Abstract：
:DNA damage induced by methylmethane sulfonate, cyclophosphamide, doxorubicin and procarbazine in male germ cells was assessed in rabbits by the demonstration of unscheduled DNA synthesis (UDS), in meiotic and postmeiotic phases of maturation. Immediately after treatment by the intravenous route tritiated thymidine was injected into both testicles. Subsequently, rabbits were ejaculated serially, sperm heads were isolated and assayed for radioactivity by liquid scintillation counting. Dose-dependent UDS was demonstrated in late spermatocytes and early spermatids. High doses of hycanthone also induced UDS, but isoniazid and metronidazole had no effect. The rabbit testis UDS test takes into account metabolic and pharmacokinetic aspects of the test substances and provides information about their penetration through the blood-testicular barrier. It is therefore useful for secondary evaluation of potential mutagens. UDS induced by procarbazine was abolished by simultaneous treatment with Ara-C. Thus, the test also recognizes substances that inhibit DNA repair synthesis.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Zbinden Gdoi
10.1007/BF00361252subject
Has Abstractpub_date
1980-11-01 00:00:00pages
139-49issue
1-2eissn
0340-5761issn
1432-0738journal_volume
46pub_type
杂志文章abstract：:The goal of the present study was to obtain an in vivo relevant prioritization method for the endocrine potencies of different polycarbonate monomers, by combining in vitro bioassay data with physiologically based kinetic (PBK) modelling. PBK models were developed for a selection of monomers, including bisphenol A (BP...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02479-6
更新日期：2019-07-01 00:00:00
abstract：:The effect of acetone pretreatment (5% in drinking water for 10 days on rat liver metabolism and toxicity of thiobenzamide (TB) was investigated. Hepatic microsomes from acetone-pretreated rats showed a significant increase of TB-S-oxidation rate which, on the basis of selective thermal inactivation of FAD-containing ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01974397
更新日期：1990-01-01 00:00:00
abstract：:Exposure to particulate matter (PM) has been related to the onset of adverse health effects including lung cancer, but the underlying molecular mechanisms are still under investigation. Epithelial-to-mesenchymal transition (EMT) is regarded as a crucial step in cancer progression. In a previous study, we reported EMT-...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2259-z
更新日期：2018-09-01 00:00:00
abstract：:The mycotoxin ochratoxin A (OTA) and its metabolite ochratoxin alpha (OT-alpha) were investigated, to examine their potency to induce sister chromatid exchanges (SCE) in cultured porcine urinary bladder epithelial cells (PUBEC) (primary culture). Serum-free cultured PUBEC were incubated for 5 h with either OTA or OT-a...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050171
更新日期：1995-01-01 00:00:00
abstract：:Chlorpyrifos (CPF) is a widely used organophosphorus pesticide. Earlier work from our laboratory and others has demonstrated that the sensitivity to CPF exposure changes markedly during maturation. A number of studies suggest that in addition to inhibiting acetylcholinesterase (AChE), CPF oxon may also interact direct...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-001-0309-3
更新日期：2002-01-01 00:00:00
abstract：:Acetaminophen (APAP) is a widely-used analgesic and a known hepatotoxic agent. Vascular endothelial growth factor (VEGF) is a growth factor with multiple functional roles. VEGF plays an important role in angiogenesis and hepatic regeneration. The aim of this study was to determine the expression of VEGF isoforms and i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-007-0201-x
更新日期：2007-10-01 00:00:00
abstract：:Epoxide hydrolases (EH) are ubiquitously expressed in all living organisms and in almost all organs and tissues. They are mainly subdivided into microsomal and soluble EH and catalyze the hydration of epoxides, three-membered-cyclic ethers, to their corresponding dihydrodiols. Owning to the high chemical reactivity of...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-014-1371-y
更新日期：2014-11-01 00:00:00
abstract：:Most dietary flavonoids have antioxidant activity in vitro however, secondary mechanisms such as the ability to influence gene expression with the consequent modulation of specific enzymatic activities involved in the intracellular response against oxidative stress, are being realized. In the following study, we exami...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-007-0210-9
更新日期：2007-11-01 00:00:00
abstract：:Intake of inorganic arsenic is known to cause vascular diseases as well as skin lesions and cancer in humans. We investigated the differences in cytotoxicity, uptake rate of arsenic, and gene expression of antioxidative enzymes between arsenite (As(3+))- and arsenate (As(5+))-exposed rat heart microvessel endothelial ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0447-x
更新日期：2003-06-01 00:00:00
abstract：:Phenobarbital pretreatment (50 mg/kg/day for 3 days orally) of male Wistar rats increased Vmax of benzene in vitro hepatic microsomal biotransformation about 6-fold without changing Km. However, benzene blood levels after oral, intraperitoneal, or subcutaneous benzene administration (3-3.5 mmoles/kg) were not influenc...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00293567
更新日期：1976-06-08 00:00:00
abstract：:The present study has investigated the ability of amitraz, a widely used formamidine pesticide, to modulate serum concentrations and liver microsomal metabolism of 17beta-estradiol (E2) and testosterone in rats. Amitraz was administered intraperitoneally to male rats for 4 days and to intact female rats or ovariectomi...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-008-0288-8
更新日期：2008-10-01 00:00:00
abstract：:Phytoestrogens have been described as weak estrogens, selective estrogen receptor mediators (SERMs) or to exhibit antiestrogenic properties. However, information about their activity in combination with xenoestrogens and 17beta-estradiol in vivo, is limited. Therefore, the combinatory activity of the phytoestrogen gen...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0102-4
更新日期：2006-12-01 00:00:00
abstract：:Many carcinogens and mutagens are electrophilic in nature and will react with nucleophilic sites in protein and nucleic acid. Determination of the extent of formation of these adducts of genotoxic agents with protein provides a practical method of monitoring human exposure and of determining the possible risk associat...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00296978
更新日期：1987-01-01 00:00:00
abstract：:The reversibility of quinolone-induced cartilage lesions has not been studied in detail. We treated five groups of five to seven juvenile Wistar rats (male and female; age: 5 weeks) with 2 x 600 mg ofloxacin/kg by gastric intubation on 1 day only (9:00 a.m. and 5:00 p.m.) and studied the knee joints histologically 3 d...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050301
更新日期：1996-01-01 00:00:00
abstract：:2C (2C-x) is the general name for the family of phenethylamines containing two methoxy groups at the 2 and 5 positions of the benzene ring. The abuse of 2C family drugs has grown rapidly, although the abuse potential and neurotoxic properties of 2C drugs have not yet been fully investigated. In this study, we investig...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-021-02980-x
更新日期：2021-01-30 00:00:00
abstract：:A new strategy for the evaluation of mixtures is presented. The mixture used was the organic extract of diesel exhaust particles (DEP). After extraction with dichloromethane (DCM), the crude extract was fractionated according to polarity into five fractions: aliphatic hydrocarbons, polycyclic aromatic hydrocarbons (PA...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050392
更新日期：1997-01-01 00:00:00
abstract：:This is with reference to the note of the Editor-in-Chief of the Archives of Toxicology. ...
journal_title：Archives of toxicology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00204-018-2221-0
更新日期：2018-07-01 00:00:00
abstract：:Adverse outcome pathways (AOPs) have been recently introduced as tools to map the mechanisms underlying toxic events relevant for chemical risk assessment. AOPs particularly depict the linkage between a molecular initiating event and an adverse outcome through a number of intermediate key events. An AOP has been previ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02691-9
更新日期：2020-04-01 00:00:00
abstract：:As part of a study on cadmium nephrotoxicity, we studied the effect of cadmium chloride (CdCl2) in isolated human renal proximal tubules metabolizing the physiological substrate lactate. Dose-effect experiments showed that 10-500 μM CdCl2 reduced lactate removal, glucose production and the cellular levels of ATP, coen...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-010-0633-6
更新日期：2011-09-01 00:00:00
abstract：:Regarding the potential impact of traffic-born air pollutants on public health, in recent years attention has increasingly been focused on the possible effects on the cardiovascular system. In order to investigate this problem further, the influence of long-term exhaust gas exposure on rats has been studied. One hundr...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00332390
更新日期：1981-07-01 00:00:00
abstract：:The acute toxicity of cyanide is determined by its peak levels reached in the body. Compared to the ingestion of free cyanide, lower peak levels may be expected after consumption of foods containing cyanogenic glycosides with the same equivalent dose of cyanide. This is due to possible delayed and/or incomplete releas...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-015-1479-8
更新日期：2016-03-01 00:00:00
abstract：:Monolayers of L6 rat skeletal myoblast cells formed surface binding isotherms with the purified tobacco leaf glycoprotein TGP1 and the enriched cigarette tar glycoprotein TGP2. Scatchard analysis showed that the binding in the range of the limited concentrations tested was to a single class molecule and the calculated...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050151
更新日期：1995-01-01 00:00:00
abstract：:Sertoli cells play a critical role in spermatogenesis, and in adults, they are terminally differentiated with loss of proliferative activity. This study revealed Sertoli cell proliferation in 17-week-old Sprague-Dawley rats whose dams had been intragastrically administered 250 ng of 3,3',4,4',5-pentachlorobiphenyl/kg ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-011-0736-8
更新日期：2012-01-01 00:00:00
abstract：:Platinum coordination complexes (PtCx) are potent against several types of cancer but are often nephrotoxic. With a view to developing a PtCx nephrotoxicity model, the toxicity of cisplatin (cDDP), transplatin (tDDP) and carboplatin (CBDCA) was studied in primary cultures of rabbit proximal tubule (RPT) cells and in t...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973705
更新日期：1993-01-01 00:00:00
abstract：:Previous human and experimental studies have demonstrated that lead exposure may modify the metabolism of lipids. Several studies have indicated that exposure to lead produces an increase in lipid peroxidation and inhibits blood superoxide dismutase activity. Recently, lipid peroxides have been shown to impair tissue ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973308
更新日期：1993-01-01 00:00:00
abstract：:The main purpose of this study was to verify the hypothesis that cognitive dysfunctions induced by arsenic exposure were related to the changes of D-serine metabolism in the hippocampus of offspring mice. Mother mice and their offsprings were exposed to 0, 15, 30 or 60 mg/L sodium arsenite (NaAsO2) through drinking wa...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02616-1
更新日期：2020-01-01 00:00:00
abstract：: ...
journal_title：Archives of toxicology
pub_type： 评论,信件
doi：10.1007/s00204-018-2384-8
更新日期：2019-01-01 00:00:00
abstract：:A pharmacokinetic profile of [14C] leptophos was determined in laying hens following a single oral dose of 400 mg/kg (0.58 muCi). Most of the radioactivity was excreted into the urine and feces. After 15 days, the total radioactivity recovered in the combined urinary-fecal excretion was 73.5% of the administered dose....
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00351968
更新日期：1976-10-28 00:00:00
abstract：:Reactive oxygen species are generated during ischaemia-reperfusion of tissue. Oxidation of thymidine by hydroxyl radicals (HO) leads to the formation of 5,6-dihydroxy-5,6-dihydrothymidine (thymidine glycol). Thymidine glycol is excreted in urine and can be used as biomarker of oxidative DNA damage. Time dependent chan...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050638
更新日期：1999-11-01 00:00:00
abstract：:Exposure to alkylanilines found in tobacco smoke and indoor air is associated with risk of bladder cancer. Genetic factors significantly influence the metabolism of arylamine carcinogens and the toxicological outcomes that result from exposure. We utilized nucleotide excision repair (NER)-deficient immortalized human ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02901-4
更新日期：2021-01-01 00:00:00
