Abstract：
:It has been suggested that prenatal exposure to cadmium may alter the cardiovascular function during adulthood. Using the left coronary artery ligation model of acute myocardial infarction, we studied the cardiac function of female adult offspring rats exposed to cadmium (30 ppm) during gestation. The cardiac ischemic zone in the control and cadmium-exposed groups was measured 72 h post-ligation using the TPT staining technique. Offspring from cadmium-treated dams showed a significantly smaller infarcted area compared with the control group (7.1 ± 1.5 vs. 19.6 ± 2.8%, P ≤ 0.05). We also performed echocardiographic and biochemical studies, which positively correlated with the differences observed previously. To evaluate whether the effects were associated to pre-infarct tissue damage and/or angiogenic molecules, we performed histological studies and measured the expression of vascular endothelial growth factor (VEGF), and platelet endothelial cellular adhesion molecule-1 (PECAM-1). Results revealed a higher heart vascularization in the exposed offspring that was associated with an increase in PECAM and a decrease in VEGF expression. We conclude that prenatal exposure to cadmium induces fetal adaptive responses involving changes in the expression of some cardiac angiogenic molecules resulting in long-term resistance to infarction.
journal_name
Cardiovasc Toxicoljournal_title
Cardiovascular toxicologyauthors
Zepeda R,Castillo P,Sáez D,Llanos MN,Ronco AMdoi
10.1007/s12012-011-9139-6subject
Has Abstractpub_date
2012-03-01 00:00:00pages
64-72issue
1eissn
1530-7905issn
1559-0259journal_volume
12pub_type
杂志文章abstract：:The anticancer drug lapatinib (Tykerb) is a dual tyrosine kinase inhibitor targeting the HER2 (ERBB2) and EGFR (ERBB1, HER1) pathways that have been shown in clinical trials to display some cardiotoxicity. Because trastuzumab also targets HER2 receptors, the lapatinib/doxorubicin combination provides a good model to p...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-012-9183-x
更新日期：2013-03-01 00:00:00
abstract：:In a previous study of breast cancer patients, we found changes in cardiac function and size during the early stages of adjuvant trastuzumab (Herceptin(®)) therapy. Here we present a subgroup analysis of this patient cohort. This subgroup received a anthracycline-embedded chemotherapy followed by at least 3 months up ...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-015-9328-9
更新日期：2016-04-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2014-06-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-012-9189-4
更新日期：2013-06-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-019-09526-9
更新日期：2019-12-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-019-09550-9
更新日期：2020-06-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-019-09527-8
更新日期：2019-12-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-007-0028-y
更新日期：2007-01-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1385/ct:4:4:375
更新日期：2004-01-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-016-9394-7
更新日期：2017-10-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1385/ct:5:1:001
更新日期：2005-01-01 00:00:00
abstract：:Cardiac hypertrophy is an adaptive response to a number of heart diseases including myocardial infarction. Although it can be compensatory at first, sustained hypertrophy is often a transition to heart failure. We have found that cardiomyocytes in culture can survive mild doses of H2O2 but develop hypertrophy involvin...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1385/ct:3:2:119
更新日期：2003-01-01 00:00:00
abstract：:Carfilzomib is a proteasome inhibitor, commonly used in multiple myeloma, but its clinical use may be limited due to cardiotoxicity. This study was aimed to evaluate the influence of rutin in carfilzomib-induced cardiotoxicity in rats. Wistar albino male rats weighing 200-250 g (approximately 10 weeks old) were taken ...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-015-9356-5
更新日期：2017-01-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2020-02-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-016-9384-9
更新日期：2017-07-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-017-9433-z
更新日期：2018-06-01 00:00:00
abstract：:Lithium is one of the classical drugs that have been widely used for treating bipolar disorder. However, several cardiac side effects including sick sinus syndrome, bundle branch block, ventricular tachycardia/fibrillation, non-specific T-wave abnormalities in addition to Brugada-type electrocardiographic changes have...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-018-9464-0
更新日期：2018-12-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-015-9318-y
更新日期：2016-04-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-014-9250-6
更新日期：2014-09-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-014-9278-7
更新日期：2015-07-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1385/ct:2:1:53
更新日期：2002-01-01 00:00:00
abstract：:Tropomyosins are a family of actin-binding proteins that show cell-specific diversity by a combination of multiple genes and alternative RNA splicing. Of the 4 different tropomyosin genes, TPM4 plays a pivotal role in myofibrillogenesis as well as cardiac contractility in amphibians. In this study, we amplified and se...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-011-9117-z
更新日期：2011-09-01 00:00:00
abstract：:Oxidative stress plays an important role in the pathogenesis of hypertension. Epigallocatechin-3-O-gallate (EGCG) is the main polyphenol present in green tea and is known for its potent antioxidant and anti-inflammatory properties. In the present study, we hypothesize that EGCG attenuates oxidative stress in the parav...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-015-9335-x
更新日期：2016-07-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-012-9192-9
更新日期：2013-06-01 00:00:00
abstract：:Erythromycin is an antibiotic that prolongs the QT-interval and causes Torsade de Pointes (TdP) by blocking the rapid delayed rectifying potassium current (IKr) without affecting either the slow delayed rectifying potassium current (IKs) or inward rectifying potassium current (IK1). Erythromycin exerts this effect in ...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-019-09532-x
更新日期：2019-12-01 00:00:00
abstract：:Cardiac troponins not only allow for risk stratification and guidance of therapy in unstable angina and non-Q-wave acute myocardial infarction but also may be useful in the diagnostic workup and monitoring of patients with ST-segment elevation myocardial infarction. In clinical practice, troponins are used for confirm...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1385/ct:1:2:099
更新日期：2001-01-01 00:00:00
abstract：:Cerium dioxide nanoparticles (CeO2 NPs) are an engineered nanomaterial (ENM) that possesses unique catalytic, oxidative, and reductive properties. Currently, CeO2 NPs are being used as a fuel catalyst but these properties are also utilized in the development of potential drug treatments for radiation and stroke protec...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-013-9213-3
更新日期：2013-12-01 00:00:00
abstract：:Anthracycline chemotherapy produces cardiac repolarization abnormalities and arrhythmias because of cardiac toxicity of drugs. Ventricular arrhythmogenesis is attributable to increase in repolarization heterogeneity that is characterized by spatial dispersion of repolarization. The purpose of this work was to study th...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-012-9172-0
更新日期：2012-12-01 00:00:00
abstract：:Elevated levels of homocysteine (Hcy) (known as hyperhomocysteinemia HHcy) are involved in dilated cardiomyopathy. Hcy chelates copper and impairs copper-dependent enzymes. Copper deficiency has been linked to cardiovascular disease. We tested the hypothesis that copper supplement regresses left ventricular hypertroph...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-008-9021-3
更新日期：2008-10-01 00:00:00
