Abstract：
:Acute alcohol intoxication leads to an inhibition of protein synthesis in heart that results in part through altered phosphorylation of protein factors controlling mRNA translation initiation. The purpose of the present set of experiments was designed to examine the effects of inhibitors of ethanol metabolism on the phosphorylation of 4E-binding protein (4EBP1) and S6k1(Thr(389)), two factors regulating mRNA translation initiation. Phosphorylation of 4E-BP1, S6k1(Thr(389)), and Erk 1/2 was reduced 2 h following IP injection of alcohol. Pretreatment with 4-methylpyrazole (4-MP), an inhibitor of alcohol dehydrogenase (ADH), did not attenuate the ethanol-induced decrease in phosphorylation of 4EBP1 and S6k1(Thr(389)). In contrast, 4-MP prevented the decrease in Erk 1/2 phosphorylation observed with acute ethanol intoxication. Pretreatment with cyanamide, an inhibitor of aldehyde dehydrogenase, did not attenuate the ethanol-induced decrease in phosphorylation S6k1(Thr(389)), but partially prevented the ethanol-induced lowering of 4EBP1 phosphorylation. The studies indicate that modulation of ethanol metabolism through inhibition of ADH or aldehyde dehydrogenase leads to preferential modulation of the phosphorylation of distinct myocardial signaling systems involved in regulating protein synthesis.
journal_name
Cardiovasc Toxicoljournal_title
Cardiovascular toxicologyauthors
Vary TC,Lang CHdoi
10.1007/s12012-008-9012-4subject
Has Abstractpub_date
2008-03-01 00:00:00pages
23-32issue
1eissn
1530-7905issn
1559-0259journal_volume
8pub_type
杂志文章abstract：:Hypertension, as one of the major risk factors for cardiovascular disease, significantly affects human health. Prostaglandin E2 (PGE2) and the E3-class prostanoid (EP3) receptor have previously been demonstrated to modulate blood pressure and hemodynamics in various animal models of hypertension. The PGE2-evoked press...
journal_title：Cardiovascular toxicology
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更新日期：2020-11-09 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-013-9238-7
更新日期：2014-06-01 00:00:00
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journal_title：Cardiovascular toxicology
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doi：10.1007/s12012-016-9384-9
更新日期：2017-07-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-017-9424-0
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
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journal_title：Cardiovascular toxicology
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-014-9283-x
更新日期：2015-04-01 00:00:00
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journal_title：Cardiovascular toxicology
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doi：10.1007/s12012-014-9250-6
更新日期：2014-09-01 00:00:00
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更新日期：2019-08-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
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更新日期：2014-12-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2019-12-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-011-9138-7
更新日期：2012-03-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-009-9042-6
更新日期：2009-06-01 00:00:00
abstract：:Anthracycline chemotherapy produces cardiac repolarization abnormalities and arrhythmias because of cardiac toxicity of drugs. Ventricular arrhythmogenesis is attributable to increase in repolarization heterogeneity that is characterized by spatial dispersion of repolarization. The purpose of this work was to study th...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-012-9172-0
更新日期：2012-12-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-015-9328-9
更新日期：2016-04-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-019-09532-x
更新日期：2019-12-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-017-9433-z
更新日期：2018-06-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-013-9229-8
更新日期：2014-03-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2015-01-01 00:00:00
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journal_title：Cardiovascular toxicology
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journal_title：Cardiovascular toxicology
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更新日期：2016-07-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-011-9139-6
更新日期：2012-03-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1385/ct:1:2:165
更新日期：2001-01-01 00:00:00
abstract：:Arsenic trioxide (ATO) is among the first-line chemotherapeutic drugs used in oncological practice. It has shown substantial efficacy in treating patients with relapsed or refractory acute promyelocytic leukaemia. The clinical use of ATO is hampered due to cardiotoxicity and hence many patients are precluded from rece...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
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更新日期：2019-04-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2007-01-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-010-9095-6
更新日期：2011-03-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-014-9301-z
更新日期：2015-10-01 00:00:00
abstract：:The aryl hydrocarbon receptor (AhR) is a member of the basic helix loop helix PAS (Per-ARNT-SIM) transcription family, which also includes hypoxiainducible factor-1alpha (HIF-1alpha) and its common dimerization partner AhR nuclear translocator (ARNT). Following ligand activation or hypoxia, AhR or HIF-1alpha, respecti...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1385/ct:2:4:263
更新日期：2002-01-01 00:00:00
abstract：:Cardiac troponins not only allow for risk stratification and guidance of therapy in unstable angina and non-Q-wave acute myocardial infarction but also may be useful in the diagnostic workup and monitoring of patients with ST-segment elevation myocardial infarction. In clinical practice, troponins are used for confirm...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1385/ct:1:2:099
更新日期：2001-01-01 00:00:00
abstract：:Epidemiological studies have associated air pollution particulate matter (PM) exposure with adverse cardiovascular effects. Identification of causal PM sources is critically needed to support regulatory decisions to protect public health. This research examines the in vitro cardiotoxicity of bioavailable constituents ...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-013-9225-z
更新日期：2013-12-01 00:00:00
