Abstract:
:This study was aimed at evaluation of changes in activities of selected antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and contents of key nonenzymatic antioxidants (glutathione, protein thiol groups, and α- and γ-tocopherols) in the left heart ventricle of young male Wistar rats subjected to endurance training (treadmill running, 1 h daily, 5 days a week, for 6 weeks) or/and testosterone propionate treatment (8 or 80 mg/kg body weight, intramuscularly, once a week, for 6 weeks) during adolescence. The training alone increased the activities of key antioxidant enzymes, but lowered the pool of nonenzymatic antioxidants and enhanced myocardial oxidative stress as evidenced by elevation of the lipid peroxidation biomarker malondialdehyde. The lower-dose testosterone treatment showed mixed effects on the individual components of the antioxidant defense system, but markedly enhanced lipid peroxidation. The higher-dose testosterone treatment decreased the activities of the antioxidant enzymes, lowered the contents of the nonenzymatic antioxidants, except for that of γ-tocopherol, reversed the effect of endurance training on the antioxidant enzymes activities, and enhanced lipid peroxidation more than the lower-dose treatment. These data demonstrate the potential risk to cardiac health from exogenous androgen use, either alone or in combination with endurance training, in adolescents.
journal_name
Cardiovasc Toxicoljournal_title
Cardiovascular toxicologyauthors
Sadowska-Krępa E,Kłapcińska B,Jagsz S,Sobczak A,Chrapusta SJ,Chalimoniuk M,Grieb P,Poprzęcki S,Langfort Jdoi
10.1007/s12012-011-9105-3subject
Has Abstractpub_date
2011-06-01 00:00:00pages
118-27issue
2eissn
1530-7905issn
1559-0259journal_volume
11pub_type
杂志文章abstract::Since an antipsychotic drug haloperidol has been clinically reported to induce QT interval prolongation and torsade de pointes, in this study its risk stratification for the onset of torsade de pointes was performed by using the chronic atrioventricular block canine model with a Holter electrocardiogram. Haloperidol i...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-016-9388-5
更新日期:2017-07-01 00:00:00
abstract::Oxidative stress plays an important role in the pathogenesis of hypertension. Epigallocatechin-3-O-gallate (EGCG) is the main polyphenol present in green tea and is known for its potent antioxidant and anti-inflammatory properties. In the present study, we hypothesize that EGCG attenuates oxidative stress in the parav...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-015-9335-x
更新日期:2016-07-01 00:00:00
abstract::Acute alcohol intoxication leads to an inhibition of protein synthesis in heart that results in part through altered phosphorylation of protein factors controlling mRNA translation initiation. The purpose of the present set of experiments was designed to examine the effects of inhibitors of ethanol metabolism on the p...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-008-9012-4
更新日期:2008-03-01 00:00:00
abstract::The effects of magnesium (Mg2+) on ischaemic complications of pathological cardiac hypertrophy are unclear. In this study, we investigated effects of Mg2+ pretreatment on ischaemia/reperfusion (I/R) injury in isoprenaline (ISO)-induced hypertrophic hearts. Wistar rats were treated for 7 days with different combination...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-015-9355-6
更新日期:2017-01-01 00:00:00
abstract::Congestive heart failure (CHF) afflicts over 5 million individuals in the United States, and most die within 5 yr of diagnosis. Because of the high morbidity and mortality associated with CHF, the search for biomarkers to predict, diagnose, and manage this disease has intensified. Calcium homeostasis and alterations i...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章,评审
doi:10.1385/ct:1:2:165
更新日期:2001-01-01 00:00:00
abstract::Choerospondias axillaris (Guangzao) is a medicinal plant used in Mongolia, and its fruit is commonly used for the treatment of cardiovascular diseases in clinic. The constituents responsible for this effect are always conceded to be the total flavonoids of C. axillaries (TFC). The present study was to evaluate the pre...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-013-9238-7
更新日期:2014-06-01 00:00:00
abstract::Carbon soot is produced in the process of diamond manufacture. Recent experimental and epidemiological studies have associated exposure to carbon nanoparticles with effects on cardiovascular system and blood cells. The objective of this study is to assess the cardiovascular effects consequent to chronic respiratory ex...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-009-9053-3
更新日期:2009-12-01 00:00:00
abstract::Cardiac hypertrophy is an adaptive response to a number of heart diseases including myocardial infarction. Although it can be compensatory at first, sustained hypertrophy is often a transition to heart failure. We have found that cardiomyocytes in culture can survive mild doses of H2O2 but develop hypertrophy involvin...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1385/ct:3:2:119
更新日期:2003-01-01 00:00:00
abstract::Doxorubicin (Dox), an antitumor anthracycline antibiotic, plays a key role in the treatment of many neoplastic diseases. However, its chronic administration induces cardiomyopathy. Increased oxidative stress is a major factor implicated in Dox-induced cardiotoxicity. We hypothesized that a pre-treatment with grape see...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-012-9155-1
更新日期:2012-06-01 00:00:00
abstract::Present study evaluates cardioprotective role of melatonin (Mel), alpha lipoic acid (ALA), a combination of melatonin and alpha lipoic acid (Mel + ALA) against cadmium (Cd)-induced oxidative damage. Female albino rats were subjected to 15-day exposure to Cd (5.12 mg/kg bw) alone or treated with ML (10 mg/kg bw) + ALA ...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-010-9092-9
更新日期:2011-03-01 00:00:00
abstract::Clopidogrel is used in patients with coronary syndromes and at risk of thrombotic events or receiving percutaneous coronary intervention (PCI) for reducing heart attack and stroke. Here we present genotype and phenotype study of Iranian patients undergoing PCI treated with clopidogrel during a 6-month period of follow...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-018-9459-x
更新日期:2018-10-01 00:00:00
abstract::We report a case of potential cardiovascular toxicity including syncope, bradycardia, and ECG pauses associated with the use of rivastigmine and atenolol. A 65-year-old African American female with a medical history of dementia, hypertension, seizure disorder, stroke, and peripheral vascular disease was admitted to th...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章,评审
doi:10.1007/s12012-010-9088-5
更新日期:2010-12-01 00:00:00
abstract::Our previous study described the cardioprotective effects of ellagic acid in an isoproterenol-induced myocardial infarction model. In this study, we are reporting the mechanism of protective action of ellagic acid with respect to apoptosis and mitochondrial respiratory enzymes. Ellagic acid (7.5 and 15 mg/kg) was admi...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-011-9138-7
更新日期:2012-03-01 00:00:00
abstract::Heart failure is a common complication of doxorubicin (DOX) therapy. Previous studies have shown that DOX adversely impacts cardiac energy metabolism, and the ensuing energy deficiencies antedate clinical manifestations of cardiac toxicity. Brief exposure of cultured cardiomyocytes to DOX significantly decreases creat...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-014-9283-x
更新日期:2015-04-01 00:00:00
abstract::The exact mechanism of acute heart dysfunction caused by jellyfish venom remains unclear for the moment. In the present study, we examined the problem caused by the tentacle extract (TE) from the jellyfish Cyanea capillata at the levels of whole animal, isolated heart, primarily cultured cardiomyocytes, and intracellu...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-014-9250-6
更新日期:2014-09-01 00:00:00
abstract::The purpose of this essay is to overview our findings that membrane-associated calcium-independent phospholipase A2 is markedly inhibited by low, clinically relevant concentrations of anthracyclines. Our studies suggest that due to the essential role of this enzyme in membrane homeostasis, its inhibition can be one of...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章,评审
doi:10.1007/s12012-007-0012-6
更新日期:2007-01-01 00:00:00
abstract::We investigated protective effect of FK506 on rat hearts subjected to ischemia/reperfusion (I/R) injury by regulating CaN and ASK1. Wistar rats were divided into four groups: Ischemia/reperfusion group (I/R), FK506 + Ischemia/reperfusion group (FK506-I/R), sham group, and FK506 + sham group (FK506-sham). Ischemia/repe...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-010-9095-6
更新日期:2011-03-01 00:00:00
abstract::Arsenic toxicity is one of the major environmental problems causing various diseases, cardiovascular disorders is one of them. Several epidemiological studies have shown that arsenic causes cardiac hypertrophy but the detailed molecular mechanism is to be studied yet. This study is designed to determine the molecules ...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-019-09550-9
更新日期:2020-06-01 00:00:00
abstract::Complete understanding of the etiology underlying endothelial damage in preeclampsia (PE) remains deficient. Recent studies suggest that autoantibodies against angiotensin II AT1 receptors (AT1-AA) may affect vascular endothelial integrity. However, direct evidence demonstrating association between AT1-AA from preecla...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-013-9229-8
更新日期:2014-03-01 00:00:00
abstract::This study investigated vildagliptin-induced vasodilation and its related mechanisms using phenylephrine induced precontracted rabbit aortic rings. Vildagliptin induced vasodilation in a concentration-dependent manner. Pretreatment with the large-conductance Ca2+-activated K+ channel blocker paxilline, ATP-sensitive K...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-018-9496-5
更新日期:2019-06-01 00:00:00
abstract::The use of anthracycline anticancer drugs is limited by a cumulative, dose-dependent cardiac toxicity. Iron chelation has long been considered as a promising strategy to limit this unfavorable side effect, either by restoring the disturbed cellular iron homeostasis or by removing redox-active iron, which may promote a...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章,评审
doi:10.1007/s12012-007-0020-6
更新日期:2007-01-01 00:00:00
abstract::Over 300,000 hip replacements occurred in the USA in 2010, and the frequency is likely increasing annually. Blood Cobalt (Co) concentrations in patients with well-functioning cobalt-chromium (Co-Cr) hip implants are usually elevated above background concentrations relative to the general population. Excessive Co expos...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章,评审
doi:10.1007/s12012-017-9433-z
更新日期:2018-06-01 00:00:00
abstract::Acute cardiovascular poisoning is a major cause of adverse outcomes in poisoning emergencies. The prognostic validity of corrected QT (QTc) and dispersed QT (QTd) in these outcomes is still limited. The present study aimed to determine the risk factors of mortality, adverse cardiovascular events (ACVE), and intensive ...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-020-09629-8
更新日期:2021-01-05 00:00:00
abstract::Tropomyosins are a family of actin-binding proteins that show cell-specific diversity by a combination of multiple genes and alternative RNA splicing. Of the 4 different tropomyosin genes, TPM4 plays a pivotal role in myofibrillogenesis as well as cardiac contractility in amphibians. In this study, we amplified and se...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-011-9117-z
更新日期:2011-09-01 00:00:00
abstract::Grape seed proanthocyanidin extract (GSPE), a polyphenolic compound with antioxidant properties, may protect against cardiac ischemia and reperfusion injury. However, its potential toxicity at higher doses is unknown. The authors tested the effects of GSPE on reactive oxygen species (ROS) generation, cell survival, la...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1385/ct:3:4:331
更新日期:2003-01-01 00:00:00
abstract::Scientific and medical evidence over the past 30 years has established striking parallels between atherosclerosis and cancer--pathogenetic relationships that cross the boundaries of fiction into the realm of reason. Both diseases in humans are characterized by uncontrolled regulation of cellular growth and differentia...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章,评审
doi:10.1385/ct:5:3:245
更新日期:2005-01-01 00:00:00
abstract::Normal pregnancy outcome is accomplished, in part, by rapid and expansive physiological adaptations to the systemic circulation, the extent of which is specific to gestational day (GD) and anatomical location. Pregnancy-related hemodynamic changes in uterine placental blood flow stimulate compensatory vascular signali...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-019-09505-0
更新日期:2019-08-01 00:00:00
abstract::Cerium dioxide nanoparticles (CeO2 NPs) are an engineered nanomaterial (ENM) that possesses unique catalytic, oxidative, and reductive properties. Currently, CeO2 NPs are being used as a fuel catalyst but these properties are also utilized in the development of potential drug treatments for radiation and stroke protec...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-013-9213-3
更新日期:2013-12-01 00:00:00
abstract::Huntington's disease is an autosomal dominant neurodegenerative disease caused by a CAG repeat expansion in the huntingtin gene. Heart disease is the second leading cause of death in patients with Huntington's disease. This study was to evaluate whether cardiac Fas-dependent and mitochondria-dependent apoptotic pathwa...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-015-9318-y
更新日期:2016-04-01 00:00:00
abstract::Carfilzomib is a proteasome inhibitor, commonly used in multiple myeloma, but its clinical use may be limited due to cardiotoxicity. This study was aimed to evaluate the influence of rutin in carfilzomib-induced cardiotoxicity in rats. Wistar albino male rats weighing 200-250 g (approximately 10 weeks old) were taken ...
journal_title:Cardiovascular toxicology
pub_type: 杂志文章
doi:10.1007/s12012-015-9356-5
更新日期:2017-01-01 00:00:00