Abstract：
:Oxidative stress plays an important role in the pathogenesis of hypertension. Epigallocatechin-3-O-gallate (EGCG) is the main polyphenol present in green tea and is known for its potent antioxidant and anti-inflammatory properties. In the present study, we hypothesize that EGCG attenuates oxidative stress in the paraventricular nucleus of hypothalamus (PVN), thereby decreasing the blood pressure and sympathetic activity in renovascular hypertensive rats. After renovascular hypertension was induced in male Sprague-Dawley rats by the two-kidney one-clip (2K-1C) method, the rats received bilateral PVN infusion of EGCG (20 μg/h) or vehicle via osmotic minipump for 4 weeks. Our results were shown as follows: (1) Hypertension induced by 2K-1C was associated with the production of reactive oxygen species in the PVN; (2) chronic infusion of EGCG in the PVN decreased stress-related NAD(P)H oxidase subunit gp91(phox) and NOX-4 and increased the activity of antioxidant enzymes (SOD-1), also balanced the content of cytokines (IL-1β, IL-6, IL-10 and MCP-1) in the PVN, and attenuated the level of norepinephrine in plasma of 2K-1C rats. Our findings provide strong evidence that PVN infusion of EGCG inhibited renovascular hypertension progression through its potent anti-oxidative and anti-inflammatory activity in the PVN.
journal_name
Cardiovasc Toxicoljournal_title
Cardiovascular toxicologyauthors
Yi QY,Qi J,Yu XJ,Li HB,Zhang Y,Su Q,Shi T,Zhang DM,Guo J,Feng ZP,Wang ML,Zhu GQ,Liu JJ,Shi XL,Kang YMdoi
10.1007/s12012-015-9335-xsubject
Has Abstractpub_date
2016-07-01 00:00:00pages
276-85issue
3eissn
1530-7905issn
1559-0259pii
10.1007/s12012-015-9335-xjournal_volume
16pub_type
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