Abstract:
:Arsenic trioxide (ATO) is among the first-line chemotherapeutic drugs used in oncological practice. It has shown substantial efficacy in treating patients with relapsed or refractory acute promyelocytic leukaemia. The clinical use of ATO is hampered due to cardiotoxicity and hence many patients are precluded from receiving this highly effective treatment. An alternative to this would be to use any drug that can ameliorate the cardiotoxic effects and allow exploiting the full therapeutic potential of ATO, with considerable impact on cancer therapy. Generation of reactive oxygen species is involved in a wide range of human diseases, including cancer, cardiovascular, pulmonary and neurological disorders. Hence, agents with the ability to protect against these reactive species may be therapeutically useful. The present review focuses on the beneficial as well as harmful effects of arsenic and ATO, the mechanisms underlying ATO toxicity and the possible ways that can be adopted to circumvent ATO-induced toxicity.
journal_name
Cardiovasc Toxicoljournal_title
Cardiovascular toxicologyauthors
Vineetha VP,Raghu KGdoi
10.1007/s12012-018-09504-7subject
Has Abstractpub_date
2019-04-01 00:00:00pages
105-119issue
2eissn
1530-7905issn
1559-0259pii
10.1007/s12012-018-09504-7journal_volume
19pub_type
杂志文章,评审abstract::The incidence of arsenic toxicity has been observed in various countries including Taiwan, Bangladesh, India, Argentina, Australia, Chile, China, Hungary, Peru, Thailand, Mexico and United States of America. Arsenic is a ubiquitous element present in drinking water, and its exposure is associated with various cardiova...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章,评审
doi:10.1007/s12012-009-9050-6
更新日期:2009-12-01 00:00:00
abstract::3,4-Methylenedioxymethamphetamine (MDMA), more commonly known as "ecstasy," is a semi-synthetic entactogenic phenylethylamine. In recent years it has gained popularity as a recreational drug whose use has registered an upward trend especially among adolescents and young adults. Despite its unwarranted reputation of be...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-019-09526-9
更新日期:2019-12-01 00:00:00
abstract::Coxsackievirus B3 (CVB3) induces myocarditis, especially in the immunodeficient or immature. To investigate whether CVB3 induced pronounced cardiomyopathy during the severe immune dysfunction of murine acquired immunodeficiency syndrome (AIDS), female C57BL/6 mice were infected with LP-BM5 retrovirus and then coinfect...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1385/ct:2:1:53
更新日期:2002-01-01 00:00:00
abstract::Arsenic trioxide (As2O3) is used clinically in the management of acute promyelocytic leukemia, and the use of electrocardiogram (ECG) in this management is important as arsenic use may cause distortion of the electrical properties with its attendant sequel. We studied the effect of As2O3 on vasomotion in rat aortic ri...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-015-9312-4
更新日期:2016-01-01 00:00:00
abstract::Peroxynitrite is a powerful oxidant, formed from the reaction of nitric oxide and superoxide. It is known to interact and modify different biological molecules such as DNA, lipids and proteins leading to alterations in their structure and functions. These events elicit various cellular responses, including cell signal...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章,评审
doi:10.1007/s12012-016-9394-7
更新日期:2017-10-01 00:00:00
abstract::Cardiovascular disease represents one of the most important public health problem in the Western countries, with sudden cardiac death (SCD) being the most common cause of death in adults under 65 years of age. The objective of the present study is to evaluate the leading causes of SCD in young adults who died suddenly...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-014-9255-1
更新日期:2014-12-01 00:00:00
abstract::Trichloroethylene is an organic solvent used as an industrial degreasing agent. Due to its widespread use and volatile nature, TCE is a common environmental contaminant. Trichloroethylene exposure has been implicated in the etiology of heart defects in human populations and animal models. Recent data suggest misregula...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-010-9066-y
更新日期:2010-06-01 00:00:00
abstract::The ubiquitous nature of plastics has raised concerns pertaining to continuous exposure to plastic polymers and human health risks. Of particular concern is the use of endocrine-disrupting chemicals in plastic production, including di(2-ethylhexyl)phthalate (DEHP) and bisphenol A (BPA). Widespread and continuous expos...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章,评审
doi:10.1007/s12012-014-9258-y
更新日期:2014-12-01 00:00:00
abstract::Hypertension, as one of the major risk factors for cardiovascular disease, significantly affects human health. Prostaglandin E2 (PGE2) and the E3-class prostanoid (EP3) receptor have previously been demonstrated to modulate blood pressure and hemodynamics in various animal models of hypertension. The PGE2-evoked press...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-020-09619-w
更新日期:2020-11-09 00:00:00
abstract::Elevated levels of homocysteine (Hcy) (known as hyperhomocysteinemia HHcy) are involved in dilated cardiomyopathy. Hcy chelates copper and impairs copper-dependent enzymes. Copper deficiency has been linked to cardiovascular disease. We tested the hypothesis that copper supplement regresses left ventricular hypertroph...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-008-9021-3
更新日期:2008-10-01 00:00:00
abstract::The objective of this study was to characterize acute coronary artery injury evoked by the endothelin A receptor (ETAR) antagonist, CI-1034. Male dogs (n = 5) were intravenously administered CI-1034 at 120 mg/kg for 4 d. Control animals (n = 3) received vehicle. Macroscopically, drug-related hemorrhage was observed in...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1385/ct:6:1:25
更新日期:2006-01-01 00:00:00
abstract::Recent evidence indicates that Ca2+ dysregulation is involved in the pathogenesis of isoproterenol (ISP)-induced biochemical toxicity and associated oxidative stress. In this study, we investigated the chemopreventive benefit of M3, a 1,4-dihydropyridine calcium channel blocker, against ISP-induced toxicity in male Wi...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-020-09587-1
更新日期:2020-12-01 00:00:00
abstract::The use of anthracycline anticancer drugs is limited by a cumulative, dose-dependent cardiac toxicity. Iron chelation has long been considered as a promising strategy to limit this unfavorable side effect, either by restoring the disturbed cellular iron homeostasis or by removing redox-active iron, which may promote a...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章,评审
doi:10.1007/s12012-007-0020-6
更新日期:2007-01-01 00:00:00
abstract::The anticancer drug lapatinib (Tykerb) is a dual tyrosine kinase inhibitor targeting the HER2 (ERBB2) and EGFR (ERBB1, HER1) pathways that have been shown in clinical trials to display some cardiotoxicity. Because trastuzumab also targets HER2 receptors, the lapatinib/doxorubicin combination provides a good model to p...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-012-9183-x
更新日期:2013-03-01 00:00:00
abstract::DLBS1425 is a bioactive compound extracted from Phaleria macrocarpa, with anti-proliferative, anti-inflammatory and anti-angiogenic properties against cancer cells. The present study was aimed to assess cardiotoxicity of DLBS1425, compared to the mainstay regimen for breast cancer, 5-fluorouracil:doxorubicin:cyclophos...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-014-9275-x
更新日期:2015-01-01 00:00:00
abstract::Carfilzomib is a proteasome inhibitor, commonly used in multiple myeloma, but its clinical use may be limited due to cardiotoxicity. This study was aimed to evaluate the influence of rutin in carfilzomib-induced cardiotoxicity in rats. Wistar albino male rats weighing 200-250 g (approximately 10 weeks old) were taken ...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-015-9356-5
更新日期:2017-01-01 00:00:00
abstract::We report a case of potential cardiovascular toxicity including syncope, bradycardia, and ECG pauses associated with the use of rivastigmine and atenolol. A 65-year-old African American female with a medical history of dementia, hypertension, seizure disorder, stroke, and peripheral vascular disease was admitted to th...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章,评审
doi:10.1007/s12012-010-9088-5
更新日期:2010-12-01 00:00:00
abstract::Anthracycline chemotherapy produces cardiac repolarization abnormalities and arrhythmias because of cardiac toxicity of drugs. Ventricular arrhythmogenesis is attributable to increase in repolarization heterogeneity that is characterized by spatial dispersion of repolarization. The purpose of this work was to study th...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-012-9172-0
更新日期:2012-12-01 00:00:00
abstract::The corticotrophin-releasing hormone-related factor, urocortin (Ucn) and the interleukin (IL)-6 family cytokine cardiotrophin-1 (CT-1) are both cardioprotective agents able to protect the heart from ischemic damage. In both cases the protective effect involves activation of the p42/p44 MAPK and PI-3 kinase/Akt pathway...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1385/ct:3:3:255
更新日期:2003-01-01 00:00:00
abstract::Heart failure is a common complication of doxorubicin (DOX) therapy. Previous studies have shown that DOX adversely impacts cardiac energy metabolism, and the ensuing energy deficiencies antedate clinical manifestations of cardiac toxicity. Brief exposure of cultured cardiomyocytes to DOX significantly decreases creat...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-014-9283-x
更新日期:2015-04-01 00:00:00
abstract::Huntington's disease is an autosomal dominant neurodegenerative disease caused by a CAG repeat expansion in the huntingtin gene. Heart disease is the second leading cause of death in patients with Huntington's disease. This study was to evaluate whether cardiac Fas-dependent and mitochondria-dependent apoptotic pathwa...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-015-9318-y
更新日期:2016-04-01 00:00:00
abstract::Cerium dioxide nanoparticles (CeO2 NPs) are an engineered nanomaterial (ENM) that possesses unique catalytic, oxidative, and reductive properties. Currently, CeO2 NPs are being used as a fuel catalyst but these properties are also utilized in the development of potential drug treatments for radiation and stroke protec...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-013-9213-3
更新日期:2013-12-01 00:00:00
abstract::We made an attempt to evaluate/compare the cardioprotective activity of two different doses (50 and 100 mg/kg body weight, given orally for 30 consecutive days) of Egyptian sweet marjoram leaf powder (MLP) and marjoram leaf aqueous extract (MLE) against isoproterenol (ISO)-induced myocardial infarcted rats (150 mg/kg ...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-012-9189-4
更新日期:2013-06-01 00:00:00
abstract::Doxorubicin (Dox) is widely used in cancer therapy, but the clinical application is limited by its cardiotoxicity. The underlying mechanism of Dox-induced cardiotoxicity remains unclear. Present study aimed to evaluate the role of NLRP3 inflammasome in Dox-induced cardiotoxicity. The NLRP3 inflammasome was activated i...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-020-09576-4
更新日期:2020-10-01 00:00:00
abstract::Acute alcohol intoxication leads to an inhibition of protein synthesis in heart that results in part through altered phosphorylation of protein factors controlling mRNA translation initiation. The purpose of the present set of experiments was designed to examine the effects of inhibitors of ethanol metabolism on the p...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-008-9012-4
更新日期:2008-03-01 00:00:00
abstract::Congestive heart failure (CHF) afflicts over 5 million individuals in the United States, and most die within 5 yr of diagnosis. Because of the high morbidity and mortality associated with CHF, the search for biomarkers to predict, diagnose, and manage this disease has intensified. Calcium homeostasis and alterations i...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章,评审
doi:10.1385/ct:1:2:165
更新日期:2001-01-01 00:00:00
abstract::Cardiac troponins not only allow for risk stratification and guidance of therapy in unstable angina and non-Q-wave acute myocardial infarction but also may be useful in the diagnostic workup and monitoring of patients with ST-segment elevation myocardial infarction. In clinical practice, troponins are used for confirm...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章,评审
doi:10.1385/ct:1:2:099
更新日期:2001-01-01 00:00:00
abstract::We present an experimental approach that allows exposure of cells plated on a single coverslip to multiple distinct environments. The original chamber design created a small region of injury using geometrically defined flows of the control and ischemic solutions. Modifications of the original chamber design presented ...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1385/ct:4:1:01
更新日期:2004-01-01 00:00:00
abstract::Epidemiological studies have associated air pollution particulate matter (PM) exposure with adverse cardiovascular effects. Identification of causal PM sources is critically needed to support regulatory decisions to protect public health. This research examines the in vitro cardiotoxicity of bioavailable constituents ...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-013-9225-z
更新日期:2013-12-01 00:00:00
abstract::Cardiac hypertrophy is an adaptive response to a number of heart diseases including myocardial infarction. Although it can be compensatory at first, sustained hypertrophy is often a transition to heart failure. We have found that cardiomyocytes in culture can survive mild doses of H2O2 but develop hypertrophy involvin...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1385/ct:3:2:119
更新日期:2003-01-01 00:00:00