当前位置： SCI文献检索 > Cardiovascular Toxicology期刊下所有文献 > Direct, DNA pol-gamma-independent effects of nucleoside reverse transcriptase inhibitors on mitochondrial bioenergetics.

Direct, DNA pol-gamma-independent effects of nucleoside reverse transcriptase inhibitors on mitochondrial bioenergetics.

Abstract：

:Nucleoside reverse transcriptase inhibitor (NRTI)-induced cardiomyopathy has been suggested to reflect mitochondrial targets of drug toxicity. The prevailing hypothesis is that, through structural mimicry, the NRTIs are mistaken as substrates for DNA polymerase and incorporated into replicating DNA, where they cause truncation of the elongating strand. Although there exist five forms of nuclear DNA polymerase, mitochondria possess solely DNA polymerase-gamma (pol-gamma), which is a preferred target for most NRTIs. Consequently, mitochondria are particularly susceptible to inhibition of DNA replication by the NRTIs, which is consistent with the phenotype of mitochondrial depletion and metabolic failure in affected patients. However, the DNA pol-gamma hypothesis by itself fails to explain the entire array of metabolic deficiencies associated with NRTI-induced disorders. In this article, we review the published literature regarding the direct effects of NRTIs on various mitochondrial targets and suggest the possibility that the initiating event in NRTI-induced cardiomyopathy is a direct mitochondrial toxicity rather than inhibition of mitochondrial DNA pol-gamma. The goal of this review is to encourage a discussion of the cause of NRTI-induced mitochondrial cardiomyopathy to include a fresh consideration of all possible targets and integrating pathways that are involved in establishing mitochondrial bioenergetic fidelity and metabolic capacity in the affected myocardium.

journal_name

Cardiovasc Toxicol

journal_title

Cardiovascular toxicology

authors

Lund KC,Wallace KB

doi

10.1385/ct:4:3:217

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

217-28

issue

3

eissn

1530-7905

issn

1559-0259

pii

CT:4:3:217

journal_volume

4

pub_type

杂志文章,评审

相关文献

Cardiovascular Toxicology文献大全
  • Preventive effect of total flavones of Choerospondias axillaries on ischemia/reperfusion-induced myocardial infarction-related MAPK signaling pathway.

    abstract：:Choerospondias axillaris (Guangzao) is a medicinal plant used in Mongolia, and its fruit is commonly used for the treatment of cardiovascular diseases in clinic. The constituents responsible for this effect are always conceded to be the total flavonoids of C. axillaries (TFC). The present study was to evaluate the pre...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-013-9238-7

    authors： Li C,He J,Gao Y,Xing Y,Hou J,Tian J

    更新日期：2014-06-01 00:00:00

  • An Overview on Arsenic Trioxide-Induced Cardiotoxicity.

    abstract：:Arsenic trioxide (ATO) is among the first-line chemotherapeutic drugs used in oncological practice. It has shown substantial efficacy in treating patients with relapsed or refractory acute promyelocytic leukaemia. The clinical use of ATO is hampered due to cardiotoxicity and hence many patients are precluded from rece...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章,评审

    doi：10.1007/s12012-018-09504-7

    authors： Vineetha VP,Raghu KG

    更新日期：2019-04-01 00:00:00

  • The cardioprotective agent urocortin induces expression of CT-1.

    abstract：:The corticotrophin-releasing hormone-related factor, urocortin (Ucn) and the interleukin (IL)-6 family cytokine cardiotrophin-1 (CT-1) are both cardioprotective agents able to protect the heart from ischemic damage. In both cases the protective effect involves activation of the p42/p44 MAPK and PI-3 kinase/Akt pathway...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1385/ct:3:3:255

    authors： Janjua S,Lawrence KM,Ng LL,Latchman DS

    更新日期：2003-01-01 00:00:00

  • Role of Peroxynitrite-Induced Activation of Poly(ADP-Ribose) Polymerase (PARP) in Circulatory Shock and Related Pathological Conditions.

    abstract：:Peroxynitrite is a powerful oxidant, formed from the reaction of nitric oxide and superoxide. It is known to interact and modify different biological molecules such as DNA, lipids and proteins leading to alterations in their structure and functions. These events elicit various cellular responses, including cell signal...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章,评审

    doi：10.1007/s12012-016-9394-7

    authors： Islam BU,Habib S,Ali SA,Moinuddin,Ali A

    更新日期：2017-10-01 00:00:00

  • Cardiac troponin T in ST-segment elevation acute myocardial infarction revisited.

    abstract：:Cardiac troponins not only allow for risk stratification and guidance of therapy in unstable angina and non-Q-wave acute myocardial infarction but also may be useful in the diagnostic workup and monitoring of patients with ST-segment elevation myocardial infarction. In clinical practice, troponins are used for confirm...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章,评审

    doi：10.1385/ct:1:2:099

    authors： Lehrke S,Giannitsis E,Steen H,Katus HA

    更新日期：2001-01-01 00:00:00

  • Grape seed proanthocyanidins induce pro-oxidant toxicity in cardiomyocytes.

    abstract：:Grape seed proanthocyanidin extract (GSPE), a polyphenolic compound with antioxidant properties, may protect against cardiac ischemia and reperfusion injury. However, its potential toxicity at higher doses is unknown. The authors tested the effects of GSPE on reactive oxygen species (ROS) generation, cell survival, la...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1385/ct:3:4:331

    authors： Shao ZH,Vanden Hoek TL,Xie J,Wojcik K,Chan KC,Li CQ,Hamann K,Qin Y,Schumacker PT,Becker LB,Yuan CS

    更新日期：2003-01-01 00:00:00

  • A combination of melatonin and alpha lipoic acid has greater cardioprotective effect than either of them singly against cadmium-induced oxidative damage.

    abstract：:Present study evaluates cardioprotective role of melatonin (Mel), alpha lipoic acid (ALA), a combination of melatonin and alpha lipoic acid (Mel + ALA) against cadmium (Cd)-induced oxidative damage. Female albino rats were subjected to 15-day exposure to Cd (5.12 mg/kg bw) alone or treated with ML (10 mg/kg bw) + ALA ...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-010-9092-9

    authors： Mukherjee R,Banerjee S,Joshi N,Singh PK,Baxi D,Ramachandran AV

    更新日期：2011-03-01 00:00:00

  • Cardiac myofibril formation is not affected by modification of both N- and C-termini of sarcomeric tropomyosin.

    abstract：:Although the role of tropomyosin is well-defined in striated muscle, the precise mechanism of how tropomyosin functions is still unclear. It has been shown that extension of either N- or C-terminal ends of sarcomeric tropomyosin do not affect cardiac myofibrillogenesis, but it is not known whether simultaneous extensi...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1385/ct:5:1:001

    authors： Narshi A,Denz CR,Nakatsugawa M,Zajdel RW,Dube S,Poiesz BJ,Dube DK

    更新日期：2005-01-01 00:00:00

  • Anthracycline-induced phospholipase A2 inhibition.

    abstract：:The purpose of this essay is to overview our findings that membrane-associated calcium-independent phospholipase A2 is markedly inhibited by low, clinically relevant concentrations of anthracyclines. Our studies suggest that due to the essential role of this enzyme in membrane homeostasis, its inhibition can be one of...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章,评审

    doi：10.1007/s12012-007-0012-6

    authors： Swift L,McHowat J,Sarvazyan N

    更新日期：2007-01-01 00:00:00

  • Autoantibodies isolated from preeclamptic patients induce endothelial dysfunction via interaction with the angiotensin II AT1 receptor.

    abstract：:Complete understanding of the etiology underlying endothelial damage in preeclampsia (PE) remains deficient. Recent studies suggest that autoantibodies against angiotensin II AT1 receptors (AT1-AA) may affect vascular endothelial integrity. However, direct evidence demonstrating association between AT1-AA from preecla...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-013-9229-8

    authors： Yang X,Wang F,Lau WB,Zhang S,Zhang S,Liu H,Ma XL

    更新日期：2014-03-01 00:00:00

  • Glyphosate-based herbicides potently affect cardiovascular system in mammals: review of the literature.

    abstract：:In glyphosate (G)-based herbicides (GBHs), the declared active principle G is mixed with several adjuvants that help it to penetrate the plants' cell membranes and its stabilization and liposolubility. Its utilization is growing with genetically modified organisms engineered to tolerate GBH. Millions of farmers suffer...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章,评审

    doi：10.1007/s12012-014-9282-y

    authors： Gress S,Lemoine S,Séralini GE,Puddu PE

    更新日期：2015-04-01 00:00:00

  • Assessment of Safety Margin of an Antipsychotic Drug Haloperidol for Torsade de Pointes Using the Chronic Atrioventricular Block Dogs.

    abstract：:Since an antipsychotic drug haloperidol has been clinically reported to induce QT interval prolongation and torsade de pointes, in this study its risk stratification for the onset of torsade de pointes was performed by using the chronic atrioventricular block canine model with a Holter electrocardiogram. Haloperidol i...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-016-9388-5

    authors： Izumi-Nakaseko H,Nakamura Y,Cao X,Wada T,Ando K,Sugiyama A

    更新日期：2017-07-01 00:00:00

  • Cardiac Fas-Dependent and Mitochondria-Dependent Apoptotic Pathways in a Transgenic Mouse Model of Huntington's Disease.

    abstract：:Huntington's disease is an autosomal dominant neurodegenerative disease caused by a CAG repeat expansion in the huntingtin gene. Heart disease is the second leading cause of death in patients with Huntington's disease. This study was to evaluate whether cardiac Fas-dependent and mitochondria-dependent apoptotic pathwa...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-015-9318-y

    authors： Wu BT,Chiang MC,Tasi CY,Kuo CH,Shyu WC,Kao CL,Huang CY,Lee SD

    更新日期：2016-04-01 00:00:00

  • The Correlation Between 9p21 Chromosome rs4977574 Polymorphism Genotypes and the Development of Coronary Artery Heart Disease.

    abstract：:Our aim is to investigate the correlation between 9p21 chromosome rs4977574 polymorphism genotypes and the development of coronary artery heart disease (CHD). Two hundred and eighty-nine patients with angiography-confirmed CHD were recruited as the CHD group, while 338 subjects without CHD symptoms were enrolled as th...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-016-9372-0

    authors： Tang O,Lv J,Cheng Y,Qin F

    更新日期：2017-04-01 00:00:00

  • p38 MAP kinase inhibitor prevents diastolic dysfunction in rats following HIV gp120 injection in vivo.

    abstract：:HIV infection in patients is associated with a surprisingly high frequency of diastolic dysfunction followed by the development of a dilated cardiomyopathy. Potential mechanisms include direct effects of HIV proteins, including gp120. We have previously reported direct inotropic and p38 MAP kinase signaling effects of...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-009-9047-1

    authors： Berzingi C,Chen F,Finkel MS

    更新日期：2009-09-01 00:00:00

  • The adverse cardiac effects of Di(2-ethylhexyl)phthalate and Bisphenol A.

    abstract：:The ubiquitous nature of plastics has raised concerns pertaining to continuous exposure to plastic polymers and human health risks. Of particular concern is the use of endocrine-disrupting chemicals in plastic production, including di(2-ethylhexyl)phthalate (DEHP) and bisphenol A (BPA). Widespread and continuous expos...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章,评审

    doi：10.1007/s12012-014-9258-y

    authors： Posnack NG

    更新日期：2014-12-01 00:00:00

  • Sudden cardiac death in young adult.

    abstract：:Cardiovascular disease represents one of the most important public health problem in the Western countries, with sudden cardiac death (SCD) being the most common cause of death in adults under 65 years of age. The objective of the present study is to evaluate the leading causes of SCD in young adults who died suddenly...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-014-9255-1

    authors： Silva AC,Santos L,Dinis-Oliveira RJ,Magalhães T,Santos A

    更新日期：2014-12-01 00:00:00

  • Doxorubicin-induced changes of ventricular repolarization heterogeneity: results of a chronic rat study.

    abstract：:Anthracycline chemotherapy produces cardiac repolarization abnormalities and arrhythmias because of cardiac toxicity of drugs. Ventricular arrhythmogenesis is attributable to increase in repolarization heterogeneity that is characterized by spatial dispersion of repolarization. The purpose of this work was to study th...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-012-9172-0

    authors： Kharin SN,Krandycheva VV,Strelkova MV,Tsvetkova AS,Shmakov DN

    更新日期：2012-12-01 00:00:00

  • M3, a 1,4-Dihydropyridine Derivative and Mixed L-/T-Type Calcium Channel Blocker, Attenuates Isoproterenol-Induced Toxicity in Male Wistar Rats.

    abstract：:Recent evidence indicates that Ca2+ dysregulation is involved in the pathogenesis of isoproterenol (ISP)-induced biochemical toxicity and associated oxidative stress. In this study, we investigated the chemopreventive benefit of M3, a 1,4-dihydropyridine calcium channel blocker, against ISP-induced toxicity in male Wi...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-020-09587-1

    authors： Kale OE,Gündüz MG,Ogunbiyi BT,Ogundare TF,Ekor M,Awodele O

    更新日期：2020-12-01 00:00:00

  • Aryl hydrocarbon receptor null mice develop cardiac hypertrophy and increased hypoxia-inducible factor-1alpha in the absence of cardiac hypoxia.

    abstract：:The aryl hydrocarbon receptor (AhR) is a member of the basic helix loop helix PAS (Per-ARNT-SIM) transcription family, which also includes hypoxiainducible factor-1alpha (HIF-1alpha) and its common dimerization partner AhR nuclear translocator (ARNT). Following ligand activation or hypoxia, AhR or HIF-1alpha, respecti...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1385/ct:2:4:263

    authors： Thackaberry EA,Gabaldon DM,Walker MK,Smith SM

    更新日期：2002-01-01 00:00:00

  • Differential phosphorylation of translation initiation regulators 4EBP1, S6k1, and Erk 1/2 following inhibition of alcohol metabolism in mouse heart.

    abstract：:Acute alcohol intoxication leads to an inhibition of protein synthesis in heart that results in part through altered phosphorylation of protein factors controlling mRNA translation initiation. The purpose of the present set of experiments was designed to examine the effects of inhibitors of ethanol metabolism on the p...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-008-9012-4

    authors： Vary TC,Lang CH

    更新日期：2008-03-01 00:00:00

  • Mammalian cardenolides as biomarkers in congestive heart failure.

    abstract：:Congestive heart failure (CHF) afflicts over 5 million individuals in the United States, and most die within 5 yr of diagnosis. Because of the high morbidity and mortality associated with CHF, the search for biomarkers to predict, diagnose, and manage this disease has intensified. Calcium homeostasis and alterations i...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章,评审

    doi：10.1385/ct:1:2:165

    authors： Jortani SA,Valdes R Jr

    更新日期：2001-01-01 00:00:00

  • eNOS deficient mice develop progressive cardiac hypertrophy with altered cytokine and calcium handling protein expression.

    abstract：:Although studies have shown that endothelial nitric oxide synthase (eNOS) homozygous knockout mice (eNOS-/-) develop left ventricular (LV) hypertrophy, well compensated at least to 24 wks, uncertainty still exists as to the cardiac functional and molecular mechanistic consequences of eNOS deficiency at later time-poin...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-007-0028-y

    authors： Flaherty MP,Brown M,Grupp IL,Schultz JE,Murphree SS,Jones WK

    更新日期：2007-01-01 00:00:00

  • Acylated Ghrelin Protects the Hearts of Rats from Doxorubicin-Induced Fas/FasL Apoptosis by Stimulating SERCA2a Mediated by Activation of PKA and Akt.

    abstract：:This study investigated if the cardioprotective effect of acylated ghrelin (AG) against doxorubicin (DOX)-induced cardiac toxicity in rats involves inhibition of Fas/FasL-mediated cell death. It also investigated if such an effect is mediated by restoring Ca+2 homeostasis from the aspect of stimulation of SERCA2a rece...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-019-09527-8

    authors： Shati AA,Dallak M

    更新日期：2019-12-01 00:00:00

  • Intracellular Ca(2+) overload induced by extracellular Ca(2+) entry plays an important role in acute heart dysfunction by tentacle extract from the jellyfish Cyanea capillata.

    abstract：:The exact mechanism of acute heart dysfunction caused by jellyfish venom remains unclear for the moment. In the present study, we examined the problem caused by the tentacle extract (TE) from the jellyfish Cyanea capillata at the levels of whole animal, isolated heart, primarily cultured cardiomyocytes, and intracellu...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-014-9250-6

    authors： Zhang L,He Q,Wang Q,Zhang B,Wang B,Xu F,Wang T,Xiao L,Zhang L

    更新日期：2014-09-01 00:00:00

  • Manipulating glutathione-S-transferases may prevent the development of tolerance to nitroglycerin.

    abstract：:Tolerance to clinically important organic nitrates such as nitroglycerin (NTG) has been experimentally related to endothelial dysfunction and vascular oxidative stress. Anti-oxidant enzymes such as the glutathione-S-transferases GSTs) could potentially play a protective role in NTG tolerance. Our previous work showed ...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1385/ct:6:2:131

    authors： Wang L,Yang Y,Dwivedi S,Xu Y,Chu ET,Li J,Fitchett K,Boor PJ

    更新日期：2006-01-01 00:00:00

  • Central Blockade of E-Prostanoid 3 Receptor Ameliorated Hypertension Partially by Attenuating Oxidative Stress and Inflammation in the Hypothalamic Paraventricular Nucleus of Spontaneously Hypertensive Rats.

    abstract：:Hypertension, as one of the major risk factors for cardiovascular disease, significantly affects human health. Prostaglandin E2 (PGE2) and the E3-class prostanoid (EP3) receptor have previously been demonstrated to modulate blood pressure and hemodynamics in various animal models of hypertension. The PGE2-evoked press...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-020-09619-w

    authors： Wang FF,Ba J,Yu XJ,Shi XL,Liu JJ,Liu KL,Fu LY,Su Q,Li HB,Kang KB,Yi QY,Wang SQ,Gao HL,Qi J,Li Y,Zhu GQ,Kang YM

    更新日期：2020-11-09 00:00:00

  • Heart rate variability in rodents: uses and caveats in toxicological studies.

    abstract：:Heart rate variability (HRV) is a measure of cardiac pacing dynamics that has recently garnered a great deal of interest in environmental health studies. While the use of these measures has become popular, much uncertainty remains in the interpretation of results, both in terms of human and animal research. In humans,...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章,评审

    doi：10.1007/s12012-007-0004-6

    authors： Rowan WH 3rd,Campen MJ,Wichers LB,Watkinson WP

    更新日期：2007-01-01 00:00:00

  • MDMA Induced Cardio-toxicity and Pathological Myocardial Effects: A Systematic Review of Experimental Data and Autopsy Findings.

    abstract：:3,4-Methylenedioxymethamphetamine (MDMA), more commonly known as "ecstasy," is a semi-synthetic entactogenic phenylethylamine. In recent years it has gained popularity as a recreational drug whose use has registered an upward trend especially among adolescents and young adults. Despite its unwarranted reputation of be...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-019-09526-9

    authors： Bonsignore A,Barranco R,Morando A,Fraternali Orcioni G,Ventura F

    更新日期：2019-12-01 00:00:00

  • Cardiovascular effects of Phaleria macrocarpa extracts combined with mainstay FAC regimen for breast cancer.

    abstract：:DLBS1425 is a bioactive compound extracted from Phaleria macrocarpa, with anti-proliferative, anti-inflammatory and anti-angiogenic properties against cancer cells. The present study was aimed to assess cardiotoxicity of DLBS1425, compared to the mainstay regimen for breast cancer, 5-fluorouracil:doxorubicin:cyclophos...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-014-9275-x

    authors： Anggadiredja K,Tjandrawinata RR

    更新日期：2015-01-01 00:00:00