Abstract：
:DLBS1425 is a bioactive compound extracted from Phaleria macrocarpa, with anti-proliferative, anti-inflammatory and anti-angiogenic properties against cancer cells. The present study was aimed to assess cardiotoxicity of DLBS1425, compared to the mainstay regimen for breast cancer, 5-fluorouracil:doxorubicin:cyclophosphamide (FAC, given at 500/50/500 mg/m(2)). Treatment with FAC regimen at standard dose resulted in very severe toxicity, so mice had no chance to survive for more than 7 days following initial drug treatment. Furthermore, histological examination on the heart revealed severe muscular damage when mice were given the FAC regimen alone (severe toxicity). FAC as chemotherapeutic regimen exerted high toxicity profile to the cardiovascular cells in this experiment. Meanwhile, treatment with DLBS1425 alone up to a dose equivalent to as high as 300 mg three times daily in human had no hazardous consequences on the heart, hematological feature, as well as general safety. In the cardiovascular cells, DLBS1425 in the presence of FAC regimen (one-eight of the initial dose) gave protection to the cardiac muscle cells as well as other hematological features. Taken together, results of the present study suggest that DLBS1425 is safe when used as adjuvant therapy for breast cancer and may be even protective against cardiac cellular damage produced by chemotherapeutic regimen.
journal_name
Cardiovasc Toxicoljournal_title
Cardiovascular toxicologyauthors
Anggadiredja K,Tjandrawinata RRdoi
10.1007/s12012-014-9275-xsubject
Has Abstractpub_date
2015-01-01 00:00:00pages
90-9issue
1eissn
1530-7905issn
1559-0259journal_volume
15pub_type
杂志文章abstract：:The aryl hydrocarbon receptor (AhR) is a member of the basic helix loop helix PAS (Per-ARNT-SIM) transcription family, which also includes hypoxiainducible factor-1alpha (HIF-1alpha) and its common dimerization partner AhR nuclear translocator (ARNT). Following ligand activation or hypoxia, AhR or HIF-1alpha, respecti...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1385/ct:2:4:263
更新日期：2002-01-01 00:00:00
abstract：:Although the role of tropomyosin is well-defined in striated muscle, the precise mechanism of how tropomyosin functions is still unclear. It has been shown that extension of either N- or C-terminal ends of sarcomeric tropomyosin do not affect cardiac myofibrillogenesis, but it is not known whether simultaneous extensi...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1385/ct:5:1:001
更新日期：2005-01-01 00:00:00
abstract：:Caffeine, a naturally occurring purine-based alkaloid, is the most consumed psychostimulant worldwide. Since caffeine pharmacokinetics shows extreme interindividual variability, it is not easy to establish its toxic dose. Only a few cases of death due to acute caffeine intoxication have been described so far, the majo...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-020-09608-z
更新日期：2021-01-01 00:00:00
abstract：:Although studies have shown that endothelial nitric oxide synthase (eNOS) homozygous knockout mice (eNOS-/-) develop left ventricular (LV) hypertrophy, well compensated at least to 24 wks, uncertainty still exists as to the cardiac functional and molecular mechanistic consequences of eNOS deficiency at later time-poin...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-007-0028-y
更新日期：2007-01-01 00:00:00
abstract：:We made an attempt to evaluate/compare the cardioprotective activity of two different doses (50 and 100 mg/kg body weight, given orally for 30 consecutive days) of Egyptian sweet marjoram leaf powder (MLP) and marjoram leaf aqueous extract (MLE) against isoproterenol (ISO)-induced myocardial infarcted rats (150 mg/kg ...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-012-9189-4
更新日期：2013-06-01 00:00:00
abstract：:The exact mechanism of acute heart dysfunction caused by jellyfish venom remains unclear for the moment. In the present study, we examined the problem caused by the tentacle extract (TE) from the jellyfish Cyanea capillata at the levels of whole animal, isolated heart, primarily cultured cardiomyocytes, and intracellu...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-014-9250-6
更新日期：2014-09-01 00:00:00
abstract：:This study was aimed at evaluation of changes in activities of selected antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and contents of key nonenzymatic antioxidants (glutathione, protein thiol groups, and α- and γ-tocopherols) in the left heart ventricle of youn...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-011-9105-3
更新日期：2011-06-01 00:00:00
abstract：:We investigated protective effect of FK506 on rat hearts subjected to ischemia/reperfusion (I/R) injury by regulating CaN and ASK1. Wistar rats were divided into four groups: Ischemia/reperfusion group (I/R), FK506 + Ischemia/reperfusion group (FK506-I/R), sham group, and FK506 + sham group (FK506-sham). Ischemia/repe...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-010-9095-6
更新日期：2011-03-01 00:00:00
abstract：:The incidence of arsenic toxicity has been observed in various countries including Taiwan, Bangladesh, India, Argentina, Australia, Chile, China, Hungary, Peru, Thailand, Mexico and United States of America. Arsenic is a ubiquitous element present in drinking water, and its exposure is associated with various cardiova...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-009-9050-6
更新日期：2009-12-01 00:00:00
abstract：:Doxorubicin (Dox), an antitumor anthracycline antibiotic, plays a key role in the treatment of many neoplastic diseases. However, its chronic administration induces cardiomyopathy. Increased oxidative stress is a major factor implicated in Dox-induced cardiotoxicity. We hypothesized that a pre-treatment with grape see...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-012-9155-1
更新日期：2012-06-01 00:00:00
abstract：:Congestive heart failure (CHF) afflicts over 5 million individuals in the United States, and most die within 5 yr of diagnosis. Because of the high morbidity and mortality associated with CHF, the search for biomarkers to predict, diagnose, and manage this disease has intensified. Calcium homeostasis and alterations i...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1385/ct:1:2:165
更新日期：2001-01-01 00:00:00
abstract：:Recent evidence indicates that Ca2+ dysregulation is involved in the pathogenesis of isoproterenol (ISP)-induced biochemical toxicity and associated oxidative stress. In this study, we investigated the chemopreventive benefit of M3, a 1,4-dihydropyridine calcium channel blocker, against ISP-induced toxicity in male Wi...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-020-09587-1
更新日期：2020-12-01 00:00:00
abstract：:Present study evaluates cardioprotective role of melatonin (Mel), alpha lipoic acid (ALA), a combination of melatonin and alpha lipoic acid (Mel + ALA) against cadmium (Cd)-induced oxidative damage. Female albino rats were subjected to 15-day exposure to Cd (5.12 mg/kg bw) alone or treated with ML (10 mg/kg bw) + ALA ...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-010-9092-9
更新日期：2011-03-01 00:00:00
abstract：:Normal pregnancy outcome is accomplished, in part, by rapid and expansive physiological adaptations to the systemic circulation, the extent of which is specific to gestational day (GD) and anatomical location. Pregnancy-related hemodynamic changes in uterine placental blood flow stimulate compensatory vascular signali...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-019-09505-0
更新日期：2019-08-01 00:00:00
abstract：:Trichloroethylene is an organic solvent used as an industrial degreasing agent. Due to its widespread use and volatile nature, TCE is a common environmental contaminant. Trichloroethylene exposure has been implicated in the etiology of heart defects in human populations and animal models. Recent data suggest misregula...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-010-9066-y
更新日期：2010-06-01 00:00:00
abstract：:Heart rate variability (HRV) is a measure of cardiac pacing dynamics that has recently garnered a great deal of interest in environmental health studies. While the use of these measures has become popular, much uncertainty remains in the interpretation of results, both in terms of human and animal research. In humans,...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-007-0004-6
更新日期：2007-01-01 00:00:00
abstract：:Peroxynitrite is a powerful oxidant, formed from the reaction of nitric oxide and superoxide. It is known to interact and modify different biological molecules such as DNA, lipids and proteins leading to alterations in their structure and functions. These events elicit various cellular responses, including cell signal...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-016-9394-7
更新日期：2017-10-01 00:00:00
abstract：:3,4-Methylenedioxymethamphetamine (MDMA), more commonly known as "ecstasy," is a semi-synthetic entactogenic phenylethylamine. In recent years it has gained popularity as a recreational drug whose use has registered an upward trend especially among adolescents and young adults. Despite its unwarranted reputation of be...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-019-09526-9
更新日期：2019-12-01 00:00:00
abstract：:Four decades of research on the link between hyperhomocysteinemia and cardiovascular disease has led to a crossroads. Several negative studies on the role of homocysteine-lowering B-vitamin therapy in reducing the risk of atherothrombotic cardiovascular disease have dampened enthusiasm for this important field of rese...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-009-9042-6
更新日期：2009-06-01 00:00:00
abstract：:The present study was undertaken to evaluate protective role of S. rhomboidea. Roxb (SR) leaf extract against in vitro low-density lipoprotein (LDL) oxidation and oxidized LDL (Ox-LDL) induced macrophage apoptosis. Copper and cell-mediated LDL oxidation, Ox-LDL-induced peroxyl radical generation, mitochondrial activit...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-011-9110-6
更新日期：2011-06-01 00:00:00
abstract：:Serotonergic drugs may lead to valvular heart disease in humans and more recently also in rats. Although clinical data suggest that dose dependency and reversibility after drug cessation might occur, proof of this is lacking. For that purpose, a total of 106 rats were prospectively enrolled: 22 control animals and 7 g...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-009-9046-2
更新日期：2009-09-01 00:00:00
abstract：:Arsenic trioxide (ATO) is among the first-line chemotherapeutic drugs used in oncological practice. It has shown substantial efficacy in treating patients with relapsed or refractory acute promyelocytic leukaemia. The clinical use of ATO is hampered due to cardiotoxicity and hence many patients are precluded from rece...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-018-09504-7
更新日期：2019-04-01 00:00:00
abstract：:Cardiac troponins not only allow for risk stratification and guidance of therapy in unstable angina and non-Q-wave acute myocardial infarction but also may be useful in the diagnostic workup and monitoring of patients with ST-segment elevation myocardial infarction. In clinical practice, troponins are used for confirm...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1385/ct:1:2:099
更新日期：2001-01-01 00:00:00
abstract：:The use of anthracycline anticancer drugs is limited by a cumulative, dose-dependent cardiac toxicity. Iron chelation has long been considered as a promising strategy to limit this unfavorable side effect, either by restoring the disturbed cellular iron homeostasis or by removing redox-active iron, which may promote a...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-007-0020-6
更新日期：2007-01-01 00:00:00
abstract：:Intracellular Na(+) ([Na(+)](i)) is an important modulator of excitation-contraction coupling via regulating Ca(2+) efflux/influx, and no investigation has been so far performed in diabetic rat heart. Here, we examined whether any change of [Na(+)](i) in paced cardiomyocytes could contribute to functional alterations ...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-012-9192-9
更新日期：2013-06-01 00:00:00
abstract：:This study was aimed at determining the efficacy of epinephrine, followed by chest compressions, in producing a return of spontaneous circulation (ROSC) during cyanide (CN)- or hydrogen sulfide (H2S)-induced toxic cardiac pulseless electrical activity (PEA) in the rat. Thirty-nine anesthetized rats were exposed to eit...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-018-9454-2
更新日期：2018-10-01 00:00:00
abstract：:This study investigated the effect of metyrosine against ketamine-induced cardiotoxicity in rats and compared the results with the effect of metoprolol. In this study, rats were divided into groups A, B and C. In group A, we investigated the effects of a single dose of metyrosine (150 mg/kg) and metoprolol (20 mg/kg) ...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-014-9301-z
更新日期：2015-10-01 00:00:00
abstract：:Elevated levels of homocysteine (Hcy) (known as hyperhomocysteinemia HHcy) are involved in dilated cardiomyopathy. Hcy chelates copper and impairs copper-dependent enzymes. Copper deficiency has been linked to cardiovascular disease. We tested the hypothesis that copper supplement regresses left ventricular hypertroph...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-008-9021-3
更新日期：2008-10-01 00:00:00
abstract：:Heart failure is a common complication of doxorubicin (DOX) therapy. Previous studies have shown that DOX adversely impacts cardiac energy metabolism, and the ensuing energy deficiencies antedate clinical manifestations of cardiac toxicity. Brief exposure of cultured cardiomyocytes to DOX significantly decreases creat...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-014-9283-x
更新日期：2015-04-01 00:00:00
abstract：:Oxygen-derived free radicals have been demonstrated to contribute to the pathogenesis of myocardial dysfunction, although the underlying mechanism remains not fully understood. This study was designed to examine the role of the superoxide generator pyrogallol on cardiac contractile function and possible intervention w...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1385/ct:4:4:375
更新日期：2004-01-01 00:00:00
