High blood pressure is one of the symptoms of paraquat-induced toxicity in rats.

abstract：:Quercetin (QC), a polyphenolic compound widely distributed in fruits and vegetables has recently gained interest due to its cisplatin (CP) sensitizing properties in cancer cells. It is currently unknown, whether quercetin also increases the susceptibility of the kidneys to cisplatin toxicity. We studied the effects of...

journal_title：Archives of toxicology

authors： Kuhlmann MK,Horsch E,Burkhardt G,Wagner M,Köhler H

更新日期：1998-07-01 00:00:00

abstract：:Previous human and experimental studies have demonstrated that lead exposure may modify the metabolism of lipids. Several studies have indicated that exposure to lead produces an increase in lipid peroxidation and inhibits blood superoxide dismutase activity. Recently, lipid peroxides have been shown to impair tissue ...

journal_title：Archives of toxicology

authors： Skoczyńska A,Smolik R,Jeleń M

更新日期：1993-01-01 00:00:00

abstract：:Many in the welding industry suffer from bronchitis, lung function changes, metal fume fever, and diseases related to respiratory damage. These phenomena are associated with welding fumes; however, the mechanism behind these findings remains to be elucidated. In this study, the lungs of cynomolgus monkeys were exposed...

journal_title：Archives of toxicology

authors： Heo JD,Oh JH,Lee K,Kim CY,Song CW,Yoon S,Han JS,Yu IJ

更新日期：2010-03-01 00:00:00

abstract：:Recently, acutely toxic doses of the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been reported to affect the hepatic distribution of essential metals in the rat. However, the reduced food intake by TCDD was not taken into account. Therefore, metal concentrations were determined in different...

journal_title：Archives of toxicology

authors： Elsenhans B,Forth W,Richter E

更新日期：1991-01-01 00:00:00

abstract：:Aspergillus versicolor and A. flavus are primary colonizers in damp dwellings, and they produce sterigmatocystin (ST) and aflatoxin B1 (AFB(1)), respectively. These hepatotoxic and carcinogenic mycotoxins and their precursors and derivates possess a furofuran ring, which has proven responsible for their toxicity. The ...

journal_title：Archives of toxicology

authors： Jakšić D,Puel O,Canlet C,Kopjar N,Kosalec I,Klarić MŠ

更新日期：2012-10-01 00:00:00

abstract：:The evaluation of developmental and reproductive toxicity of food contact materials (FCMs) is an important task for food safety. Since traditional experiments are both time-consuming and labor-intensive, only a small number of FCMs have sufficient toxicological data for evaluating their effects on human health. While ...

journal_title：Archives of toxicology

authors： Tung CW,Cheng HJ,Wang CC,Wang SS,Lin P

更新日期：2020-02-01 00:00:00

abstract：:Cadmium chloride was administered by gavage to female rats 5 days a week for 5 weeks, then during mating and gestation periods at doses of 0.04, 0.4, and 4 mg Cd/kg/day. Treatment with cadmium neither affected the survival and fertility of females, nor produced overt fetotoxic effects. Fetal cadmium concentration was ...

journal_title：Archives of toxicology

authors： Barański B,Stetkiewicz I,Sitarek K,Szymczak W

更新日期：1983-12-01 00:00:00

abstract：:Monolayers of L6 rat skeletal myoblast cells formed surface binding isotherms with the purified tobacco leaf glycoprotein TGP1 and the enriched cigarette tar glycoprotein TGP2. Scatchard analysis showed that the binding in the range of the limited concentrations tested was to a single class molecule and the calculated...

journal_title：Archives of toxicology

authors： Santos-Buch CA,Hall HR,Farfan F,Orlow I,Firpo A,von Kreuter BF,Becker CG

更新日期：1995-01-01 00:00:00

abstract：:The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-κB family members and their regula...

journal_title：Archives of toxicology

authors： Li F,Zhang J,Arfuso F,Chinnathambi A,Zayed ME,Alharbi SA,Kumar AP,Ahn KS,Sethi G

更新日期：2015-05-01 00:00:00

abstract：:False-negative judgment due to poor chemical solubility is a problem with in vitro skin sensitisation tests. Water-insoluble chemicals are typically dissolved in DMSO in most sensitisation tests but precipitate when diluted with medium beyond their solubility in water. Such tests lack procedures to rule out false-nega...

journal_title：Archives of toxicology

authors： Kimura Y,Fujimura C,Aiba S

更新日期：2020-10-17 00:00:00

abstract：:Cadmium (Cd), an occupational and environmental pollutant, induces nephrotoxicity by primarily damaging renal proximal tubular cells. In this study, we hypothesized that pyroptosis, a caspase-1-dependent inflammatory programmed cell death mechanism, mediates Cd-induced nephrotoxicity. Human proximal tubular epithelial...

journal_title：Archives of toxicology

authors： Chou X,Ding F,Zhang X,Ding X,Gao H,Wu Q

更新日期：2019-04-01 00:00:00

abstract：:Acrylamide (AA) is a widely studied industrial chemical that is neurotoxic, mutagenic to somatic and germ cells, and carcinogenic in rodents. The recent discovery of AA at ppm levels in a wide variety of commonly consumed foods has energized research efforts worldwide to define toxicity and prevention. Metabolism and ...

journal_title：Archives of toxicology

authors： Kurebayashi H,Ohno Y

更新日期：2006-12-01 00:00:00

abstract：:The reliable analytical method for total morphine in hair was established by GC/MS-SIM. The calibration curve for morphine in hair showed linear over 0.5-100 ng/mg hair. Though the limit of detection was 0.1 ng/mg hair with an S/N > 3 of the base ion(m/z 429) for morphine, the limit of confirmation by detection of thr...

journal_title：Archives of toxicology

authors： Nakahara Y,Takahashi K,Shimamine M,Saitoh A

更新日期：1992-01-01 00:00:00

abstract：:Neurotoxic properties of acrylamide and seven related compounds in rats were studied with regard to the effects on rotarod performance, morphology of nerves and neurotubulin. Compounds used in the present study were acrylamide, N-hydroxymethylacrylamide, N-isopropylacrylamide, methacrylamide, N-methylacrylamide, croto...

journal_title：Archives of toxicology

authors： Tanii H,Hashimoto K

更新日期：1983-11-01 00:00:00

abstract：:Female C57/BL/6 x DBA/2 hybrid mice were exposed to two concentrations (270 and 135 ppm) of tetrachloroethylene (PER) in inhalation chambers for 6 h/day, 5 days per week, up to 11.5 weeks (270 ppm) and 7.5 weeks (135 ppm), respectively, followed by a 3-week exposure-free period. In the peripheral blood a reduction of ...

journal_title：Archives of toxicology

authors： Seidel HJ,Weber L,Barthel E

更新日期：1992-01-01 00:00:00

abstract：:In vitro assays are often used for the hazard characterisation of compounds, but their application for quantitative risk assessment purposes is limited. This is because in vitro assays cannot provide a complete in vivo dose-response curve from which a point of departure (PoD) for risk assessment can be derived, like t...

journal_title：Archives of toxicology

authors： Strikwold M,Spenkelink B,Woutersen RA,Rietjens IM,Punt A

更新日期：2013-09-01 00:00:00

abstract：:In the isolated liver transient perfusion without calcium results in cholestasis which was characterized by an increased efflux rate across the sinusoidal membrane and inhibition of the concentrative transport of bromosulfophthalein to the canalicular side of the cell. Cholestasis could not be reversed within the usua...

journal_title：Archives of toxicology

authors： Höke H,Krell H,Pfaff E

更新日期：1980-03-01 00:00:00

abstract：:Rats were administered a sublethal dose of thallium (12.35 mg/kg as aqueous thallous sulfate, Tl2SO4, equivalent to 10 mg Tl+/kg per os) on day 0. Urine and feces were collected separately every day for 8 days and analyzed by atomic absorption spectroscopy. Based on information in the literature, five antidotal treatm...

journal_title：Archives of toxicology

authors： Lehmann PA,Favari L

更新日期：1985-04-01 00:00:00

abstract：:Long-term exposure of rats to cadmium (Cd) resulted in a marked suppression of erythropoietin (Epo) mRNA expression in the kidneys and the development of severe anemia. A recent report revealed that Cd inhibited hypoxia-inducible factor 1 (HIF-1) binding activity and Epo mRNA expression and protein production. However...

journal_title：Archives of toxicology

authors： Obara N,Imagawa S,Nakano Y,Suzuki N,Yamamoto M,Nagasawa T

更新日期：2003-05-01 00:00:00

abstract：:The elevations of blood urea nitrogen and serum creatinine caused by cis-platinum in rats can be prevented by a combination of procedures centered around the administration of sodium N-methyl-N-dithiocarboxyglucamine (NaG), before and very soon after the cis-platinum is administered in hypertonic (4.5%) saline. Elevat...

journal_title：Archives of toxicology

authors： Jones MM,Basinger MA,Craft WD,Domingo JL,Llobet JM

更新日期：1986-10-01 00:00:00

abstract：:The possible interrelationships between the effects of dietary selenium and perfluorodecanoic acid (PFDA) on growth and lipid metabolism were studied in the male Sprague Dawley rat. Rats were divided into groups and placed on diets containing three levels of selenium (0.04, 0.2, and 1.0 ppm as sodium selenite). Two we...

journal_title：Archives of toxicology

authors： Borges T,Glauert HP,Chen LC,Chow CK,Robertson LW

更新日期：1990-01-01 00:00:00

abstract：:Due to its unique physical structure and chemical properties, graphene family nanomaterials (GFNs) and derived commodities have been widely used in commercial products, particularly biomedical applications, which has significantly increased the risk of human exposure. There exists significant evidence that GFNs are ac...

journal_title：Archives of toxicology

authors： Xiaoli F,Qiyue C,Weihong G,Yaqing Z,Chen H,Junrong W,Longquan S

更新日期：2020-06-01 00:00:00

abstract：:The involvement of oxidative stress has been suggested as a mechanism for neurotoxicity caused by methylmercury (MeHg), but the mechanism for MeHg selective toxicity in the central nervous system is still unclear. In this research, to clarify the mechanism of selective neurotoxicity caused by MeHg, the oxygen consumpt...

journal_title：Archives of toxicology

authors： Mori N,Yasutake A,Hirayama K

更新日期：2007-11-01 00:00:00

abstract：:203Pb(NO3)2 was administered i.v. to pregnant C57BL mice at different stages, from day 8 to day 18 of gestation. The whole animals or excised uteri were subjected to autoradiography or were autopsied for scintillation counting of excised organs. Lead appeared in embryonic and fetal tissues at all stages of gestation. ...

journal_title：Archives of toxicology

authors： Danielsson BR,Dencker L,Lindgren A

更新日期：1983-10-01 00:00:00

abstract：:People living in damp buildings are typically exposed to spore and mycelial fragments of the fungi that grow on damp building materials. There is experimental evidence that this exposure to triple-helical (1, 3)-β-D glucan and low molecular weight toxins may be associated with non-atopic asthma observed in damp and mo...

journal_title：Archives of toxicology

authors： Rand TG,Robbins C,Rajaraman D,Sun M,Miller JD

更新日期：2013-10-01 00:00:00

abstract：:The binding characteristics of [14C]ortho-toluidine (OT), a suspect human carcinogen, were investigated in male Sprague-Dawley rats. Rats were administered [14C]OT i.p. at 10, 20, 40, 50, or 100 mg/kg body weight, then sacrificed at 2, 4, 8, 18, 24, 48, or 72 h, or 7, 14, or 28 days. Hemoglobin (Hb) and albumin (Alb) ...

journal_title：Archives of toxicology

authors： DeBord DG,Swearengin TF,Cheever KL,Booth-Jones AD,Wissinger LA

更新日期：1992-01-01 00:00:00

abstract：:Previously we reported that exposure of mouse and human mast cells to aryl hydrocarbon receptor (AhR) ligands resulted in reactive oxygen species (ROS)- and calcium (Ca2+)-dependent activation of mast cells in vitro and in vivo. However, the mechanisms through which the AhR-ligand axis mediates stress response, Ca2+ s...

journal_title：Archives of toxicology

authors： Wang HC,Zhou Y,Huang SK

更新日期：2017-04-01 00:00:00

abstract：:Amygdalin (D-mandelonitrile-beta-D-gentiobioside) is a cyanogenic glycoside claimed to show anti-cancer activity, sold under the incorrect name "Laetrile". For a sensible discussion of its alleged activity and its established toxicity it is necessary that its fate in the organism is known. The pharmacokinetics of amyg...

journal_title：Archives of toxicology

authors： Rauws AG,Olling M,Timmerman A

更新日期：1982-03-01 00:00:00

abstract：:Cadmium, copper and zinc have been determined in kidney cortex, kidney medulla and liver from 51 cadmium-polluted and 122 nonpolluted autopsied subjects. Liver cadmium and zinc were significantly higher in the cadmium-polluted subjects than in the nonpolluted subjects. Kidney cadmium, copper and zinc were lower in the...

journal_title：Archives of toxicology

authors： Honda R,Nogawa K

更新日期：1987-04-01 00:00:00

abstract：:Chemical formation of dichlorvos (2, 2-dichlorovinyl dimethyl phosphate) was found to occur in mouse brain after i.p. injection of metrifonate (2, 2, 2-trichloro-1-hydroxyethyl dimethyl phosphonate). A mass fragmentographic technique was used. Different isotopic variants were used both as internal standards and to com...

journal_title：Archives of toxicology

authors： Nordgren I,Bergström M,Holmstedt B,Sandoz M

更新日期：1978-10-13 00:00:00