Abstract:
:Oxidative stress is discussed as a possible hepatocarcinogenic mechanism of peroxisome proliferators (PP) in rodents and is suggested to result from the induction of peroxisomal beta-oxidation (PBOX) by PP. The induced PBOX is assumed to produce excessive H2O2 from the degradation of fatty acids, ultimately leading to oxidative stress and lipid peroxidation. In the present short term-study, we attempted to stimulate lipid peroxidation in male Wistar rats by (1) inducing PBOX enzymes with the peroxisome proliferator nafenopin at 90 mg/kg body weight per day in the diet for 10-11 days, and (2) by supplying the induced PBOX with an abundant amount of fatty acid as substrate, using a corn oil gavage at 20 ml/kg body weight. The corn-oil gavage alone, i.e. without preceding nafenopin treatment, enhanced liver triacylglycerol nine- to tenfold and hepatic lipid peroxidation, measured as thiobarbituric acid reactive substances (TBARS), was increased 50% compared with controls. Both observations were made after 18 h when the peak elevations occurred. Upon pretreatment with nafenopin, associated with a sevenfold induction of PBOX, the corn oil gavage however caused only a threefold maximal increase in hepatic triacylglycerol, also at the 18 h time-point; TBARS remained almost at control levels, as monitored at seven time points over 24-25 h. These results suggest that nafenopin reduces rather than enhances lipid peroxidation, despite the provision, in a short term study, of high doses of substrate to the induced enzyme system that is hypothetically causing oxidative stress in the liver.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Huber WW,Grasl-Kraupp B,Stekel H,Gschwentner C,Lang H,Schulte-Hermann Rdoi
10.1007/s002040050429subject
Has Abstractpub_date
1997-01-01 00:00:00pages
575-81issue
9eissn
0340-5761issn
1432-0738journal_volume
71pub_type
杂志文章abstract::To investigate possible persistent nephrotoxic effects of trichloroethylene (TRI), a retrospective study was carried out on 39 workers exposed to high levels of TRI from 1956 to 1975. Total protein levels in urine, as well as serum and urine creatinine and serum urea were unchanged in comparison with the control. Sodi...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050613
更新日期:1999-06-01 00:00:00
abstract::The lacrimatory agent CS was examined for genotoxic properties. In vitro, Salmonella typhimurium was exposed to CS at concentrations up to 1.5 mg per plate and reverse mutations were assayed. In vivo: male Drosophilae were fed with CS and sex-linked recessive lethal mutations in sperm cells were assayed using the Basc...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01261386
更新日期:1983-10-01 00:00:00
abstract::Forty-eight hours after a single dose of 14C-imipramine to rats, 14C-radioactivity could be measured in the following organs: liver greater than kidney greater than serum greater than fat greater than spleen greater than duodenum greater than lung greater than muscle and brain. Liver microsomes contained the main part...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00353357
更新日期:1976-12-23 00:00:00
abstract::Oxime-type acetylcholinesterase reactivators (oxime-AChER) are used as an adjunct in the treatment for organophosphorus anticholinesterase poisoning. Because of the widespread usage and exposure of organophosphorus compounds (OPCs), its poisoning and fatalities is obvious in pregnant women, embryos and fetuses. OPCs i...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-013-1160-z
更新日期:2014-03-01 00:00:00
abstract::The hepatotoxicity of acetaminophen (APAP) overdose depends on metabolic activation to a toxic reactive metabolite via hepatic mixed function oxidase. In vitro studies have indicated that APAP may also be cooxidized by prostaglandin H synthetase. The present experiments were designed to assess the possible contributio...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01972990
更新日期:1990-01-01 00:00:00
abstract::The increasing number of man-made chemicals in the environment that may pose a carcinogenic risk emphasizes the need to develop reliable time- and cost-effective approaches for carcinogen detection. To address this issue, we have investigated the utility of human hepatocytes for the in vitro identification of genotoxi...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02569-5
更新日期:2019-11-01 00:00:00
abstract::This study examined the effect of tamoxifen, an anti-breast cancer drug, on Ca2+ handling in bladder female transitional cancer cells. Changes in cytosolic free Ca2+ levels were recorded by using the Ca2+-sensitive dye fura-2. In a dose-dependent manner, tamoxifen induced intracellular free Ca2+ concentrations ([Ca2+]...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040100212
更新日期:2001-05-01 00:00:00
abstract::Pathological changes induced by cadmium aerosol had features common to the changes evoked by oxidants. Female rats were exposed to fumes of lead, antimony, zinc and cadmium (15-100 nmoles/m3). One hour after termination of exposure, superoxide dismutase (SOD) activity in erythrocytes of the exposed rats lowered by 15-...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00347869
更新日期:1982-03-01 00:00:00
abstract::The treatment of poisoning by highly toxic organophosphorus compounds (nerve agents) is unsatisfactory. Until now, the efficacy of new potential antidotes has primarily been evaluated in animals. However, the extrapolation of these results to humans is hampered by species differences. Since oximes are believed to act ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050495
更新日期:1998-03-01 00:00:00
abstract::We recently presented a modified local lymph node test which made it possible to quickly and reliably differentiate between irritative and allergic skin reactions with extremely simple parameters. The Integrated Model for the Differentiation of Skin Reactions (IMDS) test combines measurement of cell proliferation in d...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050001
更新日期:2000-01-01 00:00:00
abstract::Cadmium chloride was administered by gavage to female rats 5 days a week for 5 weeks, then during mating and gestation periods at doses of 0.04, 0.4, and 4 mg Cd/kg/day. Treatment with cadmium neither affected the survival and fertility of females, nor produced overt fetotoxic effects. Fetal cadmium concentration was ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01234482
更新日期:1983-12-01 00:00:00
abstract::Two Ceria nanomaterials (NM-211 and NM-212) were tested for inhalation toxicity and organ burdens in order to design a chronic and carcinogenicity inhalation study (OECD TG No. 453). Rats inhaled aerosol concentrations of 0.5, 5, and 25 mg/m(3) by whole-body exposure for 6 h/day on 5 consecutive days for 1 or 4 weeks ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1349-9
更新日期:2014-11-01 00:00:00
abstract::A dual-label time-resolved fluoroimmunoassay (TRFIA) for simultaneous quantification of aflatoxin B1 (AFB1) and ochratoxin A (OTA) is described. For this, microtitration wells were coated with AFB1-horse radish peroxidase (HRP) and OTA-bovine serum albumin. The standards and samples were loaded on the coated plates, a...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-009-0410-6
更新日期:2009-06-01 00:00:00
abstract::With the development of nanotechnologies, the potential adverse effects of nanomaterials such as multi-walled carbon nanotubes (MWCNT) on the respiratory tract of asthmatics are questioned. Furthermore, investigations are necessary to understand how these effects might arise. In the present study, we hypothesized that...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-013-1116-3
更新日期:2014-02-01 00:00:00
abstract::The aim of this study was to investigate the electrophilic tissue burden (ETB) formation, assessed as covalent binding of the ultimate carcinogen benzo( a)pyrene diolepoxide (BaPDE) with cellular proteins, in liver, lung and heart, as well as with haemoglobin (Hb) following repeated exposure to binary mixtures of benz...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-003-0518-z
更新日期:2004-02-01 00:00:00
abstract::Carbon tetrachloride (CCl4) caused a dose-dependent increase in urinary taurine which correlated with both the histological and biochemical assessment of liver damage. The peak elevation in urinary taurine occurred within the first 48 h after dosing but there was still significant taurinuria 72 and 96 h after the inte...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01973715
更新日期:1991-01-01 00:00:00
abstract::Free radical processes are proposed to play a crucial role in the development of procainamide adverse effects. Therefore, selenium, as a potent antioxidant, may modified procainamide toxicity. To test this hypothesis plasma and liver thiobarbituric acid-reacting substances (TBARS), plasma antioxidant activity (AOA), e...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01973693
更新日期:1993-01-01 00:00:00
abstract::With the development of nanotechnology, myriad types of novel materials have been discovered at the nanoscale, among which the most interesting material is graphene. However, the toxicity data available on graphene are extremely limited. In this study, we explored toxic response of commercially available graphene nano...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1303-x
更新日期:2015-09-01 00:00:00
abstract::3-(Phenylamino)alanine (PAA), a contaminant found in L-tryptophan tablets, has been discussed as a possible cause of eosinophilia-myalgia syndrome (EMS). We administered PAA (100 mg/kg) by gastric gavage to Wistar rats to determine its distribution and metabolism. We developed a purification procedure, using Bond Elut...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050102
更新日期:1994-01-01 00:00:00
abstract::Knowledge about established breast carcinogens can support improved and modernized toxicological testing methods by identifying key mechanistic events. Ionizing radiation (IR) increases the risk of breast cancer, especially for women and for exposure at younger ages, and evidence overall supports a linear dose-respons...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-020-02752-z
更新日期:2020-05-01 00:00:00
abstract::Metabolism of isobutene (2-methylpropene) in rats (Sprague Dawley) and mice (B6C3F1) follows kinetics according to Michaelis-Menten. The maximal metabolic elimination rates are 340 mumol/kg/h for rats and 560 mumol/kg/h for mice. The atmospheric concentration at which Vmax/2 is reached is 1200 ppm for rats and 1800 pp...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF02034934
更新日期:1991-01-01 00:00:00
abstract::This study is aimed at exploring the possible mechanism of hypnosis-enhancing effect of HgS or cinnabar (a traditional Chinese medicine containing more than 95% HgS) in mice treated with pentobarbital. We also examined whether the effect of HgS is different from that of the well-known methyl mercury (MeHg). After a sh...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-007-0255-9
更新日期:2008-06-01 00:00:00
abstract::A new class of potent anticancer drugs, alkylphosphocholines has been recognized lately. Miltefosine (Hexadecylphosphochlorine, HPC) has been found to express select antineoplastic effect on human breast cancer skin metastases with simultaneous preservation of bone marrow proliferative activity and low clastogenicity....
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-005-0010-z
更新日期:2006-01-01 00:00:00
abstract::The consumption of plants containing the diterpenoid atractyloside (ATR) causes selective proximal tubule injury, renal failure and death in humans. We have compared the effects of ATR in freshly isolated renal proximal tubules and glomeruli from rat and also in cell lines: NRK, derived from the proximal tubules, and ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050362
更新日期:1996-01-01 00:00:00
abstract::Using isolated rat hepatocytes the biochemical effects of hydrazine have been investigated using both conventional assay techniques and high resolution proton NMR. High resolution proton NMR revealed that hydrazine caused a significant increase in alanine and lactate levels in the incubation buffer, whereas levels of ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01981506
更新日期:1992-01-01 00:00:00
abstract::The aim of our study was to determine the period of maximum sensitivity for the induction of characteristic malformations with thalidomide (TH) in Himalayan rabbits. TH was administered orally in different doses (50, 100, 150 and 200 mg/kg) four times at 24-h intervals starting at 192 h of gestation. The malformations...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00295758
更新日期:1987-07-01 00:00:00
abstract::Recent work concerned with the mechanism underlying the development of organophosphorous compound-induced delayed neurotoxicity (OPIDN) is reviewed. Topics covered include the prophylaxis of OPIDN by phenylmethylsulfonyl fluoride and other agents, neurotoxic esterase (NTE) as measured using either labelled di-isopropy...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/BF00316365
更新日期:1989-01-01 00:00:00
abstract::Tributyltin (TBT) has been shown to disrupt the ability of natural killer (NK) cells to destroy tumor targets in vitro even at exposures of 25 nM for 24 h, but cell viability was not significantly impacted. Thus, evaluation of intracellular molecular events that regulate cell viability in TBT exposed NK cells are of i...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-006-0155-4
更新日期:2007-04-01 00:00:00
abstract::Rhabdomyolysis has been reported in patients who abuse synthetic cannabinoids. However, no studies have yet assessed whether these cases reflect the direct cytotoxicity of synthetic cannabinoids on skeletal muscle, a possibility that the present study sought to address. Specifically, this study investigated the cytoto...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-020-02944-7
更新日期:2020-11-10 00:00:00
abstract::The hypothesis that methylmercury (MeHg) potently induces formation of reactive oxygen species (ROS) in the brain is supported by observations on the neuroprotective effects of various classes of antioxidants. Flavonoids have been reported to possess divalent metal chelating properties, antioxidant activities and to r...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-009-0482-3
更新日期:2010-02-01 00:00:00