Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose-response curves for developmental toxicity of phenol in rat and human.

abstract：:Okadaic acid (OA) is produced by several types of dinoflagellates (marine plankton) and has been implicated as the causative agent of diarrhetic shellfish syndrome. Previous studies have shown that okadaic acid is a tumor promoter and a specific potent inhibitor of protein phosphatases and protein synthesis. These eff...

journal_title：Archives of toxicology

authors： Traoré A,Baudrimont I,Dano S,Sanni A,Larondelle Y,Schneider YJ,Creppy EE

更新日期：2003-11-01 00:00:00

abstract：:Arsenic-containing hydrocarbons (AsHCs), a subgroup of arsenolipids found in fish and algae, elicit substantial toxic effects in various human cell lines and have a considerable impact on cellular energy levels. The underlying mode of action, however, is still unknown. The present study analyzes the effects of two AsH...

journal_title：Archives of toxicology

authors： Müller SM,Finke H,Ebert F,Kopp JF,Schumacher F,Kleuser B,Francesconi KA,Raber G,Schwerdtle T

更新日期：2018-05-01 00:00:00

abstract：:Using male ICR mice, the LC50 and acute and subacute inhalation toxicity of dichlorosilane (SiH2Cl2, DCS) and the fate of DCS released into the air were investigated. DCS resolved and minute particles including silicon and chloride were observed, when DCS was released into the air. Most particles were under 1 micron i...

journal_title：Archives of toxicology

authors： Nakashima H,Omae K,Takebayashi T,Ishizuka C,Sakurai H,Yamazaki K,Nakaza M,Shibata T,Kudo M,Koshi S

更新日期：1996-01-01 00:00:00

abstract：:The ultimate purpose of the present study was to evaluate correlations between acute in vivo and in vitro toxicity and log P (P is n-octanol-water partition coefficient). The in vitro toxicity to cloned cells (neuroblastoma N18TG-2 and glioma C6) in culture (ED50) and the in vivo toxicity to mice (LD50) of ethylene gl...

journal_title：Archives of toxicology

authors： Tanii H,Saito S,Hashimoto K

更新日期：1992-01-01 00:00:00

abstract：:Exposure to alkylanilines found in tobacco smoke and indoor air is associated with risk of bladder cancer. Genetic factors significantly influence the metabolism of arylamine carcinogens and the toxicological outcomes that result from exposure. We utilized nucleotide excision repair (NER)-deficient immortalized human ...

journal_title：Archives of toxicology

authors： Leggett CS,Doll MA,States JC,Hein DW

更新日期：2021-01-01 00:00:00

abstract：:Cytotoxic effects of cyclophosphamide (CPA), paclitaxel (PCT), and docetaxel (DTX) and their modulation by cytochrome P450 (CYP) metabolism were studied by incubating cell lines L929 and P388D1 with or without rat liver microsomes. The microsomes themselves were not cytotoxic. P388D1 cells were more sensitive to CPA, ...

journal_title：Archives of toxicology

authors： Gut I,Danielová V,Holubová J,Soucek P,Klucková H

更新日期：2000-10-01 00:00:00

abstract：:The inhibitory effect and mechanism of action of nicotinamide to paraquat toxicity were studied in male Sprague-Dawley rats. Proteins of submitochondrial particles (SMP), especially of mol. wt. 25-30 kDa, in rat lungs were destroyed by paraquat radicals, and aggregated protein bands approximately 100 kDa were observed...

journal_title：Archives of toxicology

authors： Fukushima T,Gao T,Tawara T,Hojo N,Isobe A,Yamane Y

更新日期：1997-01-01 00:00:00

abstract：:The circadian rhythms of HMG-CoA reductase and cholesterol-7 alpha-hydroxylase (low values, during light, rising in the evening with maximum at 12.00 p.m.) are investigated in rats under diverse conditions. Intragastral administration of cholestyramine (bile acid-absorbing resin) leads to an increased rhythm of both e...

journal_title：Archives of toxicology

authors： Mayer D

更新日期：1976-12-17 00:00:00

abstract：:DNA damage induced by methylmethane sulfonate, cyclophosphamide, doxorubicin and procarbazine in male germ cells was assessed in rabbits by the demonstration of unscheduled DNA synthesis (UDS), in meiotic and postmeiotic phases of maturation. Immediately after treatment by the intravenous route tritiated thymidine was...

journal_title：Archives of toxicology

authors： Zbinden G

更新日期：1980-11-01 00:00:00

abstract：:Manufactured nanomaterials (MNMs) selected from a library of over 120 different MNMs with varied compositions, sizes, and surface coatings were tested by four different laboratories for toxicity by high-throughput/-content (HT/C) techniques. The selected particles comprise 14 MNMs composed of CeO2, Ag, TiO2, ZnO and S...

journal_title：Archives of toxicology

authors： Hansjosten I,Rapp J,Reiner L,Vatter R,Fritsch-Decker S,Peravali R,Palosaari T,Joossens E,Gerloff K,Macko P,Whelan M,Gilliland D,Ojea-Jimenez I,Monopoli MP,Rocks L,Garry D,Dawson K,Röttgermann PJF,Murschhauser A,Rädl

更新日期：2018-02-01 00:00:00

abstract：:The lacrimatory agent CS was examined for genotoxic properties. In vitro, Salmonella typhimurium was exposed to CS at concentrations up to 1.5 mg per plate and reverse mutations were assayed. In vivo: male Drosophilae were fed with CS and sex-linked recessive lethal mutations in sperm cells were assayed using the Basc...

journal_title：Archives of toxicology

authors： Wild D,Eckhardt K,Harnasch D,King MT

更新日期：1983-10-01 00:00:00

abstract：:New strategies are needed to address the data gap between the bioactivity of chemicals in the environment versus existing hazard information. We address whether a high-throughput screening (HTS) system using a vertebrate organism (embryonic zebrafish) can characterize chemical-elicited behavioral responses at an early...

journal_title：Archives of toxicology

authors： Reif DM,Truong L,Mandrell D,Marvel S,Zhang G,Tanguay RL

更新日期：2016-06-01 00:00:00

abstract：:Cholestasis underlies one of the major manifestations of drug-induced liver injury. Drug-induced cholestatic liver toxicity is a complex process, as it can be triggered by a variety of factors that induce 2 types of biological responses, namely a deteriorative response, caused by bile acid accumulation, and an adaptiv...

journal_title：Archives of toxicology

authors： Gijbels E,Vilas-Boas V,Deferm N,Devisscher L,Jaeschke H,Annaert P,Vinken M

更新日期：2019-05-01 00:00:00

abstract：:A young drug consumer died after sniffing and drinking chloroform. The method to determine chloroform in body fluids and tissues is described. The influence of the oral and pulmonary absorption in the view to cause of death is discussed. ...

journal_title：Archives of toxicology

authors： Iffland R,Ramme H

更新日期：1983-08-01 00:00:00

abstract：:The α,β-unsaturated carbonyl group is recognized as alert for mutagenicity, attributed to (1) its direct reaction with DNA, counteractable by glutathione (GSH), and (2) oxidative stress caused indirectly by GSH depletion. Accordingly, the α,β,γ,δ-unsaturated lactone patulin (PAT), a mycotoxin detected in fruits and pr...

journal_title：Archives of toxicology

authors： Pfenning C,Esch HL,Fliege R,Lehmann L

更新日期：2016-02-01 00:00:00

abstract：:Platinum coordination complexes (PtCx) are potent against several types of cancer but are often nephrotoxic. With a view to developing a PtCx nephrotoxicity model, the toxicity of cisplatin (cDDP), transplatin (tDDP) and carboplatin (CBDCA) was studied in primary cultures of rabbit proximal tubule (RPT) cells and in t...

journal_title：Archives of toxicology

authors： Courjault F,Leroy D,Coquery L,Toutain H

更新日期：1993-01-01 00:00:00

abstract：:Recently, acutely toxic doses of the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been reported to affect the hepatic distribution of essential metals in the rat. However, the reduced food intake by TCDD was not taken into account. Therefore, metal concentrations were determined in different...

journal_title：Archives of toxicology

authors： Elsenhans B,Forth W,Richter E

更新日期：1991-01-01 00:00:00

abstract：:Spin trapping in vivo was first achieved in the author's laboratory and is shown to be a feasible method for demonstrating that highly reactive free radical intermediates are generated in the tissues of intact animals as a result of the exposure to certain toxic compounds and to ionizing radiation. The method is based...

journal_title：Archives of toxicology

authors： McCay PB

更新日期：1987-01-01 00:00:00

abstract：:Drug-induced liver injury (DILI) continues to be a major source of clinical attrition, precautionary warnings, and post-market withdrawal of drugs. Accordingly, there is a need for more predictive tools to assess hepatotoxicity risk in drug discovery. Three-dimensional (3D) spheroid hepatic cultures have emerged as pr...

journal_title：Archives of toxicology

authors： Proctor WR,Foster AJ,Vogt J,Summers C,Middleton B,Pilling MA,Shienson D,Kijanska M,Ströbel S,Kelm JM,Morgan P,Messner S,Williams D

更新日期：2017-08-01 00:00:00

abstract：:The aim of this study was to assess the neurotoxicity of diazinon oxon (DZO), a major in vivo metabolite of the phosphorothionate insecticide diazinon (DZ), on differentiating mouse N2a neuroblastoma cells. When used at concentrations of 1, 5 and 10 microM, DZO did not cause cell death but it impaired the outgrowth of...

journal_title：Archives of toxicology

authors： Sidiropoulou E,Sachana M,Flaskos J,Harris W,Hargreaves AJ,Woldehiwet Z

更新日期：2009-04-01 00:00:00

abstract：:We have used the minipig as a prospective animal model for human risk characterization to study primary biochemical alterations upon oral contaminant intake. The effects of three orally administered soils containing polycyclic aromatic hydrocarbons (PAH) on the expression pattern of the cytochrome P450 enzyme CYP1A1 i...

journal_title：Archives of toxicology

authors： Roos PH,Tschirbs S,Welge P,Hack A,Theegarten D,Mogilevski G,Wilhelm M

更新日期：2002-06-01 00:00:00

abstract：:Previous studies indicate that benzanthrone, an anthraquinone dye intermediate, caused significant depletion of ascorbic acid (AsA). In this investigation the effect of benzanthrone on the status of different forms of AsA and other bio-antioxidants such as glutathione (GSH) was studied. Oral administration of benzanth...

journal_title：Archives of toxicology

authors： Dwivedi N,Das M,Khanna SK

更新日期：2001-06-01 00:00:00

abstract：:Garenoxacin is a des-F(6)-quinolone with a broad antibacterial spectrum, which has previously been shown to exhibit low chondrotoxicity in juvenile dogs compared with several other quinolones. A study was performed to determine whether the low chondrotoxicity observed in immature rats following garenoxacin treatment c...

journal_title：Archives of toxicology

authors： Kastner M,Rahm U,Baumann-Wilschke I,Bello A,Stahlmann R

更新日期：2004-02-01 00:00:00

abstract：:Inhalation exposure to toluene diisocyanate (TDI) can result in a variety of airway diseases. Concern has been expressed that a putative carcinogenic potential of TDI exists as a result of the formation of toluenediamine (TDA) by hydrolysis of the isocyanate in the body. Results from long-term bioassays (TDI inhalatio...

journal_title：Archives of toxicology

authors： Kennedy AL,Wilson TR,Stock MF,Alarie Y,Brown WE

更新日期：1994-01-01 00:00:00

abstract：:Etridiazole, 5-ethoxy-3-trichloromethyl-1,2,4-thiadiazole, was orally administered to rats and human volunteers. Two metabolites of etridiazole were synthesized: 5-ethoxy-1,2,4-thiadiazole-3-carboxylic acid (ET-CA) and N-acetyl-S-(5-ethoxy-1,2,4-thiadiazol-3-yl-methyl)-L-cysteine (ET-MA). Selective and sensitive analy...

journal_title：Archives of toxicology

authors： van Welie RT,Mensert R,Van Duyn P,Vermeulen NP

更新日期：1991-01-01 00:00:00

abstract：:A rapid gas-chromatographic method for the qualitative and quantitative measurement of various drugs in human plasma and other body fluids has been developed. The extraction procedure is done within 5 min, and gas-chromatographic measurement carried out on 2 diverse columns with detection by flame ionisation detectors...

journal_title：Archives of toxicology

authors： Pentz R,Schütt A

更新日期：1978-01-25 00:00:00

abstract：:A method is outlined to estimate from hemodialysis or hemoperfusion data, respectively, the rate constants, the distribution volume in the beta-phase, and other pharmacokinetic parameters of toxic substances. All calculations are based on the assumption that the usual linear open two-compartment system is also the app...

journal_title：Archives of toxicology

authors： Wellhöner HH

更新日期：1983-05-01 00:00:00

abstract：:Nine bispyridinium oximes containing two pyridinium rings linked by dimethylether were synthesised. Each compound had on one of the pyridinium rings a hydroxyiminomethyl group in position 2 or 4, while the other ring was unsubstituted or had a methyl or a hydroxyiminomethyl group in position 2 or 4. The reactivating p...

journal_title：Archives of toxicology

authors： Simeon V,Wilhelm K,Granov A,Besarović-Lazarev S,Buntić A,Fajdetić A,Binenfeld Z

更新日期：1979-02-23 00:00:00

abstract：:The objective of this study was to evaluate the role of apoptosis in the development of the newborn cochlear structures and hearing loss caused by prenatal cis-diaminedichloroplatinum (cisplatin) exposure. Pregnant albino guinea pigs were intraperitoneally injected with 1.5 mg/kg body weight cisplatin once a day for s...

journal_title：Archives of toxicology

authors： Hao S,Jiang X,Yan A,Yang B

更新日期：2011-01-01 00:00:00

abstract：:Organophosphorus (OP) pesticides and nerve agents still pose a threat to the population. Treatment of OP poisoning is an ongoing challenge and burden for medical services. Standard drug treatment consists of atropine and an oxime as reactivator of OP-inhibited acetylcholinesterase and is virtually unchanged since more...

journal_title：Archives of toxicology

authors： Worek F,Thiermann H,Wille T

更新日期：2020-07-01 00:00:00