Abstract：
:Caffeine, a naturally occurring purine-based alkaloid, is the most consumed psychostimulant worldwide. Since caffeine pharmacokinetics shows extreme interindividual variability, it is not easy to establish its toxic dose. Only a few cases of death due to acute caffeine intoxication have been described so far, the majority of which attributable to massive assumption of caffeine-based medications. We present a case of acute caffeine overdose due to ingestion of pure caffeine. The extremely high blood concentration of caffeine determined a strong cardiovascular response, leading to fatal arrhythmia, as supported by histological evidence of myocardial injury. Quantitation of catecholamines and their metabolites in urine samples was performed and showed level near the highest limit of normal ranges for norepinephrine and high level of epinephrine. Contraction band is a pathological modification of the myocell caused by the catecholaminergic action and can occur in conditions of alteration due to the interaction between calcium and catecholamines. We demonstrated the β1-adrenoceptor involvement in our fatal case by immunohistochemical analysis.
journal_name
Cardiovasc Toxicoljournal_title
Cardiovascular toxicologyauthors
Maiese A,La Russa R,Del Fante Z,Turillazzi E,David MC,Frati P,Fineschi Vdoi
10.1007/s12012-020-09608-zsubject
Has Abstractpub_date
2021-01-01 00:00:00pages
88-92issue
1eissn
1530-7905issn
1559-0259pii
10.1007/s12012-020-09608-zjournal_volume
21pub_type
杂志文章abstract：:In glyphosate (G)-based herbicides (GBHs), the declared active principle G is mixed with several adjuvants that help it to penetrate the plants' cell membranes and its stabilization and liposolubility. Its utilization is growing with genetically modified organisms engineered to tolerate GBH. Millions of farmers suffer...
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journal_title：Cardiovascular toxicology
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journal_title：Cardiovascular toxicology
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journal_title：Cardiovascular toxicology
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journal_title：Cardiovascular toxicology
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journal_title：Cardiovascular toxicology
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journal_title：Cardiovascular toxicology
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更新日期：2013-06-01 00:00:00
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journal_title：Cardiovascular toxicology
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journal_title：Cardiovascular toxicology
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journal_title：Cardiovascular toxicology
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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journal_title：Cardiovascular toxicology
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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journal_title：Cardiovascular toxicology
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