Abstract:
:Pregnant mice administered per os during the days 1--3 (plug day = day 0) post conception (p.c.) with 375 mg 2,2'-dichlorobiphenyl/kilograms/day revealed on day 18 p.c. increased number of resorptions and doses up from 500 milligrams/kilograms/day led to a substantial retardation of the prenatal development. Based on the investigations during the early development it is concluded, that retardation of the fetus is caused by a delayed implantation. It is assumed, that increased resorption is due to kyematopathies detected during the periimplantation period.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Török Pdoi
10.1007/BF00310329keywords:
subject
Has Abstractpub_date
1978-08-09 00:00:00pages
249-54issue
4eissn
0340-5761issn
1432-0738journal_volume
40pub_type
杂志文章abstract::Blooms of cyanobacteria have been documented throughout history, all over the world. Mass populations of these organisms typically present hazards to human health and are known for the production of a wide range of highly toxic metabolites-cyanotoxins, of which among the most common and most investigated are the micro...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1921-6
更新日期:2017-02-01 00:00:00
abstract::The trichothecene mycotoxin deoxynivalenol (DON) is produced in wheat, barley and corn following infestation by the fungus Fusarium in the field and during storage. Colloquially known as "vomitoxin" because of its emetic effects in pigs, DON has been associated with human gastroenteritis. Since DON is commonly detecte...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-010-0579-8
更新日期:2010-09-01 00:00:00
abstract::Epoxide hydrolases (EH) are ubiquitously expressed in all living organisms and in almost all organs and tissues. They are mainly subdivided into microsomal and soluble EH and catalyze the hydration of epoxides, three-membered-cyclic ethers, to their corresponding dihydrodiols. Owning to the high chemical reactivity of...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-014-1371-y
更新日期:2014-11-01 00:00:00
abstract::Tributyltin (TBT) has been shown to disrupt the ability of natural killer (NK) cells to destroy tumor targets in vitro even at exposures of 25 nM for 24 h, but cell viability was not significantly impacted. Thus, evaluation of intracellular molecular events that regulate cell viability in TBT exposed NK cells are of i...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-006-0155-4
更新日期:2007-04-01 00:00:00
abstract::MDMA-induced impairments of memory performance have been reported in different human and animal studies. However, the correlation between spatial memory impairment, brain mitochondrial function, and concentrations of MDMA and its metabolites has not yet been investigated despite it being needed for comparison with hum...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-020-02673-x
更新日期:2020-03-01 00:00:00
abstract::Nine bispyridinium oximes containing two pyridinium rings linked by dimethylether were synthesised. Each compound had on one of the pyridinium rings a hydroxyiminomethyl group in position 2 or 4, while the other ring was unsubstituted or had a methyl or a hydroxyiminomethyl group in position 2 or 4. The reactivating p...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00296900
更新日期:1979-02-23 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-020-02691-9
更新日期:2020-04-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01973712
更新日期:1991-01-01 00:00:00
abstract::Rats were administered a sublethal dose of thallium (12.35 mg/kg as aqueous thallous sulfate, Tl2SO4, equivalent to 10 mg Tl+/kg per os) on day 0. Urine and feces were collected separately every day for 8 days and analyzed by atomic absorption spectroscopy. Based on information in the literature, five antidotal treatm...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00286576
更新日期:1985-04-01 00:00:00
abstract::We investigated the hepatotoxicity induced by AQ using a glutathione (GSH)-depleted mice model. Although sole administration of either AQ or L-buthionine-S,R-sulfoxinine (BSO), a well-known GSH synthesis inhibitor, produced no significant hepatotoxicity, combined administration of AQ with BSO induced hepatotoxicity ch...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-009-0436-9
更新日期:2009-07-01 00:00:00
abstract::Sulfur mustard (SM) is a highly toxic war chemical that causes significant morbidity and mortality and lacks any effective therapy. Rats exposed to aerosolized CEES (2-chloroethyl ethyl sulfide; 10% in ethanol), an analog of SM, developed acute respiratory distress syndrome (ARDS), which is characterized by increased ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-020-02699-1
更新日期:2020-04-01 00:00:00
abstract::Changes in the urinary excretion of hippuric acid (HIA) and phenaceturic acid (PUA) as well as their metabolic precursors, i.e. benzoic (BA) and phenylacetic acid (PAA), in rats housed in glass metabolic cages for 4 days were monitored using gas-liquid chromatography. The amount of HIA excreted was 128 +/- 63 mumol/kg...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00324554
更新日期:1987-01-01 00:00:00
abstract::This study was conducted to determine the functional role of phospholipase D (PLD) involved in testicular Leydig cell damage caused by di (2-ethylhexyl) phthalate (DEHP) in Sprague-Dawley rats. DEHP (500 mg/kg/day) was administered orally to prepubertal rats for 1, 7, 14, 21 or 28 days. After 7 days of exposure, DEHP ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-010-0618-5
更新日期:2011-08-01 00:00:00
abstract::Delta 9-THC at the dose of 1 mg/kg/die was administered subcutaneously in growing rats, from the second to the 30th day of life. A statistically significant myeloid hyperplasia was demonstrated, which persisted up to 4 months after the end of the treatment, together with significant blood granulocytosis. ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00353318
更新日期:1975-10-20 00:00:00
abstract::In this review, we introduce a new concept, precision toxicology: the mode of action of chemical- or drug-induced toxicity can be sensitively and specifically investigated by isolating a small group of cells or even a single cell with typical phenotype of interest followed by a single cell sequencing-based analysis. P...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-017-1971-4
更新日期:2017-07-01 00:00:00
abstract::In female rats dosed orally with 14C-hexachlorobenzene the extent of intestinal absorption of carbon-14 has been found to be dependent on the form of application. When the substance was given as a solution in oil about 80% of the dose administered was absorbed, but when given as an aqueous suspension only 6%. In anima...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00353283
更新日期:1975-11-20 00:00:00
abstract::Reduced gluconeogenesis due to decreased activity of key gluconeogenic enzymes in liver, together with feed refusal, has been suggested to play an important role in 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-induced lethality in rats. This study was carried out to further analyse the toxicological significance of red...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050626
更新日期:1999-08-01 00:00:00
abstract::Female wistar rats, conventional albino mice, and Chinese hamsters were given a single dose of acrylonitrile, 0.5 or 0.75 mM/kg body weight. The elimination in the urine of thiocyanate, which is the main metabolite of acrylonitrile, indicated a decreasing proportion of biotransformation after oral (over 20%), intraper...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00353240
更新日期:1975-02-14 00:00:00
abstract::Rats were exposed to nickel sulfate (NiSO4) either by intratracheal (IT) instillation or by acute aerosol inhalation, and pulmonary clearance of Ni and pulmonary inflammatory responses were studied. The half-time of Ni in the lung (initial lung burden = 50 micrograms Ni/rat) was about 32 h in both the IT instillation ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050112
更新日期:1994-01-01 00:00:00
abstract::2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD) is known to influence vitamin A homeostasis. In order to investigate the mechanism behind this retinoid disruption, male Sprague-Dawley rats were exposed to TCDD at doses ranging from 0.1 to 100 micro g/kg body weight, and were killed 3 days after exposure. Additional groups...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-003-0457-8
更新日期:2003-07-01 00:00:00
abstract::Metabolism of isobutene (2-methylpropene) in rats (Sprague Dawley) and mice (B6C3F1) follows kinetics according to Michaelis-Menten. The maximal metabolic elimination rates are 340 mumol/kg/h for rats and 560 mumol/kg/h for mice. The atmospheric concentration at which Vmax/2 is reached is 1200 ppm for rats and 1800 pp...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF02034934
更新日期:1991-01-01 00:00:00
abstract::Emerging mycotoxins produced by Alternaria spp. were previously reported to exert cytotoxic, genotoxic, but also estrogenic effects in human cells. The involved mechanisms are very complex and not fully elucidated yet. Thus, we followed an in silico target fishing approach to extend knowledge on the possible biologica...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-020-02746-x
更新日期:2020-06-01 00:00:00
abstract::N-methyl-D-aspartate (NMDA) and non-NMDA receptors were found to be involved in development of functional disorders caused by hexachlorophene. In order to specify the role of glutamate receptors we studied the protective effects of the selective antagonist of the kainate/(+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050011
更新日期:2000-01-01 00:00:00
abstract::Cisplatin and its derivatives are widely used chemotherapeutic drugs for cancer treatment. However, they have debilitating side effects in normal tissues and induce ototoxicity, neurotoxicity, and nephrotoxicity. In kidneys, cisplatin preferentially accumulates in renal tubular cells causing tubular cell injury and de...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-015-1633-3
更新日期:2015-12-01 00:00:00
abstract::To evaluate the developmental neurotoxicity of arsenic in offspring rats by transplacental and early life exposure to sodium arsenite in drinking water, the pregnant rats or lactating dams, and weaned pups were given free access to drinking water, which contained arsenic at concentrations of 0, 10, 50, 100 mg/L from G...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-009-0403-5
更新日期:2009-06-01 00:00:00
abstract::Liquorice [main ingredient, glycyrrhizin (GL)] is widely used as a food sweetener and herbal medicine. Occasionally, liquorice consumption causes pseudoaldosteronism as a side effect which causes oedema, hypokalaemia, and hypertension due to hyperactivity of mineral corticoid receptor. We aimed to detect GL metabolite...
journal_title:Archives of toxicology
pub_type: 杂志文章,meta分析
doi:10.1007/s00204-019-02588-2
更新日期:2019-11-01 00:00:00
abstract::The effect of dental composite components triethyleneglycoldimethacrylate (TEGDMA) and hydroxyethylmethacrylate (HEMA) as well as mercuric chloride (HgCl(2)) and methylmercury chloride (MeHgCl) on gluconeogenesis was investigated in isolated rat kidney tubules. From starved rats kidney tubules were prepared and isolat...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050677
更新日期:1999-09-01 00:00:00
abstract::The evaluation of developmental and reproductive toxicity of food contact materials (FCMs) is an important task for food safety. Since traditional experiments are both time-consuming and labor-intensive, only a small number of FCMs have sufficient toxicological data for evaluating their effects on human health. While ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02641-0
更新日期:2020-02-01 00:00:00
abstract::Chronic ciprofibrate administration resulted in distinct differences in hepatic responses between the two species examined. In the rat, hepatomegaly was observed with the coordinate induction of carnitine acetyltransferase, peroxisomal beta-oxidation and cytochrome P450IVA1 activities. The latter induction of cytochro...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF02034935
更新日期:1991-01-01 00:00:00
abstract::Carbon tetrachloride-induced liver injury is a thoroughly studied model for regeneration and fibrosis in rodents. Nevertheless, its pattern of liver fibrosis is frequently misinterpreted as portal type. To clarify this, we show that collagen type IV+ "streets" and α-SMA+ cells accumulate pericentrally and extend to ne...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2040-8
更新日期:2017-11-01 00:00:00