Abstract:
:The possible interrelationships between the effects of dietary selenium and perfluorodecanoic acid (PFDA) on growth and lipid metabolism were studied in the male Sprague Dawley rat. Rats were divided into groups and placed on diets containing three levels of selenium (0.04, 0.2, and 1.0 ppm as sodium selenite). Two weeks later, half the rats in each group received a single 35 mg/kg IP injection of PFDA in corn oil, while their pair-fed companion received only vehicle. Rats injected with PFDA stopped gaining weight, and weighed less than pair-fed controls, despite equal food intakes. Two weeks following PFDA administration the rats were killed and plasma cholesterol and triglycerides, and liver peroxisomal enzyme activities were quantified. In contrast to other peroxisome proliferators, PFDA increased plasma triglycerides while decreasing plasma cholesterol. The rate of peroxisomal fatty acid beta-oxidation was decreased, even though the activity of fatty acyl-CoA oxidase, the first enzyme in the peroxisomal fatty acid beta-oxidation pathway, was increased. Dietary selenium, other than increasing the liver to body weight ratio, did not alter growth or lipid metabolism. This study demonstrates, for the first time, the existence of a "non-hypotriglyceridemic" peroxisome proliferator - PFDA.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Borges T,Glauert HP,Chen LC,Chow CK,Robertson LWdoi
10.1007/BF01973372subject
Has Abstractpub_date
1990-01-01 00:00:00pages
26-30issue
1eissn
0340-5761issn
1432-0738journal_volume
64pub_type
杂志文章abstract::Cocaine is an intrinsic hepatotoxin in laboratory animals, and there is growing evidence that high doses of cocaine can precipitate hepatic necrosis in humans. The rodent model of cocaine hepatotoxicity is commensurate with the concept that a multistep mainly cytochrome P-450 dependent N-oxidative pathway is responsib...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/BF02284256
更新日期:1991-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
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journal_title:Archives of toxicology
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doi:10.1007/BF01974011
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00343121
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1870-0
更新日期:2017-05-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02549-9
更新日期:2019-10-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050253
更新日期:1996-01-01 00:00:00
abstract::Cadmium chloride was administered by gavage to female rats 5 days a week for 5 weeks, then during mating and gestation periods at doses of 0.04, 0.4, and 4 mg Cd/kg/day. Treatment with cadmium neither affected the survival and fertility of females, nor produced overt fetotoxic effects. Fetal cadmium concentration was ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01234482
更新日期:1983-12-01 00:00:00
abstract::The possible formation of singlet oxygen via photoexcited psoralens has been associated with the occurrence of, amongst others, erythema. Therefore it has been suggested to combine PUVA with the topical or systemic administration of antioxidants. However, the effect of these antioxidants on the photobinding of psorale...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01977362
更新日期:1991-01-01 00:00:00
abstract::To clarify whether oxidative stress is involved in the development of hepatocellular preneoplastic foci induced by fenofibrate (FF), a peroxisome proliferator-activated receptor alpha agonist, male F344/N rats were fed a diet containing 6,000, 3,000, or 0 ppm of FF for 13 weeks after N-diethylnitrosamine initiation. T...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-007-0278-2
更新日期:2008-09-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040000123
更新日期:2000-09-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01969264
更新日期:1993-01-01 00:00:00
abstract::Metabolism of carbaryl by rat liver and skin post-mitochondrial fraction has been measured in the presence and absence of cofactors to promote different metabolic pathways. The metabolic capacity was compared with the metabolism of carbaryl during percutaneous absorption in a static skin diffusion system using a varie...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01973722
更新日期:1991-01-01 00:00:00
abstract::Early hepatocyte death occurs in most liver injury cases and triggers liver inflammation, which in combination with other risk factors leads to the development of liver disease. However, the pathogenesis of early phase hepatocyte death remains poorly understood. Here, C57BL/6J mice were treated with the hepatotoxic dr...
journal_title:Archives of toxicology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00290882
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050151
更新日期:1995-01-01 00:00:00
abstract::The aim was to study the long-term response in the olfactory mucosa of NMRI mice after exposure to the olfactory toxicants dichlobenil (a herbicide) or methimazole (an antithyroid drug). Three and six months after exposure to dichlobenil (2x or 1 x 25 mg/kg i.p.), the dorsomedial part of the olfactory region showed a ...
journal_title:Archives of toxicology
pub_type: 杂志文章
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更新日期:2002-03-01 00:00:00
abstract::Tacrolimus (FK506) and cyclosporin A (CsA) are two potent immunosuppressants mainly metabolized by hepatic cytochrome P-450 3A (CYP3A) monooxygenase. The aim of this study was to compare the toxic effects of the two drugs on hepatocytes in primary culture as a function of their metabolism and to explore the variations...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050499
更新日期:1998-04-01 00:00:00
abstract::The US Environmental Protection Agency's ToxCast program has generated toxicity data for thousands of chemicals but does not adequately assess potential neurotoxicity. Networks of neurons grown on microelectrode arrays (MEAs) offer an efficient approach to screen compounds for neuroactivity and distinguish between com...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02636-x
更新日期:2020-02-01 00:00:00
abstract::2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the most potent tumor promoter ever tested in rodents. Although it is known that most of the effects of TCDD are mediated by binding to the aryl hydrocarbon receptor (AhR), the mechanisms leading to tumor promotion still remain to be elucidated. Loss of contact inhibition ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-004-0601-0
更新日期:2005-01-01 00:00:00
abstract::O,O,S-Trimethyl phosphorothioate (OOS-TMP) is known to induce unique symptoms, which are characterized by hypophagia, progressive weight loss, and hypothermia. To determine whether there is the possibility of a causal relationship between these toxic symptoms and a direct action of OOS-TMP on the central nervous syste...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050212
更新日期:1995-01-01 00:00:00
abstract::Microsomal and soluble epoxide hydrolase (mEH and sEH) fulfill apparently distinct roles: Whereas mEH detoxifies xenobiotics, sEH hydrolyzes fatty acid (FA) signaling molecules and is thus implicated in a variety of physiological functions. These epoxy FAs comprise epoxyeicosatrienoic acids (EETs) and epoxy-octadeceno...
journal_title:Archives of toxicology
pub_type: 杂志文章
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abstract::Acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure. Prolonged c-Jun N-terminal kinase (JNK) activation plays a central role in APAP-induced liver injury; however, growth arrest and DNA damage-inducible 45 beta (GADD45β) is known to inhibit JNK phosphorylation. The orphan nuclear recep...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2247-3
更新日期:2018-08-01 00:00:00
abstract::The treatment of poisoning by highly toxic organophosphorus compounds (nerve agents) is unsatisfactory. Until now, the efficacy of new potential antidotes has primarily been evaluated in animals. However, the extrapolation of these results to humans is hampered by species differences. Since oximes are believed to act ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050495
更新日期:1998-03-01 00:00:00