当前位置： SCI文献检索 > Cardiovascular Toxicology期刊下所有文献 > Epigenetic regulation of cardiac myofibril gene expression during heart development.

Epigenetic regulation of cardiac myofibril gene expression during heart development.

Abstract：

:Cardiac gene expression regulation is controlled not only by genetic factors but also by environmental, i.e., epigenetic factors. Several environmental toxic effects such as oxidative stress and ischemia can result in abnormal myofibril gene expression during heart development. Troponin, one of the regulatory myofibril proteins in the heart, is a well-known model in study of cardiac gene regulation during the development. In our previous studies, we have demonstrated that fetal form troponin I (ssTnI) expression in the heart is partially regulated by hormones, such as thyroid hormone. In the present study, we have explored the epigenetic role of histone modification in the regulation of ssTnI expression. Mouse hearts were collected at different time of heart development, i.e., embryonic day 15.5, postnatal day 1, day 7, day 14 and day 21. Levels of histone H3 acetylation (acH3) and histone H3 lysine 9 trimethylation (H3K9me(3)) were detected using chromatin immunoprecipitation assays in slow upstream regulatory element (SURE) domain (TnI slow upstream regulatory element), 300-bp proximal upstream domain and the first intron of ssTnI gene, which are recognized as critical regions for ssTnI regulation. We found that the levels of acH3 on the SURE region were gradually decreased, corresponding to a similar decrease of ssTnI expression in the heart, whereas the levels of H3K9me(3) in the first intron of ssTnI gene were gradually increased. Our results indicate that both histone acetylation and methylation are involved in the epigenetic regulation of ssTnI expression in the heart during the development, which are the targets for environmental factors.

journal_name

Cardiovasc Toxicol

journal_title

Cardiovascular toxicology

authors

Zhao W,Liu L,Pan B,Xu Y,Zhu J,Nan C,Huang X,Tian J

doi

10.1007/s12012-014-9278-7

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

203-9

issue

3

eissn

1530-7905

issn

1559-0259

journal_volume

15

pub_type

杂志文章

相关文献

Cardiovascular Toxicology文献大全
  • A combination of melatonin and alpha lipoic acid has greater cardioprotective effect than either of them singly against cadmium-induced oxidative damage.

    abstract：:Present study evaluates cardioprotective role of melatonin (Mel), alpha lipoic acid (ALA), a combination of melatonin and alpha lipoic acid (Mel + ALA) against cadmium (Cd)-induced oxidative damage. Female albino rats were subjected to 15-day exposure to Cd (5.12 mg/kg bw) alone or treated with ML (10 mg/kg bw) + ALA ...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-010-9092-9

    authors： Mukherjee R,Banerjee S,Joshi N,Singh PK,Baxi D,Ramachandran AV

    更新日期：2011-03-01 00:00:00

  • Mechanistic clues in the protective effect of ellagic acid against apoptosis and decreased mitochondrial respiratory enzyme activities in myocardial infarcted rats.

    abstract：:Our previous study described the cardioprotective effects of ellagic acid in an isoproterenol-induced myocardial infarction model. In this study, we are reporting the mechanism of protective action of ellagic acid with respect to apoptosis and mitochondrial respiratory enzymes. Ellagic acid (7.5 and 15 mg/kg) was admi...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-011-9138-7

    authors： Mari Kannan M,Darlin Quine S

    更新日期：2012-03-01 00:00:00

  • The Protective Effect of Crataegus aronia Against High-Fat Diet-Induced Vascular Inflammation in Rats Entails Inhibition of the NLRP-3 Inflammasome Pathway.

    abstract：:This study investigated whether the whole-plant aqueous extract of Crataegus aronia (C. aronia) could protect against or alleviate high-fat diet (HFD)-induced aortic vascular inflammation in rats by inhibiting the NLRP-3 inflammasome pathway and examined some mechanisms of action with respect to its antioxidant and hy...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-019-09534-9

    authors： Shatoor AS,Al Humayed S

    更新日期：2020-02-01 00:00:00

  • Sudden cardiac death in young adult.

    abstract：:Cardiovascular disease represents one of the most important public health problem in the Western countries, with sudden cardiac death (SCD) being the most common cause of death in adults under 65 years of age. The objective of the present study is to evaluate the leading causes of SCD in young adults who died suddenly...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-014-9255-1

    authors： Silva AC,Santos L,Dinis-Oliveira RJ,Magalhães T,Santos A

    更新日期：2014-12-01 00:00:00

  • Creatine supplementation reduces doxorubicin-induced cardiomyocellular injury.

    abstract：:Heart failure is a common complication of doxorubicin (DOX) therapy. Previous studies have shown that DOX adversely impacts cardiac energy metabolism, and the ensuing energy deficiencies antedate clinical manifestations of cardiac toxicity. Brief exposure of cultured cardiomyocytes to DOX significantly decreases creat...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-014-9283-x

    authors： Santacruz L,Darrabie MD,Mantilla JG,Mishra R,Feger BJ,Jacobs DO

    更新日期：2015-04-01 00:00:00

  • Exposure to low-dose trichloroethylene alters shear stress gene expression and function in the developing chick heart.

    abstract：:Trichloroethylene is an organic solvent used as an industrial degreasing agent. Due to its widespread use and volatile nature, TCE is a common environmental contaminant. Trichloroethylene exposure has been implicated in the etiology of heart defects in human populations and animal models. Recent data suggest misregula...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-010-9066-y

    authors： Makwana O,King NM,Ahles L,Selmin O,Granzier HL,Runyan RB

    更新日期：2010-06-01 00:00:00

  • Synchronization in the Heart Rate and the Vasomotion in Rat Aorta: Effect of Arsenic Trioxide.

    abstract：:Arsenic trioxide (As2O3) is used clinically in the management of acute promyelocytic leukemia, and the use of electrocardiogram (ECG) in this management is important as arsenic use may cause distortion of the electrical properties with its attendant sequel. We studied the effect of As2O3 on vasomotion in rat aortic ri...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-015-9312-4

    authors： Cifuentes F,Palacios J,Nwokocha CR

    更新日期：2016-01-01 00:00:00

  • Grape seed proanthocyanidins induce pro-oxidant toxicity in cardiomyocytes.

    abstract：:Grape seed proanthocyanidin extract (GSPE), a polyphenolic compound with antioxidant properties, may protect against cardiac ischemia and reperfusion injury. However, its potential toxicity at higher doses is unknown. The authors tested the effects of GSPE on reactive oxygen species (ROS) generation, cell survival, la...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1385/ct:3:4:331

    authors： Shao ZH,Vanden Hoek TL,Xie J,Wojcik K,Chan KC,Li CQ,Hamann K,Qin Y,Schumacker PT,Becker LB,Yuan CS

    更新日期：2003-01-01 00:00:00

  • The Use of iPSC-Derived Cardiomyocytes and Optical Mapping for Erythromycin Arrhythmogenicity Testing.

    abstract：:Erythromycin is an antibiotic that prolongs the QT-interval and causes Torsade de Pointes (TdP) by blocking the rapid delayed rectifying potassium current (IKr) without affecting either the slow delayed rectifying potassium current (IKs) or inward rectifying potassium current (IK1). Erythromycin exerts this effect in ...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-019-09532-x

    authors： Podgurskaya AD,Tsvelaya VA,Slotvitsky MM,Dementyeva EV,Valetdinova KR,Agladze KI

    更新日期：2019-12-01 00:00:00

  • Preventive effects of Egyptian sweet marjoram (Origanum majorana L.) leaves on haematological changes and cardiotoxicity in isoproterenol-treated albino rats.

    abstract：:We made an attempt to evaluate/compare the cardioprotective activity of two different doses (50 and 100 mg/kg body weight, given orally for 30 consecutive days) of Egyptian sweet marjoram leaf powder (MLP) and marjoram leaf aqueous extract (MLE) against isoproterenol (ISO)-induced myocardial infarcted rats (150 mg/kg ...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-012-9189-4

    authors： Ramadan G,El-Beih NM,Arafa NM,Zahra MM

    更新日期：2013-06-01 00:00:00

  • Cardiac myofibril formation is not affected by modification of both N- and C-termini of sarcomeric tropomyosin.

    abstract：:Although the role of tropomyosin is well-defined in striated muscle, the precise mechanism of how tropomyosin functions is still unclear. It has been shown that extension of either N- or C-terminal ends of sarcomeric tropomyosin do not affect cardiac myofibrillogenesis, but it is not known whether simultaneous extensi...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1385/ct:5:1:001

    authors： Narshi A,Denz CR,Nakatsugawa M,Zajdel RW,Dube S,Poiesz BJ,Dube DK

    更新日期：2005-01-01 00:00:00

  • Massive β1-Adrenergic Receptor Reaction Explains Irreversible Acute Arrhythmia in a Fatal Case of Acute Pure Caffeine Intoxication.

    abstract：:Caffeine, a naturally occurring purine-based alkaloid, is the most consumed psychostimulant worldwide. Since caffeine pharmacokinetics shows extreme interindividual variability, it is not easy to establish its toxic dose. Only a few cases of death due to acute caffeine intoxication have been described so far, the majo...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-020-09608-z

    authors： Maiese A,La Russa R,Del Fante Z,Turillazzi E,David MC,Frati P,Fineschi V

    更新日期：2021-01-01 00:00:00

  • Vildagliptin, an Anti-diabetic Drug of the DPP-4 Inhibitor, Induces Vasodilation via Kv Channel and SERCA Pump Activation in Aortic Smooth Muscle.

    abstract：:This study investigated vildagliptin-induced vasodilation and its related mechanisms using phenylephrine induced precontracted rabbit aortic rings. Vildagliptin induced vasodilation in a concentration-dependent manner. Pretreatment with the large-conductance Ca2+-activated K+ channel blocker paxilline, ATP-sensitive K...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-018-9496-5

    authors： Seo MS,Li H,An JR,Jung ID,Jung WK,Ha KS,Han ET,Hong SH,Choi IW,Park WS

    更新日期：2019-06-01 00:00:00

  • Heart rate variability in rodents: uses and caveats in toxicological studies.

    abstract：:Heart rate variability (HRV) is a measure of cardiac pacing dynamics that has recently garnered a great deal of interest in environmental health studies. While the use of these measures has become popular, much uncertainty remains in the interpretation of results, both in terms of human and animal research. In humans,...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章,评审

    doi：10.1007/s12012-007-0004-6

    authors： Rowan WH 3rd,Campen MJ,Wichers LB,Watkinson WP

    更新日期：2007-01-01 00:00:00

  • Clopidogrel Pharmacogenetics in Iranian Patients Undergoing Percutaneous Coronary Intervention.

    abstract：:Clopidogrel is used in patients with coronary syndromes and at risk of thrombotic events or receiving percutaneous coronary intervention (PCI) for reducing heart attack and stroke. Here we present genotype and phenotype study of Iranian patients undergoing PCI treated with clopidogrel during a 6-month period of follow...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-018-9459-x

    authors： Mahdieh N,Rabbani A,Firouzi A,Zahedmehr A,Hoseinimoghaddam M,Saedi S,Sanati H,Basiri H,Noohi F,Rabbani B,Maleki M

    更新日期：2018-10-01 00:00:00

  • Rutin Attenuates Carfilzomib-Induced Cardiotoxicity Through Inhibition of NF-κB, Hypertrophic Gene Expression and Oxidative Stress.

    abstract：:Carfilzomib is a proteasome inhibitor, commonly used in multiple myeloma, but its clinical use may be limited due to cardiotoxicity. This study was aimed to evaluate the influence of rutin in carfilzomib-induced cardiotoxicity in rats. Wistar albino male rats weighing 200-250 g (approximately 10 weeks old) were taken ...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-015-9356-5

    authors： Imam F,Al-Harbi NO,Al-Harbia MM,Korashy HM,Ansari MA,Sayed-Ahmed MM,Nagi MN,Iqbal M,Khalid Anwer M,Kazmi I,Afzal M,Bahashwan S

    更新日期：2017-01-01 00:00:00

  • p38 MAP kinase inhibitor prevents diastolic dysfunction in rats following HIV gp120 injection in vivo.

    abstract：:HIV infection in patients is associated with a surprisingly high frequency of diastolic dysfunction followed by the development of a dilated cardiomyopathy. Potential mechanisms include direct effects of HIV proteins, including gp120. We have previously reported direct inotropic and p38 MAP kinase signaling effects of...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-009-9047-1

    authors： Berzingi C,Chen F,Finkel MS

    更新日期：2009-09-01 00:00:00

  • Protective effect of FK506 on myocardial ischemia/reperfusion injury by suppression of CaN and ASK1 signaling circuitry.

    abstract：:We investigated protective effect of FK506 on rat hearts subjected to ischemia/reperfusion (I/R) injury by regulating CaN and ASK1. Wistar rats were divided into four groups: Ischemia/reperfusion group (I/R), FK506 + Ischemia/reperfusion group (FK506-I/R), sham group, and FK506 + sham group (FK506-sham). Ischemia/repe...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-010-9095-6

    authors： Feng X,Li J,Liu J,Jin M,Liu X,Du H,Zhang L,Sun Z,Li X

    更新日期：2011-03-01 00:00:00

  • Paraventricular Nucleus Infusion of Epigallocatechin-3-O-Gallate Improves Renovascular Hypertension.

    abstract：:Oxidative stress plays an important role in the pathogenesis of hypertension. Epigallocatechin-3-O-gallate (EGCG) is the main polyphenol present in green tea and is known for its potent antioxidant and anti-inflammatory properties. In the present study, we hypothesize that EGCG attenuates oxidative stress in the parav...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-015-9335-x

    authors： Yi QY,Qi J,Yu XJ,Li HB,Zhang Y,Su Q,Shi T,Zhang DM,Guo J,Feng ZP,Wang ML,Zhu GQ,Liu JJ,Shi XL,Kang YM

    更新日期：2016-07-01 00:00:00

  • Selenium supplementation decreases coxsackievirus heart disease during murine AIDS.

    abstract：:Coxsackievirus B3 (CVB3) induces myocarditis, especially in the immunodeficient or immature. To investigate whether CVB3 induced pronounced cardiomyopathy during the severe immune dysfunction of murine acquired immunodeficiency syndrome (AIDS), female C57BL/6 mice were infected with LP-BM5 retrovirus and then coinfect...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1385/ct:2:1:53

    authors： Sepúlveda RT,Zhang J,Watson RR

    更新日期：2002-01-01 00:00:00

  • In vitro evidence for the protective role of Sida rhomboidea. Roxb extract against LDL oxidation and oxidized LDL-induced apoptosis in human monocyte-derived macrophages.

    abstract：:The present study was undertaken to evaluate protective role of S. rhomboidea. Roxb (SR) leaf extract against in vitro low-density lipoprotein (LDL) oxidation and oxidized LDL (Ox-LDL) induced macrophage apoptosis. Copper and cell-mediated LDL oxidation, Ox-LDL-induced peroxyl radical generation, mitochondrial activit...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-011-9110-6

    authors： Thounaojam MC,Jadeja RN,Devkar RV,Ramachandran AV

    更新日期：2011-06-01 00:00:00

  • Validation of Corrected and Dispersed QT as Predictors of Adverse Outcomes in Acute Cardiotoxicities.

    abstract：:Acute cardiovascular poisoning is a major cause of adverse outcomes in poisoning emergencies. The prognostic validity of corrected QT (QTc) and dispersed QT (QTd) in these outcomes is still limited. The present study aimed to determine the risk factors of mortality, adverse cardiovascular events (ACVE), and intensive ...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-020-09629-8

    authors： El-Sarnagawy GN,Shaban AE,Lashin HI

    更新日期：2021-01-05 00:00:00

  • Effect of Gestational Age on Maternofetal Vascular Function Following Single Maternal Engineered Nanoparticle Exposure.

    abstract：:Normal pregnancy outcome is accomplished, in part, by rapid and expansive physiological adaptations to the systemic circulation, the extent of which is specific to gestational day (GD) and anatomical location. Pregnancy-related hemodynamic changes in uterine placental blood flow stimulate compensatory vascular signali...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-019-09505-0

    authors： Fournier SB,Kallontzi S,Fabris L,Love C,Stapleton PA

    更新日期：2019-08-01 00:00:00

  • The cardioprotective agent urocortin induces expression of CT-1.

    abstract：:The corticotrophin-releasing hormone-related factor, urocortin (Ucn) and the interleukin (IL)-6 family cytokine cardiotrophin-1 (CT-1) are both cardioprotective agents able to protect the heart from ischemic damage. In both cases the protective effect involves activation of the p42/p44 MAPK and PI-3 kinase/Akt pathway...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1385/ct:3:3:255

    authors： Janjua S,Lawrence KM,Ng LL,Latchman DS

    更新日期：2003-01-01 00:00:00

  • Arsenic exposure and cardiovascular disorders: an overview.

    abstract：:The incidence of arsenic toxicity has been observed in various countries including Taiwan, Bangladesh, India, Argentina, Australia, Chile, China, Hungary, Peru, Thailand, Mexico and United States of America. Arsenic is a ubiquitous element present in drinking water, and its exposure is associated with various cardiova...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章,评审

    doi：10.1007/s12012-009-9050-6

    authors： Balakumar P,Kaur J

    更新日期：2009-12-01 00:00:00

  • Involvement of ROS/NLRP3 Inflammasome Signaling Pathway in Doxorubicin-Induced Cardiotoxicity.

    abstract：:Doxorubicin (Dox) is widely used in cancer therapy, but the clinical application is limited by its cardiotoxicity. The underlying mechanism of Dox-induced cardiotoxicity remains unclear. Present study aimed to evaluate the role of NLRP3 inflammasome in Dox-induced cardiotoxicity. The NLRP3 inflammasome was activated i...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-020-09576-4

    authors： Wei S,Ma W,Li X,Jiang C,Sun T,Li Y,Zhang B,Li W

    更新日期：2020-10-01 00:00:00

  • Mammalian cardenolides as biomarkers in congestive heart failure.

    abstract：:Congestive heart failure (CHF) afflicts over 5 million individuals in the United States, and most die within 5 yr of diagnosis. Because of the high morbidity and mortality associated with CHF, the search for biomarkers to predict, diagnose, and manage this disease has intensified. Calcium homeostasis and alterations i...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章,评审

    doi：10.1385/ct:1:2:165

    authors： Jortani SA,Valdes R Jr

    更新日期：2001-01-01 00:00:00

  • The dual-targeted HER1/HER2 tyrosine kinase inhibitor lapatinib strongly potentiates the cardiac myocyte-damaging effects of doxorubicin.

    abstract：:The anticancer drug lapatinib (Tykerb) is a dual tyrosine kinase inhibitor targeting the HER2 (ERBB2) and EGFR (ERBB1, HER1) pathways that have been shown in clinical trials to display some cardiotoxicity. Because trastuzumab also targets HER2 receptors, the lapatinib/doxorubicin combination provides a good model to p...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-012-9183-x

    authors： Hasinoff BB,Patel D,Wu X

    更新日期：2013-03-01 00:00:00

  • On the Efficacy of Cardio-Pulmonary Resuscitation and Epinephrine Following Cyanide- and H2S Intoxication-Induced Cardiac Asystole.

    abstract：:This study was aimed at determining the efficacy of epinephrine, followed by chest compressions, in producing a return of spontaneous circulation (ROSC) during cyanide (CN)- or hydrogen sulfide (H2S)-induced toxic cardiac pulseless electrical activity (PEA) in the rat. Thirty-nine anesthetized rats were exposed to eit...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1007/s12012-018-9454-2

    authors： Judenherc-HaouzI A,Sonobe T,Bebarta VS,Haouzi P

    更新日期：2018-10-01 00:00:00

  • Distinct roles of p42/p44(ERK) and p38 MAPK in oxidant-induced AP-1 activation and cardiomyocyte hypertrophy.

    abstract：:Cardiac hypertrophy is an adaptive response to a number of heart diseases including myocardial infarction. Although it can be compensatory at first, sustained hypertrophy is often a transition to heart failure. We have found that cardiomyocytes in culture can survive mild doses of H2O2 but develop hypertrophy involvin...

    journal_title：Cardiovascular toxicology

    pub_type： 杂志文章

    doi：10.1385/ct:3:2:119

    authors： Tu VC,Bahl JJ,Chen QM

    更新日期：2003-01-01 00:00:00