Abstract：
:Single doses of procarbazine (MIH) were injected IP at 0, 50, 100, 200, and 400 mg/kg body weight to CD-1 male mice. Activities of hyaluronidase, lactate dehydrogenase isoenzyme-X, and the dehydrogenases of sorbitol, alpha-glycerophosphate, glucose-6-phosphate, malate, isocitrate, and glyceraldehyde-3-phosphate in the testes of the mice were determined and correlated with changes in spermatogenic cell types in seminiferous tubules. All enzyme activities were higher than controls or remained unchanged on days 10-20 after drug treatment. Activities of hyaluronidase, sorbitol dehydrogenase, and lactate dehydrogenase isoenzyme-X decreased significantly to below normal levels on day 30 after drug treatment for all doses, whereas those of the other five dehydrogenases remained significantly higher than controls. All enzyme activities approached control levels with the concomitant recovery of spermatogenesis by day 60 after drug treatment. Histological examination of seminiferous tubules revealed that premeiotic spermatocytes were significantly reduced on days 10-20 but reappeared on day 30 after MIH treatment (400 mg/kg). The postmeiotic spermatogenic cells were unaffected at the time of MIH treatment, but had disappeared completely on day 30 after drug treatment. MIH, at the highest dosage, selectively destroyed spermatogonia and premeiotic spermatocytes; however spermatozoa and elongated spermatides were unaffected. This study demonstrated that the cytotoxic effect of MIH on spermatogenesis could be evaluated via changes in testicular enzyme activities. The present studies demonstrated that hyaluronidase, sorbitol dehydrogenase, and lactate dehydrogenase isoenzyme-X could serve as useful biochemical markers for assessing testicular toxicity induced by drugs and chemicals.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Shen RS,Lee IPdoi
10.1007/BF00341017subject
Has Abstractpub_date
1984-10-01 00:00:00pages
233-8issue
4eissn
0340-5761issn
1432-0738journal_volume
55pub_type
杂志文章abstract：:A pharmacokinetic profile of [14C] leptophos was determined in laying hens following a single oral dose of 400 mg/kg (0.58 muCi). Most of the radioactivity was excreted into the urine and feces. After 15 days, the total radioactivity recovered in the combined urinary-fecal excretion was 73.5% of the administered dose....
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00351968
更新日期：1976-10-28 00:00:00
abstract：:Certain esterase inhibitors such as O-(2-chloro-2,3,3-trifluorocyclobutyl) O-ethyl S-propyl phosphorothioate (KBR-2822) and phenylmethanesulfonyl fluoride (PMSF) cause exacerbation (promotion) of toxic and traumatic axonopathies. Although these chemicals are capable of inhibiting neuropathy target esterase (NTE), whic...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050473
更新日期：1998-01-01 00:00:00
abstract：:Chronic arsenite exposure induces immunosuppression, but the precise mechanisms remain elusive. Our previous studies demonstrated that arsenite exposure for 24 h induces G0/G1 arrest in mouse B lymphoma A20 cells and the arrest is caused through induction of cyclin-dependent kinase inhibitor p16(INK4a) followed by acc...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-015-1500-2
更新日期：2016-04-01 00:00:00
abstract：:Tributyltin (TBT) has been shown to disrupt the ability of natural killer (NK) cells to destroy tumor targets in vitro even at exposures of 25 nM for 24 h, but cell viability was not significantly impacted. Thus, evaluation of intracellular molecular events that regulate cell viability in TBT exposed NK cells are of i...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0155-4
更新日期：2007-04-01 00:00:00
abstract：:To explain the mechanism of renal injury caused by liver ischemia-reperfusion, we investigated biochemical and morphological changes in the liver and kidney in rats. After reperfusion following 60 min of liver ischemia, numerous changes were found. The level of serum transaminases and lipid peroxide formation in the l...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01969922
更新日期：1993-01-01 00:00:00
abstract：:The effect of acute and subchronic acrylamide treatment on levels of dopamine, serotonin, and their metabolites was determined in several brain regions of the rat. Concentrations of several neuropeptides and circulating hormones were also measured. Both a single and repeated doses of acrylamide resulted in elevated le...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00317980
更新日期：1983-01-01 00:00:00
abstract：:Hexamoll® DINCH® (diisononyl-cyclohexane-1,2-dicarboxylate) is a new high molecular weight plasticizer and a non-aromatic phthalate substitute. In this follow-up study, we further investigated the extensive oxidative metabolism of Hexamoll® DINCH® after oral dosage of 50 mg to three male volunteers (0.552-0.606 mg/kg ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1688-9
更新日期：2017-01-01 00:00:00
abstract：:Hibiscus protocatechuic acid (PCA), a phenolic compound found in the dried flowers of Hibiscus sabdariffa L. (Malvaceae), was demonstrated to have an antioxidant effect in vitro and in vivo, and an antitumor property in our previous study. In the present study, we used lipopolysaccharide (LPS, an endotoxin) to induce ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-002-0404-0
更新日期：2003-01-01 00:00:00
abstract：:Drug-induced liver injuries have been a major focus of current research in drug development, and are also one of the major reasons for the failure and withdrawal of drugs in development. Drug-induced liver injuries have been systematically recorded in many public databases, which have become valuable resources in this...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-017-2024-8
更新日期：2017-09-01 00:00:00
abstract：:Targeted therapies against cancer have improved both survival and quality of life of patients. However, metabolic rewiring evokes cellular mechanisms that reduce therapeutic mightiness. Resistant cells generate more glutathione, elicit nuclear factor erythroid 2-related factor 2 (NRF2) activation, and overexpress many...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-020-02838-8
更新日期：2020-08-01 00:00:00
abstract：:A recent intervention study demonstrated the occurrence of irilone as second most abundant isoflavone next to daidzein in human plasma after consumption of a red clover-based dietary supplement (RCDS) containing predominately formononetin ≫ biochanin A > irilone (12 % of these isoflavones). To elucidate the relevance ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1114-5
更新日期：2014-02-01 00:00:00
abstract：:The effect of acute and chronic cadmium administration on hepatic drug metabolism was investigated in the male rat. 3 days after the acute administration of cadmium by either the intraperitoneal (0.84 mg Cd/kg) or the oral (greater than 80 mg Cd/kg) route, there was a significant potentiation in duration of hexobarbit...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00310332
更新日期：1978-08-09 00:00:00
abstract：:Many carcinogens and mutagens are electrophilic in nature and will react with nucleophilic sites in protein and nucleic acid. Determination of the extent of formation of these adducts of genotoxic agents with protein provides a practical method of monitoring human exposure and of determining the possible risk associat...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00296978
更新日期：1987-01-01 00:00:00
abstract：:Hydrogen sulfide (H2S), the third gasotransmitter, has been shown to act as a neuroprotective factor in numerous pathological processes; however, its underlying mechanism(s) of action remain unclear. It is widely accepted that activation of moderate autophagy and the Nrf2/ARE signaling pathway play important roles in ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2208-x
更新日期：2018-06-01 00:00:00
abstract：:In vivo screening methods for detection of thyroid function modulators are now under development in many research laboratories. We assessed the applicability of the Hershberger assay protocol to screen for thyroid function modulators. In experiment 1, castrated male BrlHan WIST@Jcl (GALAS) rats were administered a pot...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-005-0677-1
更新日期：2005-11-01 00:00:00
abstract：:We analyzed adverse events in a clinical phase I trial to assess dose-dependent metabolic effects of St. John's wort co-administered with rifampicin in 12 healthy volunteers. Within 3-6 days after increasing the St. John's wort dose from 300 to 600 mg TID, five of six female participants developed ambient temperature-...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-015-1532-7
更新日期：2016-04-01 00:00:00
abstract：:Experimental and/or epidemiological studies suggest that prenatal exposure to bisphenol A (BPA) may delay fetal lung development and maturation and increase the susceptibility to childhood respiratory disease. However, the underlying mechanisms remain to be elucidated. In our previous study with cultured human fetal l...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-2150-3
更新日期：2018-04-01 00:00:00
abstract：:Engineered amorphous silica nanoparticles (nanosilica) are widely used in industry yet can induce adverse effects, which might be classified according to the oxidative stress model. However, the underlying mechanisms as well as the potential interactions of the three postulated different tiers of toxicity-i.e. oxidati...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2223-y
更新日期：2018-07-01 00:00:00
abstract：:The binding characteristics of [14C]ortho-toluidine (OT), a suspect human carcinogen, were investigated in male Sprague-Dawley rats. Rats were administered [14C]OT i.p. at 10, 20, 40, 50, or 100 mg/kg body weight, then sacrificed at 2, 4, 8, 18, 24, 48, or 72 h, or 7, 14, or 28 days. Hemoglobin (Hb) and albumin (Alb) ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF02307167
更新日期：1992-01-01 00:00:00
abstract：:This review summarises the current state of knowledge regarding the physiology and control of production of thyroid hormones, the effects of chemicals in perturbing their synthesis and release that result in thyroid cancer. It does not consider the potential neurodevelopmental consequences of low thyroid hormones. The...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-020-02961-6
更新日期：2021-01-05 00:00:00
abstract：:Previous studies in our laboratory identified retinoid-induced defects that are mediated by RAR-RXR heterodimerization using interaction of synthetic ligands selective for the retinoid receptors RAR and RXR in mice (Elmazar et al. 1997, Toxicol Appl Pharmacol 146:21-28; Elmazar et al. 2001, Toxicol Appl Pharmacol 170:...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-004-0586-8
更新日期：2004-11-01 00:00:00
abstract：:Reactive oxygen species are generated during ischaemia-reperfusion of tissue. Oxidation of thymidine by hydroxyl radicals (HO) leads to the formation of 5,6-dihydroxy-5,6-dihydrothymidine (thymidine glycol). Thymidine glycol is excreted in urine and can be used as biomarker of oxidative DNA damage. Time dependent chan...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050638
更新日期：1999-11-01 00:00:00
abstract：:Cadmium, copper and zinc have been determined in kidney cortex, kidney medulla and liver from 51 cadmium-polluted and 122 nonpolluted autopsied subjects. Liver cadmium and zinc were significantly higher in the cadmium-polluted subjects than in the nonpolluted subjects. Kidney cadmium, copper and zinc were lower in the...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316211
更新日期：1987-04-01 00:00:00
abstract：:The cytotoxicity of trivalent and pentavalent inorganic arsenic salts was determined in mouse fibroblasts in vitro. Concentrations of As (III) in the microM range led to a reduction of proliferation and viability with a concomitant increase in LDH release and stimulation of lactic acid production. Similar effects were...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00290882
更新日期：1985-08-01 00:00:00
abstract：:A number of industrial chemicals and therapeutic agents cause liver tumors in rats and mice by activating the nuclear receptor peroxisome proliferator-activated receptor α (PPARα). The molecular and cellular events by which PPARα activators induce rodent hepatocarcinogenesis have been extensively studied elucidating a...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-017-2094-7
更新日期：2018-01-01 00:00:00
abstract：:The ability of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), 3,5-diethoxycarbonyl-4-ethyl-1,4-dihydro-2,6-dimethylpyridine (EDDC) and griseofulvin to induce porphyria in primary cultures of mouse hepatocytes has been examined. Exposure of cultured mouse hepatocytes to DDC, EDDC or griseofulvin resulted in a marked ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01974011
更新日期：1992-01-01 00:00:00
abstract：:In his Nobel Prize Lecture of December 12, 1946, Hermann J. Muller argued that the dose-response for radiation-induced germ cell mutations was linear and that there was "no escape from the conclusion that there is no threshold". However, assessment of correspondence between Muller and Curt Stern 1 month prior to his N...
journal_title：Archives of toxicology
pub_type： 历史文章,杂志文章
doi：10.1007/s00204-011-0728-8
更新日期：2011-12-01 00:00:00
abstract：:Human precision-cut liver slices (hPCLS) are a valuable ex vivo model that can be used in acute toxicity studies. However, a rapid decline in metabolic enzyme activity limits their use in studies that require a prolonged xenobiotic exposure. The aim of the study was to extend the viability and function of hPCLS to 5 d...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1865-x
更新日期：2017-05-01 00:00:00
abstract：:We recently presented a modified local lymph node test which made it possible to quickly and reliably differentiate between irritative and allergic skin reactions with extremely simple parameters. The Integrated Model for the Differentiation of Skin Reactions (IMDS) test combines measurement of cell proliferation in d...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050001
更新日期：2000-01-01 00:00:00
abstract：:Liver microsomes were prepared from Wistar rat by the Ca2+ aggregation method. Under various conditions, ethyl mercury chloride (EtHgCl) or methyl mercury chloride (MeHgCl) was incubated with the microsomal preparations. After the incubation, the amounts of inorganic Hg and hydroxyl radical (.OH) in the preparations w...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF02035129
更新日期：1992-01-01 00:00:00
