Vildagliptin, an Anti-diabetic Drug of the DPP-4 Inhibitor, Induces Vasodilation via Kv Channel and SERCA Pump Activation in Aortic Smooth Muscle.

abstract：:Choerospondias axillaris (Guangzao) is a medicinal plant used in Mongolia, and its fruit is commonly used for the treatment of cardiovascular diseases in clinic. The constituents responsible for this effect are always conceded to be the total flavonoids of C. axillaries (TFC). The present study was to evaluate the pre...

journal_title：Cardiovascular toxicology

authors： Li C,He J,Gao Y,Xing Y,Hou J,Tian J

更新日期：2014-06-01 00:00:00

abstract：:Heart rate variability (HRV) is a measure of cardiac pacing dynamics that has recently garnered a great deal of interest in environmental health studies. While the use of these measures has become popular, much uncertainty remains in the interpretation of results, both in terms of human and animal research. In humans,...

journal_title：Cardiovascular toxicology

authors： Rowan WH 3rd,Campen MJ,Wichers LB,Watkinson WP

更新日期：2007-01-01 00:00:00

abstract：:Intracellular Na(+) ([Na(+)](i)) is an important modulator of excitation-contraction coupling via regulating Ca(2+) efflux/influx, and no investigation has been so far performed in diabetic rat heart. Here, we examined whether any change of [Na(+)](i) in paced cardiomyocytes could contribute to functional alterations ...

journal_title：Cardiovascular toxicology

authors： Bilginoglu A,Kandilci HB,Turan B

更新日期：2013-06-01 00:00:00

abstract：:Carbon soot is produced in the process of diamond manufacture. Recent experimental and epidemiological studies have associated exposure to carbon nanoparticles with effects on cardiovascular system and blood cells. The objective of this study is to assess the cardiovascular effects consequent to chronic respiratory ex...

journal_title：Cardiovascular toxicology

authors： Beniwal R,Shivgotra VK

更新日期：2009-12-01 00:00:00

abstract：:Doxorubicin (Dox) is widely used in cancer therapy, but the clinical application is limited by its cardiotoxicity. The underlying mechanism of Dox-induced cardiotoxicity remains unclear. Present study aimed to evaluate the role of NLRP3 inflammasome in Dox-induced cardiotoxicity. The NLRP3 inflammasome was activated i...

journal_title：Cardiovascular toxicology

authors： Wei S,Ma W,Li X,Jiang C,Sun T,Li Y,Zhang B,Li W

更新日期：2020-10-01 00:00:00

abstract：:Peroxynitrite is a powerful oxidant, formed from the reaction of nitric oxide and superoxide. It is known to interact and modify different biological molecules such as DNA, lipids and proteins leading to alterations in their structure and functions. These events elicit various cellular responses, including cell signal...

journal_title：Cardiovascular toxicology

authors： Islam BU,Habib S,Ali SA,Moinuddin,Ali A

更新日期：2017-10-01 00:00:00

abstract：:Normal pregnancy outcome is accomplished, in part, by rapid and expansive physiological adaptations to the systemic circulation, the extent of which is specific to gestational day (GD) and anatomical location. Pregnancy-related hemodynamic changes in uterine placental blood flow stimulate compensatory vascular signali...

journal_title：Cardiovascular toxicology

authors： Fournier SB,Kallontzi S,Fabris L,Love C,Stapleton PA

更新日期：2019-08-01 00:00:00

abstract：:This study was aimed at determining the efficacy of epinephrine, followed by chest compressions, in producing a return of spontaneous circulation (ROSC) during cyanide (CN)- or hydrogen sulfide (H2S)-induced toxic cardiac pulseless electrical activity (PEA) in the rat. Thirty-nine anesthetized rats were exposed to eit...

journal_title：Cardiovascular toxicology

authors： Judenherc-HaouzI A,Sonobe T,Bebarta VS,Haouzi P

更新日期：2018-10-01 00:00:00

abstract：:Cardiac troponins not only allow for risk stratification and guidance of therapy in unstable angina and non-Q-wave acute myocardial infarction but also may be useful in the diagnostic workup and monitoring of patients with ST-segment elevation myocardial infarction. In clinical practice, troponins are used for confirm...

journal_title：Cardiovascular toxicology

authors： Lehrke S,Giannitsis E,Steen H,Katus HA

更新日期：2001-01-01 00:00:00

abstract：:Cardiovascular disease represents one of the most important public health problem in the Western countries, with sudden cardiac death (SCD) being the most common cause of death in adults under 65 years of age. The objective of the present study is to evaluate the leading causes of SCD in young adults who died suddenly...

journal_title：Cardiovascular toxicology

authors： Silva AC,Santos L,Dinis-Oliveira RJ,Magalhães T,Santos A

更新日期：2014-12-01 00:00:00

abstract：:This study investigated if the cardioprotective effect of acylated ghrelin (AG) against doxorubicin (DOX)-induced cardiac toxicity in rats involves inhibition of Fas/FasL-mediated cell death. It also investigated if such an effect is mediated by restoring Ca+2 homeostasis from the aspect of stimulation of SERCA2a rece...

journal_title：Cardiovascular toxicology

authors： Shati AA,Dallak M

更新日期：2019-12-01 00:00:00

abstract：:Grape seed proanthocyanidin extract (GSPE), a polyphenolic compound with antioxidant properties, may protect against cardiac ischemia and reperfusion injury. However, its potential toxicity at higher doses is unknown. The authors tested the effects of GSPE on reactive oxygen species (ROS) generation, cell survival, la...

journal_title：Cardiovascular toxicology

authors： Shao ZH,Vanden Hoek TL,Xie J,Wojcik K,Chan KC,Li CQ,Hamann K,Qin Y,Schumacker PT,Becker LB,Yuan CS

更新日期：2003-01-01 00:00:00

abstract：:Dofetilide is a class III antiarrhythmic used for treating atrial dysrhythmias. Though its adverse effects are well described in routine use, very little is known about dofetilide toxicity in overdose. This is a retrospective case series of consecutive patients reported to our poison center after dofetilide overdose. ...

journal_title：Cardiovascular toxicology

authors： Hieger MA,Maskell KF,Moss MJ,Powell SW,Cumpston KL

更新日期：2017-07-01 00:00:00

abstract：:Oxidative stress plays an important role in the pathogenesis of hypertension. Epigallocatechin-3-O-gallate (EGCG) is the main polyphenol present in green tea and is known for its potent antioxidant and anti-inflammatory properties. In the present study, we hypothesize that EGCG attenuates oxidative stress in the parav...

journal_title：Cardiovascular toxicology

authors： Yi QY,Qi J,Yu XJ,Li HB,Zhang Y,Su Q,Shi T,Zhang DM,Guo J,Feng ZP,Wang ML,Zhu GQ,Liu JJ,Shi XL,Kang YM

更新日期：2016-07-01 00:00:00

abstract：:The effects of magnesium (Mg2+) on ischaemic complications of pathological cardiac hypertrophy are unclear. In this study, we investigated effects of Mg2+ pretreatment on ischaemia/reperfusion (I/R) injury in isoprenaline (ISO)-induced hypertrophic hearts. Wistar rats were treated for 7 days with different combination...

journal_title：Cardiovascular toxicology

authors： Amoni M,Kelly-Laubscher R,Petersen M,Gwanyanya A

更新日期：2017-01-01 00:00:00

abstract：:Nucleoside reverse transcriptase inhibitor (NRTI)-induced cardiomyopathy has been suggested to reflect mitochondrial targets of drug toxicity. The prevailing hypothesis is that, through structural mimicry, the NRTIs are mistaken as substrates for DNA polymerase and incorporated into replicating DNA, where they cause t...

journal_title：Cardiovascular toxicology

authors： Lund KC,Wallace KB

更新日期：2004-01-01 00:00:00

abstract：:Arsenic trioxide (ATO) is among the first-line chemotherapeutic drugs used in oncological practice. It has shown substantial efficacy in treating patients with relapsed or refractory acute promyelocytic leukaemia. The clinical use of ATO is hampered due to cardiotoxicity and hence many patients are precluded from rece...

journal_title：Cardiovascular toxicology

authors： Vineetha VP,Raghu KG

更新日期：2019-04-01 00:00:00

abstract：:Doxorubicin (Dox), an antitumor anthracycline antibiotic, plays a key role in the treatment of many neoplastic diseases. However, its chronic administration induces cardiomyopathy. Increased oxidative stress is a major factor implicated in Dox-induced cardiotoxicity. We hypothesized that a pre-treatment with grape see...

journal_title：Cardiovascular toxicology

authors： Mokni M,Hamlaoui-Guesmi S,Amri M,Marzouki L,Limam F,Aouani E

更新日期：2012-06-01 00:00:00

abstract：:Complete understanding of the etiology underlying endothelial damage in preeclampsia (PE) remains deficient. Recent studies suggest that autoantibodies against angiotensin II AT1 receptors (AT1-AA) may affect vascular endothelial integrity. However, direct evidence demonstrating association between AT1-AA from preecla...

journal_title：Cardiovascular toxicology

authors： Yang X,Wang F,Lau WB,Zhang S,Zhang S,Liu H,Ma XL

更新日期：2014-03-01 00:00:00

abstract：:Coxsackievirus B3 (CVB3) induces myocarditis, especially in the immunodeficient or immature. To investigate whether CVB3 induced pronounced cardiomyopathy during the severe immune dysfunction of murine acquired immunodeficiency syndrome (AIDS), female C57BL/6 mice were infected with LP-BM5 retrovirus and then coinfect...

journal_title：Cardiovascular toxicology

authors： Sepúlveda RT,Zhang J,Watson RR

更新日期：2002-01-01 00:00:00

abstract：:We have compared the cardiotoxicity of five platinum complexes in a model of isolated rat heart using the Langendorff technique. These effects were assessed via coronary flow (CF) and cardiac functional parameters. cis-Diamminedichloroplatinum(II) (cisplatin, CDDP), dichloro-(1,2-diaminocyclohexane)platinum(II) (Pt((I...

journal_title：Cardiovascular toxicology

authors： Misic MM,Jakovljevic VL,Bugarcic ZD,Zivkovic VI,Srejovic IM,Barudzic NS,Djuric DM,Novokmet SS

更新日期：2015-07-01 00:00:00

abstract：:The present study was designed to evaluate the cardioprotective potential of water extract of rhizomes of Acorus gramineus (AGR) against isoproterenol (ISO)-induced myocardial infarction. Male pigs were orally administered with 250 or 500 mg/kg of AGR or with vehicle for 9 days, with concurrent subcutaneous injections...

journal_title：Cardiovascular toxicology

authors： Kim JH,Chung HS,Antonisamy P,Lee SR,Bae H

更新日期：2014-06-01 00:00:00

abstract：:Cerium dioxide nanoparticles (CeO2 NPs) are an engineered nanomaterial (ENM) that possesses unique catalytic, oxidative, and reductive properties. Currently, CeO2 NPs are being used as a fuel catalyst but these properties are also utilized in the development of potential drug treatments for radiation and stroke protec...

journal_title：Cardiovascular toxicology

authors： Minarchick VC,Stapleton PA,Porter DW,Wolfarth MG,Çiftyürek E,Barger M,Sabolsky EM,Nurkiewicz TR

更新日期：2013-12-01 00:00:00

abstract：:Over 300,000 hip replacements occurred in the USA in 2010, and the frequency is likely increasing annually. Blood Cobalt (Co) concentrations in patients with well-functioning cobalt-chromium (Co-Cr) hip implants are usually elevated above background concentrations relative to the general population. Excessive Co expos...

journal_title：Cardiovascular toxicology

authors： Fung ES,Monnot A,Kovochich M,Unice KM,Tvermoes BE,Galbraith D,Finley BL,Paustenbach DJ

更新日期：2018-06-01 00:00:00

abstract：:Heart failure is a common complication of doxorubicin (DOX) therapy. Previous studies have shown that DOX adversely impacts cardiac energy metabolism, and the ensuing energy deficiencies antedate clinical manifestations of cardiac toxicity. Brief exposure of cultured cardiomyocytes to DOX significantly decreases creat...

journal_title：Cardiovascular toxicology

authors： Santacruz L,Darrabie MD,Mantilla JG,Mishra R,Feger BJ,Jacobs DO

更新日期：2015-04-01 00:00:00

abstract：:High-salt-induced inflammation and oxidative stress in the hypothalamic paraventricular nucleus (PVN) contribute to the pathogenesis of salt-sensitive hypertension. In this study, we hypothesized that chronic inhibition of nuclear factor-κB (NF-κB) activity in the PVN delays the progression of hypertension by upregula...

journal_title：Cardiovascular toxicology

authors： Qi J,Yu XJ,Shi XL,Gao HL,Yi QY,Tan H,Fan XY,Zhang Y,Song XA,Cui W,Liu JJ,Kang YM

更新日期：2016-10-01 00:00:00

abstract：:Lithium is one of the classical drugs that have been widely used for treating bipolar disorder. However, several cardiac side effects including sick sinus syndrome, bundle branch block, ventricular tachycardia/fibrillation, non-specific T-wave abnormalities in addition to Brugada-type electrocardiographic changes have...

journal_title：Cardiovascular toxicology

authors： Goto A,Nakamura Y,Lubna NJ,Chiba K,Hagiwara-Nagasawa M,Izumi-Nakaseko H,Ando K,Naito AT,Sugiyama A

更新日期：2018-12-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a member of the basic helix loop helix PAS (Per-ARNT-SIM) transcription family, which also includes hypoxiainducible factor-1alpha (HIF-1alpha) and its common dimerization partner AhR nuclear translocator (ARNT). Following ligand activation or hypoxia, AhR or HIF-1alpha, respecti...

journal_title：Cardiovascular toxicology

authors： Thackaberry EA,Gabaldon DM,Walker MK,Smith SM

更新日期：2002-01-01 00:00:00

abstract：:The ubiquitous nature of plastics has raised concerns pertaining to continuous exposure to plastic polymers and human health risks. Of particular concern is the use of endocrine-disrupting chemicals in plastic production, including di(2-ethylhexyl)phthalate (DEHP) and bisphenol A (BPA). Widespread and continuous expos...

journal_title：Cardiovascular toxicology

authors： Posnack NG

更新日期：2014-12-01 00:00:00

abstract：:We present an experimental approach that allows exposure of cells plated on a single coverslip to multiple distinct environments. The original chamber design created a small region of injury using geometrically defined flows of the control and ischemic solutions. Modifications of the original chamber design presented ...

journal_title：Cardiovascular toxicology

authors： Arutunyan A,Swift L,Sarvazyan N

更新日期：2004-01-01 00:00:00