听力与言语-语言病理学

行为科学

医学伦理学

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  • New designer phenethylamines 2C-C and 2C-P have abuse potential and induce neurotoxicity in rodents.

    abstract::2C (2C-x) is the general name for the family of phenethylamines containing two methoxy groups at the 2 and 5 positions of the benzene ring. The abuse of 2C family drugs has grown rapidly, although the abuse potential and neurotoxic properties of 2C drugs have not yet been fully investigated. In this study, we investig...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-021-02980-x

    authors: Kim YJ,Ma SX,Hur KH,Lee Y,Ko YH,Lee BR,Kim SK,Sung SJ,Kim KM,Kim HC,Lee SY,Jang CG

    更新日期:2021-01-30 00:00:00

  • A review of species differences in the control of, and response to, chemical-induced thyroid hormone perturbations leading to thyroid cancer.

    abstract::This review summarises the current state of knowledge regarding the physiology and control of production of thyroid hormones, the effects of chemicals in perturbing their synthesis and release that result in thyroid cancer. It does not consider the potential neurodevelopmental consequences of low thyroid hormones. The...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审

    doi:10.1007/s00204-020-02961-6

    authors: Foster JR,Tinwell H,Melching-Kollmuss S

    更新日期:2021-01-05 00:00:00

  • Anticancer potential of myricetin bulk and nano forms in vitro in lymphocytes from myeloma patients.

    abstract::Evading apoptosis and chemo-resistance are considered as very important factors which help tumour progression and metastasis. Hence, to overcome chemo-resistance, there is an urgent requirement for emergence of more effective treatment options. Myricetin, a naturally occurring flavonoid, is present in various plant-de...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02938-5

    authors: Akhtar S,Najafzadeh M,Isreb M,Newton L,Gopalan RC,Anderson D

    更新日期:2021-01-01 00:00:00

  • Acetylation of putative arylamine and alkylaniline carcinogens in immortalized human fibroblasts transfected with rapid and slow acetylator N-acetyltransferase 2 haplotypes.

    abstract::Exposure to alkylanilines found in tobacco smoke and indoor air is associated with risk of bladder cancer. Genetic factors significantly influence the metabolism of arylamine carcinogens and the toxicological outcomes that result from exposure. We utilized nucleotide excision repair (NER)-deficient immortalized human ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02901-4

    authors: Leggett CS,Doll MA,States JC,Hein DW

    更新日期:2021-01-01 00:00:00

  • Acute and subacute oral administration of mycotoxin deoxynivalenol exacerbates the pro-inflammatory and pro-pruritic responses in a mouse model of allergic dermatitis.

    abstract::Deoxynivalenol (DON) contamination in food is a public health concern; however, the effect of DON exposure on immune disorders including allergies remains unclear. The aim of this study is to elucidate the effect of oral exposure to DON on pro-inflammatory and pro-pruritic responses in a mouse model of allergic dermat...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02875-3

    authors: Aihara R,Ookawara T,Morimoto A,Iwashita N,Takagi Y,Miyasaka A,Kushiro M,Miyake S,Fukuyama T

    更新日期:2020-12-01 00:00:00

  • The explosive trinitrotoluene (TNT) induces gene expression of carbonyl reductase in the blue mussel (Mytilus spp.): a new promising biomarker for sea dumped war relicts?

    abstract::Millions of tons of all kind of munitions, including mines, bombs and torpedoes have been dumped after World War II in the marine environment and do now pose a new threat to the seas worldwide. Beside the acute risk of unwanted detonation, there is a chronic risk of contamination, because the metal vessels corrode and...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02931-y

    authors: Strehse JS,Brenner M,Kisiela M,Maser E

    更新日期:2020-12-01 00:00:00

  • Synthetic cannabinoid CP-55,940 induces apoptosis in a human skeletal muscle model via regulation of CB1 receptors and L-type Ca2+ channels.

    abstract::Rhabdomyolysis has been reported in patients who abuse synthetic cannabinoids. However, no studies have yet assessed whether these cases reflect the direct cytotoxicity of synthetic cannabinoids on skeletal muscle, a possibility that the present study sought to address. Specifically, this study investigated the cytoto...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02944-7

    authors: Tomiyama KI,Funada M

    更新日期:2020-11-10 00:00:00

  • Neurotoxic effects in zebrafish embryos by valproic acid and nine of its analogues: the fish-mouse connection?

    abstract::Since teratogenicity testing in mammals is a particular challenge from an animal welfare perspective, there is a great need for the development of alternative test systems. In this context, the zebrafish (Danio rerio) embryo has received increasing attention as a non-protected embryonic vertebrate in vivo model. The p...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02928-7

    authors: Brotzmann K,Wolterbeek A,Kroese D,Braunbeck T

    更新日期:2020-10-27 00:00:00

  • The modified IL-8 Luc assay, an in vitro skin sensitisation test, can significantly improve the false-negative judgment of lipophilic sensitizers with logKow values > 3.5.

    abstract::False-negative judgment due to poor chemical solubility is a problem with in vitro skin sensitisation tests. Water-insoluble chemicals are typically dissolved in DMSO in most sensitisation tests but precipitate when diluted with medium beyond their solubility in water. Such tests lack procedures to rule out false-nega...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02934-9

    authors: Kimura Y,Fujimura C,Aiba S

    更新日期:2020-10-17 00:00:00

  • Ochratoxin A induces epithelial-to-mesenchymal transition and renal fibrosis through TGF-β/Smad2/3 and Wnt1/β-catenin signaling pathways in vitro and in vivo.

    abstract::Ochratoxin A (OTA) is a toxin produced by fungi such as Aspergillus spp. and Penicillium spp. The key target organ of OTA toxicity is the kidney, and it is known that epithelial-to-mesenchymal transition (EMT) leading to fibrosis is enhanced after long-term exposure of the kidney to OTA. However, the mechanisms respon...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02829-9

    authors: Pyo MC,Chae SA,Yoo HJ,Lee KW

    更新日期:2020-09-01 00:00:00

  • Human variability in isoform-specific UDP-glucuronosyltransferases: markers of acute and chronic exposure, polymorphisms and uncertainty factors.

    abstract::UDP-glucuronosyltransferases (UGTs) are involved in phase II conjugation reactions of xenobiotics and differences in their isoform activities result in interindividual kinetic differences of UGT probe substrates. Here, extensive literature searches were performed to identify probe substrates (14) for various UGT isofo...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02765-8

    authors: Kasteel EEJ,Darney K,Kramer NI,Dorne JLCM,Lautz LS

    更新日期:2020-08-01 00:00:00

  • Glutaminases regulate glutathione and oxidative stress in cancer.

    abstract::Targeted therapies against cancer have improved both survival and quality of life of patients. However, metabolic rewiring evokes cellular mechanisms that reduce therapeutic mightiness. Resistant cells generate more glutathione, elicit nuclear factor erythroid 2-related factor 2 (NRF2) activation, and overexpress many...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审

    doi:10.1007/s00204-020-02838-8

    authors: Matés JM,Campos-Sandoval JA,de Los Santos-Jiménez J,Márquez J

    更新日期:2020-08-01 00:00:00

  • 25C-NBF, a new psychoactive substance, has addictive and neurotoxic potential in rodents.

    abstract::The use of new psychoactive substances (NPSs) as a substitute for illegal drugs is increasing rapidly and is a serious threat to public health. 25C-NBF is a newly synthesized phenethylamine-type NPS that acts as a 5-hydroxyindoleacetic acid (5-HT) receptor agonist, but little is known about its pharmacological effects...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02740-3

    authors: Hur KH,Kim SE,Lee BR,Ko YH,Seo JY,Kim SK,Ma SX,Kim YJ,Jeong Y,Pham DT,Trinh QD,Shin EJ,Kim HC,Lee YS,Lee SY,Jang CG

    更新日期:2020-07-01 00:00:00

  • Long-term simulation of lead concentrations in agricultural soils in relation to human adverse health effects.

    abstract::Lead (Pb) exposure of consumers and the environment has been reduced over the past decades. Despite all measures taken, immission of Pb onto agricultural soils still occurs, with fertilizer application, lead shot from hunting activities, and Pb from air deposition representing major sources. Little is known about the ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02762-x

    authors: Schupp T,Damm G,Foth H,Freyberger A,Gebel T,Gundert-Remy U,Hengstler JG,Mangerich A,Partosch F,Röhl C,Wollin KM

    更新日期:2020-07-01 00:00:00

  • Identification of compound causing yellow bone discoloration following alpha-glycosyl isoquercitrin exposure in Sprague-Dawley rats.

    abstract::Previous rat toxicity studies of alpha-glycosyl isoquercitrin (AGIQ), a water-soluble flavonol glycoside derived from rutin, revealed systemic yellow bone discoloration. This investigative study was conducted to determine the AGIQ metabolite(s) responsible for the discoloration. Female Sprague-Dawley rats were adminis...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02760-z

    authors: Davis JP,Koyanagi M,Maronpot RR,Recio L,Hayashi SM

    更新日期:2020-07-01 00:00:00

  • Treatments of a phthalocyanine-based green ink for tattoo removal purposes: generation of toxic fragments and potentially harmful morphologies.

    abstract::Since tattoos became overwhelmingly fashionable worldwide, the demand for removal has proportionally increased, Nd:YAG Q-switch laser being the most commonly used tool for the purpose. In this framework we investigated the composition and products of laser treatment of green tattoo ink, the Green Concentrate from Eter...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02790-7

    authors: Bauer EM,Scibetta EV,Cecchetti D,Piccirillo S,Antonaroli S,Sennato S,Cerasa M,Tagliatesta P,Carbone M

    更新日期:2020-07-01 00:00:00

  • Organophosphorus compounds and oximes: a critical review.

    abstract::Organophosphorus (OP) pesticides and nerve agents still pose a threat to the population. Treatment of OP poisoning is an ongoing challenge and burden for medical services. Standard drug treatment consists of atropine and an oxime as reactivator of OP-inhibited acetylcholinesterase and is virtually unchanged since more...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审

    doi:10.1007/s00204-020-02797-0

    authors: Worek F,Thiermann H,Wille T

    更新日期:2020-07-01 00:00:00

  • Toxicology data of graphene-family nanomaterials: an update.

    abstract::Due to its unique physical structure and chemical properties, graphene family nanomaterials (GFNs) and derived commodities have been widely used in commercial products, particularly biomedical applications, which has significantly increased the risk of human exposure. There exists significant evidence that GFNs are ac...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审

    doi:10.1007/s00204-020-02717-2

    authors: Xiaoli F,Qiyue C,Weihong G,Yaqing Z,Chen H,Junrong W,Longquan S

    更新日期:2020-06-01 00:00:00

  • Alternaria toxins as casein kinase 2 inhibitors and possible consequences for estrogenicity: a hybrid in silico/in vitro study.

    abstract::Emerging mycotoxins produced by Alternaria spp. were previously reported to exert cytotoxic, genotoxic, but also estrogenic effects in human cells. The involved mechanisms are very complex and not fully elucidated yet. Thus, we followed an in silico target fishing approach to extend knowledge on the possible biologica...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02746-x

    authors: Aichinger G,Dellafiora L,Pantazi F,Del Favero G,Galaverna G,Dall'Asta C,Marko D

    更新日期:2020-06-01 00:00:00

  • Culprit or correlate? An application of the Bradford Hill criteria to Vitamin E acetate.

    abstract::Vitamin E acetate (VEA) has come under significant scrutiny due to its association with e-cigarette, or vaping, product use-associated lung injury (EVALI). In 1965, Sir Austin Bradford Hill proposed a set of criteria used to critically assess an association for causality. In this article, we apply the Bradford Hill ca...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审

    doi:10.1007/s00204-020-02770-x

    authors: Feldman R,Meiman J,Stanton M,Gummin DD

    更新日期:2020-06-01 00:00:00

  • Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and interaction with hormonal regulation of the breast.

    abstract::Knowledge about established breast carcinogens can support improved and modernized toxicological testing methods by identifying key mechanistic events. Ionizing radiation (IR) increases the risk of breast cancer, especially for women and for exposure at younger ages, and evidence overall supports a linear dose-respons...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,评审

    doi:10.1007/s00204-020-02752-z

    authors: Helm JS,Rudel RA

    更新日期:2020-05-01 00:00:00

  • Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury.

    abstract::Adverse outcome pathways (AOPs) have been recently introduced as tools to map the mechanisms underlying toxic events relevant for chemical risk assessment. AOPs particularly depict the linkage between a molecular initiating event and an adverse outcome through a number of intermediate key events. An AOP has been previ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02691-9

    authors: Gijbels E,Vilas-Boas V,Annaert P,Vanhaecke T,Devisscher L,Vinken M

    更新日期:2020-04-01 00:00:00

  • Extracellular nucleic acid scavenging rescues rats from sulfur mustard analog-induced lung injury and mortality.

    abstract::Sulfur mustard (SM) is a highly toxic war chemical that causes significant morbidity and mortality and lacks any effective therapy. Rats exposed to aerosolized CEES (2-chloroethyl ethyl sulfide; 10% in ethanol), an analog of SM, developed acute respiratory distress syndrome (ARDS), which is characterized by increased ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02699-1

    authors: Mariappan N,Husain M,Zafar I,Singh V,Smithson KG,Crowe DR,Pittet JF,Ahmad S,Ahmad A

    更新日期:2020-04-01 00:00:00

  • Comparative biological properties of the four stereoisomers of difethialone, a second-generation anticoagulant rodenticide, in rats: development of a model allowing to choose the appropriate stereoisomeric ratio.

    abstract::The current management of rodent pest populations is based on second-generation anticoagulant rodenticides (SGAR). These molecules, of which difethialone is part, are much more efficient than the first generation. Nevertheless, this efficiency comes with a major drawback, SGARs are tissue persistent that increases the...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02662-0

    authors: Lefebvre S,Fourel I,Chatron N,Caruel H,Benoit E,Lattard V

    更新日期:2020-03-01 00:00:00

  • Dose concentration and spatial memory and brain mitochondrial function association after 3,4-methylenedioxymethamphetamine (MDMA) administration in rats.

    abstract::MDMA-induced impairments of memory performance have been reported in different human and animal studies. However, the correlation between spatial memory impairment, brain mitochondrial function, and concentrations of MDMA and its metabolites has not yet been investigated despite it being needed for comparison with hum...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-020-02673-x

    authors: Taghizadeh G,Mehdizadeh H,Lavasani H,Hosseinzadeh Ardakani Y,Foroumadi A,Halvaei Khankahdani Z,Moshtagh A,Pourahmad J,Sharifzadeh M,Rouini MR

    更新日期:2020-03-01 00:00:00

  • Toxic effects of A2E in human ARPE-19 cells were prevented by resveratrol: a potential nutritional bioactive for age-related macular degeneration treatment.

    abstract::Age-related macular degeneration (AMD) is a late-onset retinal disease and the leading cause of central vision loss in the elderly. Degeneration of retinal pigment epithelial cells (RPE) is a crucial contributing factor responsible for the onset and progression of AMD. The toxic fluorophore N-retinyl-N-retinylidene et...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-019-02637-w

    authors: Alaimo A,Di Santo MC,Domínguez Rubio AP,Chaufan G,García Liñares G,Pérez OE

    更新日期:2020-02-01 00:00:00

  • Hepatocyte CREBH deficiency aggravates inflammatory liver injury following chemokine-dependent neutrophil infiltration through upregulation of NF-κB p65 in mice.

    abstract::Fulminant hepatitis is a serious inflammatory condition of the liver characterized by massive necrosis of liver parenchyma following excessive immune cell infiltration into the liver, and possibly causing sudden hepatic failure and medical emergency. However, the underlying mechanisms are not fully understood. Here, w...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-019-02633-0

    authors: Noh JR,Kim JH,Na SY,Lee IB,Seo YJ,Choi JH,Seo Y,Lee TG,Choi HS,Kim YH,Lee CH

    更新日期:2020-02-01 00:00:00

  • Concentration-response evaluation of ToxCast compounds for multivariate activity patterns of neural network function.

    abstract::The US Environmental Protection Agency's ToxCast program has generated toxicity data for thousands of chemicals but does not adequately assess potential neurotoxicity. Networks of neurons grown on microelectrode arrays (MEAs) offer an efficient approach to screen compounds for neuroactivity and distinguish between com...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-019-02636-x

    authors: Kosnik MB,Strickland JD,Marvel SW,Wallis DJ,Wallace K,Richard AM,Reif DM,Shafer TJ

    更新日期:2020-02-01 00:00:00

  • Leveraging complementary computational models for prioritizing chemicals of developmental and reproductive toxicity concern: an example of food contact materials.

    abstract::The evaluation of developmental and reproductive toxicity of food contact materials (FCMs) is an important task for food safety. Since traditional experiments are both time-consuming and labor-intensive, only a small number of FCMs have sufficient toxicological data for evaluating their effects on human health. While ...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-019-02641-0

    authors: Tung CW,Cheng HJ,Wang CC,Wang SS,Lin P

    更新日期:2020-02-01 00:00:00

  • The pyrrolizidine alkaloid senecionine induces CYP-dependent destruction of sinusoidal endothelial cells and cholestasis in mice.

    abstract::Pyrrolizidine alkaloids (PAs) are widely occurring phytotoxins which can induce severe liver damage in humans and other mammalian species by mechanisms that are not fully understood. Therefore, we investigated the development of PA hepatotoxicity in vivo, using an acutely toxic dose of the PA senecionine in mice, in c...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-019-02582-8

    authors: Hessel-Pras S,Braeuning A,Guenther G,Adawy A,Enge AM,Ebmeyer J,Henderson CJ,Hengstler JG,Lampen A,Reif R

    更新日期:2020-01-01 00:00:00

  • Effects of arsenic exposure on D-serine metabolism in the hippocampus of offspring mice at different developmental stages.

    abstract::The main purpose of this study was to verify the hypothesis that cognitive dysfunctions induced by arsenic exposure were related to the changes of D-serine metabolism in the hippocampus of offspring mice. Mother mice and their offsprings were exposed to 0, 15, 30 or 60 mg/L sodium arsenite (NaAsO2) through drinking wa...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-019-02616-1

    authors: Wang Y,Yang X,Yu H,Wang H,Qi Y,Geng M

    更新日期:2020-01-01 00:00:00

  • Gene expression and cytosine DNA methylation alterations in induced pluripotent stem-cell-derived human hepatocytes treated with low doses of chemical carcinogens.

    abstract::The increasing number of man-made chemicals in the environment that may pose a carcinogenic risk emphasizes the need to develop reliable time- and cost-effective approaches for carcinogen detection. To address this issue, we have investigated the utility of human hepatocytes for the in vitro identification of genotoxi...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-019-02569-5

    authors: Tryndyak V,Borowa-Mazgaj B,Beland FA,Pogribny IP

    更新日期:2019-11-01 00:00:00

  • Identification of glycyrrhizin metabolites in humans and of a potential biomarker of liquorice-induced pseudoaldosteronism: a multi-centre cross-sectional study.

    abstract::Liquorice [main ingredient, glycyrrhizin (GL)] is widely used as a food sweetener and herbal medicine. Occasionally, liquorice consumption causes pseudoaldosteronism as a side effect which causes oedema, hypokalaemia, and hypertension due to hyperactivity of mineral corticoid receptor. We aimed to detect GL metabolite...

    journal_title:Archives of toxicology

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00204-019-02588-2

    authors: Takahashi K,Yoshino T,Maki Y,Ishiuchi K,Namiki T,Ogawa-Ochiai K,Minamizawa K,Makino T,Nakamura T,Mimura M,Watanabe K

    更新日期:2019-11-01 00:00:00

  • Biophysical and biomechanical properties of neural progenitor cells as indicators of developmental neurotoxicity.

    abstract::Conventional in vitro toxicity studies have focused on identifying IC50 and the underlying mechanisms, but how toxicants influence biophysical and biomechanical changes in human cells, especially during developmental stages, remain understudied. Here, using an atomic force microscope, we characterized changes in bioph...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-019-02549-9

    authors: Mahajan G,Lee MY,Kothapalli C

    更新日期:2019-10-01 00:00:00

  • Interleukin-6 selectively induces drug metabolism to potentiate the genotoxicity of dietary carcinogens in mammary cells.

    abstract::Breast cancer is the most commonly diagnosed malignancy in females, the etiology being multifactorial and includes the role of lifestyle exposure to DNA-damaging chemicals such as dietary carcinogens benzo (a) pyrene (BaP) and 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP). Both compounds require cytochrome...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-019-02558-8

    authors: Malik DE,David RM,Gooderham NJ

    更新日期:2019-10-01 00:00:00

  • Critical assessment and integration of separate lines of evidence for risk assessment of chemical mixtures.

    abstract::Humans are exposed to multiple chemicals on a daily basis instead of to just a single chemical, yet the majority of existing toxicity data comes from single-chemical exposure. Multiple factors must be considered such as the route, concentration, duration, and the timing of exposure when determining toxicity to the org...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-019-02547-x

    authors: Hernandez AF,Buha A,Constantin C,Wallace DR,Sarigiannis D,Neagu M,Antonijevic B,Hayes AW,Wilks MF,Tsatsakis A

    更新日期:2019-10-01 00:00:00

  • Model-based estimation of lowest observed effect concentration from replicate experiments to identify potential biomarkers of in vitro neurotoxicity.

    abstract::A paradigm shift is occurring in toxicology following the report of the National Research Council of the USA National Academies entitled "Toxicity testing in the 21st Century: a vision and strategy". This new vision encourages the use of in vitro and in silico models for toxicity testing. In the goal to identify new r...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-019-02520-8

    authors: Calderazzo S,Tavel D,Zurich MG,Kopp-Schneider A

    更新日期:2019-09-01 00:00:00

  • Role of the human N-acetyltransferase 2 genetic polymorphism in metabolism and genotoxicity of 4, 4'-methylenedianiline.

    abstract::4, 4'-Methylenedianiline (MDA) is used extensively as a curing agent in the production of elastomers and is classified as reasonably anticipated to be a human carcinogen based on sufficient evidence in animal experiments. Human N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the N-acetylation of aromatic amines and...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-019-02516-4

    authors: Salazar-González RA,Zhang X,Doll MA,Lykoudi A,Hein DW

    更新日期:2019-08-01 00:00:00

  • In vivo evaluation of the effect of arsenite on the intestinal epithelium and associated microbiota in mice.

    abstract::Chronic exposure to inorganic arsenic (As) [As(III) + As(V)], which affects millions of people, increases the incidence of some kinds of cancer and other non-carcinogenic pathologies. Although the oral pathway is the main form of exposure, in vivo studies have not been conducted to verify the intestinal toxicity of th...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-019-02510-w

    authors: Chiocchetti GM,Domene A,Kühl AA,Zúñiga M,Vélez D,Devesa V,Monedero V

    更新日期:2019-08-01 00:00:00

  • Behavioural and metabolomic changes from chronic dietary exposure to low-level deoxynivalenol reveal impact on mouse well-being.

    abstract::The mycotoxin deoxynivalenol (DON) has a high global prevalence in grain-based products. Biomarkers of exposure are detectable in most humans and farm animals. Considering the acute emetic and chronic anorexigenic toxicity of DON, maximum levels for food and feed have been implemented by food authorities. The tolerabl...

    journal_title:Archives of toxicology

    pub_type: 杂志文章

    doi:10.1007/s00204-019-02470-1

    authors: Faeste CK,Pierre F,Ivanova L,Sayyari A,Massotte D

    更新日期:2019-07-01 00:00:00

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