Regulation of metal transporters by dietary iron, and the relationship between body iron levels and cadmium uptake.

abstract：:The cardiovascular effects were investigated after acute and subacute treatment with chlorodibromomethane (CDBM; 0.4 to 3.2 mmol/kg p.o.), trichloromethane (TCM; 0.31 and 1.25 mmol/kg p.o.) and mixtures of CDBM and TCM (acute, 0.8 mmol CDBM/kg + 1.25 mmol TCM/kg p.o.; subacute, 0.4 mmol CDBM/kg + 0.31 mmol TCM/kg p.o....

journal_title：Archives of toxicology

authors： Müller SP,Wolna P,Wünscher U,Pankow D

更新日期：1997-01-01 00:00:00

abstract：:Between 0.25-25 micrograms of an aqueous solution of either mercuric chloride or methyl mercuric acetate was injected directly into the sciatic nerve of 28 adult Wistar rats. The resultant pathological changes in the nerve were examined by teasing individual fibres and by light and electron microscopy. In most respect...

journal_title：Archives of toxicology

authors： Mitchell J,Gallagher PJ

更新日期：1980-12-01 00:00:00

abstract：:Arsenic-containing hydrocarbons (AsHCs), a subgroup of arsenolipids found in fish and algae, elicit substantial toxic effects in various human cell lines and have a considerable impact on cellular energy levels. The underlying mode of action, however, is still unknown. The present study analyzes the effects of two AsH...

journal_title：Archives of toxicology

authors： Müller SM,Finke H,Ebert F,Kopp JF,Schumacher F,Kleuser B,Francesconi KA,Raber G,Schwerdtle T

更新日期：2018-05-01 00:00:00

abstract：:Pregnane X receptor (PXR) is a nuclear receptor that plays a key regulatory role in xenobiotic metabolism in a ligand-dependent manner. Recently, ethanol was reported to be either an inducer or inhibitor of Cytochrome P450 (CYP) 3A expression. According to our recent microarray data, chronic ethanol upregulates the ex...

journal_title：Archives of toxicology

authors： Je YT,Sim WC,Kim DG,Jung BH,Shin HS,Lee BH

更新日期：2015-04-01 00:00:00

abstract：:Bisphenol A (BPA) is a chemical in widespread use that is under scientific discussion due to its endocrine activity. Controversies exist about how to interpret reportedly high blood concentrations measured in uncontrolled situations. Physiologically based pharmaco-/toxicokinetic modelling resulted in 10-100-fold lower...

journal_title：Archives of toxicology

authors： Partosch F,Mielke H,Gundert-Remy U

更新日期：2013-07-01 00:00:00

abstract：:Cyclin-dependent kinases (CDKs) are a family of kinases associated predominantly with cell cycle control, making CDK inhibitors interesting candidates for anti-cancer therapeutics. However, retinal toxicity (loss of photoreceptors) has been associated with CDK inhibitors, including the pan-CDK inhibitor AG-012896. The...

journal_title：Archives of toxicology

authors： Wright P,Kelsall J,Healing G,Sanderson J

更新日期：2019-03-01 00:00:00

abstract：:A method is described for the determination of lorazepam plasma levels involving extraction from the sample and analysis of the intact lorazepam by electron capture gas-liquid chromatography. Using mass spectrometry it is demonstrated, that lorazepam shows a thermal rearrangement under gas chromatographic conditions. ...

journal_title：Archives of toxicology

authors： de Groot G,Maes RA,Lemmens HH

更新日期：1976-06-08 00:00:00

abstract：:Drug-induced liver injury (DILI) continues to be a major source of clinical attrition, precautionary warnings, and post-market withdrawal of drugs. Accordingly, there is a need for more predictive tools to assess hepatotoxicity risk in drug discovery. Three-dimensional (3D) spheroid hepatic cultures have emerged as pr...

journal_title：Archives of toxicology

authors： Proctor WR,Foster AJ,Vogt J,Summers C,Middleton B,Pilling MA,Shienson D,Kijanska M,Ströbel S,Kelm JM,Morgan P,Messner S,Williams D

更新日期：2017-08-01 00:00:00

abstract：:The OECD has developed an "enhanced Test Guideline 407" (TG 407) protocol for detecting endocrine effects during the course of a 28-day testing scheme. This protocol has gone through a validation process with (anti)estrogenic and (anti)androgenic compounds and substances that affect the thyroid (thyroxine and propylth...

journal_title：Archives of toxicology

authors： Cunha GC,van Ravenzwaay B

更新日期：2005-07-01 00:00:00

abstract：:The acute toxicity of cyanide is determined by its peak levels reached in the body. Compared to the ingestion of free cyanide, lower peak levels may be expected after consumption of foods containing cyanogenic glycosides with the same equivalent dose of cyanide. This is due to possible delayed and/or incomplete releas...

journal_title：Archives of toxicology

authors： Abraham K,Buhrke T,Lampen A

更新日期：2016-03-01 00:00:00

abstract：:4-Nonylphenol (para-nonylphenol, 4-NP), metabolites including linear and branched isoforms of nonylphenol (n-NP and t-NP, respectively), has been considered an endocrine disrupting substance resulting in reproductive dysfunction and increasing reactive oxygen species production in testis, liver, kidney, and brain. How...

journal_title：Archives of toxicology

authors： Hsieh CY,Miaw CL,Hsieh CC,Tseng HC,Yang YH,Yen CH

更新日期：2009-10-01 00:00:00

abstract：:Exposure to alkylanilines found in tobacco smoke and indoor air is associated with risk of bladder cancer. Genetic factors significantly influence the metabolism of arylamine carcinogens and the toxicological outcomes that result from exposure. We utilized nucleotide excision repair (NER)-deficient immortalized human ...

journal_title：Archives of toxicology

authors： Leggett CS,Doll MA,States JC,Hein DW

更新日期：2021-01-01 00:00:00

abstract：:To examine the demethylation reaction of methylmercury (MeHg) in rat liver, slices prepared from MeHg-treated rats were incubated in L-15 medium under 95% O2/5% CO2 atmosphere. During the incubation, the amount of inorganic Hg in the slices markedly increased in a time-dependent manner, although the concentration of t...

journal_title：Archives of toxicology

authors： Yasutake A,Hirayama K

更新日期：2001-09-01 00:00:00

abstract：:Drug-induced liver injuries have been a major focus of current research in drug development, and are also one of the major reasons for the failure and withdrawal of drugs in development. Drug-induced liver injuries have been systematically recorded in many public databases, which have become valuable resources in this...

journal_title：Archives of toxicology

authors： Luo G,Shen Y,Yang L,Lu A,Xiang Z

更新日期：2017-09-01 00:00:00

abstract：:The effect of intracerebroventricular (i.c.v.) administration of cadmium or magnesium on central calcium-dependent blood pressure regulation was investigated. The systolic blood pressure of spontaneously hypertensive rats (SHR; male, 13 weeks of age) decreased following i.c.v. administration of cadmium chloride (20 nm...

journal_title：Archives of toxicology

authors： Sutoo D,Akiyama K

更新日期：2000-03-01 00:00:00

abstract：:The effects of equimolar doses of the triphenylethylene antiestrogens tamoxifen and toremifene on female Sprague-Dawley rat liver were studied in a 52-week toxicity study which included a 13-week recovery period. Liver tumors were found in four out of five rats at the highest dose level of tamoxifen (45 mg/kg per day)...

journal_title：Archives of toxicology

authors： Hirsimäki P,Hirsimäki Y,Nieminen L,Payne BJ

更新日期：1993-01-01 00:00:00

abstract：:The mycotoxin deoxynivalenol (DON) has a high global prevalence in grain-based products. Biomarkers of exposure are detectable in most humans and farm animals. Considering the acute emetic and chronic anorexigenic toxicity of DON, maximum levels for food and feed have been implemented by food authorities. The tolerabl...

journal_title：Archives of toxicology

authors： Faeste CK,Pierre F,Ivanova L,Sayyari A,Massotte D

更新日期：2019-07-01 00:00:00

abstract：:In his Nobel Prize Lecture of December 12, 1946, Hermann J. Muller argued that the dose-response for radiation-induced germ cell mutations was linear and that there was "no escape from the conclusion that there is no threshold". However, assessment of correspondence between Muller and Curt Stern 1 month prior to his N...

journal_title：Archives of toxicology

authors： Calabrese EJ

更新日期：2011-12-01 00:00:00

abstract：:The effects of acetone on liver, kidney, and lung monooxygenases were studied using hamsters administered 8% acetone in drinking water. Binding of aniline to liver microsomes induced a type II difference spectrum, and the spectral binding was enhanced in hamsters pretreated with acetone. Administration of acetone caus...

journal_title：Archives of toxicology

authors： Ueng TH,Tsai JN,Ju JM,Ueng YF,Iwasaki M,Guengerich FP

更新日期：1991-01-01 00:00:00

abstract：:The neurotoxicity of "ecstasy" (3,4-methylenedioxymethamphetamine, MDMA) is thought to involve hepatic metabolism, though its real contribution is not completely understood. Most in vitro neurotoxicity studies concern isolated exposures of MDMA or its metabolites, at high concentrations, not considering their mixture,...

journal_title：Archives of toxicology

authors： Barbosa DJ,Capela JP,Silva R,Vilas-Boas V,Ferreira LM,Branco PS,Fernandes E,Bastos Mde L,Carvalho F

更新日期：2014-02-01 00:00:00

abstract：:The present study was designed to evaluate the possible protective effects of 3,3'-diselenodipropionic acid (DSePA), a potent radioprotector, against oxidative organ damage induced by whole body γ-irradiation and explore its mechanistic effects. The mice were subjected to whole body γ-irradiation at 5 Gy for the detec...

journal_title：Archives of toxicology

authors： Kunwar A,Bag PP,Chattopadhyay S,Jain VK,Priyadarsini KI

更新日期：2011-11-01 00:00:00

abstract：:2C (2C-x) is the general name for the family of phenethylamines containing two methoxy groups at the 2 and 5 positions of the benzene ring. The abuse of 2C family drugs has grown rapidly, although the abuse potential and neurotoxic properties of 2C drugs have not yet been fully investigated. In this study, we investig...

journal_title：Archives of toxicology

authors： Kim YJ,Ma SX,Hur KH,Lee Y,Ko YH,Lee BR,Kim SK,Sung SJ,Kim KM,Kim HC,Lee SY,Jang CG

更新日期：2021-01-30 00:00:00

abstract：:The possible interrelationships between the effects of dietary selenium and perfluorodecanoic acid (PFDA) on growth and lipid metabolism were studied in the male Sprague Dawley rat. Rats were divided into groups and placed on diets containing three levels of selenium (0.04, 0.2, and 1.0 ppm as sodium selenite). Two we...

journal_title：Archives of toxicology

authors： Borges T,Glauert HP,Chen LC,Chow CK,Robertson LW

更新日期：1990-01-01 00:00:00

abstract：:Sodium diethyldithiocarbamate (DETC) is the main metabolite of disulfiram. Recently, we reported that mechanism of disulfiram cytotoxicity in V79 cells might be partially connected with thiol redox-state imbalance. Here, we examined the effect of DETC on the level of intracellular glutathione (GSH), protein oxidation ...

journal_title：Archives of toxicology

authors： Rahden-Staroń I,Grosicka-Maciąg E,Kurpios-Piec D,Czeczot H,Grzela T,Szumiło M

更新日期：2012-12-01 00:00:00

abstract：:Hexamoll® DINCH® (diisononyl-cyclohexane-1,2-dicarboxylate) is a new high molecular weight plasticizer and a non-aromatic phthalate substitute. In this follow-up study, we further investigated the extensive oxidative metabolism of Hexamoll® DINCH® after oral dosage of 50 mg to three male volunteers (0.552-0.606 mg/kg ...

journal_title：Archives of toxicology

authors： Schütze A,Otter R,Modick H,Langsch A,Brüning T,Koch HM

更新日期：2017-01-01 00:00:00

abstract：:Nanoparticles (NP) have a tendency to agglomerate after dispersion in physiological media, which can be prevented by the addition of serum. This may however result in modification of the toxic potential of particles due to the formation of protein corona. Our study aimed to analyze the role of serum that is added to i...

journal_title：Archives of toxicology

authors： Vranic S,Gosens I,Jacobsen NR,Jensen KA,Bokkers B,Kermanizadeh A,Stone V,Baeza-Squiban A,Cassee FR,Tran L,Boland S

更新日期：2017-01-01 00:00:00

abstract：:The effect of duration of employment at a North American cadmium smelter on urinary metallothionein (MT), total protein, beta 2-microglobulin (beta 2-MG), glucose, cadmium, copper and zinc of 53 men was studied. The levels of all urinary parameters increased with the duration of employment. Smoking history did not aff...

journal_title：Archives of toxicology

authors： Shaikh ZA,Tohyama C,Nolan CV

更新日期：1987-02-01 00:00:00

abstract：:The main purpose of this study was to verify the hypothesis that cognitive dysfunctions induced by arsenic exposure were related to the changes of D-serine metabolism in the hippocampus of offspring mice. Mother mice and their offsprings were exposed to 0, 15, 30 or 60 mg/L sodium arsenite (NaAsO2) through drinking wa...

journal_title：Archives of toxicology

authors： Wang Y,Yang X,Yu H,Wang H,Qi Y,Geng M

更新日期：2020-01-01 00:00:00

abstract：:Second order rate constants for the initial reaction of 12 mammalian oxyhemoglobins (Hb) with equimolar phenylhydrazine (PHZ), a compound inducing Heinz body hemolytic anemia, were determined by recording continuous changes in absorbance with time at 577 nm. The rate constants were varied in a range from 43 m-1.s-1 wi...

journal_title：Archives of toxicology

authors： Kinuta M,Matteson JL,Itano HA

更新日期：1995-01-01 00:00:00

abstract：:To clarify whether oxidative stress is involved in the development of hepatocellular preneoplastic foci induced by fenofibrate (FF), a peroxisome proliferator-activated receptor alpha agonist, male F344/N rats were fed a diet containing 6,000, 3,000, or 0 ppm of FF for 13 weeks after N-diethylnitrosamine initiation. T...

journal_title：Archives of toxicology

authors： Nishimura J,Dewa Y,Okamura T,Muguruma M,Jin M,Saegusa Y,Umemura T,Mitsumori K

更新日期：2008-09-01 00:00:00