Abstract:
:Complete understanding of the etiology underlying endothelial damage in preeclampsia (PE) remains deficient. Recent studies suggest that autoantibodies against angiotensin II AT1 receptors (AT1-AA) may affect vascular endothelial integrity. However, direct evidence demonstrating association between AT1-AA from preeclamptic patients and vascular endothelial injury is lacking. The current study determined the effects of AT1-AA isolated from preeclamptic patients (Pre-IgG) upon the endothelium and attempted to elucidate the underlying mechanisms of injury. Pre-IgG markedly induced dose-dependent vasoconstriction in aortic vascular rings, an effect blocked by AT1 receptor antagonist losartan. Pre-IgG-induced vasoconstriction was increased in the absence of intact endothelium (1.59 ± 0.04 g vs. 1.63 ± 0.08 g, P < 0.05). Additionally, Pre-IgG incubation with human umbilical vein endothelial cells significantly increased lactate dehydrogenase release in a time-dependent manner (0.84 ± 0.07 vs. 3.50 ± 0.09, 24 vs. 72-h exposure group, P < 0.01) and increased caspase-3 and -8 activities (peaking at 48 h), but did not affect caspase-9 activity. Taken together, these results support the contribution of AT1-AA to endothelial cell injury and dysfunction in PE.
journal_name
Cardiovasc Toxicoljournal_title
Cardiovascular toxicologyauthors
Yang X,Wang F,Lau WB,Zhang S,Zhang S,Liu H,Ma XLdoi
10.1007/s12012-013-9229-8subject
Has Abstractpub_date
2014-03-01 00:00:00pages
21-9issue
1eissn
1530-7905issn
1559-0259journal_volume
14pub_type
杂志文章abstract::In a previous study of breast cancer patients, we found changes in cardiac function and size during the early stages of adjuvant trastuzumab (Herceptin(®)) therapy. Here we present a subgroup analysis of this patient cohort. This subgroup received a anthracycline-embedded chemotherapy followed by at least 3 months up ...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-015-9328-9
更新日期:2016-04-01 00:00:00
abstract::Cardiac hypertrophy is an adaptive response to a number of heart diseases including myocardial infarction. Although it can be compensatory at first, sustained hypertrophy is often a transition to heart failure. We have found that cardiomyocytes in culture can survive mild doses of H2O2 but develop hypertrophy involvin...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1385/ct:3:2:119
更新日期:2003-01-01 00:00:00
abstract::The use of anthracycline anticancer drugs is limited by a cumulative, dose-dependent cardiac toxicity. Iron chelation has long been considered as a promising strategy to limit this unfavorable side effect, either by restoring the disturbed cellular iron homeostasis or by removing redox-active iron, which may promote a...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章,评审
doi:10.1007/s12012-007-0020-6
更新日期:2007-01-01 00:00:00
abstract::We have compared the cardiotoxicity of five platinum complexes in a model of isolated rat heart using the Langendorff technique. These effects were assessed via coronary flow (CF) and cardiac functional parameters. cis-Diamminedichloroplatinum(II) (cisplatin, CDDP), dichloro-(1,2-diaminocyclohexane)platinum(II) (Pt((I...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-014-9293-8
更新日期:2015-07-01 00:00:00
abstract::Four decades of research on the link between hyperhomocysteinemia and cardiovascular disease has led to a crossroads. Several negative studies on the role of homocysteine-lowering B-vitamin therapy in reducing the risk of atherothrombotic cardiovascular disease have dampened enthusiasm for this important field of rese...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章,评审
doi:10.1007/s12012-009-9042-6
更新日期:2009-06-01 00:00:00
abstract::Asiatic acid (AA), a pentacyclic triterpenoid, is a key phytoconstituent of Centella asiatica. AA is a patented as a cytotoxic substance, and it exerts cytotoxicity against Hep3B, Hela and MCF-7 cell lines. However, pentacyclic triterpenoids also modulate the expression and transcriptional activities of Nrf2 and exert...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-017-9424-0
更新日期:2018-04-01 00:00:00
abstract::Our previous study described the cardioprotective effects of ellagic acid in an isoproterenol-induced myocardial infarction model. In this study, we are reporting the mechanism of protective action of ellagic acid with respect to apoptosis and mitochondrial respiratory enzymes. Ellagic acid (7.5 and 15 mg/kg) was admi...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-011-9138-7
更新日期:2012-03-01 00:00:00
abstract::It is generally considered that the genetics of atherosclerosis and its complications involves a large number of genes with common alleles having weak effects on disease risk but possibly interacting with each other and with non-genetic factors. In such a complex system, absence of marginal effects (effects of polymor...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章,评审
doi:10.1385/ct:5:2:143
更新日期:2005-01-01 00:00:00
abstract::Carbon soot is produced in the process of diamond manufacture. Recent experimental and epidemiological studies have associated exposure to carbon nanoparticles with effects on cardiovascular system and blood cells. The objective of this study is to assess the cardiovascular effects consequent to chronic respiratory ex...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-009-9053-3
更新日期:2009-12-01 00:00:00
abstract::The exact mechanism of acute heart dysfunction caused by jellyfish venom remains unclear for the moment. In the present study, we examined the problem caused by the tentacle extract (TE) from the jellyfish Cyanea capillata at the levels of whole animal, isolated heart, primarily cultured cardiomyocytes, and intracellu...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-014-9250-6
更新日期:2014-09-01 00:00:00
abstract::Cardiac gene expression regulation is controlled not only by genetic factors but also by environmental, i.e., epigenetic factors. Several environmental toxic effects such as oxidative stress and ischemia can result in abnormal myofibril gene expression during heart development. Troponin, one of the regulatory myofibri...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-014-9278-7
更新日期:2015-07-01 00:00:00
abstract::Arsenic trioxide (ATO) is among the first-line chemotherapeutic drugs used in oncological practice. It has shown substantial efficacy in treating patients with relapsed or refractory acute promyelocytic leukaemia. The clinical use of ATO is hampered due to cardiotoxicity and hence many patients are precluded from rece...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章,评审
doi:10.1007/s12012-018-09504-7
更新日期:2019-04-01 00:00:00
abstract::Clopidogrel is used in patients with coronary syndromes and at risk of thrombotic events or receiving percutaneous coronary intervention (PCI) for reducing heart attack and stroke. Here we present genotype and phenotype study of Iranian patients undergoing PCI treated with clopidogrel during a 6-month period of follow...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-018-9459-x
更新日期:2018-10-01 00:00:00
abstract::Huntington's disease is an autosomal dominant neurodegenerative disease caused by a CAG repeat expansion in the huntingtin gene. Heart disease is the second leading cause of death in patients with Huntington's disease. This study was to evaluate whether cardiac Fas-dependent and mitochondria-dependent apoptotic pathwa...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-015-9318-y
更新日期:2016-04-01 00:00:00
abstract::Caffeine, a naturally occurring purine-based alkaloid, is the most consumed psychostimulant worldwide. Since caffeine pharmacokinetics shows extreme interindividual variability, it is not easy to establish its toxic dose. Only a few cases of death due to acute caffeine intoxication have been described so far, the majo...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-020-09608-z
更新日期:2021-01-01 00:00:00
abstract::Acute cardiovascular poisoning is a major cause of adverse outcomes in poisoning emergencies. The prognostic validity of corrected QT (QTc) and dispersed QT (QTd) in these outcomes is still limited. The present study aimed to determine the risk factors of mortality, adverse cardiovascular events (ACVE), and intensive ...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-020-09629-8
更新日期:2021-01-05 00:00:00
abstract::Heart failure is a common complication of doxorubicin (DOX) therapy. Previous studies have shown that DOX adversely impacts cardiac energy metabolism, and the ensuing energy deficiencies antedate clinical manifestations of cardiac toxicity. Brief exposure of cultured cardiomyocytes to DOX significantly decreases creat...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-014-9283-x
更新日期:2015-04-01 00:00:00
abstract::Since an antipsychotic drug haloperidol has been clinically reported to induce QT interval prolongation and torsade de pointes, in this study its risk stratification for the onset of torsade de pointes was performed by using the chronic atrioventricular block canine model with a Holter electrocardiogram. Haloperidol i...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-016-9388-5
更新日期:2017-07-01 00:00:00
abstract::Arsenic toxicity is one of the major environmental problems causing various diseases, cardiovascular disorders is one of them. Several epidemiological studies have shown that arsenic causes cardiac hypertrophy but the detailed molecular mechanism is to be studied yet. This study is designed to determine the molecules ...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-019-09550-9
更新日期:2020-06-01 00:00:00
abstract::Peroxynitrite is a powerful oxidant, formed from the reaction of nitric oxide and superoxide. It is known to interact and modify different biological molecules such as DNA, lipids and proteins leading to alterations in their structure and functions. These events elicit various cellular responses, including cell signal...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章,评审
doi:10.1007/s12012-016-9394-7
更新日期:2017-10-01 00:00:00
abstract::Cardiovascular disease represents one of the most important public health problem in the Western countries, with sudden cardiac death (SCD) being the most common cause of death in adults under 65 years of age. The objective of the present study is to evaluate the leading causes of SCD in young adults who died suddenly...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-014-9255-1
更新日期:2014-12-01 00:00:00
abstract::This study investigated if the cardioprotective effect of acylated ghrelin (AG) against doxorubicin (DOX)-induced cardiac toxicity in rats involves inhibition of Fas/FasL-mediated cell death. It also investigated if such an effect is mediated by restoring Ca+2 homeostasis from the aspect of stimulation of SERCA2a rece...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-019-09527-8
更新日期:2019-12-01 00:00:00
abstract::3,4-Methylenedioxymethamphetamine (MDMA), more commonly known as "ecstasy," is a semi-synthetic entactogenic phenylethylamine. In recent years it has gained popularity as a recreational drug whose use has registered an upward trend especially among adolescents and young adults. Despite its unwarranted reputation of be...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-019-09526-9
更新日期:2019-12-01 00:00:00
abstract::Grape seed proanthocyanidin extract (GSPE), a polyphenolic compound with antioxidant properties, may protect against cardiac ischemia and reperfusion injury. However, its potential toxicity at higher doses is unknown. The authors tested the effects of GSPE on reactive oxygen species (ROS) generation, cell survival, la...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1385/ct:3:4:331
更新日期:2003-01-01 00:00:00
abstract::The purpose of this essay is to overview our findings that membrane-associated calcium-independent phospholipase A2 is markedly inhibited by low, clinically relevant concentrations of anthracyclines. Our studies suggest that due to the essential role of this enzyme in membrane homeostasis, its inhibition can be one of...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章,评审
doi:10.1007/s12012-007-0012-6
更新日期:2007-01-01 00:00:00
abstract::Recent evidence indicates that Ca2+ dysregulation is involved in the pathogenesis of isoproterenol (ISP)-induced biochemical toxicity and associated oxidative stress. In this study, we investigated the chemopreventive benefit of M3, a 1,4-dihydropyridine calcium channel blocker, against ISP-induced toxicity in male Wi...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-020-09587-1
更新日期:2020-12-01 00:00:00
abstract::Coxsackievirus B3 (CVB3) induces myocarditis, especially in the immunodeficient or immature. To investigate whether CVB3 induced pronounced cardiomyopathy during the severe immune dysfunction of murine acquired immunodeficiency syndrome (AIDS), female C57BL/6 mice were infected with LP-BM5 retrovirus and then coinfect...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1385/ct:2:1:53
更新日期:2002-01-01 00:00:00
abstract::Although studies have shown that endothelial nitric oxide synthase (eNOS) homozygous knockout mice (eNOS-/-) develop left ventricular (LV) hypertrophy, well compensated at least to 24 wks, uncertainty still exists as to the cardiac functional and molecular mechanistic consequences of eNOS deficiency at later time-poin...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-007-0028-y
更新日期:2007-01-01 00:00:00
abstract::Cerium dioxide nanoparticles (CeO2 NPs) are an engineered nanomaterial (ENM) that possesses unique catalytic, oxidative, and reductive properties. Currently, CeO2 NPs are being used as a fuel catalyst but these properties are also utilized in the development of potential drug treatments for radiation and stroke protec...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-013-9213-3
更新日期:2013-12-01 00:00:00
abstract::Normal pregnancy outcome is accomplished, in part, by rapid and expansive physiological adaptations to the systemic circulation, the extent of which is specific to gestational day (GD) and anatomical location. Pregnancy-related hemodynamic changes in uterine placental blood flow stimulate compensatory vascular signali...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-019-09505-0
更新日期:2019-08-01 00:00:00