Abstract：
:Carbon soot is produced in the process of diamond manufacture. Recent experimental and epidemiological studies have associated exposure to carbon nanoparticles with effects on cardiovascular system and blood cells. The objective of this study is to assess the cardiovascular effects consequent to chronic respiratory exposure of carbon soot. A cross-sectional occupational health survey was conducted in all consenting workers who employed in the production wing of diamond-processing industries. Blood pressure, ECGs, height, weight, and blood counts were measured and evaluated. Blood pressure measurements revealed a high prevalence of hypertension in young workers. Left atrial abnormality (LAA) was the major finding in the electrocardiograms. We found a high prevalence of hypertension in young diamond workers. The LASER saw operators had highest prevalence of LAA. White cell count and prevalence of hypertension was highest for the workers in grinder operations.
journal_name
Cardiovasc Toxicoljournal_title
Cardiovascular toxicologyauthors
Beniwal R,Shivgotra VKdoi
10.1007/s12012-009-9053-3subject
Has Abstractpub_date
2009-12-01 00:00:00pages
194-200issue
4eissn
1530-7905issn
1559-0259journal_volume
9pub_type
杂志文章abstract：:The present study was undertaken to evaluate protective role of S. rhomboidea. Roxb (SR) leaf extract against in vitro low-density lipoprotein (LDL) oxidation and oxidized LDL (Ox-LDL) induced macrophage apoptosis. Copper and cell-mediated LDL oxidation, Ox-LDL-induced peroxyl radical generation, mitochondrial activit...
journal_title：Cardiovascular toxicology
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doi：10.1007/s12012-011-9110-6
更新日期：2011-06-01 00:00:00
abstract：:Cerium dioxide nanoparticles (CeO2 NPs) are an engineered nanomaterial (ENM) that possesses unique catalytic, oxidative, and reductive properties. Currently, CeO2 NPs are being used as a fuel catalyst but these properties are also utilized in the development of potential drug treatments for radiation and stroke protec...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-013-9213-3
更新日期：2013-12-01 00:00:00
abstract：:We report a case of potential cardiovascular toxicity including syncope, bradycardia, and ECG pauses associated with the use of rivastigmine and atenolol. A 65-year-old African American female with a medical history of dementia, hypertension, seizure disorder, stroke, and peripheral vascular disease was admitted to th...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-010-9088-5
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abstract：:This study investigated whether the whole-plant aqueous extract of Crataegus aronia (C. aronia) could protect against or alleviate high-fat diet (HFD)-induced aortic vascular inflammation in rats by inhibiting the NLRP-3 inflammasome pathway and examined some mechanisms of action with respect to its antioxidant and hy...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-019-09534-9
更新日期：2020-02-01 00:00:00
abstract：:Normal pregnancy outcome is accomplished, in part, by rapid and expansive physiological adaptations to the systemic circulation, the extent of which is specific to gestational day (GD) and anatomical location. Pregnancy-related hemodynamic changes in uterine placental blood flow stimulate compensatory vascular signali...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-019-09505-0
更新日期：2019-08-01 00:00:00
abstract：:Epidemiological studies have associated air pollution particulate matter (PM) exposure with adverse cardiovascular effects. Identification of causal PM sources is critically needed to support regulatory decisions to protect public health. This research examines the in vitro cardiotoxicity of bioavailable constituents ...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-013-9225-z
更新日期：2013-12-01 00:00:00
abstract：:Since an antipsychotic drug haloperidol has been clinically reported to induce QT interval prolongation and torsade de pointes, in this study its risk stratification for the onset of torsade de pointes was performed by using the chronic atrioventricular block canine model with a Holter electrocardiogram. Haloperidol i...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2017-07-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-017-9413-3
更新日期：2018-02-01 00:00:00
abstract：:HIV infection in patients is associated with a surprisingly high frequency of diastolic dysfunction followed by the development of a dilated cardiomyopathy. Potential mechanisms include direct effects of HIV proteins, including gp120. We have previously reported direct inotropic and p38 MAP kinase signaling effects of...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-009-9047-1
更新日期：2009-09-01 00:00:00
abstract：:Carfilzomib is a proteasome inhibitor, commonly used in multiple myeloma, but its clinical use may be limited due to cardiotoxicity. This study was aimed to evaluate the influence of rutin in carfilzomib-induced cardiotoxicity in rats. Wistar albino male rats weighing 200-250 g (approximately 10 weeks old) were taken ...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-015-9356-5
更新日期：2017-01-01 00:00:00
abstract：:In a previous study of breast cancer patients, we found changes in cardiac function and size during the early stages of adjuvant trastuzumab (Herceptin(®)) therapy. Here we present a subgroup analysis of this patient cohort. This subgroup received a anthracycline-embedded chemotherapy followed by at least 3 months up ...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-015-9328-9
更新日期：2016-04-01 00:00:00
abstract：:The purpose of this essay is to overview our findings that membrane-associated calcium-independent phospholipase A2 is markedly inhibited by low, clinically relevant concentrations of anthracyclines. Our studies suggest that due to the essential role of this enzyme in membrane homeostasis, its inhibition can be one of...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-007-0012-6
更新日期：2007-01-01 00:00:00
abstract：:Congestive heart failure (CHF) afflicts over 5 million individuals in the United States, and most die within 5 yr of diagnosis. Because of the high morbidity and mortality associated with CHF, the search for biomarkers to predict, diagnose, and manage this disease has intensified. Calcium homeostasis and alterations i...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1385/ct:1:2:165
更新日期：2001-01-01 00:00:00
abstract：:Asiatic acid (AA), a pentacyclic triterpenoid, is a key phytoconstituent of Centella asiatica. AA is a patented as a cytotoxic substance, and it exerts cytotoxicity against Hep3B, Hela and MCF-7 cell lines. However, pentacyclic triterpenoids also modulate the expression and transcriptional activities of Nrf2 and exert...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-017-9424-0
更新日期：2018-04-01 00:00:00
abstract：:Scientific and medical evidence over the past 30 years has established striking parallels between atherosclerosis and cancer--pathogenetic relationships that cross the boundaries of fiction into the realm of reason. Both diseases in humans are characterized by uncontrolled regulation of cellular growth and differentia...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1385/ct:5:3:245
更新日期：2005-01-01 00:00:00
abstract：:Anthracycline chemotherapy produces cardiac repolarization abnormalities and arrhythmias because of cardiac toxicity of drugs. Ventricular arrhythmogenesis is attributable to increase in repolarization heterogeneity that is characterized by spatial dispersion of repolarization. The purpose of this work was to study th...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-012-9172-0
更新日期：2012-12-01 00:00:00
abstract：:The use of anthracycline anticancer drugs is limited by a cumulative, dose-dependent cardiac toxicity. Iron chelation has long been considered as a promising strategy to limit this unfavorable side effect, either by restoring the disturbed cellular iron homeostasis or by removing redox-active iron, which may promote a...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-007-0020-6
更新日期：2007-01-01 00:00:00
abstract：:It is generally considered that the genetics of atherosclerosis and its complications involves a large number of genes with common alleles having weak effects on disease risk but possibly interacting with each other and with non-genetic factors. In such a complex system, absence of marginal effects (effects of polymor...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1385/ct:5:2:143
更新日期：2005-01-01 00:00:00
abstract：:Choerospondias axillaris (Guangzao) is a medicinal plant used in Mongolia, and its fruit is commonly used for the treatment of cardiovascular diseases in clinic. The constituents responsible for this effect are always conceded to be the total flavonoids of C. axillaries (TFC). The present study was to evaluate the pre...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-013-9238-7
更新日期：2014-06-01 00:00:00
abstract：:Doxorubicin (Dox) is widely used in cancer therapy, but the clinical application is limited by its cardiotoxicity. The underlying mechanism of Dox-induced cardiotoxicity remains unclear. Present study aimed to evaluate the role of NLRP3 inflammasome in Dox-induced cardiotoxicity. The NLRP3 inflammasome was activated i...
journal_title：Cardiovascular toxicology
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journal_title：Cardiovascular toxicology
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abstract：:Tropomyosins are a family of actin-binding proteins that show cell-specific diversity by a combination of multiple genes and alternative RNA splicing. Of the 4 different tropomyosin genes, TPM4 plays a pivotal role in myofibrillogenesis as well as cardiac contractility in amphibians. In this study, we amplified and se...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-011-9117-z
更新日期：2011-09-01 00:00:00
abstract：:Our previous study described the cardioprotective effects of ellagic acid in an isoproterenol-induced myocardial infarction model. In this study, we are reporting the mechanism of protective action of ellagic acid with respect to apoptosis and mitochondrial respiratory enzymes. Ellagic acid (7.5 and 15 mg/kg) was admi...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-011-9138-7
更新日期：2012-03-01 00:00:00
abstract：:Erythromycin is an antibiotic that prolongs the QT-interval and causes Torsade de Pointes (TdP) by blocking the rapid delayed rectifying potassium current (IKr) without affecting either the slow delayed rectifying potassium current (IKs) or inward rectifying potassium current (IK1). Erythromycin exerts this effect in ...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-019-09532-x
更新日期：2019-12-01 00:00:00
abstract：:Serotonergic drugs may lead to valvular heart disease in humans and more recently also in rats. Although clinical data suggest that dose dependency and reversibility after drug cessation might occur, proof of this is lacking. For that purpose, a total of 106 rats were prospectively enrolled: 22 control animals and 7 g...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-009-9046-2
更新日期：2009-09-01 00:00:00
abstract：:DLBS1425 is a bioactive compound extracted from Phaleria macrocarpa, with anti-proliferative, anti-inflammatory and anti-angiogenic properties against cancer cells. The present study was aimed to assess cardiotoxicity of DLBS1425, compared to the mainstay regimen for breast cancer, 5-fluorouracil:doxorubicin:cyclophos...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-014-9275-x
更新日期：2015-01-01 00:00:00
abstract：:Oxygen-derived free radicals have been demonstrated to contribute to the pathogenesis of myocardial dysfunction, although the underlying mechanism remains not fully understood. This study was designed to examine the role of the superoxide generator pyrogallol on cardiac contractile function and possible intervention w...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1385/ct:4:4:375
更新日期：2004-01-01 00:00:00
abstract：:Nucleoside reverse transcriptase inhibitor (NRTI)-induced cardiomyopathy has been suggested to reflect mitochondrial targets of drug toxicity. The prevailing hypothesis is that, through structural mimicry, the NRTIs are mistaken as substrates for DNA polymerase and incorporated into replicating DNA, where they cause t...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1385/ct:4:3:217
更新日期：2004-01-01 00:00:00
abstract：:3,4-Methylenedioxymethamphetamine (MDMA), more commonly known as "ecstasy," is a semi-synthetic entactogenic phenylethylamine. In recent years it has gained popularity as a recreational drug whose use has registered an upward trend especially among adolescents and young adults. Despite its unwarranted reputation of be...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-019-09526-9
更新日期：2019-12-01 00:00:00
abstract：:Arsenic trioxide (ATO) is among the first-line chemotherapeutic drugs used in oncological practice. It has shown substantial efficacy in treating patients with relapsed or refractory acute promyelocytic leukaemia. The clinical use of ATO is hampered due to cardiotoxicity and hence many patients are precluded from rece...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-018-09504-7
更新日期：2019-04-01 00:00:00
