Preventive effect of total flavones of Choerospondias axillaries on ischemia/reperfusion-induced myocardial infarction-related MAPK signaling pathway.

abstract：:Doxorubicin (Dox), an antitumor anthracycline antibiotic, plays a key role in the treatment of many neoplastic diseases. However, its chronic administration induces cardiomyopathy. Increased oxidative stress is a major factor implicated in Dox-induced cardiotoxicity. We hypothesized that a pre-treatment with grape see...

journal_title：Cardiovascular toxicology

authors： Mokni M,Hamlaoui-Guesmi S,Amri M,Marzouki L,Limam F,Aouani E

更新日期：2012-06-01 00:00:00

abstract：:This study was aimed at determining the efficacy of epinephrine, followed by chest compressions, in producing a return of spontaneous circulation (ROSC) during cyanide (CN)- or hydrogen sulfide (H2S)-induced toxic cardiac pulseless electrical activity (PEA) in the rat. Thirty-nine anesthetized rats were exposed to eit...

journal_title：Cardiovascular toxicology

authors： Judenherc-HaouzI A,Sonobe T,Bebarta VS,Haouzi P

更新日期：2018-10-01 00:00:00

abstract：:Anthracycline chemotherapy produces cardiac repolarization abnormalities and arrhythmias because of cardiac toxicity of drugs. Ventricular arrhythmogenesis is attributable to increase in repolarization heterogeneity that is characterized by spatial dispersion of repolarization. The purpose of this work was to study th...

journal_title：Cardiovascular toxicology

authors： Kharin SN,Krandycheva VV,Strelkova MV,Tsvetkova AS,Shmakov DN

更新日期：2012-12-01 00:00:00

abstract：:This study investigated whether the whole-plant aqueous extract of Crataegus aronia (C. aronia) could protect against or alleviate high-fat diet (HFD)-induced aortic vascular inflammation in rats by inhibiting the NLRP-3 inflammasome pathway and examined some mechanisms of action with respect to its antioxidant and hy...

journal_title：Cardiovascular toxicology

authors： Shatoor AS,Al Humayed S

更新日期：2020-02-01 00:00:00

abstract：:HIV infection in patients is associated with a surprisingly high frequency of diastolic dysfunction followed by the development of a dilated cardiomyopathy. Potential mechanisms include direct effects of HIV proteins, including gp120. We have previously reported direct inotropic and p38 MAP kinase signaling effects of...

journal_title：Cardiovascular toxicology

authors： Berzingi C,Chen F,Finkel MS

更新日期：2009-09-01 00:00:00

abstract：:Since an antipsychotic drug haloperidol has been clinically reported to induce QT interval prolongation and torsade de pointes, in this study its risk stratification for the onset of torsade de pointes was performed by using the chronic atrioventricular block canine model with a Holter electrocardiogram. Haloperidol i...

journal_title：Cardiovascular toxicology

authors： Izumi-Nakaseko H,Nakamura Y,Cao X,Wada T,Ando K,Sugiyama A

更新日期：2017-07-01 00:00:00

abstract：:Tolerance to clinically important organic nitrates such as nitroglycerin (NTG) has been experimentally related to endothelial dysfunction and vascular oxidative stress. Anti-oxidant enzymes such as the glutathione-S-transferases GSTs) could potentially play a protective role in NTG tolerance. Our previous work showed ...

journal_title：Cardiovascular toxicology

authors： Wang L,Yang Y,Dwivedi S,Xu Y,Chu ET,Li J,Fitchett K,Boor PJ

更新日期：2006-01-01 00:00:00

abstract：:Carfilzomib is a proteasome inhibitor, commonly used in multiple myeloma, but its clinical use may be limited due to cardiotoxicity. This study was aimed to evaluate the influence of rutin in carfilzomib-induced cardiotoxicity in rats. Wistar albino male rats weighing 200-250 g (approximately 10 weeks old) were taken ...

journal_title：Cardiovascular toxicology

authors： Imam F,Al-Harbi NO,Al-Harbia MM,Korashy HM,Ansari MA,Sayed-Ahmed MM,Nagi MN,Iqbal M,Khalid Anwer M,Kazmi I,Afzal M,Bahashwan S

更新日期：2017-01-01 00:00:00

abstract：:Caffeine, a naturally occurring purine-based alkaloid, is the most consumed psychostimulant worldwide. Since caffeine pharmacokinetics shows extreme interindividual variability, it is not easy to establish its toxic dose. Only a few cases of death due to acute caffeine intoxication have been described so far, the majo...

journal_title：Cardiovascular toxicology

authors： Maiese A,La Russa R,Del Fante Z,Turillazzi E,David MC,Frati P,Fineschi V

更新日期：2021-01-01 00:00:00

abstract：:Our aim is to investigate the correlation between 9p21 chromosome rs4977574 polymorphism genotypes and the development of coronary artery heart disease (CHD). Two hundred and eighty-nine patients with angiography-confirmed CHD were recruited as the CHD group, while 338 subjects without CHD symptoms were enrolled as th...

journal_title：Cardiovascular toxicology

authors： Tang O,Lv J,Cheng Y,Qin F

更新日期：2017-04-01 00:00:00

abstract：:Cardiovascular disease represents one of the most important public health problem in the Western countries, with sudden cardiac death (SCD) being the most common cause of death in adults under 65 years of age. The objective of the present study is to evaluate the leading causes of SCD in young adults who died suddenly...

journal_title：Cardiovascular toxicology

authors： Silva AC,Santos L,Dinis-Oliveira RJ,Magalhães T,Santos A

更新日期：2014-12-01 00:00:00

abstract：:Fresh vehicular emissions potentially represent a ubiquitous environmental concern for cardiovascular health. We compared electrocardiographic effects of fresh gasoline engine emissions with resuspended paved road dust in a mouse model of coronary insufficiency. Apolipoprotein E (ApoE)-/- mice on a high fat diet were ...

journal_title：Cardiovascular toxicology

authors： Campen MJ,McDonald JD,Reed MD,Seagrave J

更新日期：2006-01-01 00:00:00

abstract：:Cerium dioxide nanoparticles (CeO2 NPs) are an engineered nanomaterial (ENM) that possesses unique catalytic, oxidative, and reductive properties. Currently, CeO2 NPs are being used as a fuel catalyst but these properties are also utilized in the development of potential drug treatments for radiation and stroke protec...

journal_title：Cardiovascular toxicology

authors： Minarchick VC,Stapleton PA,Porter DW,Wolfarth MG,Çiftyürek E,Barger M,Sabolsky EM,Nurkiewicz TR

更新日期：2013-12-01 00:00:00

abstract：:Cardiac toxicity has been associated with HIV infection and exposure to nucleoside reverse transcriptase inhibitors (NRTIs), but the role of the latter in the development of cardiac disease of HIV-infected patients is uncertain. To investigate the cardiotoxicity of transplacentally administered zidovudine (AZT) or AZT...

journal_title：Cardiovascular toxicology

authors： Walker DM,Poirier MC,Campen MJ,Cook DL Jr,Divi RL,Nagashima K,Lund AK,Cossey PY,Hahn FF,Walker VE

更新日期：2004-01-01 00:00:00

abstract：:Cardiac hypertrophy is an adaptive response to a number of heart diseases including myocardial infarction. Although it can be compensatory at first, sustained hypertrophy is often a transition to heart failure. We have found that cardiomyocytes in culture can survive mild doses of H2O2 but develop hypertrophy involvin...

journal_title：Cardiovascular toxicology

authors： Tu VC,Bahl JJ,Chen QM

更新日期：2003-01-01 00:00:00

abstract：:The anticancer drug lapatinib (Tykerb) is a dual tyrosine kinase inhibitor targeting the HER2 (ERBB2) and EGFR (ERBB1, HER1) pathways that have been shown in clinical trials to display some cardiotoxicity. Because trastuzumab also targets HER2 receptors, the lapatinib/doxorubicin combination provides a good model to p...

journal_title：Cardiovascular toxicology

authors： Hasinoff BB,Patel D,Wu X

更新日期：2013-03-01 00:00:00

abstract：:This study investigated the effect of metyrosine against ketamine-induced cardiotoxicity in rats and compared the results with the effect of metoprolol. In this study, rats were divided into groups A, B and C. In group A, we investigated the effects of a single dose of metyrosine (150 mg/kg) and metoprolol (20 mg/kg) ...

journal_title：Cardiovascular toxicology

authors： Ahiskalioglu A,Ince I,Aksoy M,Ahiskalioglu EO,Comez M,Dostbil A,Celik M,Alp HH,Coskun R,Taghizadehghalehjoughi A,Suleyman B

更新日期：2015-10-01 00:00:00

abstract：:The corticotrophin-releasing hormone-related factor, urocortin (Ucn) and the interleukin (IL)-6 family cytokine cardiotrophin-1 (CT-1) are both cardioprotective agents able to protect the heart from ischemic damage. In both cases the protective effect involves activation of the p42/p44 MAPK and PI-3 kinase/Akt pathway...

journal_title：Cardiovascular toxicology

authors： Janjua S,Lawrence KM,Ng LL,Latchman DS

更新日期：2003-01-01 00:00:00

abstract：:The use of anthracycline anticancer drugs is limited by a cumulative, dose-dependent cardiac toxicity. Iron chelation has long been considered as a promising strategy to limit this unfavorable side effect, either by restoring the disturbed cellular iron homeostasis or by removing redox-active iron, which may promote a...

journal_title：Cardiovascular toxicology

authors： Kaiserová H,Simunek T,Sterba M,den Hartog GJ,Schröterová L,Popelová O,Gersl V,Kvasnicková E,Bast A

更新日期：2007-01-01 00:00:00

abstract：:We investigated protective effect of FK506 on rat hearts subjected to ischemia/reperfusion (I/R) injury by regulating CaN and ASK1. Wistar rats were divided into four groups: Ischemia/reperfusion group (I/R), FK506 + Ischemia/reperfusion group (FK506-I/R), sham group, and FK506 + sham group (FK506-sham). Ischemia/repe...

journal_title：Cardiovascular toxicology

authors： Feng X,Li J,Liu J,Jin M,Liu X,Du H,Zhang L,Sun Z,Li X

更新日期：2011-03-01 00:00:00

abstract：:Acute cardiovascular poisoning is a major cause of adverse outcomes in poisoning emergencies. The prognostic validity of corrected QT (QTc) and dispersed QT (QTd) in these outcomes is still limited. The present study aimed to determine the risk factors of mortality, adverse cardiovascular events (ACVE), and intensive ...

journal_title：Cardiovascular toxicology

authors： El-Sarnagawy GN,Shaban AE,Lashin HI

更新日期：2021-01-05 00:00:00

abstract：:This study investigated if the cardioprotective effect of acylated ghrelin (AG) against doxorubicin (DOX)-induced cardiac toxicity in rats involves inhibition of Fas/FasL-mediated cell death. It also investigated if such an effect is mediated by restoring Ca+2 homeostasis from the aspect of stimulation of SERCA2a rece...

journal_title：Cardiovascular toxicology

authors： Shati AA,Dallak M

更新日期：2019-12-01 00:00:00

abstract：:Controlled activation of the complement system is critical to the host-defense response of the immune system. Activated complement is responsible for the stimulation of a localized protective inflammatory response to either invading microorganisms or foreign molecules (toxins). However, the autologous activation of th...

journal_title：Cardiovascular toxicology

authors： Pugsley MK,Abramova M,Cole T,Yang X,Ammons WS

更新日期：2003-01-01 00:00:00

abstract：:High-salt-induced inflammation and oxidative stress in the hypothalamic paraventricular nucleus (PVN) contribute to the pathogenesis of salt-sensitive hypertension. In this study, we hypothesized that chronic inhibition of nuclear factor-κB (NF-κB) activity in the PVN delays the progression of hypertension by upregula...

journal_title：Cardiovascular toxicology

authors： Qi J,Yu XJ,Shi XL,Gao HL,Yi QY,Tan H,Fan XY,Zhang Y,Song XA,Cui W,Liu JJ,Kang YM

更新日期：2016-10-01 00:00:00

abstract：:Dofetilide is a class III antiarrhythmic used for treating atrial dysrhythmias. Though its adverse effects are well described in routine use, very little is known about dofetilide toxicity in overdose. This is a retrospective case series of consecutive patients reported to our poison center after dofetilide overdose. ...

journal_title：Cardiovascular toxicology

authors： Hieger MA,Maskell KF,Moss MJ,Powell SW,Cumpston KL

更新日期：2017-07-01 00:00:00

abstract：:Complete understanding of the etiology underlying endothelial damage in preeclampsia (PE) remains deficient. Recent studies suggest that autoantibodies against angiotensin II AT1 receptors (AT1-AA) may affect vascular endothelial integrity. However, direct evidence demonstrating association between AT1-AA from preecla...

journal_title：Cardiovascular toxicology

authors： Yang X,Wang F,Lau WB,Zhang S,Zhang S,Liu H,Ma XL

更新日期：2014-03-01 00:00:00

abstract：:Lithium is one of the classical drugs that have been widely used for treating bipolar disorder. However, several cardiac side effects including sick sinus syndrome, bundle branch block, ventricular tachycardia/fibrillation, non-specific T-wave abnormalities in addition to Brugada-type electrocardiographic changes have...

journal_title：Cardiovascular toxicology

authors： Goto A,Nakamura Y,Lubna NJ,Chiba K,Hagiwara-Nagasawa M,Izumi-Nakaseko H,Ando K,Naito AT,Sugiyama A

更新日期：2018-12-01 00:00:00

abstract：:Although studies have shown that endothelial nitric oxide synthase (eNOS) homozygous knockout mice (eNOS-/-) develop left ventricular (LV) hypertrophy, well compensated at least to 24 wks, uncertainty still exists as to the cardiac functional and molecular mechanistic consequences of eNOS deficiency at later time-poin...

journal_title：Cardiovascular toxicology

authors： Flaherty MP,Brown M,Grupp IL,Schultz JE,Murphree SS,Jones WK

更新日期：2007-01-01 00:00:00

abstract：:The exact mechanism of acute heart dysfunction caused by jellyfish venom remains unclear for the moment. In the present study, we examined the problem caused by the tentacle extract (TE) from the jellyfish Cyanea capillata at the levels of whole animal, isolated heart, primarily cultured cardiomyocytes, and intracellu...

journal_title：Cardiovascular toxicology

authors： Zhang L,He Q,Wang Q,Zhang B,Wang B,Xu F,Wang T,Xiao L,Zhang L

更新日期：2014-09-01 00:00:00

abstract：:Oxygen-derived free radicals have been demonstrated to contribute to the pathogenesis of myocardial dysfunction, although the underlying mechanism remains not fully understood. This study was designed to examine the role of the superoxide generator pyrogallol on cardiac contractile function and possible intervention w...

journal_title：Cardiovascular toxicology

authors： Esberg LB,Ren J

更新日期：2004-01-01 00:00:00