Nephrotoxicity of cisplatin, carboplatin and transplatin. A comparative in vitro study.

abstract：:This study investigated whether paraquat (Pq)-induced lipidic peroxidation (LP) is accompanied by changes in blood pressure and heart rate (HR) in rats. Groups of adult male Wistar rats were studied 2 and 12 h after Pq (35 mg/kg, i.p.) administration. The LP was evaluated by monitoring thiobarbituric acid reactive sub...

journal_title：Archives of toxicology

authors： Oliveira MV,Albuquerque JA,Paixão AD,Guedes LS,Cabral AM

更新日期：2005-09-01 00:00:00

abstract：:The efficacy of oxime (HI-6, toxogonin or PAM Cl) therapy against GF (cyclohexyl methylphosphonofluoridate) poisoning was assessed in mice. It was found that the combinations of atropine and either toxogonin or HI-6 were effective therapies against GF poisoning. PAM therapy was ineffective. HI-6 was the only oxime whi...

journal_title：Archives of toxicology

authors： Clement JG

更新日期：1992-01-01 00:00:00

abstract：:The lacrimatory agent CS was examined for genotoxic properties. In vitro, Salmonella typhimurium was exposed to CS at concentrations up to 1.5 mg per plate and reverse mutations were assayed. In vivo: male Drosophilae were fed with CS and sex-linked recessive lethal mutations in sperm cells were assayed using the Basc...

journal_title：Archives of toxicology

authors： Wild D,Eckhardt K,Harnasch D,King MT

更新日期：1983-10-01 00:00:00

abstract：:Cadmium chloride was administered by gavage to female rats 5 days a week for 5 weeks, then during mating and gestation periods at doses of 0.04, 0.4, and 4 mg Cd/kg/day. Treatment with cadmium neither affected the survival and fertility of females, nor produced overt fetotoxic effects. Fetal cadmium concentration was ...

journal_title：Archives of toxicology

authors： Barański B,Stetkiewicz I,Sitarek K,Szymczak W

更新日期：1983-12-01 00:00:00

abstract：:Initially, mice were pretreated with atropine (17.4 mg/kg; IP) and the oxime reactivator HI-6 (50 mg/kg; IP) 5 min prior to an injection of soman (287 micrograms/kg, SC); approximately 2.1 x LD50 dose). More than 95% of the mice survived this dose of soman with atropine and HI-6 pretreatment. In these survivors of som...

journal_title：Archives of toxicology

authors： Clement JG

更新日期：1989-01-01 00:00:00

abstract：:A new class of potent anticancer drugs, alkylphosphocholines has been recognized lately. Miltefosine (Hexadecylphosphochlorine, HPC) has been found to express select antineoplastic effect on human breast cancer skin metastases with simultaneous preservation of bone marrow proliferative activity and low clastogenicity....

journal_title：Archives of toxicology

authors： Martinova Y,Topashka-Ancheva M,Konstantinov S,Petkova S,Karaivanova M,Berger M

更新日期：2006-01-01 00:00:00

abstract：:As part of a study on cadmium nephrotoxicity, we studied the effect of cadmium chloride (CdCl2) in isolated human renal proximal tubules metabolizing the physiological substrate lactate. Dose-effect experiments showed that 10-500 μM CdCl2 reduced lactate removal, glucose production and the cellular levels of ATP, coen...

journal_title：Archives of toxicology

authors： Faiz H,Conjard-Duplany A,Boghossian M,Martin G,Baverel G,Ferrier B

更新日期：2011-09-01 00:00:00

abstract：:Recently, acutely toxic doses of the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been reported to affect the hepatic distribution of essential metals in the rat. However, the reduced food intake by TCDD was not taken into account. Therefore, metal concentrations were determined in different...

journal_title：Archives of toxicology

authors： Elsenhans B,Forth W,Richter E

更新日期：1991-01-01 00:00:00

abstract：:Tea (Camellia sinensis, Theaceace), a popular beverage consumed world-wide, has been studied for its preventive effects against cancer as well as cardiovascular, neurodegenerative, and other diseases. Most of the proposed beneficial effects have been attributed to the polyphenolic compounds in tea, but the nature of t...

journal_title：Archives of toxicology

authors： Yang CS,Lambert JD,Sang S

更新日期：2009-01-01 00:00:00

abstract：:The effect of pretreatment with SKF-525A, which inhibits hepatic cytochrome P450 enzymes, on metabolism and hepatotoxicity was examined in mice orally administered tributyltin chloride (TBTC) or dibutyltin dichloride (DBTC) at a dose of 180 mumol/kg. Analysis of butyltin compounds showed that the main metabolites in l...

journal_title：Archives of toxicology

authors： Ueno S,Suzuki T,Susa N,Furukawa Y,Sugiyama M

更新日期：1997-01-01 00:00:00

abstract：:5-Hydroxymethylfurfural (HMF) and furfuryl alcohol (FFA) are moderately potent rodent carcinogens that are present in thermally processed foodstuffs. The carcinogenic effects were hypothesized to originate from sulfotransferase (SULT)-mediated bioactivation yielding DNA-reactive and mutagenic sulfate esters, a confirm...

journal_title：Archives of toxicology

authors： Sachse B,Meinl W,Sommer Y,Glatt H,Seidel A,Monien BH

更新日期：2016-01-01 00:00:00

abstract：:A number of industrial chemicals and therapeutic agents cause liver tumors in rats and mice by activating the nuclear receptor peroxisome proliferator-activated receptor α (PPARα). The molecular and cellular events by which PPARα activators induce rodent hepatocarcinogenesis have been extensively studied elucidating a...

journal_title：Archives of toxicology

authors： Corton JC,Peters JM,Klaunig JE

更新日期：2018-01-01 00:00:00

abstract：:A wide variety of immunosuppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in experimental animals has been documented. In contrast, the impact of dioxin on the human immune system remains controversial, although adverse health effects have been reported in humans after occupational or accidental exposu...

journal_title：Archives of toxicology

authors： Lang DS,Becker S,Clark GC,Devlin RB,Koren HS

更新日期：1994-01-01 00:00:00

abstract：:With the development of nanotechnologies, the potential adverse effects of nanomaterials such as multi-walled carbon nanotubes (MWCNT) on the respiratory tract of asthmatics are questioned. Furthermore, investigations are necessary to understand how these effects might arise. In the present study, we hypothesized that...

journal_title：Archives of toxicology

authors： Ronzani C,Casset A,Pons F

更新日期：2014-02-01 00:00:00

abstract：:203Pb(NO3)2 was administered i.v. to pregnant C57BL mice at different stages, from day 8 to day 18 of gestation. The whole animals or excised uteri were subjected to autoradiography or were autopsied for scintillation counting of excised organs. Lead appeared in embryonic and fetal tissues at all stages of gestation. ...

journal_title：Archives of toxicology

authors： Danielsson BR,Dencker L,Lindgren A

更新日期：1983-10-01 00:00:00

abstract：:Hydrogen sulfide (H2S), the third gasotransmitter, has been shown to act as a neuroprotective factor in numerous pathological processes; however, its underlying mechanism(s) of action remain unclear. It is widely accepted that activation of moderate autophagy and the Nrf2/ARE signaling pathway play important roles in ...

journal_title：Archives of toxicology

authors： Yang B,Bai Y,Yin C,Qian H,Xing G,Wang S,Li F,Bian J,Aschner M,Lu R

更新日期：2018-06-01 00:00:00

abstract：:Quercetin (QC), a polyphenolic compound widely distributed in fruits and vegetables has recently gained interest due to its cisplatin (CP) sensitizing properties in cancer cells. It is currently unknown, whether quercetin also increases the susceptibility of the kidneys to cisplatin toxicity. We studied the effects of...

journal_title：Archives of toxicology

authors： Kuhlmann MK,Horsch E,Burkhardt G,Wagner M,Köhler H

更新日期：1998-07-01 00:00:00

abstract：:Cocaine is an intrinsic hepatotoxin in laboratory animals, and there is growing evidence that high doses of cocaine can precipitate hepatic necrosis in humans. The rodent model of cocaine hepatotoxicity is commensurate with the concept that a multistep mainly cytochrome P-450 dependent N-oxidative pathway is responsib...

journal_title：Archives of toxicology

authors： Boelsterli UA,Göldlin C

更新日期：1991-01-01 00:00:00

abstract：:Cadmium (Cd), a highly toxic heavy metal, is distributed widely in the general environment of today. The characteristic clinical manifestations of chronic Cd intoxication include renal proximal tubular dysfunction, general osteomalacia with severe pains, and anemia. We have recently reported that the serum level of er...

journal_title：Archives of toxicology

authors： Horiguchi H,Sato M,Konno N,Fukushima M

更新日期：1996-01-01 00:00:00

abstract：:Chemical formation of dichlorvos (2, 2-dichlorovinyl dimethyl phosphate) was found to occur in mouse brain after i.p. injection of metrifonate (2, 2, 2-trichloro-1-hydroxyethyl dimethyl phosphonate). A mass fragmentographic technique was used. Different isotopic variants were used both as internal standards and to com...

journal_title：Archives of toxicology

authors： Nordgren I,Bergström M,Holmstedt B,Sandoz M

更新日期：1978-10-13 00:00:00

abstract：:Epoxide hydrolases (EH) are ubiquitously expressed in all living organisms and in almost all organs and tissues. They are mainly subdivided into microsomal and soluble EH and catalyze the hydration of epoxides, three-membered-cyclic ethers, to their corresponding dihydrodiols. Owning to the high chemical reactivity of...

journal_title：Archives of toxicology

authors： El-Sherbeni AA,El-Kadi AO

更新日期：2014-11-01 00:00:00

abstract：:Some nucleoside analogues are used to treat herpes simplex and other viral infections. They are known to impair spermatogenesis, but published data are scarce. We studied the effects of four nucleosides on SerW3 cells, a rat Sertoli cell line. Cells were cultured for 3 days in DMEM supplemented with four different con...

journal_title：Archives of toxicology

authors： Qiu R,Horvath A,Stahlmann R

更新日期：2016-08-01 00:00:00

abstract：:The ultimate purpose of the present study was to evaluate correlations between acute in vivo and in vitro toxicity and log P (P is n-octanol-water partition coefficient). The in vitro toxicity to cloned cells (neuroblastoma N18TG-2 and glioma C6) in culture (ED50) and the in vivo toxicity to mice (LD50) of ethylene gl...

journal_title：Archives of toxicology

authors： Tanii H,Saito S,Hashimoto K

更新日期：1992-01-01 00:00:00

abstract：:Several aromatic amines (AAs) are known to be carcinogens for humans. AAs are considered to be substantially absorbed through the skin. However, the database for dermal absorption of AAs in general is limited and no specific studies on dermal absorption of beta-naphthylamine (BNA) and o-toluidine (OT) have been publis...

journal_title：Archives of toxicology

authors： Lüersen L,Wellner T,Koch HM,Angerer J,Drexler H,Korinth G

更新日期：2006-10-01 00:00:00

abstract：:Male F344/DuCrj (Fischer) rats were given bisphenol A (BPA) in the diet at levels of 0 (control), 0.25, 0.50 and 1.00%, equivalent to 0, 235, 466 and 950 mg/kg per day, respectively, for 44 days. Body weight gains were depressed dose-dependently in BPA-treated rats, and those of 0.50 and 1.00% groups were significant....

journal_title：Archives of toxicology

authors： Takahashi O,Oishi S

更新日期：2001-03-01 00:00:00

abstract：:This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocytes and 20 % non-parenchymal cells, the latter being involved in a seco...

journal_title：Archives of toxicology

authors： Godoy P,Hewitt NJ,Albrecht U,Andersen ME,Ansari N,Bhattacharya S,Bode JG,Bolleyn J,Borner C,Böttger J,Braeuning A,Budinsky RA,Burkhardt B,Cameron NR,Camussi G,Cho CS,Choi YJ,Craig Rowlands J,Dahmen U,Damm G,Dirsch

更新日期：2013-08-01 00:00:00

abstract：:To investigate possible persistent nephrotoxic effects of trichloroethylene (TRI), a retrospective study was carried out on 39 workers exposed to high levels of TRI from 1956 to 1975. Total protein levels in urine, as well as serum and urine creatinine and serum urea were unchanged in comparison with the control. Sodi...

journal_title：Archives of toxicology

authors： Brüning T,Sundberg AG,Birner G,Lammert M,Bolt HM,Appelkvist EL,Nilsson R,Dallner G

更新日期：1999-06-01 00:00:00

abstract：:The urinary and faecal excretion of chrysene and its phenolic metabolites after oral, intraperitoneal, intratracheal, and intrapulmonary administration to rats have been studied by means of gas chromatography/mass spectrometry. The metabolite profile was found to depend on the mode of excretion and on the route of adm...

journal_title：Archives of toxicology

authors： Grimmer G,Brune H,Dettbarn G,Heinrich U,Jacob J,Mohtashamipur E,Norpoth K,Pott F,Wenzel-Hartung R

更新日期：1988-01-01 00:00:00

abstract：:Vitamin E acetate (VEA) has come under significant scrutiny due to its association with e-cigarette, or vaping, product use-associated lung injury (EVALI). In 1965, Sir Austin Bradford Hill proposed a set of criteria used to critically assess an association for causality. In this article, we apply the Bradford Hill ca...

journal_title：Archives of toxicology

authors： Feldman R,Meiman J,Stanton M,Gummin DD

更新日期：2020-06-01 00:00:00

abstract：:The toxicity of 60 micrograms/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) given IP in corn oil/5% acetone was examined in male Sprague-Dawley rats adapted to 25 degrees C or 4 degrees C ambient temperature. Cold exposure significantly reduced mean time to death and tended to increase mortality. Body weight at the ti...

journal_title：Archives of toxicology

authors： Rozman K,Greim H

更新日期：1986-12-01 00:00:00