Abstract:
:The present study was undertaken to evaluate protective role of S. rhomboidea. Roxb (SR) leaf extract against in vitro low-density lipoprotein (LDL) oxidation and oxidized LDL (Ox-LDL) induced macrophage apoptosis. Copper and cell-mediated LDL oxidation, Ox-LDL-induced peroxyl radical generation, mitochondrial activity, and apoptosis in human monocyte-derived macrophages (HMDMs) were assessed in presence of SR extract. Results clearly indicated that SR was capable of reducing LDL oxidation and formation of intermediary oxidation products. Also, SR successfully attenuated peroxyl radical formation, mitochondrial dysfunction, nuclear condensation, and apoptosis in Ox-LDL-exposed HMDMs. This scientific report is the first detailed investigation that establishes anti-atherosclerotic potential of SR extract.
journal_name
Cardiovasc Toxicoljournal_title
Cardiovascular toxicologyauthors
Thounaojam MC,Jadeja RN,Devkar RV,Ramachandran AVdoi
10.1007/s12012-011-9110-6subject
Has Abstractpub_date
2011-06-01 00:00:00pages
168-79issue
2eissn
1530-7905issn
1559-0259journal_volume
11pub_type
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