Abstract：
:The use of anthracycline anticancer drugs is limited by a cumulative, dose-dependent cardiac toxicity. Iron chelation has long been considered as a promising strategy to limit this unfavorable side effect, either by restoring the disturbed cellular iron homeostasis or by removing redox-active iron, which may promote anthracycline-induced oxidative stress. Aroylhydrazone lipophilic iron chelators have shown promising results in the rabbit model of daunorubicin-induced cardiomyopathy as well as in cellular models. The lack of interference with the antiproliferative effects of the anthracyclines also favors their use in clinical settings. The dose, however, should be carefully titrated to prevent iron depletion, which apparently also applies for other strong iron chelators. We have shown that a mere ability of a compound to chelate iron is not the sole determinant of a good cardioprotector and the protective potential does not directly correlate with the ability of the chelators to prevent hydroxyl radical formation. These findings, however, do not weaken the role of iron in doxorubicin cardiotoxicity as such, they rather appeal for further investigations into the molecular mechanisms how anthracyclines interact with iron and how iron chelation may interfere with these processes.
journal_name
Cardiovasc Toxicoljournal_title
Cardiovascular toxicologyauthors
Kaiserová H,Simunek T,Sterba M,den Hartog GJ,Schröterová L,Popelová O,Gersl V,Kvasnicková E,Bast Adoi
10.1007/s12012-007-0020-6subject
Has Abstractpub_date
2007-01-01 00:00:00pages
145-50issue
2eissn
1530-7905issn
1559-0259pii
CT:7:2:145journal_volume
7pub_type
杂志文章,评审abstract：:This study investigated if the cardioprotective effect of acylated ghrelin (AG) against doxorubicin (DOX)-induced cardiac toxicity in rats involves inhibition of Fas/FasL-mediated cell death. It also investigated if such an effect is mediated by restoring Ca+2 homeostasis from the aspect of stimulation of SERCA2a rece...
journal_title：Cardiovascular toxicology
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更新日期：2019-12-01 00:00:00
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更新日期：2020-02-01 00:00:00
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journal_title：Cardiovascular toxicology
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
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更新日期：2018-06-01 00:00:00
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journal_title：Cardiovascular toxicology
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更新日期：2018-02-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-009-9047-1
更新日期：2009-09-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
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更新日期：2010-12-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
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更新日期：2005-01-01 00:00:00
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journal_title：Cardiovascular toxicology
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更新日期：2003-01-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-011-9139-6
更新日期：2012-03-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2011-03-01 00:00:00
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journal_title：Cardiovascular toxicology
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更新日期：2011-06-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-018-9454-2
更新日期：2018-10-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-011-9138-7
更新日期：2012-03-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2010-06-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2004-01-01 00:00:00
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journal_title：Cardiovascular toxicology
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journal_title：Cardiovascular toxicology
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abstract：:Doxorubicin (Dox), an antitumor anthracycline antibiotic, plays a key role in the treatment of many neoplastic diseases. However, its chronic administration induces cardiomyopathy. Increased oxidative stress is a major factor implicated in Dox-induced cardiotoxicity. We hypothesized that a pre-treatment with grape see...
journal_title：Cardiovascular toxicology
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更新日期：2012-06-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-008-9012-4
更新日期：2008-03-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
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更新日期：2001-01-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2013-06-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-012-9192-9
更新日期：2013-06-01 00:00:00
abstract：:Tropomyosins are a family of actin-binding proteins that show cell-specific diversity by a combination of multiple genes and alternative RNA splicing. Of the 4 different tropomyosin genes, TPM4 plays a pivotal role in myofibrillogenesis as well as cardiac contractility in amphibians. In this study, we amplified and se...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-011-9117-z
更新日期：2011-09-01 00:00:00
abstract：:Hypertension, as one of the major risk factors for cardiovascular disease, significantly affects human health. Prostaglandin E2 (PGE2) and the E3-class prostanoid (EP3) receptor have previously been demonstrated to modulate blood pressure and hemodynamics in various animal models of hypertension. The PGE2-evoked press...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-020-09619-w
更新日期：2020-11-09 00:00:00
abstract：:Oxidative stress plays an important role in the pathogenesis of hypertension. Epigallocatechin-3-O-gallate (EGCG) is the main polyphenol present in green tea and is known for its potent antioxidant and anti-inflammatory properties. In the present study, we hypothesize that EGCG attenuates oxidative stress in the parav...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-015-9335-x
更新日期：2016-07-01 00:00:00
abstract：:The purpose of this essay is to overview our findings that membrane-associated calcium-independent phospholipase A2 is markedly inhibited by low, clinically relevant concentrations of anthracyclines. Our studies suggest that due to the essential role of this enzyme in membrane homeostasis, its inhibition can be one of...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-007-0012-6
更新日期：2007-01-01 00:00:00
