Effect of acrylamide on neurotransmitter metabolism and neuropeptide levels in several brain regions and upon circulating hormones.

abstract：:The oxidizing capacity of phagocytic cells is suspected to play a major role in the generation of immunogenic drug metabolites, in particular those that cause extrahepatic immunopathological lesions. In the case of the antirheumatic drug gold(I) disodium thiomalate (Na2Au(I)TM), oxidation of the Au(I) ion to Au(III) a...

journal_title：Archives of toxicology

authors： Goebel C,Kubicka-Muranyi M,Tonn T,Gonzalez J,Gleichmann E

更新日期：1995-01-01 00:00:00

abstract：:Zearalenone, a cereal mycotoxin with mycoestrogen activity and effect on fertility, is known to trigger apoptosis of a variety of nucleated cell types including hematopoietic progenitor cells. In analogy to apoptosis of nucleated cells, eryptosis, the suicidal death of erythrocytes, leads to cell shrinkage and cell me...

journal_title：Archives of toxicology

authors： Jilani K,Lang F

更新日期：2013-10-01 00:00:00

abstract：:The aim was to study the long-term response in the olfactory mucosa of NMRI mice after exposure to the olfactory toxicants dichlobenil (a herbicide) or methimazole (an antithyroid drug). Three and six months after exposure to dichlobenil (2x or 1 x 25 mg/kg i.p.), the dorsomedial part of the olfactory region showed a ...

journal_title：Archives of toxicology

authors： Bergman U,Ostergren A,Gustafson AL,Brittebo B

更新日期：2002-03-01 00:00:00

abstract：:The organophosphorus compound trichlorfon, dimethyl (2,2,2-trichloro-1-hydroxyethyl) phosphonate, was administered by stomach tube (100 mg/kg) to pregnant guinea pigs at two different stages of gestation (days 36, 37, 38 and 51, 52, 53). The pups developed locomotory disturbances, and post mortem examination revealed ...

journal_title：Archives of toxicology

authors： Berge GN,Nafstad I,Fonnum F

更新日期：1986-05-01 00:00:00

abstract：:Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node ass...

journal_title：Archives of toxicology

authors： van der Veen JW,Gremmer ER,Vermeulen JP,van Loveren H,Ezendam J

更新日期：2013-04-01 00:00:00

abstract：:Iron (Fe) plays essential roles in biological processes, whereas cadmium (Cd) is a toxic and non-essential metal. Two metal transporters, divalent metal transporter 1 (DMT1) and metal transporter protein 1 (MTP1), are responsible for Fe transport in mammals. Here, we studied the effect of dietary Fe on the expression ...

journal_title：Archives of toxicology

authors： Kim DW,Kim KY,Choi BS,Youn P,Ryu DY,Klaassen CD,Park JD

更新日期：2007-05-01 00:00:00

abstract：:Standard treatment of poisoning by organophosphates (OP) includes the administration of an antimuscarinic agent, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime). The presently available oximes, obidoxime and pralidoxime (2-PAM), are considered to be insufficient for highly toxic OPs, e.g. sari...

journal_title：Archives of toxicology

authors： Worek F,Reiter G,Eyer P,Szinicz L

更新日期：2002-09-01 00:00:00

abstract：:Chemical allergens are small molecules able to form a sensitizing complex once they bound to proteins. One of the most frequent manifestations of chemical allergy is contact hypersensitivity, which can have serious impact on quality of life. Allergic contact dermatitis is a predominantly CD8 + T cell-mediated immune d...

journal_title：Archives of toxicology

authors： Corsini E,Engin AB,Neagu M,Galbiati V,Nikitovic D,Tzanakakis G,Tsatsakis AM

更新日期：2018-10-01 00:00:00

abstract：:In the present study, spiking was used as a strategy to evaluate the mutagenicity of individual compounds in a mixture. Mutagenicity of individual polycyclic aromatic hydrocarbons (PAH) was evaluated in an organic extract of diesel exhaust particles (DEP). The particles were extracted with dichloromethane (DCM). After...

journal_title：Archives of toxicology

authors： Bostrøm E,Engen S,Eide I

更新日期：1998-10-01 00:00:00

abstract：:Effect of repeated oral administration of hexachlorocyclohexane (HCH; 10 and 20 mg/kg body weight per day for 7, 15 and 30 days) on antioxidant defence system and lipid peroxidation (LPX) in the testis was compared between immature (15-day-old) and mature (90-day-old) rats. In both age-groups of rats, the pesticide el...

journal_title：Archives of toxicology

authors： Samanta L,Sahoo A,Chainy GB

更新日期：1999-03-01 00:00:00

abstract：:Our previous study suggested the possibilities that dicyclanil (DC), a nongenotoxic carcinogen, produces oxidative stress in the liver of the two-stage hepatocarcinogenesis model of mice and the stress induced probably causes secondary oxidative DNA damage. However, clear evidences demonstrating the relationship betwe...

journal_title：Archives of toxicology

authors： Moto M,Umemura T,Okamura M,Muguruma M,Ito T,Jin M,Kashida Y,Mitsumori K

更新日期：2006-10-01 00:00:00

abstract：:The significance of urinary trehalase as a possible early indicator of renal disorder was examined using Cd-treated rabbits, which received 1 mg/kg Cd thrice weekly for 3 months subcutaneously. The results showed that urinary trehalase increased significantly from 1 week after treatment, earlier than LAP, ALP, protein...

journal_title：Archives of toxicology

authors： Nishimura N,Oshima H,Nakano M

更新日期：1986-12-01 00:00:00

abstract：:Acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure. Prolonged c-Jun N-terminal kinase (JNK) activation plays a central role in APAP-induced liver injury; however, growth arrest and DNA damage-inducible 45 beta (GADD45β) is known to inhibit JNK phosphorylation. The orphan nuclear recep...

journal_title：Archives of toxicology

authors： Kim YH,Noh JR,Hwang JH,Kim KS,Choi DH,Kim JH,Moon SJ,Choi JH,Hérault Y,Lee TG,Choi HS,Lee CH

更新日期：2018-08-01 00:00:00

abstract：:Recently, acutely toxic doses of the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been reported to affect the hepatic distribution of essential metals in the rat. However, the reduced food intake by TCDD was not taken into account. Therefore, metal concentrations were determined in different...

journal_title：Archives of toxicology

authors： Elsenhans B,Forth W,Richter E

更新日期：1991-01-01 00:00:00

abstract：:Carbromal is metabolized extensively in humans. The major metabolites known to date are bromoethylbutyramide, ethylbutyrylurea and inorganic bromide. After ingestion of a therapeutic dose of 1.0 g carbromal (4.2 mmoles) by four healthy volunteers highest concentrations in serum were found to be for carbromal 30 mumole...

journal_title：Archives of toxicology

authors： Vohland HW,Schirop T,Barckow D,Kreutz G,Streichert B

更新日期：1978-06-16 00:00:00

abstract：:The present study was designed to compare the nephrotoxicity induced by the three platinum compounds cisplatin (CDDP), carboplatin (CBDCA) and transplatin (TDDP) in vitro and to obtain information to elucidate the mechanism of platinum compound-induced nephrotoxicity. Rat or rabbit renal cortical slices were incubated...

journal_title：Archives of toxicology

authors： Hannemann J,Baumann K

更新日期：1990-01-01 00:00:00

abstract：:Amanita phalloides is responsible for more than 90 % of mushroom-related fatalities, and no effective antidote is available. α-Amanitin, the main toxin of A. phalloides, inhibits RNA polymerase II (RNAP II), causing hepatic and kidney failure. In silico studies included docking and molecular dynamics simulation couple...

journal_title：Archives of toxicology

authors： Garcia J,Costa VM,Carvalho AT,Silvestre R,Duarte JA,Dourado DF,Arbo MD,Baltazar T,Dinis-Oliveira RJ,Baptista P,de Lourdes Bastos M,Carvalho F

更新日期：2015-12-01 00:00:00

abstract：:Exposure to toxic metals is a well-known problem in industrialized countries. Metals interfere with a number of physiological processes, including central nervous system (CNS), haematopoietic, hepatic and renal functions. In the evaluation of the toxicity of a particular metal it is crucial to consider many parameters...

journal_title：Archives of toxicology

authors： Sinicropi MS,Amantea D,Caruso A,Saturnino C

更新日期：2010-07-01 00:00:00

abstract：:Platinum coordination complexes (PtCx) are potent against several types of cancer but are often nephrotoxic. With a view to developing a PtCx nephrotoxicity model, the toxicity of cisplatin (cDDP), transplatin (tDDP) and carboplatin (CBDCA) was studied in primary cultures of rabbit proximal tubule (RPT) cells and in t...

journal_title：Archives of toxicology

authors： Courjault F,Leroy D,Coquery L,Toutain H

更新日期：1993-01-01 00:00:00

abstract：:The effects of intravenously (i.v.) administered or inhaled amyl nitrite (AN) were followed under chloralose anaesthesia in intact and cyanide-poisoned, spontaneously breathing beagles. The i.v. doses of AN were 0.03 and 0.15 mmol/kg and the i.v. dose of KCN was 0.06 mmol/kg. AN was inhaled in a closed system at 0.15 ...

journal_title：Archives of toxicology

authors： Klimmek R,Krettek C

更新日期：1988-01-01 00:00:00

abstract：:This is with reference to the note of the Editor-in-Chief of the Archives of Toxicology. ...

journal_title：Archives of toxicology

authors： Khan F,Niaz K,Ismail Hassan F,Abdollahi M

更新日期：2018-07-01 00:00:00

abstract：:As part of a study on cadmium nephrotoxicity, we studied the effect of cadmium chloride (CdCl2) in isolated human renal proximal tubules metabolizing the physiological substrate lactate. Dose-effect experiments showed that 10-500 μM CdCl2 reduced lactate removal, glucose production and the cellular levels of ATP, coen...

journal_title：Archives of toxicology

authors： Faiz H,Conjard-Duplany A,Boghossian M,Martin G,Baverel G,Ferrier B

更新日期：2011-09-01 00:00:00

abstract：:A method is described for the determination of lorazepam plasma levels involving extraction from the sample and analysis of the intact lorazepam by electron capture gas-liquid chromatography. Using mass spectrometry it is demonstrated, that lorazepam shows a thermal rearrangement under gas chromatographic conditions. ...

journal_title：Archives of toxicology

authors： de Groot G,Maes RA,Lemmens HH

更新日期：1976-06-08 00:00:00

abstract：:The first step in the oxidative metabolism of cocaine is N-demethylation to norcocaine, which is further N-hydroxylated to more toxic N-hydroxynorcocaine. In this study we examined the kinetics of norcocaine N-hydroxylation mediated by cytochrome P450 (CYP) in mouse and human liver microsomes. N-hydroxynorcocaine was ...

journal_title：Archives of toxicology

authors： Pellinen P,Kulmala L,Konttila J,Auriola S,Pasanen M,Juvonen R

更新日期：2000-11-01 00:00:00

abstract：:Volunteers inhaled a constant concentration of 50 ppm trichloroethylene (Tri) for 6 hrs per day on 5 consecutive days. Simultaneous ethanol (EtOH) ingestion (blood level 0.6%) inhibits the metabolization of Tri to trichloroethanol (TCE) and trichloroacetic acid (TCA) by 40% on the average. Oxidation of Tri to TCA does...

journal_title：Archives of toxicology

authors： Müller G,Spassowski M,Henschler D

更新日期：1975-01-01 00:00:00

abstract：:Targeted therapies against cancer have improved both survival and quality of life of patients. However, metabolic rewiring evokes cellular mechanisms that reduce therapeutic mightiness. Resistant cells generate more glutathione, elicit nuclear factor erythroid 2-related factor 2 (NRF2) activation, and overexpress many...

journal_title：Archives of toxicology

authors： Matés JM,Campos-Sandoval JA,de Los Santos-Jiménez J,Márquez J

更新日期：2020-08-01 00:00:00

abstract：:Organotin compounds such as tributyltin (TBT) and triphenyltin can induce diabetes and insulin resistance. However, the development of diabetes caused by organotins and its underlying mechanisms remain unclear. In the present study, male KM mice were orally administered with TBT (0.5, 5, and 50 μg/kg) once every 3 day...

journal_title：Archives of toxicology

authors： Li B,Guo J,Xi Z,Xu J,Zuo Z,Wang C

更新日期：2017-10-01 00:00:00

abstract：:Male F344/DuCrj (Fischer) rats were given bisphenol A (BPA) in the diet at levels of 0 (control), 0.25, 0.50 and 1.00%, equivalent to 0, 235, 466 and 950 mg/kg per day, respectively, for 44 days. Body weight gains were depressed dose-dependently in BPA-treated rats, and those of 0.50 and 1.00% groups were significant....

journal_title：Archives of toxicology

authors： Takahashi O,Oishi S

更新日期：2001-03-01 00:00:00

abstract：:The toxicity of amphetamines is conditioned by a complex array of mechanisms, involving the increase of neurotransmission (e.g. leading to hyperthermia) and enzymatic and non-enzymatic oxidation of amphetamines and biogenic amines. Considering that all these processes may increase the generation of hydrogen peroxide (...

journal_title：Archives of toxicology

authors： Carvalho F,Duarte JA,Neuparth MJ,Carmo H,Fernandes E,Remião F,Bastos ML

更新日期：2001-10-01 00:00:00

abstract：:To examine the demethylation reaction of methylmercury (MeHg) in rat liver, slices prepared from MeHg-treated rats were incubated in L-15 medium under 95% O2/5% CO2 atmosphere. During the incubation, the amount of inorganic Hg in the slices markedly increased in a time-dependent manner, although the concentration of t...

journal_title：Archives of toxicology

authors： Yasutake A,Hirayama K

更新日期：2001-09-01 00:00:00