Abstract：
:The influence of pivalic acid (PIV), a compound often used to make pro-drugs, and of the structurally related trichloroacetic acid (TCA), on several hepatic and renal enzymes was investigated in Sprague-Dawley rats, following a 4-day treatment period. The PIV and TCA treatments resulted in a similar and selective induction (2-3 times) of peroxisomal palmitoyl-CoA oxidase and the cytochrome P-450 4A dependent microsomal (omega)- and (omega-1)-lauric acid activities, both in liver and kidney. Western blot analysis of liver and kidney microsomes from PIV- and TCA-treated rats, using antibody to the P-450 4A1, revealed induction of members of the P-450 4A subfamily. These results suggest that PIV, like TCA, is a renal and hepatic peroxisome proliferator in rats, and further support the previously indicated close association between the peroxisomal fatty acid beta-oxidation enzymes and microsomal P-450 4A sub-family enzymes.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Zanelli U,Puccini P,Acerbi D,Ventura P,Gervasi PGdoi
10.1007/s002040050253subject
Has Abstractpub_date
1996-01-01 00:00:00pages
145-9issue
3-4eissn
0340-5761issn
1432-0738journal_volume
70pub_type
杂志文章abstract：:In order to clarify the possible mechanism of hepatocarcinogenesis induced by piperonyl butoxide, we attempted to identify the transcription factor activated by piperonyl butoxide in the male ICR mouse liver. Administration of 0.6% piperonyl butoxide for 24 h elevated the level of liver nuclear proteins that bind to a...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-008-0283-0
更新日期：2008-10-01 00:00:00
abstract：:Inhalation exposure to toluene diisocyanate (TDI) can result in a variety of airway diseases. Concern has been expressed that a putative carcinogenic potential of TDI exists as a result of the formation of toluenediamine (TDA) by hydrolysis of the isocyanate in the body. Results from long-term bioassays (TDI inhalatio...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050094
更新日期：1994-01-01 00:00:00
abstract：:The evaluation of developmental and reproductive toxicity of food contact materials (FCMs) is an important task for food safety. Since traditional experiments are both time-consuming and labor-intensive, only a small number of FCMs have sufficient toxicological data for evaluating their effects on human health. While ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02641-0
更新日期：2020-02-01 00:00:00
abstract：:Rats were exposed to single periods of inhalation of fumes generated by arc welding. Two processes were compared: either manual metal arc (MMA) using flux-coated mild steel (MS) electrodes or metal inert-gas (MIG) welding with stainless steel (SS). Widespread but small deposits of fume particles were cleared effective...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316578
更新日期：1984-03-01 00:00:00
abstract：:Cytokeratins (CK) constitute a family of cytoskeletal intermediate filament proteins that are typically expressed in epithelial cells. An abnormal structure and function are effects that are clearly related to liver diseases as non-alcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma. We have previously o...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-007-0192-7
更新日期：2007-09-01 00:00:00
abstract：:Amygdalin (D-mandelonitrile-beta-D-gentiobioside) is a cyanogenic glycoside claimed to show anti-cancer activity, sold under the incorrect name "Laetrile". For a sensible discussion of its alleged activity and its established toxicity it is necessary that its fate in the organism is known. The pharmacokinetics of amyg...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00347879
更新日期：1982-03-01 00:00:00
abstract：:Some nucleoside analogues are used to treat herpes simplex and other viral infections. They are known to impair spermatogenesis, but published data are scarce. We studied the effects of four nucleosides on SerW3 cells, a rat Sertoli cell line. Cells were cultured for 3 days in DMEM supplemented with four different con...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1743-6
更新日期：2016-08-01 00:00:00
abstract：:Fulminant hepatitis is a serious inflammatory condition of the liver characterized by massive necrosis of liver parenchyma following excessive immune cell infiltration into the liver, and possibly causing sudden hepatic failure and medical emergency. However, the underlying mechanisms are not fully understood. Here, w...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02633-0
更新日期：2020-02-01 00:00:00
abstract：:Sulfur mustard (SM) is a bifunctional alkylating agent. Its primary toxic consequence is severe skin damage with blisters, occurring after skin contact. These vesicant properties of SM have been linked to cell death of proliferating keratinocytes in the basal layer of the skin. Catalytic activation of the nuclear enzy...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-007-0265-7
更新日期：2008-07-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01981507
更新日期：1992-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02746-x
更新日期：2020-06-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-016-1727-6
更新日期：2016-07-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-008-0372-0
更新日期：2009-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050335
更新日期：1996-01-01 00:00:00
abstract：:Interactions between chemicals in a mixture and interactions of mixture components with the skin can significantly alter the rate and extent of percutaneous absorption, as well as the cutaneous disposition of a topically applied chemical. The predictive ability of dermal absorption models, and consequently the dermal ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040100242
更新日期：2001-08-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1685-z
更新日期：2017-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0460-0
更新日期：2003-11-01 00:00:00
abstract：:A rapid gas-chromatographic method for the qualitative and quantitative measurement of various drugs in human plasma and other body fluids has been developed. The extraction procedure is done within 5 min, and gas-chromatographic measurement carried out on 2 diverse columns with detection by flame ionisation detectors...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00368231
更新日期：1978-01-25 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-008-0288-8
更新日期：2008-10-01 00:00:00
abstract：:The possible interrelationships between the effects of dietary selenium and perfluorodecanoic acid (PFDA) on growth and lipid metabolism were studied in the male Sprague Dawley rat. Rats were divided into groups and placed on diets containing three levels of selenium (0.04, 0.2, and 1.0 ppm as sodium selenite). Two we...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973372
更新日期：1990-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-2060-4
更新日期：2017-11-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-004-0644-2
更新日期：2005-07-01 00:00:00
abstract：:The aryl hydrocarbon receptor (AHR) is known to mediate the cellular response to numerous xenobiotics including dioxin. Surprisingly AHR knockout mice provide evidence for the involvement of the AHR signalling cascade in estrogen regulated physiological functions of the female reproductive system. Several studies alre...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-0870-y
更新日期：2012-10-01 00:00:00
abstract：:Oxidative stress is discussed as a possible hepatocarcinogenic mechanism of peroxisome proliferators (PP) in rodents and is suggested to result from the induction of peroxisomal beta-oxidation (PBOX) by PP. The induced PBOX is assumed to produce excessive H2O2 from the degradation of fatty acids, ultimately leading to...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050429
更新日期：1997-01-01 00:00:00
abstract：:The in vitro DNA strand breaking activity of metallothionein (MT) containing Cd2+ and Zn2+ in a molar ratio of 5:2 is described. Studies with radical scavengers and electron paramagnetic resonance spectroscopy indicate that the DNA damage might be caused by a radical species formed by the native protein (i.e., MT) cha...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973498
更新日期：1991-01-01 00:00:00
abstract：:Acetaminophen (APAP) is a widely-used analgesic and a known hepatotoxic agent. Vascular endothelial growth factor (VEGF) is a growth factor with multiple functional roles. VEGF plays an important role in angiogenesis and hepatic regeneration. The aim of this study was to determine the expression of VEGF isoforms and i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-007-0201-x
更新日期：2007-10-01 00:00:00
abstract：:Clark 1 (diphenylarsine chloride) and Clark 2 (diphenylarsine cyanide) were used as chemical weapon agents (CWA), and the soil contamination by these CWA and their degraded products, diphenyl and phenyl arsenicals, has been one of the most serious environmental issues. In a series of comparisons in toxicity between tr...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-004-0598-4
更新日期：2005-01-01 00:00:00
abstract：:Sodium diethyldithiocarbamate (DETC) is the main metabolite of disulfiram. Recently, we reported that mechanism of disulfiram cytotoxicity in V79 cells might be partially connected with thiol redox-state imbalance. Here, we examined the effect of DETC on the level of intracellular glutathione (GSH), protein oxidation ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-0909-0
更新日期：2012-12-01 00:00:00
abstract：:Due to its unique physical structure and chemical properties, graphene family nanomaterials (GFNs) and derived commodities have been widely used in commercial products, particularly biomedical applications, which has significantly increased the risk of human exposure. There exists significant evidence that GFNs are ac...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-020-02717-2
更新日期：2020-06-01 00:00:00
abstract：:Groups of rats were exposed simultaneously to manganese chloride (3 mg Mn2+/ml water) through drinking water and lead acetate intraperitoneally at dosages of 5.0, 8.0 and 12.0 mgPb2+/kg daily for a period of 14 days. The magnitude of changes in the behavioral pattern, contents of biogenic amines and accumulation of le...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00352071
更新日期：1981-11-01 00:00:00
