Abstract:
:Regarding the potential impact of traffic-born air pollutants on public health, in recent years attention has increasingly been focused on the possible effects on the cardiovascular system. In order to investigate this problem further, the influence of long-term exhaust gas exposure on rats has been studied. One hundred Wistar rats of either sex were exposed 5 X 8 h/week up to 28 months to an atmosphere polluted by the emissions of an idling Otto engine, CO concentrations held constant at 90 ppm. A second group (50 rats) was exposed to 250 ppm for 6 months. Blood parameters and body weight were controlled. Specimens of CNS, heart, vessels, kidney etc. were investigated light microscopically. Focal necroses of the myocardium with inflammatory reactions as well as interstitial fibrosis were found in the heart muscle of the 90 ppm group. In the 250 ppm group endothelial proliferations, edema of the intima and deposits of proteoglycanes in the media were observed. We conclude that subtoxic concentrations of CO which only lead to slight morphologic changes may aggravate preexisting lesions caused by high risk conditions, e.g., hypertension or hypercholesteremia.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Roggendorf W,Neumann H,Thron HL,Schneider H,Sarasa-Corral JLdoi
10.1007/BF00332390subject
Has Abstractpub_date
1981-07-01 00:00:00pages
247-56issue
4eissn
0340-5761issn
1432-0738journal_volume
47pub_type
杂志文章abstract::O,O,S-Trimethyl phosphorothioate (OOS-TMP) is known to induce unique symptoms, which are characterized by hypophagia, progressive weight loss, and hypothermia. To determine whether there is the possibility of a causal relationship between these toxic symptoms and a direct action of OOS-TMP on the central nervous syste...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050212
更新日期:1995-01-01 00:00:00
abstract::Rats were administered a sublethal dose of thallium (12.35 mg/kg as aqueous thallous sulfate, Tl2SO4, equivalent to 10 mg Tl+/kg per os) on day 0. Urine and feces were collected separately every day for 8 days and analyzed by atomic absorption spectroscopy. Based on information in the literature, five antidotal treatm...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00286576
更新日期:1985-04-01 00:00:00
abstract::To investigate the effect of long term hashish use on T-lymphocytes we have measured the incorporation of 14C-thymidine by peripheral blood lymphocytes, unstimulated and stimulated by phytohemagglutinin, as well as the proportion and number of E-rosettes in 12 healthy male chronic users of the drug before and after a ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01891963
更新日期:1978-04-27 00:00:00
abstract::This study aimed to investigate the effect of single and repeated administration of fenarimol on murine liver, kidney and lung microsomal CYP-catalyzed drug metabolism. The modulation of the regio- and stereo-selective hydroxylation of testosterone by fenarimol was considered in evaluating cocarcinogenic properties. I...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050298
更新日期:1996-01-01 00:00:00
abstract::The results from a survey of the expert information that is publicly accessible on the use of the dog as test species during the regulatory evaluation of agricultural chemicals and pesticides are reported. Methods that are being used or considered in order to reduce the number of dogs used for this purpose are describ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-005-0678-0
更新日期:2005-11-01 00:00:00
abstract::We have used the minipig as a prospective animal model for human risk characterization to study primary biochemical alterations upon oral contaminant intake. The effects of three orally administered soils containing polycyclic aromatic hydrocarbons (PAH) on the expression pattern of the cytochrome P450 enzyme CYP1A1 i...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-002-0334-x
更新日期:2002-06-01 00:00:00
abstract::The effect of ethanol on metabolism of 20 nitriles was studied in vivo and in vitro in mice. The hepatic microsomal metabolizing activity for nitriles was at a maximum 13 h after ethanol dosing (4.0 g/kg). Using microsomes from mice pretreated with ethanol under the above conditions, enhancement of the in vitro metabo...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00340977
更新日期:1986-02-01 00:00:00
abstract::Humans are exposed to multiple chemicals on a daily basis instead of to just a single chemical, yet the majority of existing toxicity data comes from single-chemical exposure. Multiple factors must be considered such as the route, concentration, duration, and the timing of exposure when determining toxicity to the org...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02547-x
更新日期:2019-10-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-013-1116-3
更新日期:2014-02-01 00:00:00
abstract::Previous studies indicate that benzanthrone, an anthraquinone dye intermediate, caused significant depletion of ascorbic acid (AsA). In this investigation the effect of benzanthrone on the status of different forms of AsA and other bio-antioxidants such as glutathione (GSH) was studied. Oral administration of benzanth...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040100222
更新日期:2001-06-01 00:00:00
abstract::Dorsal root ganglia from control and methylmercury (MeHg)-treated rats were incubated in vitro with 35S-methionine ant the proteins synthesized were analyzed by two-dimensional electrophoresis. The double labelling method, in which proteins of control dorsal root ganglia labelled in vitro with 3H-leucine were added to...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00316373
更新日期:1989-01-01 00:00:00
abstract::Etridiazole, 5-ethoxy-3-trichloromethyl-1,2,4-thiadiazole, was orally administered to rats and human volunteers. Two metabolites of etridiazole were synthesized: 5-ethoxy-1,2,4-thiadiazole-3-carboxylic acid (ET-CA) and N-acetyl-S-(5-ethoxy-1,2,4-thiadiazol-3-yl-methyl)-L-cysteine (ET-MA). Selective and sensitive analy...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF02098027
更新日期:1991-01-01 00:00:00
abstract::3H-soman (specific activity 10 Ci/mMol), a potent irreversible cholinesterase inhibitor, was administered IV to mice in a dose of one LD-50, which corresponds to 0.25 mCi/mouse. Animals were sacrificed at 5 min, 2 h and 24 h, and whole body autoradiography was performed. High levels of radioactivity in lung and skin w...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00292616
更新日期:1985-10-01 00:00:00
abstract::The effect of 1-deamino-2-tyr(ethyl) oxytocin (dEtOT) upon peri- and postnatal development of the rat was studied in two experiments when administered between day 15 of pregnancy and the day of parturition. The investigation showed that dEtOT did not affect the pups at birth, that dEtOT caused a dose-related growth re...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00324786
更新日期:1985-09-01 00:00:00
abstract::Drug-induced liver injuries have been a major focus of current research in drug development, and are also one of the major reasons for the failure and withdrawal of drugs in development. Drug-induced liver injuries have been systematically recorded in many public databases, which have become valuable resources in this...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-017-2024-8
更新日期:2017-09-01 00:00:00
abstract::2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the most potent tumor promoter ever tested in rodents. Although it is known that most of the effects of TCDD are mediated by binding to the aryl hydrocarbon receptor (AhR), the mechanisms leading to tumor promotion still remain to be elucidated. Loss of contact inhibition ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-004-0601-0
更新日期:2005-01-01 00:00:00
abstract::The associations of four single nucleotide polymorphisms (p.Arg194Trp, p.Arg280His, p.Pro206Pro, and p.Arg399Gln) in X-ray repair cross-complementing group 1 with urinary arsenic metabolites and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were investigated in a Vietnamese population (n = 100). Individuals with genotype AA in...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1490-0
更新日期:2016-04-01 00:00:00
abstract::The pregnancy outcomes of 109 women who were intoxicated during pregnancy due to excessive amounts of drugs and other agents were studied. Seventy per cent of the women attempted suicide, and the intoxication in 78% of all cases was caused by drugs. The stillbirth rate (4%) was higher than that in previous and subsequ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00316249
更新日期:1988-08-01 00:00:00
abstract::The effects of diabetes on cytochrome P450 (CYP)-dependent drug metabolizing enzymes are yet to be clarified. The most widely used animals in these studies have been rats, and information on the effects of diabetes on rabbit liver drug metabolizing enzymes have been unavailable until now. In this study, for the first ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-005-0654-8
更新日期:2005-08-01 00:00:00
abstract::Alternative methods to detect non-genotoxic carcinogens are urgently needed, as this class of carcinogens goes undetected in the current testing strategy for carcinogenicity under REACH. A complicating factor is that non-genotoxic carcinogens act through several distinctive modes of action, which makes prediction of t...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1368-6
更新日期:2015-12-01 00:00:00
abstract::Single doses of procarbazine (MIH) were injected IP at 0, 50, 100, 200, and 400 mg/kg body weight to CD-1 male mice. Activities of hyaluronidase, lactate dehydrogenase isoenzyme-X, and the dehydrogenases of sorbitol, alpha-glycerophosphate, glucose-6-phosphate, malate, isocitrate, and glyceraldehyde-3-phosphate in the...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00341017
更新日期:1984-10-01 00:00:00
abstract::Sulfites whether ingested or produced through the sulfur-containing amino acids metabolism of the animal are very active molecules and can cause cellular toxicity. Sulfite oxidase (SOX), a heme- and molybdenum containing mitochondrial enzyme, prevents mammalian cells from adverse effects of sulfite toxicity by metabol...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-006-0125-x
更新日期:2006-10-01 00:00:00
abstract::To evaluate the developmental neurotoxicity of arsenic in offspring rats by transplacental and early life exposure to sodium arsenite in drinking water, the pregnant rats or lactating dams, and weaned pups were given free access to drinking water, which contained arsenic at concentrations of 0, 10, 50, 100 mg/L from G...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-009-0403-5
更新日期:2009-06-01 00:00:00
abstract::The covalent binding of 14C-1,1,2-trichloroethylene (14C-TRI) metabolites to calf thymus DNA in vitro and to RNA and DNA of mouse brain, lung, liver, kidney, spleen, pancreas, and testis after repeated i.p. injections has been studied. Hydrolysates of DNA reacted with 14C-TRI in vitro and hydrolysates of RNA and DNA f...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01239202
更新日期:1983-11-01 00:00:00
abstract::The goal of the present study was to obtain an in vivo relevant prioritization method for the endocrine potencies of different polycarbonate monomers, by combining in vitro bioassay data with physiologically based kinetic (PBK) modelling. PBK models were developed for a selection of monomers, including bisphenol A (BP...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02479-6
更新日期:2019-07-01 00:00:00
abstract::Intermittent inhalation of 300 ppm of xylene vapour 6 h daily for 2 weeks caused a marked accumulation of the solvent in the perirenal fat. Simultaneous ethanol ingestion reduced the solvent load significantly although the perirenal xylene concentration increased in both test groups between the first and second week o...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00354091
更新日期:1978-12-28 00:00:00
abstract::Intravenous administration of lead acetate to rabbits for 10 weeks at 2 week intervals resulted in significantly elevated blood lead levels, slight anemia with marked microspherocytosis and moderate basophilic stippling, and marked depression of red cell delta-aminolevulinic acid (ALA) dehydratase activity. However th...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00695874
更新日期:1979-10-01 00:00:00
abstract::A paradigm shift is occurring in toxicology following the report of the National Research Council of the USA National Academies entitled "Toxicity testing in the 21st Century: a vision and strategy". This new vision encourages the use of in vitro and in silico models for toxicity testing. In the goal to identify new r...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02520-8
更新日期:2019-09-01 00:00:00
abstract::The effects of six iv infusions of an emulsion containing the plasticizer di(2-ethylhexyl) phthalate (DEHP) on the liver and testes were investigated in 40-day-old rats. Groups of five to six animals received the emulsion every other day in doses of 0, 5, 50 or 500 mg DEHP/kg body weight. Liver effects were studied by...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00348313
更新日期:1985-12-01 00:00:00
abstract::Although shorter chain homologues and other types of fluorinated chemicals are currently used as alternatives to long-chain perfluoroalkyl substances (PFASs), their safety information remains unclear and urgently needed. Here, the cytotoxicity of several fluorinated alternatives (i.e., 6:2 fluorotelomer carboxylic aci...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2055-1
更新日期:2018-01-01 00:00:00