Abstract：
:Metabolism of isobutene (2-methylpropene) in rats (Sprague Dawley) and mice (B6C3F1) follows kinetics according to Michaelis-Menten. The maximal metabolic elimination rates are 340 mumol/kg/h for rats and 560 mumol/kg/h for mice. The atmospheric concentration at which Vmax/2 is reached is 1200 ppm for rats and 1800 ppm for mice. At steady state, below atmospheric concentrations of about 500 ppm the rate of metabolism of isobutene is direct proportional to its concentration. 1,1-Dimethyloxirane is formed as a primary reactive intermediate during metabolism of isobutene in rats and can be detected in the exhaled air of the animals. Under conditions of saturation of isobutene metabolism the concentration of 1,1-dimethyloxirane in the atmosphere of a closed exposure system is only about 1/15 of that observed for ethene oxide and about 1/100 of that observed for 1,2-epoxy-3-butene as intermediates in the metabolism of ethene or 1,3-butadiene.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Csanády GA,Freise D,Denk B,Filser JG,Cornet M,Rogiers V,Laib RJdoi
10.1007/BF02034934subject
Has Abstractpub_date
1991-01-01 00:00:00pages
100-5issue
2eissn
0340-5761issn
1432-0738journal_volume
65pub_type
杂志文章abstract：:Female wistar rats, conventional albino mice, and Chinese hamsters were given a single dose of acrylonitrile, 0.5 or 0.75 mM/kg body weight. The elimination in the urine of thiocyanate, which is the main metabolite of acrylonitrile, indicated a decreasing proportion of biotransformation after oral (over 20%), intraper...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00353240
更新日期：1975-02-14 00:00:00
abstract：:This study is aimed at exploring the possible mechanism of hypnosis-enhancing effect of HgS or cinnabar (a traditional Chinese medicine containing more than 95% HgS) in mice treated with pentobarbital. We also examined whether the effect of HgS is different from that of the well-known methyl mercury (MeHg). After a sh...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-007-0255-9
更新日期：2008-06-01 00:00:00
abstract：:Platinum coordination complexes (PtCx) are potent against several types of cancer but are often nephrotoxic. With a view to developing a PtCx nephrotoxicity model, the toxicity of cisplatin (cDDP), transplatin (tDDP) and carboplatin (CBDCA) was studied in primary cultures of rabbit proximal tubule (RPT) cells and in t...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973705
更新日期：1993-01-01 00:00:00
abstract：:The role of the functional substituents on the pyridinium ring of bisquaternary pyridinium compounds, mostly oximes, in exerting reversible and irreversible inhibition of binding of [3H]-N-methyl-4-piperidyl benzilate [( 3H]-4NMPB) to rat brain stem muscarinic receptors was studied. The drugs tested, i.e. HGG-42, HGG-...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00292614
更新日期：1985-10-01 00:00:00
abstract：:People living in damp buildings are typically exposed to spore and mycelial fragments of the fungi that grow on damp building materials. There is experimental evidence that this exposure to triple-helical (1, 3)-β-D glucan and low molecular weight toxins may be associated with non-atopic asthma observed in damp and mo...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1042-4
更新日期：2013-10-01 00:00:00
abstract：:Tacrolimus (FK506) and cyclosporin A (CsA) are two potent immunosuppressants mainly metabolized by hepatic cytochrome P-450 3A (CYP3A) monooxygenase. The aim of this study was to compare the toxic effects of the two drugs on hepatocytes in primary culture as a function of their metabolism and to explore the variations...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050499
更新日期：1998-04-01 00:00:00
abstract：:The present study was designed to compare the nephrotoxicity induced by the three platinum compounds cisplatin (CDDP), carboplatin (CBDCA) and transplatin (TDDP) in vitro and to obtain information to elucidate the mechanism of platinum compound-induced nephrotoxicity. Rat or rabbit renal cortical slices were incubated...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973462
更新日期：1990-01-01 00:00:00
abstract：:The first withdrawal of certain polybrominated diphenyl ethers flame retardants from the US market occurred in 2004. Since then, use of brominated non-PBDE compounds such as bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (BEH-TEBP) and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB) in commercial formulations has incr...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-015-1489-6
更新日期：2016-03-01 00:00:00
abstract：:To explain the mechanism of renal injury caused by liver ischemia-reperfusion, we investigated biochemical and morphological changes in the liver and kidney in rats. After reperfusion following 60 min of liver ischemia, numerous changes were found. The level of serum transaminases and lipid peroxide formation in the l...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01969922
更新日期：1993-01-01 00:00:00
abstract：:2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD) is known to influence vitamin A homeostasis. In order to investigate the mechanism behind this retinoid disruption, male Sprague-Dawley rats were exposed to TCDD at doses ranging from 0.1 to 100 micro g/kg body weight, and were killed 3 days after exposure. Additional groups...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0457-8
更新日期：2003-07-01 00:00:00
abstract：:The inhibitory effect and mechanism of action of nicotinamide to paraquat toxicity were studied in male Sprague-Dawley rats. Proteins of submitochondrial particles (SMP), especially of mol. wt. 25-30 kDa, in rat lungs were destroyed by paraquat radicals, and aggregated protein bands approximately 100 kDa were observed...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050437
更新日期：1997-01-01 00:00:00
abstract：:To investigate the effect of long term hashish use on T-lymphocytes we have measured the incorporation of 14C-thymidine by peripheral blood lymphocytes, unstimulated and stimulated by phytohemagglutinin, as well as the proportion and number of E-rosettes in 12 healthy male chronic users of the drug before and after a ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01891963
更新日期：1978-04-27 00:00:00
abstract：:Chronic ethanol consumption is a strong risk factor for the development of liver disease. Multiple mechanisms are involved in ethanol-mediated liver injury; oxidative stress being pointed has an important factor. However, it should be noted that moderate consumption of red wine has been associated with hepatoprotectiv...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-015-1538-1
更新日期：2015-10-01 00:00:00
abstract：:The object of this study was to compare the relative sensitivity of markers of exposure and effects in the lung of rats exposed to polymeric diphenyl-methane-4,4'-diisocyanate (pMDI) aerosol. Rats were repeatedly exposed to 12.9 mg pMDI/m(3) (6 h/day, 5 days/week for 14 days; exposure was from days 0--17 followed by a...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-001-0301-y
更新日期：2002-02-01 00:00:00
abstract：:Menadione is a naphthoquinone used as a vitamin K source in animal feed that can generate reactive oxygen species (ROS) and cause apoptosis. Here, we examined whether menadione reduces development of preimplantation bovine embryos in a ROS-dependent process and tested the hypothesis that actions of menadione would be ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-009-0458-3
更新日期：2009-11-01 00:00:00
abstract：:Previous studies in our laboratory identified retinoid-induced defects that are mediated by RAR-RXR heterodimerization using interaction of synthetic ligands selective for the retinoid receptors RAR and RXR in mice (Elmazar et al. 1997, Toxicol Appl Pharmacol 146:21-28; Elmazar et al. 2001, Toxicol Appl Pharmacol 170:...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-004-0586-8
更新日期：2004-11-01 00:00:00
abstract：:Zearalenone, a cereal mycotoxin with mycoestrogen activity and effect on fertility, is known to trigger apoptosis of a variety of nucleated cell types including hematopoietic progenitor cells. In analogy to apoptosis of nucleated cells, eryptosis, the suicidal death of erythrocytes, leads to cell shrinkage and cell me...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1037-1
更新日期：2013-10-01 00:00:00
abstract：:In anaesthetized and artificially ventilated rabbits an intravenous infusion of paraoxon (0.8 mg/kg) was given over 30 min. The effects on cardiac output, blood flow to various vascular beds, and on the mass discharge of the postganglionic sympathetic efferents to the spleen and kidney were monitored. Immediately foll...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00310857
更新日期：1982-09-01 00:00:00
abstract：:Natural and synthetic chemicals are often used in the fragrance industry. A toxicological profile of the synthetic fragrance booster, 4-cycloocten-1-carbaldehyde, was generated using a test program including the following methods: acute oral toxicity, acute dermal toxicity, acute skin and eye irritation, skin sensitiz...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-004-0596-6
更新日期：2004-12-01 00:00:00
abstract：:Liver disease is an escalating global health issue. While liver transplantation is an effective mode of therapy, patient mortality has increased due to the shortage of donor organs. Developing renewable sources of human liver tissue is therefore attractive. Pluripotent stem cell-derived liver tissue represents a poten...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2280-2
更新日期：2018-10-01 00:00:00
abstract：:The ethylene oxide adduct formed on the N-terminal valine in haemoglobin was investigated as a biological monitor of tobacco smoke intake. The modified method developed for the determination of the hydroxyethylvaline adduct (HOEtVal) involved reaction of globin with pentafluorophenyl isothiocyanate, extraction of the ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00332482
更新日期：1988-01-01 00:00:00
abstract：:Nucleotide excision repair (NER) is a versatile pathway that removes helix-distorting DNA lesions from the genomes of organisms across the evolutionary scale, from bacteria to humans. The serial steps in NER involve recognition of lesions, adducts or structures that disrupt the DNA double helix, removal of a short oli...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-016-1820-x
更新日期：2016-11-01 00:00:00
abstract：:Using the rat liver foci bioassay a dose-response relationship was evaluated for the promoting activity of the ubiquitous and persistent environmental pollutants polychlorinated biphenyls (PCBs) and chloroform. Initiation of liver foci was performed by oral administration of a single dose of 8 mg/kg body wt of diethyl...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00296982
更新日期：1987-01-01 00:00:00
abstract：:N-Methyl-2-pyrrolidone (NMP) is a versatile organic solvent frequently used for surface cleaning such as paint stripping or graffiti removal. Liquid NMP is rapidly absorbed through the skin but dermal vapour phase absorption might also play an important role for the uptake of the solvent. This particular aspect was in...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-007-0230-5
更新日期：2008-01-01 00:00:00
abstract：:Daily administration of 2g/kg/day di(2-ethylhexyl)phthalate (DEHP) to immature rats was found to cause testicular atrophy and reduce zinc concentration. Specific activities of testicular enzymes associated with postmeiotic spermatogenic cells, such as lactate dehydrogenase isozyme-X, hyaluronidase and sorbitol dehydro...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00290553
更新日期：1986-12-01 00:00:00
abstract：:Heat shock proteins (HSPs) are a group of proteins that are rapidly induced in response to physiological stress, including hyperthermia and exposure to toxicants. Thus they may provide a useful index of toxicity in in vitro systems for screening for toxicity. We have recently developed a rat nasal explant system for i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-004-0541-8
更新日期：2004-06-01 00:00:00
abstract：:The kinetic analysis of esterase inhibition by acylating compounds (organophosphorus carbamates and sulfonyl fluorides) is sometimes unable to yield consistent results by fitting simple inhibition kinetic models to experimental data of complex systems. In this work, kinetic data were obtained for phenylmethylsulfonyl ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-012-0817-3
更新日期：2012-05-01 00:00:00
abstract：:Doppler and M-mode echocardiography (EC) were used to investigate the effects of minoxidil on the cardiac function of the dog and potentially to clarify the pathogenesis of cardiac lesions, in particular the necrotic lesion in the left ventricle and the haemorrhagic lesion in the right atrium. Groups of three dogs wer...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0503-6
更新日期：2004-01-01 00:00:00
abstract：:The mycotoxin ochratoxin A (OTA) and its metabolite ochratoxin alpha (OT-alpha) were investigated, to examine their potency to induce sister chromatid exchanges (SCE) in cultured porcine urinary bladder epithelial cells (PUBEC) (primary culture). Serum-free cultured PUBEC were incubated for 5 h with either OTA or OT-a...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050171
更新日期：1995-01-01 00:00:00
abstract：:Carbon tetrachloride (CCl4) caused a dose-dependent increase in urinary taurine which correlated with both the histological and biochemical assessment of liver damage. The peak elevation in urinary taurine occurred within the first 48 h after dosing but there was still significant taurinuria 72 and 96 h after the inte...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973715
更新日期：1991-01-01 00:00:00
