Abstract:
:The effect of duration of employment at a North American cadmium smelter on urinary metallothionein (MT), total protein, beta 2-microglobulin (beta 2-MG), glucose, cadmium, copper and zinc of 53 men was studied. The levels of all urinary parameters increased with the duration of employment. Smoking history did not affect any of the above parameters studied. Although age was responsible for some of the changes noted in protein, glucose and beta 2-MG levels, its effect on MT and cadmium was insignificant. All urinary parameters were significantly related with each other. The relationship of elevated urinary MT levels with respect to renal dysfunction was also examined. Subjects with abnormal renal function excreted significantly higher amounts of MT than did those with normal renal function. The results confirm not only that occupational exposure to cadmium over long periods results in renal dysfunction but also that urinary MT could be used to monitor exposure and ultimately the appearance of the renal dysfunction.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Shaikh ZA,Tohyama C,Nolan CVdoi
10.1007/BF00295090subject
Has Abstractpub_date
1987-02-01 00:00:00pages
360-4issue
5eissn
0340-5761issn
1432-0738journal_volume
59pub_type
杂志文章abstract::Insulin-exposed rat mammary cancer cells were flow sorted based on a c-myc reporter plasmid encoding a destabilized green fluorescent protein. Sorted cells exhibited gradual increases in c-myc levels. Cells overexpressing c-myc by only 10% exhibited phenotypic changes attributable to c-myc overexpression, such as cell...
journal_title:Archives of toxicology
pub_type: 杂志文章
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journal_title:Archives of toxicology
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pub_type: 杂志文章
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journal_title:Archives of toxicology
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pub_type: 杂志文章,评审
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journal_title:Archives of toxicology
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更新日期:1981-04-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章,已发布勘误
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