Abstract：
:Recently, acutely toxic doses of the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been reported to affect the hepatic distribution of essential metals in the rat. However, the reduced food intake by TCDD was not taken into account. Therefore, metal concentrations were determined in different rat tissues at the end of a toxicity study with TCDD in which a pair-fed control group was introduced. Male Sprague-Dawley rats received a single i.p. injection of corn oil/acetone with or without TCDD at 125 micrograms/kg. Controls and TCDD-treated rats were fed ad libitum; additionally, pair-fed controls received the amount of food consumed by their TCDD-treated partners 1 day before. Twenty-one days after dosing rats were killed and samples of liver, kidney and jejunum were taken for the analysis of Ca, Cu, Fe, Mg, Mn, and Zn. After acid digestion of the tissues metals were determined by atomic emission spectrometry (AES). The most outstanding effect of TCDD treatment was an increase of the copper levels in the kidney (4-fold, versus pair-fed controls) and in the liver (greater than 2-fold, versus pair-fed controls). Other metals were mainly affected by the reduced food intake only. Since Cu represents a trace metal the homeostasis of which depends on its biliary excretion and since TCDD is known to impair biliary flow and excretion, an impaired biliary excretion of Cu by TCDD is suggested as the causal mechanism.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Elsenhans B,Forth W,Richter Edoi
10.1007/BF02284268subject
Has Abstractpub_date
1991-01-01 00:00:00pages
429-32issue
5eissn
0340-5761issn
1432-0738journal_volume
65pub_type
杂志文章abstract：:The influence of haemoperfusion on some immunological parameters was investigated in a pilot study involving two groups of three patients each. In columns containing cellulose-coated activated charcoal or polystyrene resin a temporary reduction of the total white cell number, particularly involving the segmented and b...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00354774
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journal_title：Archives of toxicology
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00361252
更新日期：1980-11-01 00:00:00
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doi：10.1007/s00204-014-1421-5
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doi：10.1007/s00204-003-0503-6
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00332493
更新日期：1988-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
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更新日期：1987-02-01 00:00:00
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journal_title：Archives of toxicology
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更新日期：1975-10-20 00:00:00
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更新日期：2000-11-01 00:00:00
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更新日期：1983-03-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
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更新日期：1996-01-01 00:00:00
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更新日期：1998-02-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
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更新日期：1982-07-01 00:00:00
abstract：: ...
journal_title：Archives of toxicology
pub_type： 评论,信件
doi：10.1007/s00204-018-2310-0
更新日期：2018-11-01 00:00:00
abstract：:The treatment of poisoning by highly toxic organophosphorus compounds (nerve agents) is unsatisfactory. Until now, the efficacy of new potential antidotes has primarily been evaluated in animals. However, the extrapolation of these results to humans is hampered by species differences. Since oximes are believed to act ...
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pub_type： 杂志文章
doi：10.1007/s002040050495
更新日期：1998-03-01 00:00:00
