Abstract：
:Although the role of tropomyosin is well-defined in striated muscle, the precise mechanism of how tropomyosin functions is still unclear. It has been shown that extension of either N- or C-terminal ends of sarcomeric tropomyosin do not affect cardiac myofibrillogenesis, but it is not known whether simultaneous extension of both ends affects the process. For studying structural/functional relationships of sarcomeric tropomyosin, we have chosen the Ambystoma mexicanum because cardiac mutant hearts are deficient in sarcomeric tropomyosin. In this study, we have made an expression construct, pEGFP.TPM4alpha.E-L-FLAG, that, on transfection into normal and mutant axolotl hearts in organ culture, expresses GFP.TPM4alpha.E-L-FLAG fusion protein in which both the N- and C-termini of TPM4alpha are being extended. TPM4alpha is one of the three tropomyosins expressed in normal axolotl hearts. Both confocal and electron microscopic analyses show that this modified sarcomeric tropomyosin can form organized myofibrils in axolotl hearts.
journal_name
Cardiovasc Toxicoljournal_title
Cardiovascular toxicologyauthors
Narshi A,Denz CR,Nakatsugawa M,Zajdel RW,Dube S,Poiesz BJ,Dube DKdoi
10.1385/ct:5:1:001keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
1-8issue
1eissn
1530-7905issn
1559-0259pii
CT:5:1:001journal_volume
5pub_type
杂志文章abstract：:Nucleoside reverse transcriptase inhibitor (NRTI)-induced cardiomyopathy has been suggested to reflect mitochondrial targets of drug toxicity. The prevailing hypothesis is that, through structural mimicry, the NRTIs are mistaken as substrates for DNA polymerase and incorporated into replicating DNA, where they cause t...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1385/ct:4:3:217
更新日期：2004-01-01 00:00:00
abstract：:This study investigated the effect of metyrosine against ketamine-induced cardiotoxicity in rats and compared the results with the effect of metoprolol. In this study, rats were divided into groups A, B and C. In group A, we investigated the effects of a single dose of metyrosine (150 mg/kg) and metoprolol (20 mg/kg) ...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-014-9301-z
更新日期：2015-10-01 00:00:00
abstract：:Normal pregnancy outcome is accomplished, in part, by rapid and expansive physiological adaptations to the systemic circulation, the extent of which is specific to gestational day (GD) and anatomical location. Pregnancy-related hemodynamic changes in uterine placental blood flow stimulate compensatory vascular signali...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-019-09505-0
更新日期：2019-08-01 00:00:00
abstract：:Carbon soot is produced in the process of diamond manufacture. Recent experimental and epidemiological studies have associated exposure to carbon nanoparticles with effects on cardiovascular system and blood cells. The objective of this study is to assess the cardiovascular effects consequent to chronic respiratory ex...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-009-9053-3
更新日期：2009-12-01 00:00:00
abstract：:Coxsackievirus B3 (CVB3) induces myocarditis, especially in the immunodeficient or immature. To investigate whether CVB3 induced pronounced cardiomyopathy during the severe immune dysfunction of murine acquired immunodeficiency syndrome (AIDS), female C57BL/6 mice were infected with LP-BM5 retrovirus and then coinfect...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1385/ct:2:1:53
更新日期：2002-01-01 00:00:00
abstract：:Choerospondias axillaris (Guangzao) is a medicinal plant used in Mongolia, and its fruit is commonly used for the treatment of cardiovascular diseases in clinic. The constituents responsible for this effect are always conceded to be the total flavonoids of C. axillaries (TFC). The present study was to evaluate the pre...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-013-9238-7
更新日期：2014-06-01 00:00:00
abstract：:Controlled activation of the complement system is critical to the host-defense response of the immune system. Activated complement is responsible for the stimulation of a localized protective inflammatory response to either invading microorganisms or foreign molecules (toxins). However, the autologous activation of th...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1385/ct:3:1:43
更新日期：2003-01-01 00:00:00
abstract：:3,4-Methylenedioxymethamphetamine (MDMA), more commonly known as "ecstasy," is a semi-synthetic entactogenic phenylethylamine. In recent years it has gained popularity as a recreational drug whose use has registered an upward trend especially among adolescents and young adults. Despite its unwarranted reputation of be...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-019-09526-9
更新日期：2019-12-01 00:00:00
abstract：:The incidence of arsenic toxicity has been observed in various countries including Taiwan, Bangladesh, India, Argentina, Australia, Chile, China, Hungary, Peru, Thailand, Mexico and United States of America. Arsenic is a ubiquitous element present in drinking water, and its exposure is associated with various cardiova...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-009-9050-6
更新日期：2009-12-01 00:00:00
abstract：:Doxorubicin (Dox), an antitumor anthracycline antibiotic, plays a key role in the treatment of many neoplastic diseases. However, its chronic administration induces cardiomyopathy. Increased oxidative stress is a major factor implicated in Dox-induced cardiotoxicity. We hypothesized that a pre-treatment with grape see...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-012-9155-1
更新日期：2012-06-01 00:00:00
abstract：:DLBS1425 is a bioactive compound extracted from Phaleria macrocarpa, with anti-proliferative, anti-inflammatory and anti-angiogenic properties against cancer cells. The present study was aimed to assess cardiotoxicity of DLBS1425, compared to the mainstay regimen for breast cancer, 5-fluorouracil:doxorubicin:cyclophos...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-014-9275-x
更新日期：2015-01-01 00:00:00
abstract：:Caffeine, a naturally occurring purine-based alkaloid, is the most consumed psychostimulant worldwide. Since caffeine pharmacokinetics shows extreme interindividual variability, it is not easy to establish its toxic dose. Only a few cases of death due to acute caffeine intoxication have been described so far, the majo...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-020-09608-z
更新日期：2021-01-01 00:00:00
abstract：:It has been suggested that prenatal exposure to cadmium may alter the cardiovascular function during adulthood. Using the left coronary artery ligation model of acute myocardial infarction, we studied the cardiac function of female adult offspring rats exposed to cadmium (30 ppm) during gestation. The cardiac ischemic...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-011-9139-6
更新日期：2012-03-01 00:00:00
abstract：:We made an attempt to evaluate/compare the cardioprotective activity of two different doses (50 and 100 mg/kg body weight, given orally for 30 consecutive days) of Egyptian sweet marjoram leaf powder (MLP) and marjoram leaf aqueous extract (MLE) against isoproterenol (ISO)-induced myocardial infarcted rats (150 mg/kg ...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-012-9189-4
更新日期：2013-06-01 00:00:00
abstract：:Cardiac gene expression regulation is controlled not only by genetic factors but also by environmental, i.e., epigenetic factors. Several environmental toxic effects such as oxidative stress and ischemia can result in abnormal myofibril gene expression during heart development. Troponin, one of the regulatory myofibri...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-014-9278-7
更新日期：2015-07-01 00:00:00
abstract：:Cardiac hypertrophy is an adaptive response to a number of heart diseases including myocardial infarction. Although it can be compensatory at first, sustained hypertrophy is often a transition to heart failure. We have found that cardiomyocytes in culture can survive mild doses of H2O2 but develop hypertrophy involvin...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1385/ct:3:2:119
更新日期：2003-01-01 00:00:00
abstract：:Four decades of research on the link between hyperhomocysteinemia and cardiovascular disease has led to a crossroads. Several negative studies on the role of homocysteine-lowering B-vitamin therapy in reducing the risk of atherothrombotic cardiovascular disease have dampened enthusiasm for this important field of rese...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-009-9042-6
更新日期：2009-06-01 00:00:00
abstract：:Oxidative stress plays an important role in the pathogenesis of hypertension. Epigallocatechin-3-O-gallate (EGCG) is the main polyphenol present in green tea and is known for its potent antioxidant and anti-inflammatory properties. In the present study, we hypothesize that EGCG attenuates oxidative stress in the parav...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-015-9335-x
更新日期：2016-07-01 00:00:00
abstract：:The objective of this study was to characterize acute coronary artery injury evoked by the endothelin A receptor (ETAR) antagonist, CI-1034. Male dogs (n = 5) were intravenously administered CI-1034 at 120 mg/kg for 4 d. Control animals (n = 3) received vehicle. Macroscopically, drug-related hemorrhage was observed in...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1385/ct:6:1:25
更新日期：2006-01-01 00:00:00
abstract：:The anticancer drug lapatinib (Tykerb) is a dual tyrosine kinase inhibitor targeting the HER2 (ERBB2) and EGFR (ERBB1, HER1) pathways that have been shown in clinical trials to display some cardiotoxicity. Because trastuzumab also targets HER2 receptors, the lapatinib/doxorubicin combination provides a good model to p...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-012-9183-x
更新日期：2013-03-01 00:00:00
abstract：:This study investigated whether the whole-plant aqueous extract of Crataegus aronia (C. aronia) could protect against or alleviate high-fat diet (HFD)-induced aortic vascular inflammation in rats by inhibiting the NLRP-3 inflammasome pathway and examined some mechanisms of action with respect to its antioxidant and hy...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-019-09534-9
更新日期：2020-02-01 00:00:00
abstract：:Although studies have shown that endothelial nitric oxide synthase (eNOS) homozygous knockout mice (eNOS-/-) develop left ventricular (LV) hypertrophy, well compensated at least to 24 wks, uncertainty still exists as to the cardiac functional and molecular mechanistic consequences of eNOS deficiency at later time-poin...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-007-0028-y
更新日期：2007-01-01 00:00:00
abstract：:Arsenic trioxide (As2O3) is used clinically in the management of acute promyelocytic leukemia, and the use of electrocardiogram (ECG) in this management is important as arsenic use may cause distortion of the electrical properties with its attendant sequel. We studied the effect of As2O3 on vasomotion in rat aortic ri...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-015-9312-4
更新日期：2016-01-01 00:00:00
abstract：:Anthracycline chemotherapy produces cardiac repolarization abnormalities and arrhythmias because of cardiac toxicity of drugs. Ventricular arrhythmogenesis is attributable to increase in repolarization heterogeneity that is characterized by spatial dispersion of repolarization. The purpose of this work was to study th...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-012-9172-0
更新日期：2012-12-01 00:00:00
abstract：:Over 300,000 hip replacements occurred in the USA in 2010, and the frequency is likely increasing annually. Blood Cobalt (Co) concentrations in patients with well-functioning cobalt-chromium (Co-Cr) hip implants are usually elevated above background concentrations relative to the general population. Excessive Co expos...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-017-9433-z
更新日期：2018-06-01 00:00:00
abstract：:This study was aimed at determining the efficacy of epinephrine, followed by chest compressions, in producing a return of spontaneous circulation (ROSC) during cyanide (CN)- or hydrogen sulfide (H2S)-induced toxic cardiac pulseless electrical activity (PEA) in the rat. Thirty-nine anesthetized rats were exposed to eit...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-018-9454-2
更新日期：2018-10-01 00:00:00
abstract：:Unintentional intravascular administration of bupivacaine may cause local anesthetic systemic toxicity (LAST). Although many systems are affected in LAST, the cardiovascular effects can be life-threatening. Remifentanil is a selective, ultra-short-acting, µ-opioid receptor agonist opioid. This study assessed the effec...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-017-9413-3
更新日期：2018-02-01 00:00:00
abstract：:HIV infection in patients is associated with a surprisingly high frequency of diastolic dysfunction followed by the development of a dilated cardiomyopathy. Potential mechanisms include direct effects of HIV proteins, including gp120. We have previously reported direct inotropic and p38 MAP kinase signaling effects of...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-009-9047-1
更新日期：2009-09-01 00:00:00
abstract：:The ubiquitous nature of plastics has raised concerns pertaining to continuous exposure to plastic polymers and human health risks. Of particular concern is the use of endocrine-disrupting chemicals in plastic production, including di(2-ethylhexyl)phthalate (DEHP) and bisphenol A (BPA). Widespread and continuous expos...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-014-9258-y
更新日期：2014-12-01 00:00:00
abstract：:The exact mechanism of acute heart dysfunction caused by jellyfish venom remains unclear for the moment. In the present study, we examined the problem caused by the tentacle extract (TE) from the jellyfish Cyanea capillata at the levels of whole animal, isolated heart, primarily cultured cardiomyocytes, and intracellu...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-014-9250-6
更新日期：2014-09-01 00:00:00
