journal_title：Cardiovascular toxicology

authors： Kamble SM,Patil CR

更新日期：2018-04-01 00:00:00

abstract：:Clopidogrel is used in patients with coronary syndromes and at risk of thrombotic events or receiving percutaneous coronary intervention (PCI) for reducing heart attack and stroke. Here we present genotype and phenotype study of Iranian patients undergoing PCI treated with clopidogrel during a 6-month period of follow...

journal_title：Cardiovascular toxicology

authors： Mahdieh N,Rabbani A,Firouzi A,Zahedmehr A,Hoseinimoghaddam M,Saedi S,Sanati H,Basiri H,Noohi F,Rabbani B,Maleki M

更新日期：2018-10-01 00:00:00

abstract：:The use of anthracycline anticancer drugs is limited by a cumulative, dose-dependent cardiac toxicity. Iron chelation has long been considered as a promising strategy to limit this unfavorable side effect, either by restoring the disturbed cellular iron homeostasis or by removing redox-active iron, which may promote a...

journal_title：Cardiovascular toxicology

authors： Kaiserová H,Simunek T,Sterba M,den Hartog GJ,Schröterová L,Popelová O,Gersl V,Kvasnicková E,Bast A

更新日期：2007-01-01 00:00:00

abstract：:Four decades of research on the link between hyperhomocysteinemia and cardiovascular disease has led to a crossroads. Several negative studies on the role of homocysteine-lowering B-vitamin therapy in reducing the risk of atherothrombotic cardiovascular disease have dampened enthusiasm for this important field of rese...

journal_title：Cardiovascular toxicology

authors： Joseph J,Handy DE,Loscalzo J

更新日期：2009-06-01 00:00:00

abstract：:Doxorubicin (Dox), an antitumor anthracycline antibiotic, plays a key role in the treatment of many neoplastic diseases. However, its chronic administration induces cardiomyopathy. Increased oxidative stress is a major factor implicated in Dox-induced cardiotoxicity. We hypothesized that a pre-treatment with grape see...

journal_title：Cardiovascular toxicology

authors： Mokni M,Hamlaoui-Guesmi S,Amri M,Marzouki L,Limam F,Aouani E

更新日期：2012-06-01 00:00:00

abstract：:We report a case of potential cardiovascular toxicity including syncope, bradycardia, and ECG pauses associated with the use of rivastigmine and atenolol. A 65-year-old African American female with a medical history of dementia, hypertension, seizure disorder, stroke, and peripheral vascular disease was admitted to th...

journal_title：Cardiovascular toxicology

authors： Paulison B,Léos CL

更新日期：2010-12-01 00:00:00

abstract：:Since an antipsychotic drug haloperidol has been clinically reported to induce QT interval prolongation and torsade de pointes, in this study its risk stratification for the onset of torsade de pointes was performed by using the chronic atrioventricular block canine model with a Holter electrocardiogram. Haloperidol i...

journal_title：Cardiovascular toxicology

authors： Izumi-Nakaseko H,Nakamura Y,Cao X,Wada T,Ando K,Sugiyama A

更新日期：2017-07-01 00:00:00

abstract：:Cardiac hypertrophy is an adaptive response to a number of heart diseases including myocardial infarction. Although it can be compensatory at first, sustained hypertrophy is often a transition to heart failure. We have found that cardiomyocytes in culture can survive mild doses of H2O2 but develop hypertrophy involvin...

journal_title：Cardiovascular toxicology

authors： Tu VC,Bahl JJ,Chen QM

更新日期：2003-01-01 00:00:00

abstract：:Serotonergic drugs may lead to valvular heart disease in humans and more recently also in rats. Although clinical data suggest that dose dependency and reversibility after drug cessation might occur, proof of this is lacking. For that purpose, a total of 106 rats were prospectively enrolled: 22 control animals and 7 g...

journal_title：Cardiovascular toxicology

authors： Droogmans S,Roosens B,Cosyns B,Degaillier C,Hernot S,Weytjens C,Garbar C,Caveliers V,Pipeleers-Marichal M,Franken PR,Bossuyt A,Schoors D,Lahoutte T,Van Camp G

更新日期：2009-09-01 00:00:00

abstract：:The anticancer drug lapatinib (Tykerb) is a dual tyrosine kinase inhibitor targeting the HER2 (ERBB2) and EGFR (ERBB1, HER1) pathways that have been shown in clinical trials to display some cardiotoxicity. Because trastuzumab also targets HER2 receptors, the lapatinib/doxorubicin combination provides a good model to p...

journal_title：Cardiovascular toxicology

authors： Hasinoff BB,Patel D,Wu X

更新日期：2013-03-01 00:00:00

abstract：:We made an attempt to evaluate/compare the cardioprotective activity of two different doses (50 and 100 mg/kg body weight, given orally for 30 consecutive days) of Egyptian sweet marjoram leaf powder (MLP) and marjoram leaf aqueous extract (MLE) against isoproterenol (ISO)-induced myocardial infarcted rats (150 mg/kg ...

journal_title：Cardiovascular toxicology

authors： Ramadan G,El-Beih NM,Arafa NM,Zahra MM

更新日期：2013-06-01 00:00:00

abstract：:Trichloroethylene is an organic solvent used as an industrial degreasing agent. Due to its widespread use and volatile nature, TCE is a common environmental contaminant. Trichloroethylene exposure has been implicated in the etiology of heart defects in human populations and animal models. Recent data suggest misregula...

journal_title：Cardiovascular toxicology

authors： Makwana O,King NM,Ahles L,Selmin O,Granzier HL,Runyan RB

更新日期：2010-06-01 00:00:00

abstract：:Choerospondias axillaris (Guangzao) is a medicinal plant used in Mongolia, and its fruit is commonly used for the treatment of cardiovascular diseases in clinic. The constituents responsible for this effect are always conceded to be the total flavonoids of C. axillaries (TFC). The present study was to evaluate the pre...

journal_title：Cardiovascular toxicology

authors： Li C,He J,Gao Y,Xing Y,Hou J,Tian J

更新日期：2014-06-01 00:00:00

abstract：:Cardiac gene expression regulation is controlled not only by genetic factors but also by environmental, i.e., epigenetic factors. Several environmental toxic effects such as oxidative stress and ischemia can result in abnormal myofibril gene expression during heart development. Troponin, one of the regulatory myofibri...

journal_title：Cardiovascular toxicology

authors： Zhao W,Liu L,Pan B,Xu Y,Zhu J,Nan C,Huang X,Tian J

更新日期：2015-07-01 00:00:00

abstract：:Carfilzomib is a proteasome inhibitor, commonly used in multiple myeloma, but its clinical use may be limited due to cardiotoxicity. This study was aimed to evaluate the influence of rutin in carfilzomib-induced cardiotoxicity in rats. Wistar albino male rats weighing 200-250 g (approximately 10 weeks old) were taken ...

journal_title：Cardiovascular toxicology

authors： Imam F,Al-Harbi NO,Al-Harbia MM,Korashy HM,Ansari MA,Sayed-Ahmed MM,Nagi MN,Iqbal M,Khalid Anwer M,Kazmi I,Afzal M,Bahashwan S

更新日期：2017-01-01 00:00:00

abstract：:The present study was designed to evaluate the cardioprotective potential of water extract of rhizomes of Acorus gramineus (AGR) against isoproterenol (ISO)-induced myocardial infarction. Male pigs were orally administered with 250 or 500 mg/kg of AGR or with vehicle for 9 days, with concurrent subcutaneous injections...

journal_title：Cardiovascular toxicology

authors： Kim JH,Chung HS,Antonisamy P,Lee SR,Bae H

更新日期：2014-06-01 00:00:00

abstract：:Cardiac troponins not only allow for risk stratification and guidance of therapy in unstable angina and non-Q-wave acute myocardial infarction but also may be useful in the diagnostic workup and monitoring of patients with ST-segment elevation myocardial infarction. In clinical practice, troponins are used for confirm...

journal_title：Cardiovascular toxicology

authors： Lehrke S,Giannitsis E,Steen H,Katus HA

更新日期：2001-01-01 00:00:00

abstract：:Huntington's disease is an autosomal dominant neurodegenerative disease caused by a CAG repeat expansion in the huntingtin gene. Heart disease is the second leading cause of death in patients with Huntington's disease. This study was to evaluate whether cardiac Fas-dependent and mitochondria-dependent apoptotic pathwa...

journal_title：Cardiovascular toxicology

authors： Wu BT,Chiang MC,Tasi CY,Kuo CH,Shyu WC,Kao CL,Huang CY,Lee SD

更新日期：2016-04-01 00:00:00

abstract：:Doxorubicin (Dox) is widely used in cancer therapy, but the clinical application is limited by its cardiotoxicity. The underlying mechanism of Dox-induced cardiotoxicity remains unclear. Present study aimed to evaluate the role of NLRP3 inflammasome in Dox-induced cardiotoxicity. The NLRP3 inflammasome was activated i...

journal_title：Cardiovascular toxicology

authors： Wei S,Ma W,Li X,Jiang C,Sun T,Li Y,Zhang B,Li W

更新日期：2020-10-01 00:00:00