当前位置： SCI文献检索 > ARCHIVES OF TOXICOLOGY期刊下所有文献 > Leveraging complementary computational models for prioritizing chemicals of developmental and reproductive toxicity concern: an example of food contact materials.

Leveraging complementary computational models for prioritizing chemicals of developmental and reproductive toxicity concern: an example of food contact materials.

Abstract：

:The evaluation of developmental and reproductive toxicity of food contact materials (FCMs) is an important task for food safety. Since traditional experiments are both time-consuming and labor-intensive, only a small number of FCMs have sufficient toxicological data for evaluating their effects on human health. While computational methods such as structural alerts and quantitative structure-activity relationships can serve as first-line tools for the identification of chemicals of high toxicity concern, models with binary outputs and unsatisfied accuracy and coverage prevent the use of computational methods for prioritizing chemicals of high concern. This study proposed a genetic algorithm-based method to develop a weight-of-evidence (WoE) model leveraging complementary methods of structural alerts, quantitative structure-activity relationships and in silico toxicogenomics models for chemical prioritization. The WoE model was applied to evaluate 623 food contact chemicals and identify 26 chemicals of high toxicity concern, where 13 chemicals have been reported to be developmental or reproductive toxic and further experiments are suggested for the remaining 13 chemicals without toxicity data related to developmental and reproductive effects. The proposed WoE model is potentially useful for prioritizing chemicals of high toxicity concern and the methodology may be applied to toxicities other than developmental and reproductive toxicity.

journal_name

Arch Toxicol

journal_title

Archives of toxicology

authors

Tung CW,Cheng HJ,Wang CC,Wang SS,Lin P

doi

10.1007/s00204-019-02641-0

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

485-494

issue

2

eissn

0340-5761

issn

1432-0738

pii

10.1007/s00204-019-02641-0

journal_volume

94

pub_type

杂志文章

相关文献

ARCHIVES OF TOXICOLOGY文献大全
  • Muller's Nobel lecture on dose-response for ionizing radiation: ideology or science?

    abstract：:In his Nobel Prize Lecture of December 12, 1946, Hermann J. Muller argued that the dose-response for radiation-induced germ cell mutations was linear and that there was "no escape from the conclusion that there is no threshold". However, assessment of correspondence between Muller and Curt Stern 1 month prior to his N...

    journal_title：Archives of toxicology

    pub_type： 历史文章,杂志文章

    doi：10.1007/s00204-011-0728-8

    authors： Calabrese EJ

    更新日期：2011-12-01 00:00:00

  • Inflammation-associated extracellular β-glucuronidase alters cellular responses to the chemical carcinogen benzo[a]pyrene.

    abstract：:Neutrophils infiltrate tissues during inflammation, and when activated, they release β-glucuronidase. Since inflammation is associated with carcinogenesis, we investigated how extracellular β-glucuronidase changed the in vitro cellular response to the chemical carcinogen benzo(a)pyrene (B[a]P). For this we exposed hum...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-015-1593-7

    authors： Shi Q,Haenen GR,Maas L,Arlt VM,Spina D,Vasquez YR,Moonen E,Veith C,Van Schooten FJ,Godschalk RWL

    更新日期：2016-09-01 00:00:00

  • Protective effect of topical iodine containing anti-inflammatory drugs against sulfur mustard-induced skin lesions.

    abstract：:Previous studies have shown the antidotal efficacy of topical iodine at 15 and 30 min post-exposure to sulfur mustard (SM). Here we demonstrate efficacy at longer intervals (20, 30, 45, and 60 min, respectively, for data) using an improved topical povidone-iodine preparation termed N66, which contains steroidal and no...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-003-0523-2

    authors： Wormser U,Sintov A,Brodsky B,Casillas RP,Nyska A

    更新日期：2004-03-01 00:00:00

  • Ability of the Hershberger assay protocol to detect thyroid function modulators.

    abstract：:In vivo screening methods for detection of thyroid function modulators are now under development in many research laboratories. We assessed the applicability of the Hershberger assay protocol to screen for thyroid function modulators. In experiment 1, castrated male BrlHan WIST@Jcl (GALAS) rats were administered a pot...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-005-0677-1

    authors： Noda S,Muroi T,Takakura S,Sakamoto S,Takatsuki M,Yamasaki K,Tateyama S,Yamaguchi R

    更新日期：2005-11-01 00:00:00

  • Binding characteristics of ortho-toluidine to rat hemoglobin and albumin.

    abstract：:The binding characteristics of [14C]ortho-toluidine (OT), a suspect human carcinogen, were investigated in male Sprague-Dawley rats. Rats were administered [14C]OT i.p. at 10, 20, 40, 50, or 100 mg/kg body weight, then sacrificed at 2, 4, 8, 18, 24, 48, or 72 h, or 7, 14, or 28 days. Hemoglobin (Hb) and albumin (Alb) ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF02307167

    authors： DeBord DG,Swearengin TF,Cheever KL,Booth-Jones AD,Wissinger LA

    更新日期：1992-01-01 00:00:00

  • Regulation of metal transporters by dietary iron, and the relationship between body iron levels and cadmium uptake.

    abstract：:Iron (Fe) plays essential roles in biological processes, whereas cadmium (Cd) is a toxic and non-essential metal. Two metal transporters, divalent metal transporter 1 (DMT1) and metal transporter protein 1 (MTP1), are responsible for Fe transport in mammals. Here, we studied the effect of dietary Fe on the expression ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-006-0160-7

    authors： Kim DW,Kim KY,Choi BS,Youn P,Ryu DY,Klaassen CD,Park JD

    更新日期：2007-05-01 00:00:00

  • Cytotoxicity of cyclophosphamide, paclitaxel, and docetaxel for tumor cell lines in vitro: effects of concentration, time and cytochrome P450-catalyzed metabolism.

    abstract：:Cytotoxic effects of cyclophosphamide (CPA), paclitaxel (PCT), and docetaxel (DTX) and their modulation by cytochrome P450 (CYP) metabolism were studied by incubating cell lines L929 and P388D1 with or without rat liver microsomes. The microsomes themselves were not cytotoxic. P388D1 cells were more sensitive to CPA, ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s002040000141

    authors： Gut I,Danielová V,Holubová J,Soucek P,Klucková H

    更新日期：2000-10-01 00:00:00

  • A genetic variant in miR-146a modifies colorectal cancer susceptibility in a Chinese population.

    abstract：:MicroRNAs (miRNAs) are a family of endogenous, small, noncoding RNA molecules that involved in a wide range of biological processes including differentiation, proliferation, and apoptosis. A polymorphism G>C (rs2910164) is located in the stem region opposite to the mature miR-146a sequence. In our study, we investigat...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-012-1004-2

    authors： Ma L,Zhu L,Gu D,Chu H,Tong N,Chen J,Zhang Z,Wang M

    更新日期：2013-05-01 00:00:00

  • The significance of covalent binding of catechols to proteins in vivo.

    abstract：:When rats were dosed with 14 microgram/kg 3H-isoproterenol, 3H-radioactivity was measurable in the liver until 48 h. This amount was not different in livers of animals which have been pretreated with diethyl maleate. After exhaustive extraction, a significant amount of 3H-radioactivity from isoproterenol could be dete...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00343273

    authors： Remmer H,Scheulen M,Kappus H,Bolt HM

    更新日期：1977-12-30 00:00:00

  • Glyphosate impairs male offspring reproductive development by disrupting gonadotropin expression.

    abstract：:Sexual differentiation in the brain takes place from late gestation to the early postnatal days. This is dependent on the conversion of circulating testosterone into estradiol by the enzyme aromatase. The glyphosate was shown to alter aromatase activity and decrease serum testosterone concentrations. Thus, the aim of ...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-011-0788-9

    authors： Romano MA,Romano RM,Santos LD,Wisniewski P,Campos DA,de Souza PB,Viau P,Bernardi MM,Nunes MT,de Oliveira CA

    更新日期：2012-04-01 00:00:00

  • Long-term arsenite exposure induces premature senescence in B cell lymphoma A20 cells.

    abstract：:Chronic arsenite exposure induces immunosuppression, but the precise mechanisms remain elusive. Our previous studies demonstrated that arsenite exposure for 24 h induces G0/G1 arrest in mouse B lymphoma A20 cells and the arrest is caused through induction of cyclin-dependent kinase inhibitor p16(INK4a) followed by acc...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-015-1500-2

    authors： Okamura K,Nohara K

    更新日期：2016-04-01 00:00:00

  • Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts.

    abstract：:Experimental and/or epidemiological studies suggest that prenatal exposure to bisphenol A (BPA) may delay fetal lung development and maturation and increase the susceptibility to childhood respiratory disease. However, the underlying mechanisms remain to be elucidated. In our previous study with cultured human fetal l...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-017-2150-3

    authors： Mahemuti L,Chen Q,Coughlan MC,Qiao C,Chepelev NL,Florian M,Dong D,Woodworth RG,Yan J,Cao XL,Scoggan KA,Jin X,Willmore WG

    更新日期：2018-04-01 00:00:00

  • A frequent misinterpretation in current research on liver fibrosis: the vessel in the center of CCl4-induced pseudolobules is a portal vein.

    abstract：:Carbon tetrachloride-induced liver injury is a thoroughly studied model for regeneration and fibrosis in rodents. Nevertheless, its pattern of liver fibrosis is frequently misinterpreted as portal type. To clarify this, we show that collagen type IV+ "streets" and α-SMA+ cells accumulate pericentrally and extend to ne...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-017-2040-8

    authors： Hammad S,Braeuning A,Meyer C,Mohamed FEZA,Hengstler JG,Dooley S

    更新日期：2017-11-01 00:00:00

  • Association of XRCC1 polymorphisms with arsenic methylation.

    abstract：:The associations of four single nucleotide polymorphisms (p.Arg194Trp, p.Arg280His, p.Pro206Pro, and p.Arg399Gln) in X-ray repair cross-complementing group 1 with urinary arsenic metabolites and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were investigated in a Vietnamese population (n = 100). Individuals with genotype AA in...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-015-1490-0

    authors： Fujihara J,Yasuda T,Iwata H,Tanabe S,Takeshita H

    更新日期：2016-04-01 00:00:00

  • Control of some aspects of cis-platinum nephrotoxicity.

    abstract：:The elevations of blood urea nitrogen and serum creatinine caused by cis-platinum in rats can be prevented by a combination of procedures centered around the administration of sodium N-methyl-N-dithiocarboxyglucamine (NaG), before and very soon after the cis-platinum is administered in hypertonic (4.5%) saline. Elevat...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00316327

    authors： Jones MM,Basinger MA,Craft WD,Domingo JL,Llobet JM

    更新日期：1986-10-01 00:00:00

  • Comet assay: an essential tool in toxicological research.

    abstract：:The comet assay is a versatile, reliable, cost-efficient, and fast technique for detecting DNA damage and repair in any tissue. It is useable in almost any cell type and applicable to both eukaryotic and prokaryotic organisms. Instead of highlighting one of the numerous specific aspects of the comet assay, the present...

    journal_title：Archives of toxicology

    pub_type： 杂志文章,评审

    doi：10.1007/s00204-016-1767-y

    authors： Glei M,Schneider T,Schlörmann W

    更新日期：2016-10-01 00:00:00

  • Occupational exposure to some synthetic pyrethroids (permethrin and fenvalerate).

    abstract：:In a two-step study on exposure control method for occupational handling of permethrin was developed. Air sampling on a filter can be used in case of exposure to permethrin in powder form. The detection limit is 0.001 mg/m3. If biological sampling is used, the acid metabolite moiety in the urine must be monitored. How...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00569234

    authors： Kolmodin-Hedman B,Swensson A,Akerblom M

    更新日期：1982-05-01 00:00:00

  • Taurine, a possible urinary marker of liver damage: a study of taurine excretion in carbon tetrachloride-treated rats.

    abstract：:Carbon tetrachloride (CCl4) caused a dose-dependent increase in urinary taurine which correlated with both the histological and biochemical assessment of liver damage. The peak elevation in urinary taurine occurred within the first 48 h after dosing but there was still significant taurinuria 72 and 96 h after the inte...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF01973715

    authors： Waterfield CJ,Turton JA,Scales MD,Timbrell JA

    更新日期：1991-01-01 00:00:00

  • Investigation of species differences in isobutene (2-methylpropene) metabolism between mice and rats.

    abstract：:Metabolism of isobutene (2-methylpropene) in rats (Sprague Dawley) and mice (B6C3F1) follows kinetics according to Michaelis-Menten. The maximal metabolic elimination rates are 340 mumol/kg/h for rats and 560 mumol/kg/h for mice. The atmospheric concentration at which Vmax/2 is reached is 1200 ppm for rats and 1800 pp...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF02034934

    authors： Csanády GA,Freise D,Denk B,Filser JG,Cornet M,Rogiers V,Laib RJ

    更新日期：1991-01-01 00:00:00

  • Distribution of 3H-soman in mice.

    abstract：:3H-soman (specific activity 10 Ci/mMol), a potent irreversible cholinesterase inhibitor, was administered IV to mice in a dose of one LD-50, which corresponds to 0.25 mCi/mouse. Animals were sacrificed at 5 min, 2 h and 24 h, and whole body autoradiography was performed. High levels of radioactivity in lung and skin w...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00292616

    authors： Kadar T,Raveh L,Cohen G,Oz N,Baranes I,Balan A,Ashani Y,Shapira S

    更新日期：1985-10-01 00:00:00

  • In vitro assessment of drug-induced liver steatosis based on human dermal stem cell-derived hepatic cells.

    abstract：:Steatosis, also known as fatty liver disease (FLD), is a disorder in which the lipid metabolism of the liver is disturbed, leading to the abnormal retention of lipids in hepatocytes. FLD can be induced by several drugs, and although it is mostly asymptomatic, it can lead to steatohepatitis, which is associated with li...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-015-1483-z

    authors： Rodrigues RM,Branson S,De Boe V,Sachinidis A,Rogiers V,De Kock J,Vanhaecke T

    更新日期：2016-03-01 00:00:00

  • Cadmium chloride inhibits lactate gluconeogenesis in isolated human renal proximal tubules: a cellular metabolomic approach with 13C-NMR.

    abstract：:As part of a study on cadmium nephrotoxicity, we studied the effect of cadmium chloride (CdCl2) in isolated human renal proximal tubules metabolizing the physiological substrate lactate. Dose-effect experiments showed that 10-500 μM CdCl2 reduced lactate removal, glucose production and the cellular levels of ATP, coen...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-010-0633-6

    authors： Faiz H,Conjard-Duplany A,Boghossian M,Martin G,Baverel G,Ferrier B

    更新日期：2011-09-01 00:00:00

  • Effectiveness of a Prudhoe Bay crude oil and its aliphatic, aromatic and heterocyclic fractions in inducing mortality and aryl hydrocarbon hydroxylase in chick embryo in ovo.

    abstract：:Prudhoe Bay crude oil (PBCO) and its aliphatic, aromatic and heterocyclic fractions were tested on the developing chick embryo for (i) embryotoxicity (ii) their ability to induce hepatic and renal cytochrome P450 levels as well as hepatic, renal and pulmonary aryl hydrocarbon hydroxylase activities. On the basis of it...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00302389

    authors： Walters P,Khan S,O'Brien PJ,Payne JF,Rahimtula AD

    更新日期：1987-08-01 00:00:00

  • Repeated small doses of a neurotoxic organophosphate. Monitoring of neurotoxic esterase in brain and spinal cord.

    abstract：:The effects of small repeated oral doses of mono-2-cresyl diphenyl phosphate (MOCP, 2.5 mg/kg/day) on hen brain and spinal cord neurotoxic esterase (NTE) were measured. The enzyme levels were depressed to about 40% and 55% of normal respectively and maintained at that level for 8 weeks. No clinical and only doubtful h...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00293807

    authors： Lotti M,Johnson MK

    更新日期：1980-10-01 00:00:00

  • In vitro studies on the metabolism of aflatoxin B1 and aldrin in testes of genetically different strains of Drosophila melanogaster.

    abstract：:As Drosophila melanogaster occupies an important position within the test battery for mutagens and carcinogens, it is of interest to study the xenobiotics metabolism of this insect. Likewise, the genetic control of these important enzyme systems falls within this interest. Our attempt was to get new strains, which sho...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF00316345

    authors： Foerster RE,Würgler FE

    更新日期：1984-11-01 00:00:00

  • Revisiting the stress paradigm for silica nanoparticles: decoupling of the anti-oxidative defense, pro-inflammatory response and cytotoxicity.

    abstract：:Engineered amorphous silica nanoparticles (nanosilica) are widely used in industry yet can induce adverse effects, which might be classified according to the oxidative stress model. However, the underlying mechanisms as well as the potential interactions of the three postulated different tiers of toxicity-i.e. oxidati...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-018-2223-y

    authors： Fritsch-Decker S,Marquardt C,Stoeger T,Diabaté S,Weiss C

    更新日期：2018-07-01 00:00:00

  • Alternaria toxins as casein kinase 2 inhibitors and possible consequences for estrogenicity: a hybrid in silico/in vitro study.

    abstract：:Emerging mycotoxins produced by Alternaria spp. were previously reported to exert cytotoxic, genotoxic, but also estrogenic effects in human cells. The involved mechanisms are very complex and not fully elucidated yet. Thus, we followed an in silico target fishing approach to extend knowledge on the possible biologica...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-020-02746-x

    authors： Aichinger G,Dellafiora L,Pantazi F,Del Favero G,Galaverna G,Dall'Asta C,Marko D

    更新日期：2020-06-01 00:00:00

  • Comparative studies on the nephrotoxicity of 2-bromoethanamine hydrobromide in the Fischer 344 rat and the multimammate desert mouse (Mastomys natalensis).

    abstract：:Renal papillary necrosis (RPN) was induced in Fischer 344 (F344) rats (n = 4) using 2-bromoethanamine hydrobromide (BEA) dosed at 150 mg/kg, and in multimammate desert mice (Mastomys natalensis) at 150 and 250 mg/kg (n = 4 per group). Control rats and Mastomys were dosed with 0.9% saline (n = 4 per group). Urine was c...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/BF02733668

    authors： Holmes E,Bonner FW,Nicholson JK

    更新日期：1995-01-01 00:00:00

  • Possible involvement of oxidative stress in fenofibrate-induced hepatocarcinogenesis in rats.

    abstract：:To clarify whether oxidative stress is involved in the development of hepatocellular preneoplastic foci induced by fenofibrate (FF), a peroxisome proliferator-activated receptor alpha agonist, male F344/N rats were fed a diet containing 6,000, 3,000, or 0 ppm of FF for 13 weeks after N-diethylnitrosamine initiation. T...

    journal_title：Archives of toxicology

    pub_type： 杂志文章

    doi：10.1007/s00204-007-0278-2

    authors： Nishimura J,Dewa Y,Okamura T,Muguruma M,Jin M,Saegusa Y,Umemura T,Mitsumori K

    更新日期：2008-09-01 00:00:00

  • Application of ESR spectroscopy in toxicology.

    abstract：:Spin trapping in vivo was first achieved in the author's laboratory and is shown to be a feasible method for demonstrating that highly reactive free radical intermediates are generated in the tissues of intact animals as a result of the exposure to certain toxic compounds and to ionizing radiation. The method is based...

    journal_title：Archives of toxicology

    pub_type： 杂志文章,评审

    doi：10.1007/BF00296966

    authors： McCay PB

    更新日期：1987-01-01 00:00:00