Abstract:
:Levels of glutathione and activity of glutamine synthetase were assayed in organs of rats following inhalation of a heterogeneous solvent mixture containing both aliphatic and aromatic hydrocarbons. This mixture was administered for 3 weeks (6 h daily) at two levels in the inhaled air (400 and 800 ppm) to young adult (5-month-old) and aged (14-month-old) rats. Depression of levels of glutamine synthetase in the P2 fraction of kidney was observed, which was more severe in aged than young adult rats. Glutamine synthetase is a cytosolic enzyme especially susceptible to oxidative damage. A parallel depression of this enzyme was also seen in the corresponding hepatic fractions. However, levels of glutamine synthetase in the hippocampus were elevated by this exposure. Glutathione levels were depressed in P2 fractions of livers of exposed rats, and also in the corresponding renal fraction. Glutathione concentration was unchanged in cerebral fractions. Overall results were interpreted to imply that pro-oxidant events were elevated in kidney and liver following prolonged inhalation of the solvent mixture. The changes found in brain tissue did not reveal evidence of oxidative stress but, however, suggested that glial activation was taking place.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Bondy SC,Lam HR,Ostergaard G,Guo SX,Ladefoged Odoi
10.1007/s002040050192subject
Has Abstractpub_date
1995-01-01 00:00:00pages
410-4issue
6eissn
0340-5761issn
1432-0738journal_volume
69pub_type
杂志文章abstract::Reactive oxygen species are generated during ischaemia-reperfusion of tissue. Oxidation of thymidine by hydroxyl radicals (HO) leads to the formation of 5,6-dihydroxy-5,6-dihydrothymidine (thymidine glycol). Thymidine glycol is excreted in urine and can be used as biomarker of oxidative DNA damage. Time dependent chan...
journal_title:Archives of toxicology
pub_type: 杂志文章
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更新日期:1999-11-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-019-02636-x
更新日期:2020-02-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
abstract::This discussion of the NEL presents some thoughts how toxicologists could be encouraged to use more sophisticated modern techniques for the study of various environmental chemicals. It is proposed to use the concept of the NEL only for data obtained by conventional techniques in routine toxicity experiments. Informati...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00695868
更新日期:1979-10-01 00:00:00
abstract::Diet is directly related with physiological alterations occurring at a cell and subcellular level. However, the role of diet manipulation on mitochondrial physiology is still largely unexplored. Aiming at correlating diet with alterations of mitochondrial membrane composition and bioenergetics, Wistar-Han male rats we...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-013-1068-7
更新日期:2013-12-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
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更新日期:1986-12-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF01973705
更新日期:1993-01-01 00:00:00
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更新日期:1991-01-01 00:00:00
abstract::3-monochloropropane-1,2-diol (3-MCPD), a rat renal and testicular carcinogen, has been reported to occur in various foods and food ingredients as free or esterified forms. Since reports about toxicity of 3-MCPD esters are limited, we conducted a 13-week rat subchronic toxicity study of 3-MCPD esters (palmitate diester...
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doi:10.1007/s00204-013-1190-6
更新日期:2014-04-01 00:00:00
abstract::Previous rat toxicity studies of alpha-glycosyl isoquercitrin (AGIQ), a water-soluble flavonol glycoside derived from rutin, revealed systemic yellow bone discoloration. This investigative study was conducted to determine the AGIQ metabolite(s) responsible for the discoloration. Female Sprague-Dawley rats were adminis...
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00324786
更新日期:1985-09-01 00:00:00
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更新日期:2020-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00204-002-0334-x
更新日期:2002-06-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040000128
更新日期:2000-08-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-004-0613-9
更新日期:2005-03-01 00:00:00
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journal_title:Archives of toxicology
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更新日期:1979-07-11 00:00:00
abstract::The mycotoxins altertoxin I and II (ATX I and II) are secondary metabolites produced by Alternaria alternata fungi and may occur as food and feed contaminants, especially after long storage periods. Although the toxic potential of altertoxins has been previously investigated, little is known about the pathways that pl...
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pub_type: 杂志文章
doi:10.1007/s00204-016-1726-7
更新日期:2017-01-01 00:00:00
abstract::Cyclic AMP (c-AMP), added on its own to rat hepatocyte cultures, caused a marked accumulation of coproporphyrin III. The results obtained by comparing the effect of c-AMP to that of exogenous 5-aminolevulinate (ALA), and from adding c-AMP and ALA together, indicated that the coproporphyrinogen III metabolism was block...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-004-0637-1
更新日期:2005-07-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050429
更新日期:1997-01-01 00:00:00
abstract::Thanks to the confluence of genome sequencing and bioinformatics, the number of metabolic databases has expanded from a handful in the mid-1990s to several thousand today. These databases lie within distinct families that have common ancestry and common attributes. The main families are the MetaCyc, KEGG, Reactome, Mo...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-011-0705-2
更新日期:2011-09-01 00:00:00
abstract::The metabolism of arsenic is generally accepted to proceed by repetitive reduction and oxidative methylation; the latter is mediated by arsenic methyltransferase (Cyt19). In human urine, the major metabolites of inorganic arsenicals such as arsenite (iAsIII) and arsenate (iAsV) are monomethylarsonic acid (MMA(V)) and ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-004-0620-x
更新日期:2005-04-01 00:00:00
abstract::Increasing incidence of multidrug-resistant bacteria presents an imminent risk to global health. Polymyxins are 'last-resort' antibiotics against Gram-negative 'superbugs'; however, nephrotoxicity remains a key impediment in their clinical use. Molecular mechanisms underlying this nephrotoxicity remain poorly defined....
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-018-2192-1
更新日期:2018-07-01 00:00:00
abstract::The present experiments were performed to test the possibility of interrupting the enterohepatic circulation of arsenic (As). Therefore the efficacy of adsorbents to bind As and/or As-DMPS adducts in vitro and their effect on the excretion of As into the feces and urine in vivo were investigated after injection of As2...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050237
更新日期:1995-01-01 00:00:00
abstract::In order to study the mechanisms of acute n-hexane intoxication, the effects of n-hexane and its metabolites 2-hexanol, methyl-n-butyl ketone, 2,5-hexanediol and 2,5-hexanedione on the cloned voltage-operated potassium channels Kv1.1, Kv1.4, Kv2.1 and Kv3.4 were investigated with electrophysiological techniques in the...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s002040050382
更新日期:1997-01-01 00:00:00
abstract::Gebel (In Arch Toxicol 87(5):923-924, 2013) replied to my Letter to the Editor (Morfeld in Arch Toxicol 87(5):921, 2013) in which I criticized the quantitative review of inhalation rat studies on the association of granular biopersistent dust exposures and lung cancer risk (Gebel in Arch Toxicol 86(7):995-1007, 2012)....
journal_title:Archives of toxicology
pub_type: 评论,信件
doi:10.1007/s00204-013-1138-x
更新日期:2013-11-01 00:00:00