Abstract：
:Elevated levels of homocysteine (Hcy) (known as hyperhomocysteinemia HHcy) are involved in dilated cardiomyopathy. Hcy chelates copper and impairs copper-dependent enzymes. Copper deficiency has been linked to cardiovascular disease. We tested the hypothesis that copper supplement regresses left ventricular hypertrophy (LVH), fibrosis and endothelial dysfunction in pressure overload DCM mice hearts. The mice were grouped as sham, sham + Cu, aortic constriction (AC), and AC + Cu. Aortic constriction was performed by transverse aortic constriction. The mice were treated with or without 20 mg/kg copper supplement in the diet for 12 weeks. The cardiac function was assessed by echocardiography and electrocardiography. The matrix remodeling was assessed by measuring matrix metalloproteinase (MMP), tissue inhibitor of metalloproteinases (TIMPs), and lysyl oxidase (LOX) by Western blot analyses. The results suggest that in AC mice, cardiac function was improved with copper supplement. TIMP-1 levels decreased in AC and were normalized in AC + Cu. Although MMP-9, TIMP-3, and LOX activity increased in AC and returned to baseline value in AC + Cu, copper supplement showed no significant effect on TIMP-4 activity after pressure overload. In conclusion, our data suggest that copper supplement helps improve cardiac function in a pressure overload dilated cardiomyopathic heart.
journal_name
Cardiovasc Toxicoljournal_title
Cardiovascular toxicologyauthors
Hughes WM Jr,Rodriguez WE,Rosenberger D,Chen J,Sen U,Tyagi N,Moshal KS,Vacek T,Kang YJ,Tyagi SCdoi
10.1007/s12012-008-9021-3subject
Has Abstractpub_date
2008-10-01 00:00:00pages
137-44issue
3eissn
1530-7905issn
1559-0259journal_volume
8pub_type
杂志文章abstract：:Our previous study described the cardioprotective effects of ellagic acid in an isoproterenol-induced myocardial infarction model. In this study, we are reporting the mechanism of protective action of ellagic acid with respect to apoptosis and mitochondrial respiratory enzymes. Ellagic acid (7.5 and 15 mg/kg) was admi...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2012-03-01 00:00:00
abstract：:The ubiquitous nature of plastics has raised concerns pertaining to continuous exposure to plastic polymers and human health risks. Of particular concern is the use of endocrine-disrupting chemicals in plastic production, including di(2-ethylhexyl)phthalate (DEHP) and bisphenol A (BPA). Widespread and continuous expos...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1007/s12012-014-9258-y
更新日期：2014-12-01 00:00:00
abstract：:Erythromycin is an antibiotic that prolongs the QT-interval and causes Torsade de Pointes (TdP) by blocking the rapid delayed rectifying potassium current (IKr) without affecting either the slow delayed rectifying potassium current (IKs) or inward rectifying potassium current (IK1). Erythromycin exerts this effect in ...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2019-12-01 00:00:00
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journal_title：Cardiovascular toxicology
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pub_type： 杂志文章,评审
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2006-01-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2011-09-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2012-12-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
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更新日期：2007-01-01 00:00:00
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journal_title：Cardiovascular toxicology
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更新日期：2017-07-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-009-9053-3
更新日期：2009-12-01 00:00:00
abstract：:Clopidogrel is used in patients with coronary syndromes and at risk of thrombotic events or receiving percutaneous coronary intervention (PCI) for reducing heart attack and stroke. Here we present genotype and phenotype study of Iranian patients undergoing PCI treated with clopidogrel during a 6-month period of follow...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-008-9012-4
更新日期：2008-03-01 00:00:00
abstract：:Arsenic trioxide (As2O3) is used clinically in the management of acute promyelocytic leukemia, and the use of electrocardiogram (ECG) in this management is important as arsenic use may cause distortion of the electrical properties with its attendant sequel. We studied the effect of As2O3 on vasomotion in rat aortic ri...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-015-9312-4
更新日期：2016-01-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-011-9105-3
更新日期：2011-06-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-015-9356-5
更新日期：2017-01-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
doi：10.1385/ct:5:3:245
更新日期：2005-01-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2015-10-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2013-12-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2010-06-01 00:00:00
abstract：:The effects of magnesium (Mg2+) on ischaemic complications of pathological cardiac hypertrophy are unclear. In this study, we investigated effects of Mg2+ pretreatment on ischaemia/reperfusion (I/R) injury in isoprenaline (ISO)-induced hypertrophic hearts. Wistar rats were treated for 7 days with different combination...
journal_title：Cardiovascular toxicology
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更新日期：2017-01-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2016-04-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章,评审
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更新日期：2003-01-01 00:00:00
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journal_title：Cardiovascular toxicology
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更新日期：2017-04-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2015-07-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2013-06-01 00:00:00
abstract：:The anticancer drug lapatinib (Tykerb) is a dual tyrosine kinase inhibitor targeting the HER2 (ERBB2) and EGFR (ERBB1, HER1) pathways that have been shown in clinical trials to display some cardiotoxicity. Because trastuzumab also targets HER2 receptors, the lapatinib/doxorubicin combination provides a good model to p...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-012-9183-x
更新日期：2013-03-01 00:00:00
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journal_title：Cardiovascular toxicology
pub_type： 杂志文章
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更新日期：2009-09-01 00:00:00
abstract：:Cardiac toxicity has been associated with HIV infection and exposure to nucleoside reverse transcriptase inhibitors (NRTIs), but the role of the latter in the development of cardiac disease of HIV-infected patients is uncertain. To investigate the cardiotoxicity of transplacentally administered zidovudine (AZT) or AZT...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1385/ct:4:2:133
更新日期：2004-01-01 00:00:00
abstract：:Choerospondias axillaris (Guangzao) is a medicinal plant used in Mongolia, and its fruit is commonly used for the treatment of cardiovascular diseases in clinic. The constituents responsible for this effect are always conceded to be the total flavonoids of C. axillaries (TFC). The present study was to evaluate the pre...
journal_title：Cardiovascular toxicology
pub_type： 杂志文章
doi：10.1007/s12012-013-9238-7
更新日期：2014-06-01 00:00:00
