Abstract：
:Heart failure is a common complication of doxorubicin (DOX) therapy. Previous studies have shown that DOX adversely impacts cardiac energy metabolism, and the ensuing energy deficiencies antedate clinical manifestations of cardiac toxicity. Brief exposure of cultured cardiomyocytes to DOX significantly decreases creatine transport, which is the cell's sole source of creatine. We present the results of a study performed to determine if physiological creatine supplementation (5 mmol/L) could protect cardiomyocytes in culture from cellular injury resulting from exposure to therapeutic levels of DOX. Creatine supplementation significantly decreased cytotoxicity, apoptosis, and reactive oxygen species production caused by DOX. The protective effect was specific to creatine and depended on its transport into the cell.
journal_name
Cardiovasc Toxicoljournal_title
Cardiovascular toxicologyauthors
Santacruz L,Darrabie MD,Mantilla JG,Mishra R,Feger BJ,Jacobs DOdoi
10.1007/s12012-014-9283-xsubject
Has Abstractpub_date
2015-04-01 00:00:00pages
180-8issue
2eissn
1530-7905issn
1559-0259journal_volume
15pub_type
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