Abstract:
:The corticotrophin-releasing hormone-related factor, urocortin (Ucn) and the interleukin (IL)-6 family cytokine cardiotrophin-1 (CT-1) are both cardioprotective agents able to protect the heart from ischemic damage. In both cases the protective effect involves activation of the p42/p44 MAPK and PI-3 kinase/Akt pathways, but the protective effect of Ucn requires de novo protein synthesis whereas that of CT-1 does not. In this study, we show that Ucn induces enhanced expression of CT-1 at both the mRNA and protein levels. This effect is mediated by activation of the CT-1 gene promoter and requires the transcription factor C/EBPbeta/NF-IL6. Hence, a specific cardioprotective factor can induce enhanced expression of another cardioprotective factor belonging to an unrelated protein family.
journal_name
Cardiovasc Toxicoljournal_title
Cardiovascular toxicologyauthors
Janjua S,Lawrence KM,Ng LL,Latchman DSdoi
10.1385/ct:3:3:255keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
255-62issue
3eissn
1530-7905issn
1559-0259pii
CT:3:3:255journal_volume
3pub_type
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