Abstract：
:Hibiscus protocatechuic acid (PCA), a phenolic compound found in the dried flowers of Hibiscus sabdariffa L. (Malvaceae), was demonstrated to have an antioxidant effect in vitro and in vivo, and an antitumor property in our previous study. In the present study, we used lipopolysaccharide (LPS, an endotoxin) to induce rat liver inducible nitric oxide synthase (iNOS), and found that pretreatment with PCA decreased the liver iNOS and the serum total nitrite induced by LPS. Our investigation showed that pretreatment of rats with PCA (0.2 and 0.5 mmol/kg dosed by gavage) for 5 days significantly decreased the serum levels of the hepatic enzyme markers alanine- and aspartate aminotransferase (ALT, alanine aminotransferase; AST, aspartate aminotransferase) induced by the 6-h treatment with LPS (i.p.; 5 mg/kg). Histopathological evaluation of the rat livers revealed that PCA reduced the incidence of liver lesions induced by LPS, including neutrophil infiltration, congestion, and liver cell swelling induced by LPS in rats. We conclude that PCA, an antioxidant, presents an inhibitory potential on iNOS and hepatic damage induced by LPS.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Lin WL,Hsieh YJ,Chou FP,Wang CJ,Cheng MT,Tseng THdoi
10.1007/s00204-002-0404-0keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
42-7issue
1eissn
0340-5761issn
1432-0738journal_volume
77pub_type
杂志文章abstract：:The regional distribution of dopamine, norepinephrine and homovanillic acid was assessed in adult male rabbits exposed to styrene vapours. The turnover of dopamine and norepinephrine was also measured in several brain regions by the decay in endogenous catecholamines after inhibition of tyrosine hydroxylase by alpha-m...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316123
更新日期：1984-09-01 00:00:00
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journal_title：Archives of toxicology
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doi：10.1007/s00204-019-02637-w
更新日期：2020-02-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050626
更新日期：1999-08-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1673-3
更新日期：2017-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00204-018-2192-1
更新日期：2018-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-04-01 00:00:00
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journal_title：Archives of toxicology
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doi：10.1007/s00204-016-1792-x
更新日期：2017-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00204-004-0596-6
更新日期：2004-12-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00332352
更新日期：1981-04-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0144-7
更新日期：2007-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00204-021-02980-x
更新日期：2021-01-30 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0138-5
更新日期：2007-03-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00310332
更新日期：1978-08-09 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00204-018-2365-y
更新日期：2019-02-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050192
更新日期：1995-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0155-4
更新日期：2007-04-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973715
更新日期：1991-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050301
更新日期：1996-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF02034935
更新日期：1991-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050352
更新日期：1996-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2247-3
更新日期：2018-08-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-011-0771-5
更新日期：2012-03-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-008-0294-x
更新日期：2008-08-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-015-1633-3
更新日期：2015-12-01 00:00:00
abstract：:In mutagenicity testing of pharmaceuticals it is advisable, whenever possible, to use in vivo mammalian systems where the pharmacokinetic properties of a drug would be more or less similar to those in man. However, although there are a number of different genetic endpoints which are important in mutagen testing, suffi...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00361248
更新日期：1980-11-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050495
更新日期：1998-03-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00295090
更新日期：1987-02-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01973700
更新日期：1993-01-01 00:00:00
abstract：:The activity of 18 vitamin D analogs on soft tissue calcification and growth impairment in neonatal rats and their effect on bone calcium mobilization, intestinal calcium absorption and binding to intestinal 1,25-dihydroxyvitamin D3 receptors in adult rats were compared. Depending on the chemical modification of the v...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00303129
更新日期：1989-01-01 00:00:00
